EXAGEN INC.

Regulatory Filings • Jun 30, 2025

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EXAGEN INC.

1261 LIBERTY WAY

VISTA, CA 92081

June 30, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Robert Augustin

Re: Exagen Inc.

Registration Statement on Form S-3

File No. 333-288199 (the “Registration Statement”)

Acceleration Request

Ladies and Gentlemen:

In accordance with Rule 461 of Regulation C promulgated under the Securities Act of 1933, as amended, Exagen Inc. (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Wednesday, July 2, 2025, at 4:01p.m., Eastern Time, or as soon as thereafter practicable.

The cooperation of the staff in meeting the timetable described above is very much appreciated.

Please contact Scott M. Stanton or Jason Miller of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (858) 314-1880 or (858) 314-2140, respectively, with any questions regarding this request.

Very truly yours,
EXAGEN INC.
/s/ John Aballi
John Aballi, Chief Executive Officer

cc: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Scott Stanton, Esq.

Jason Miller, Esq.