EXELIXIS, INC. — Director's Dealing 2025

Nov 25, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: EXELIXIS, INC. (EXEL)
CIK: 0000939767
Period of Report: 2025-11-20

Reporting Person: Haley Patrick J. (EVP, Commercial)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-11-20	Common Stock	S	10000	$42.11	Disposed	402072	Direct
2025-11-20	Common Stock	S	23539	$41.93	Disposed	0	Indirect
2025-11-20	Common Stock	S	10648	$41.77	Disposed	0	Indirect
2025-11-21	Common Stock	S	28043	$42.58	Disposed	374029	Direct

Footnotes

F1: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $42.10 to $42.13. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 1 to this Form 4.

F2: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based
restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

F3: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $41.87 to $41.99. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 3 to this Form 4.

F4: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $41.77 to $41.79. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 4 to this Form 4.

F5: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $42.51 to $42.71. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 5 to this Form 4.