EXELIXIS, INC. — Director's Dealing 2025

Dec 5, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: EXELIXIS, INC. (EXEL)
CIK: 0000939767
Period of Report: 2025-12-03

Reporting Person: Hefti Brenda (SVP and General Counsel)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-12-03	Common Stock	A	30170	—	Acquired	120611	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	5527	Indirect

Footnotes

F1: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on February 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each February 15th until fully vested.

F2: Includes 110,745 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

F3: Represents shares of Common Stock under the Exelixis, Inc. 401(k) Plan, pursuant to a plan statement dated as of December 2, 2025.