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Evotec SE — Interim / Quarterly Report 2022
Nov 9, 2022
151_10-q_2022-11-09_e88941db-3854-44a0-b664-853d9c605b44.pdf
Interim / Quarterly Report
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INTERIM STATEMENT 9M 2022


HIGHLIGHTS
- MULTIPLE NEW AND EXTENDED ALLIANCES IN ALL AREAS
- PARADIGM SHIFT IN BIOLOGICS STARTING ITS MARKET ENTRY STRATEGY
- COMMERCIAL LAUNCH OF NEXT-GENERATION MULTI-OMICS DATA ANALYSIS PLATFORM PANHUNTER
EVOTEC'S TOPLINE SUCCESS REFLECTS STRONG OVERALL DEMAND
- Group revenues increased by 19% (13% excluding fx-effects) to € 510.8 m (9M 2021: € 431.0 m), despite significantly lower milestones, upfronts and license payments compared to a very strong comparable basis in 2021 (9M 2022: € 8.1 m vs. € 36.5 m in 9M 2021); base business at € 502.7 m continued to show very strong growth of 27% (9M 2021: € 394.5 m).
- Strong progress in both segments: Total EVT Execute revenues (incl. intersegment revenues) up 23% to € 526.7 m (9M 2021: € 429.8 m); EVT Innovate revenues up 20% to € 121.9 m (9M 2021: € 101.9 m), against a very high comparable basis.
- Other non-operating result of € (119.6) m (9M 2021: € 228.8 m), mainly driven by the non-cash fair value adjustments of the equity investment in publicly listed Exscientia plc.
- Adjusted Group EBITDA totalled € 44.6 m (9M 2021: € 70.1 m); influenced by high expenses for capacity expansion to support the overall growth of Evotec, significantly inflated energy costs as well as lower contribution from milestones, upfronts and licenses, partially offset by positive fx-effects (€ 12.4 m); Just – Evotec Biologics is in its planned ramp up phase; Adjusted EBITDA excluding Just - Evotec Biologics at € 84.6 m (9M 2021: € 74.0 m).
SHARED R&D PLATFORMS FOR HIGHER PROBABILITIES OF SUCCESS (POS)
- Multiple new and extended integrated drug discovery and development agreements all along the drug discovery & development value chain (e.g., integrated drug discovery agreement with Viotika, commercial manufacturing with Zogenix, ADME Tox agreements with UCB…)
- Successful achievement of four performance-based milestones within existing partnerships; one IND submission, one preclinical development candidate nomination and one lead optimisation start
- Significant progress within neuroscience collaboration with Bristol Myers Squibb ("BMS")
- Expansion of E.MPD molecular patient database into autoimmune diseases through partnership with Hannover Medical School ("MHH") (after period-end)
- Paradigm shift in biologics with Just Evotec Biologics: Foundation laid for accelerated revenue growth through multiple new development and manufacturing agreements, e.g., with Alpine Immune Sciences; ground-breaking for second new biologics facility J.POD® Toulouse, France, on 16 September
- J.POD® Redmond, Washington (US) joined the U.S. Department of Defense's ("DOD") Advanced Development and Manufacturing network of facilities and wins a first contract worth up to \$ 49.9 m; second award with the U.S. Department of Defense ("DOD") granted after period end.
- Commercial launch of proprietary next-generation multi-omics data analysis platform PanHunter (after period-end).
- Expansion of BRIDGE LAB150 to include Amgen as a strategic partner (after period-end)

CORPORATE
Expansion of clinical and commercial drug substance manufacturing capacities through acquisition of Central Glass Germany, operating as Evotec Drug Substance (Germany) GmbH ("Evotec DS").
BUSINESS OUTLOOK FOR FULL-YEAR 2022 UNCHANGED AND MID-TERM TARGETS 2025 CONFIRMED
- Group revenues expected to be in a range of € 715 735 m or € 690 710 m at constant exchange rates (2021: € 618 m).
- Adjusted Group EBITDA expected to be unchanged in the range of € 105 120 m, translating into € 85 – 100 m at constant exchange rates (2021: € 107 m).
- Unpartnered research and development expenses expected to be in a range of € 70 80 m (2021: € 58 m).
- Mid-term goals target revenue growth to > € 1,000 m, adjusted EBITDA of ≥ € 300 m and unpartnered research and development expenses of > € 100 m.
The forecast takes in account – as far as possible – the current increased global uncertainties related to e.g., the COVID-19 pandemic and the war in Ukraine, resulting in uncertainty around the global price and supply situation for energy, other raw materials and supplies as well as logistics relevant to the business. M&A related costs have not been part of the initial guidance and will therefore be excluded.

FINANCIAL HIGHLIGHTS
The following table provides an overview of the financial performance in the first nine months of 2022 compared to the same period in 2021. More detailed information can be found on page 7 of this interim statement.
Key figures of consolidated income statement & segment information
Evotec SE & subsidiaries – First nine months of 2022
| In T€ | EVT Execute |
EVT Innovate |
Intersegment Eliminations |
Evotec Group 9M 2022 |
Evotec Group 9M 2021 |
|---|---|---|---|---|---|
| Revenues1) | 388,828 | 121,931 | – | 510,759 | 430,963 |
| Intersegment revenues | 137,876 | – | (137,876) | – | – |
| Costs of revenues | (441,332) | (104,578) | 126,760 | (419,150) | (331,494) |
| Gross profit | 85,372 | 17,353 | (11,116) | 91,609 | 99,469 |
| Gross margin in % | 16.2 | 14.2 | – | 17.9 | 23.1 |
| R&D expenses2) | (4,231) | (62,206) | 11,116 | (55,321) | (53,472) |
| SG&A expenses | (88,178) | (21,680) | – | (109,858) | (71,037) |
| Impairments of intangible assets |
– | – | – | – | (683) |
| Other operating income (expenses), net |
25,288 | 31,446 | – | 56,734 | 51,776 |
| Net operating income (loss) |
18,251 | (35,087) | – | (16,836) | 26,053 |
| Adjusted EBITDA3) | 75,826 | (31,226) | – | 44,600 | 70,086 |
1) Adjusted for exchange rate effects of € 26.1 m, Group revenues would have amounted to € 484.6 m
2) Includes unpartnered R&D expenses of € 50.7 m in 9M 2022 (9M 2021: € 42.6 m)
3) Before changes in contingent consideration, income from bargain purchase and excluding impairments on goodwill, other intangible and tangible assets as well as the total non-operating result
OPERATIONAL HIGHLIGHTS
Note: In the wake of the Russian invasion of Ukraine, rising energy prices are significantly affecting Evotec. We have analysed related effects on our operations and results, and we are actively implementing measures to save energy in order to reduce the impact.
Evotec does not entertain any direct business relations with Russian companies and is therefore not directly affected on the revenue side.
Multiple new and extended integrated drug discovery and development agreements
In the first nine months of 2022, Evotec showed a strong operational and scientific performance based on its fully integrated R&D platform. Initiation of new partnerships in addition to the extension of existing alliances across the various stages of drug discovery and development, as well as across modalities and business areas have taken place, such as:
- Signing of several new CMC and INDiGO agreements
- Initiation of multiple integrated drug discovery collaboration agreements e.g., with Viotika
- Cyprotec extended and initiated multiple agreements in ADME Tox (e.g., UCB)
- Successful achievement of four performance-based milestones within existing partnerships; one IND submission, one preclinical development candidate nomination and one lead optimisation start
Paradigm shift in biologics with Just – Evotec Biologics
In September, the construction of the second J.POD® facility, J.POD® Toulouse, France (EU) at Evotec's Campus Curie has been initiated. The facility is expected to be operational in H2 2024. Also, in September, Just – Evotec Biologics' existing facility J.POD® Redmond, Washington (US) joined the U.S. Department of Defense's ("DOD") Advanced Development and Manufacturing network of facilities. Following a
thorough vetting process this led to the signing of a contract worth up to \$ 49.9 m for the rapid development of monoclonal antibody-based drug product prototypes targeting plague. After period-end, Just – Evotec Biologics has been selected for a second award under the DOD's Accelerated Antibodies Program.
In August, Evotec's Seattle-based subsidiary expanded a multi-year partnership with Alpine Immune Sciences, leveraging its data-driven technology platform to develop a commercial manufacturing process for ALPN-303.
Several other projects are currently under negotiation.
Significant progress within neuroscience collaboration with Bristol Myers Squibb
In Q3 2022, BMS designated a target-based programme for further development. The collaboration was initiated in December 2016 with the goal of identifying diseasemodifying treatments for a broad range of neurodegenerative diseases. The collaboration leverages Evotec's industrialised iPSC platform using patientderived disease models, which is one of the largest and most sophisticated platforms in the industry. A first programme originating from the collaboration, EVT8683, was in-licensed by BMS in September 2021, following the successful filing of an IND application with the FDA.
Several important milestone payments are expected within this alliance in Q4.
Expansion of Evotec's E.MPD molecular database into autoimmune diseases through partnership with Hannover Medical School ("MHH")
After period-end, Evotec announced a partnership with Hannover Medical School ("MHH"), one of the leading German universities, to generate a molecular patient database for Sjögren's syndrome ("SjS") and systemic lupus erythematosus ("SLE"). The strategic partnership between Evotec and MHH aims at achieving a better disease understanding of SjS and SLE by creating a unique longitudinal PanOmics
database from the analysis of patient material. Biospecimens from several hundred SjS and SLE patients will be collected by MHH and analysed on Evotec's PanOmics platform, which includes genomics, transcriptomics, proteomics, and metabolomics as well as single-cell sequencing technologies.
Launch of proprietary next-generation multiomics data analysis platform PanHunter (after period-end)
After period-end, Evotec launched a first commercial version of its PanOmics data analysis platform PanHunter at Bio-IT World. PanHunter is Evotec's PanOmics data access and analytics platform and was developed and used successfully internally and in industry-shaping drug discovery partnerships over many years. Evotec now makes PanHunter available to collaborators and partners as a software-as-a-service ("SaaS") product. PanHunter originates from Evotec's commitment towards patient-centric, PanOmics-driven drug discovery and is unique in its ability to integrate the analysis of PanOmics data, designed as an easy-touser yet fully comprehensive PanOmics data analysis platform.
CORPORATE
Expansion of clinical and commercial drug substance manufacturing capacities through acquisition of Central Glass Germany, now Evotec Drug Substance (Germany) GmbH ("Evotec DS")
On 3 November, Evotec announced that the acquisition of Central Glass Germany GmbH from the Japanese chemical manufacturing company Central Glass Co. Ltd., signed in August 2022, had been completed. Through this acquisition, the Company expands its clinical and commercial manufacturing platform for small molecule therapeutics and enhances and accelerates Evotec's strategy of pursuing integrated discovery and development of new medicines that matter. The significant reactor capacity and longstanding chemical expertise within Evotec DS provide a high quality, European-based solution to Evotec's partners for the development and commercialisation of drug substance. Once integrated into Evotec's existing drug substance development and manufacturing platform, the new site will offer the Company's partners highly flexible product lifecycle management strategies, particularly in the field of precision medicines and in rare diseases.
REPORT ON THE FINANCIAL SITUATION AND RESULTS
1. Results of operations
During the nine months ended 30 September 2022 Group revenues increased significantly by 19% to € 510.8 m compared with the same period of the previous year (9M 2021: € 431.0 m). The substantial rise against the prior-year period is based on a strong performance of the base business, compensating two effects: Just - Evotec Biologics is still in its ramp-up phase and revenues from milestones, upfronts and licenses were exceptionally strong last year. Excluding the recognition of positive fx -effects, Group revenues grew by 13% to € 487.3 m. Growth of the base business was 27% from € 394.5 m in 9M 2021 to € 502.7 m in the first nine months of 2022 (+32%, excluding Just - Evotec Biologics). Evotec received milestone, upfront and license payments of € 8.1 m (9M 2021: € 36.5 m). Just - Evotec Biologics contributed € 28.0 m during the nine months ended 30 September 2022 versus € 34.7 m in the comparable prior year period.
The Costs of revenue for the nine months ended 30 September 2022 amounted to € 419.2 m (9M 2021: € 331.5 m) yielding a gross margin of 17.9% (9M 2021: 23.1%). The increase was attributable to costs related to the strong growth of the overall business and the recognition of expenses related to expanding Evotec's precision medicine platforms as well as the nextgeneration biologics manufacturing facility in Redmond (US). Excluding effects related to the capacity build-up at Just – Evotec Biologics, total gross margin amounted to 27%.
R&D expenses were € 55.3 m, compared to € 53.5 m in the nine months ended 30 September 2021 (+3%), reflecting continued strong investments in Evotec's capabilities to improve our efficiency and precision medicine platforms. Therefore, the increase in unpartnered R&D expenses by 19% (€ 50.7 m vs. 9M 2021: € 42.6 m) was driving the growth in overall R&D expenses while partnered R&D expenses decreased to € 4.6 m (9M 2021: € 10.9 m).
SG&A expenses for the nine months ended 30 September 2022 amounted to € 109.9 m and were thus € 38.9 m or 55% higher compared to last year (9M 2021: € 71.0 m). Expanding Evotec's number of people to facilitate further growth as well as fees for consulting services were the main drivers. Consulting costs were incurred due to the start of SAP implementation in 2022 and to M&A activities. SG&A expenses also went up due to facility-related expenses which included significantly higher energy costs and also direct depreciation costs and allocated expenses for maintenance of facilities, predominantly the new J.POD® Redmond (US) manufacturing site as well as the Biopark in Toulouse. Lastly, year-over-year comparison through September is affected significantly from being a publicly listed company in the US since November 2021.
For the nine months ended 30 September 2022, other net operating income and expenses amounted to a higher level 0f € 56.7 m, compared to € 51.8 m for the comparative prior year period. Key drivers of other operating income were related to Sanofi recharges and R&D tax credits, in particular from France and Italy.
The Total non-operating result amounted to € (119.6) m after € 228.8 m in the first nine months of 2021, mainly due to fair value adjustments of the participation in Exscientia plc. Fair value measurement were positive in the first nine months of 2021 after Exscientia went public at NASDAQ in Q3 2021. In 9M 2022, Exscientia's ordinary share price dropped by 58% from \$ 19.76 at the end of 2021 to \$ 8.21 as of 30 September 2022, which resulted in a non-cash loss from equity investments of € 126.7 m. The total non-operating result was also influenced by an interest result of € (5.8) m as well as losses from other share in equity investments of € (11.2) m, both countered by positive fx-effects of € 23.5 m.
The net income as of 30 September 2022 amounted to € (148.5) m (9M 2021: € 247.0 m), almost exclusively due to the loss from equity investments of Evotec's shareholding in Exscientia plc.
Adjusted Group EBITDA for the nine months ended 30 September 2022 amounted to € 44.6 m (9M 2021: € 70.1 m) which is the result of a well-balanced development between the very favourable growth and profitability of Evotec's base business, preparations for future growth of the J.POD®s which will make a valuable contribution in future, and a visibly lower contribution from milestones, upfronts and licenses. Moreover, higher energy and electricity costs, overall inflation and recurring costs related to the listing in the U.S., not recognised in the previous year affect the yearover-year comparison. 9M 2022 adjusted EBITDA, excluding Just – Evotec Biologics, would have reached € 84.6 m (9M 2021: € 74.0 m).
2. Progressing convergence of offering
Total revenues, consisting of revenues from EVT Execute and EVT Innovate showed progress over all business areas. In the EVT Execute segment revenues (incl. intersegment revenues) increased by a significant 23% to € 526.7 m (9M 2021: € 429.8 m), despite a modest contribution of revenues from Just – Evotec Biologics. Growth was driven by a very strong base business. Intersegment revenues amounted to € 137.9 m (9M 2021: € 100.8m), which is a leading indicator for the upside potential and development of EVT Innovate. Intersegment sales are reflective of the progress of projects recognised within EVT Innovate where Evotec maintains rights to participate in the success of partnered projects in the future.
Costs of revenue of EVT Execute came in at € 441.3 m in the nine months ended 30 September 2022 (9M 2021: € 343.4 m), corresponding to a gross margin of 16.2% (9M 2021: 20.1%). The decrease was mainly caused by ramp-up costs at Evotec's J.POD® facility in Redmond. EVT Execute gross margin excluding Just - Evotec Biologics would have reached 26.7% in 9M 2022, a 2.8 basis point improvement compared to 23.9% in the same period 2021. R&D expenses came in at € 4.2 m (9M 2021: € 2.1 m), SG&A expenses increased to € 88.2 m (9M 2021: € 56.7 m). The operating result of the EVT Execute segment reached € 18.3 m
(9M 2021: € 45.1 m), leading to an adjusted EBITDA of the segment of € 75.8 m (9M 2021: € 86.0 m).
Revenues in the EVT Innovate segment increased to € 121.9 m (9M 2021: € 101.9 m). This growth of 20% was driven by higher base revenues and project-related revenues from BMS. In the first nine months of 2022, the EVT Innovate gross margin decreased to 14.2% from 21.7% in the first nine months of 2021, mainly related to delay of revenues from milestones, upfronts and licenses. Research and development expenses amounted to € 62.2 m for the first nine months of 2022, compared to € 60.4 m for the same period of 2021. The increase in SG&A expenses (9M 2022: € 21.7 m vs. 9M 2021: € 14.3 m) was mainly caused by expanded business development activities. Investments in further growth and lower revenues from milestones resulted in an operating result of € (35.1) m (9M 2021: € (19.0) m) and an adjusted EBITDA of € (31.2) m (9M 2021: € (15.9) m).
3. Financing and financial position
Cash flow from operating activities was € 236.6 m compared with € 61.9 m in the first nine months of 2021. This was driven by the good operating business performance and the prepayment of \$ 200 m received in May in connection with the BMS collaboration in the field of Targeted Protein Degradation.
Cash flow from investing activities for the nine months ended 30 September 2022 amounted to € (435.0) m compared to € (146.7) m in the same period of the previous year. Purchases/Proceeds from current investments (net) amounted to € 203.2 m (9M 2021: € 23.8 m) as proceeds from the BMS prepayment were invested short-term. The figure also included capital expenditure on property plant and equipment of € 157.2 m (9M 2021: € 100.2 m) which resulted mainly from site expansions – in particular related to the start of construction of the J.POD® facility in Toulouse and continued capital expenditures in the J.POD® facility in Redmond. Apart from growth projects, capital expenditures include investments in Drug Discovery Services (DDS) and Integrated Drug Discovery (IDD)
capacities. Furthermore, equity investments in associated companies and other long-term investments totalled € 47.7 m (9M 2021: € 18.7 m). The increase in payments made for investments in equity holdings was mainly driven by the participation in Sernova Corp. with € 20.3 m whereas the acquisition of Rigenerand Srl, now operating as Evotec (Modena) Srl, accounted for € 23.0 m, reported under purchase of investments in affiliates.
Financing activities resulted in a net cash outflow of € (50.5) m in the nine months ended 30 September 2022 (9M 2021: € (7.1) m). The main reason was the € 35 m repayment of the 3-year tranche of the promissory note ("Schuldscheindarlehen") in June.
Cash and cash equivalents were € 463.9 m as of 30 September 2022 (31 December 2021: € 699.3 m). Total Liquidity decreased slightly to € 823.7 m (31 December 2021: € 858.2 m).
4. Assets, liabilities, and stockholders' equity
Assets
Between 31 December 2021 and 3o September 2022, total assets increased slightly by € 27.5 m to € 2,262.7 m (31 December 2021: € 2,235.2 m).
Trade accounts receivable and accounts receivable from associated companies and other long-term investments decreased in the nine months ended 30 September 2022 by € 11.7 m to € 123.0 m (31 December 2021: € 134.7 m). Both balance sheet dates showed a relatively high level of Trade accounts receivables as they included considerable receivables from BMS. Due to the progress with BMS at the end of September, Days Sales Outstanding (DSO) of 66 days are temporarily above Evotec's target-range of 50 and 60 days, the related payment has been received in October and should bring back DSO to the targeted corridor (DSO as of 31 December 2021: 80 days).
Current tax receivables increased from € 23.4 m as per 31 December 2021 to € 41.7 m as per
30 September 2022 mainly related to increased receivables relating to R&D tax credits in Italy and France.
Prepaid expenses and other current assets as of 30 September 2022 increased by € 8.3 m to € 48.2 m compared to 31 December 2021 (€ 39.9 m) primarily due to an increase in VAT receivable.
Property, plant, and equipment rose by € 115.9 m to € 600.5 m (31 December 2021: € 484.6 m) caused by capital expenditures for site expansions, significantly exceeding depreciations.
Goodwill and intangibles increased by € 15.8 m compared with 31 December 2021, to € 304.2 m (31 December 2021: € 288.4 m), primarily due to the initial consolidation of Evotec (Modena) Srl.
Long-term investments amounted to € 183.4 m (31 December 2021: € 281.9 m). This decrease resulted mainly from the fair value adjustment to Evotec's stake in Exscientia plc.
Liabilities
Trade accounts payable increased by € 11.4 m in the nine months ended 30 September 2022 to € 84.0 m (31 December 2021: € 72.6 m) in accordance with the overall business growth.
Provisions decreased by € 6.5 m to € 32.8 m (31 December 2021: € 39.3 m) due to annual bonus payments in the second quarter 2022.
Other current financial liabilities increased to € 38.5 m (31 December 2021: € 12.1 m) mainly due to foreign exchange forward valuations.
Current and non-current contract liabilities increased visibly by € 166.9 m to € 312.4 m (31 December 2021: € 145.5 m) due to the recognition of the prepayments from BMS.
The decrease in current and non-current loan liabilities of € 35.5 m to € 327.0 m mainly relates to the repayment of the 3-year tranche of the promissory note of € 35 m.
Compared to 31 December 2021 (€ 150.4 m), current and non-current lease obligations increased by € 14.7 m to € 165.1 m primarily due to new leases in Evotec Munich and Cyprotex UK.
Net debt leverage ratio of (7.7)x adjusted EBITDA, excl. IFRS 16 effect and (4.0)x incl. IFRS 16 improved versus Q4 2021 with reference to the overall positive net cash position.
Stockholders' equity
As of 30 September 2022, Evotec's overall capital structure remained at a strong equity balance compared with the end of 2021. Although total stockholders' equity declined by € 149.2 m to € 1,228.5 m (31 December 2021: € 1,377.7 m) mainly resulting from the fair value adjustment of Evotec's Exscientia stake. Due to the exercise of stock options and Share Performance Awards, a total amount of 176,952,653 shares were issued and outstanding with a nominal value of € 1.00 per share as of 30 September 2022.
Evotec's equity ratio as of 30 September 2022 decreased accordingly to 54.3% (31 December 2021: 61.6%).
5. Human Resources
Employees
Headquartered in Hamburg, Germany, the Evotec Group employs 4,715 people globally as of 30 September 2022 (31 December 2021: 4,198 employees), which corresponds to a total increase of 12% compared to the prior year's end. Overall, the number of employees grew by 517 in the first nine months of 2022 (9M 2021: 509 employees).
FINANCIAL OUTLOOK
Guidance for full-year 2022 confirmed
Evotec confirms its outlook. Revenues are expected to grow in the range of € 715-735 m. Revenues adjusted for fx-effects are expected in a range between € 690-710 m. This assumption is based on current orders in hand, a strong base business compensating for slower revenues ramp up related to biologics manufacturing, foreseeable new contracts and the extension of contracts collaborations as well as prospective milestone payments.
Positive fx-effects partially mitigate unfavourable macro-economic developments such as significantly higher energy prices and inflation of e.g., material and logistics costs. Nevertheless, Evotec vigorously continues to increase expenses for promising R&D projects, the adoption of organisation structures to ensure sustainable growth and the ramp-up of the Just – Evotec Biologics business by further expanding its J.POD® capacities in the US and the construction of a second J.POD® in Europe (Toulouse, France).
In a highly volatile environment, Evotec maintains its outlook for adjusted EBITDA 2022 unchanged at a range of € 105-120 m. The outlook at constant fx-rates is at a range of € 85-100 m.
The outlook for unpartnered R&D expenses remains unchanged: Evotec's activities are all related to R&D. Aside from the partnered and funded R&D, Evotec will continue to strongly invest in its own unpartnered R&D to further expand its long-term and sustainable pipeline of first-in-class projects and platforms. Evotec expects unpartnered R&D investments unchanged in this area between € 70-80 m in 2022.

| Guidance 2022 | Guidance 20221) at constant fx |
Actual 31 December 2021 |
||
|---|---|---|---|---|
| Group revenues | € 715 - 735 m | € 690 - 710 m | € 618 m | |
| Unpartnered R&D expenses | € 70 - 80 m | - | € 58 m | |
| Adjusted Group EBITDA2) | € 105 - 120 m | € 85 - 100 m | € 107 m |
1) 2021: USD/€ 1.18; €/GBP 0.86
2) EBITDA is defined as earnings before interest, taxes, depreciation, and amortisation of intangibles. Adjusted EBITDA excludes changes of contingent considerations, income from bargain purchase and impairments on goodwill, other intangible and tangible assets as well as the total non-operating result
Unchanged mid-term targets
Evotec's Management targets revenues growing to more than € 1,000 m and adjusted EBITDA reaching at least € 300 m by 2025. Furthermore, Evotec underlines once more its commitment to innovation and thus plans to increase investments in R&D to more than € 100 m by 2025.

Evotec SE and Subsidiaries Consolidated interim statement of financial position as of 30 September 2022
| in T€ except share data | as of 30 September 2022 |
as of 31 December 2021 |
|---|---|---|
| ASSETS | ||
| Current assets: | ||
| — Cash and cash equivalents | 463,913 | 699,326 |
| — Investments | 359,755 | 158,908 |
| — Trade accounts receivable | 117,309 | 132,078 |
| — Accounts receivables from associated companies and other | ||
| long-term investments | 5,695 | 2,643 |
| — Inventories | 30,874 | 25,793 |
| — Current tax receivables | 41,671 | 23,419 |
| — Contract assets | 23,322 | 18,614 |
| — Other current financial assets | 5,127 | 264 |
| — Prepaid expenses and other current assets | 48,150 | 39,895 |
| Total current assets | 1,095,817 | 1,100,940 |
| Non-current assets: | ||
| — Long-term investments | 171,885 | 268,793 |
| — Long-term investments accounted for using the equity method | 11,517 | 13,068 |
| 484,597 | ||
| — Property, plant, and equipment | 600,499 | |
| — Intangible assets, excluding goodwill | 25,736 | 30,851 |
| — Goodwill | 278,417 | 257,569 |
| — Deferred tax asset | 16,039 | 17,359 |
| — Non-current tax receivables | 56,911 | 55,966 |
| — Other non-current financial assets | 5,843 | 5,148 |
| — Other non-current assets | - | 870 |
| Total non-current assets | 1,166,847 | 1,134,221 |
| Total assets | 2,262,664 | 2,235,161 |
| LIABILITIES AND STOCKHOLDERS' EQUITY | ||
| Current liabilities: | ||
| — Current loan liabilities | 223 | 36,136 |
| — Current portion of lease obligations | 13,885 | 14,473 |
| — Trade accounts payable | 83,965 | 72,598 |
| — Provisions | 32,820 | 39,260 |
| — Contract liabilities | 132,393 | 112,061 |
| — Deferred income | 14,575 | 14,718 |
| — Current income tax payables | 9,776 | 10,596 |
| — Other current financial liabilities | 38,504 | 12,115 |
| — Other current liabilities | 14,660 | 12,559 |
| Total current liabilities | 340,802 | 324,516 |
| Non-current liabilities: | ||
| — Non-current loan liabilities | 326,776 | 326,344 |
| — Long-term lease obligations | 151,208 | 135,964 |
| — Deferred tax liabilities | 17,179 | 17,688 |
| — Provisions | 17,740 | 18,021 |
| — Contract liabilities | 179,969 | 33,476 |
| — Deferred income | - | 1,000 |
| — Other non-current financial liabilities | 466 | 467 |
| Total non-current liabilities | 693,337 | 532,960 |
| Stockholders' equity: | ||
| — Share capital1) | 176,953 | 176,608 |
| — Additional paid-in capital | 1,437,552 | 1,430,136 |
| — Accumulated other comprehensive income | (21,348) | (12.638) |
| — Accumulated deficit | (364,631) | (216,421) |
| Equity attributable to shareholders of Evotec SE | 1,228,526 | 1,377,685 |
| — Non-controlling interest | - | - |
| Total stockholders' equity | 1,228,526 | 1,377,685 |
| Total liabilities and stockholders' equity | 2,262,664 | 2,235,161 |
1) 176,952,653 and 176,608,195 shares issued and outstanding in 2022 and 2021, respectively

Evotec SE and Subsidiaries
Consolidated interim income statement for the period from 1 January to 30 September 2022
| Nine months ended 30 September |
Nine months ended 30 September |
Three months ended 30 Septs |
Three months ended 30 Sept |
|
|---|---|---|---|---|
| in T€ except share and per share data | 2022 | 2021 | 2022s | 2021 |
| Revenues | 510,759 | 430,963 | 173,884 | 159,661 |
| Costs of revenue | (419,150) | (331,494) | (145,464) | (116,494) |
| Gross profit | 91,609 | 99,469 | 28,420 | 43,167 |
| Operating income (expenses) | ||||
| — Research and development expenses | (55,320) | (53,472) | (18,482) | (18,038) |
| — Selling, general and administrative expenses | (109,858) | (71,037) | (42,462) | (24,654) |
| — Impairment of intangible assets | - | (683) | - | - |
| — Other operating income | 58,188 | 53,723 | 19,330 | 17,544 |
| — Other operating expenses | (1,455) | (1,947) | (335) | (281) |
| Total operating income (expenses) | (108,445) | (73,416) | (41,949) | (25,429) |
| Operating income (loss) | (16,836) | 26,053 | (13,529) | 17,738 |
| Non-operating income (expense) | ||||
| — Interest income | 5,026 | 1,678 | 3,005 | 637 |
| — Interest expense | (10,872) | (6,239) | (3,055) | (1,938) |
| — Measurement result from investments | (126,658) | 245,195 | (28,940) | 129,047 |
| — Share of the result of associates accounted for using the equity method |
(11,240) | (13,685) | (3,612) | (3,867) |
| — Impairment of financial assets | - | (4,491) | - | (4,491) |
| — Other income from financial assets | 751 | 24 | 751 | 13 |
| — Other expense from financial assets | - | - | - | - |
| — Foreign currency exchange gain (loss), net | 23,501 | 6,324 | 2,045 | 3,235 |
| — Other non-operating income | 6 | 79 | (1) | 59 |
| — Other non-operating expense | (111) | (122) | (28) | (42) |
| Total non-operating income (expense) | (119,597) | 228,763 | (29,835) | 122,653 |
| Income before taxes | (136,433) | 254,816 | (43,364) | 140,391 |
| — Current tax income (expense) | (10,248) | (8,061) | (3,456) | (4,629) |
| — Deferred tax income (expense) | (1,773) | 233 | (455) | (1,491) |
| Total taxes | (12,021) | (7,828) | (3,911) | (6,120) |
| Net income (loss) | (148,454) | 246,988 | (47,275) | 134,271 |
| thereof attributable to: | ||||
| Shareholders of Evotec SE | (148,454) | 246,988 | (47,275) | 134,271 |
| Weighted average shares outstanding | 176,702,653 | 164,315,412 | 176,702,653 | 164,525,457 |
| Net income per share (basic) | (0.84) | 1.50 | (0.27) | 0.82 |
| Net income per share (diluted) | (0.84) | 1.50 | (0.27) | 0.82 |

Evotec SE and Subsidiaries
Condensed consolidated interim statement of cash flows for the nine months ended 30 September 2022
| in T€ | Nine months ended 30 September 2022 |
Nine months ended 30 September 2021 |
|---|---|---|
| Cash flow from operating activities: | ||
| — Net income | (148,454) | 246,988 |
| — Adjustments to reconcile net income to net cash provided by operating activities | 241,483 | (169,023) |
| — Change in assets and liabilities | 143,604 | (16,063) |
| Net cash provided by operating activities | 236,633 | 61,902 |
| Cash flow from investing activities: | ||
| — Purchase of current investments | (308,504) | (38,401) |
| — Purchase of investments in affiliates | (23,000) | - |
| — Purchase of investments in associated companies and other long-term investments | (47,746) | (18,657) |
| — Purchase of property, plant, and equipment | (157,210) | (100,183) |
| — Issue of convertible loan | (4,127) | (4,145) |
| — Acquisitions, cash acquired | 250 | - |
| — Proceeds from sale of current investments | 105,303 | 14,646 |
| Net cash used in investing activities | (435,034) | (146,740) |
| Cash flow from financing activities: | ||
| — Proceeds from capital increase | ||
| — Proceeds from option exercise | 355 | 1,196 |
| — Proceeds from loans | 344 | 22,141 |
| — Repayment finance lease obligation | (14,235) | (14,736) |
| — Repayment of loans | (36,918) | (15,749) |
| Net cash provided by (used in) financing activities | (50,454) | (7,148) |
| Net increase in cash and cash equivalents | (248,855) | (91,986) |
| — Exchange rate difference | 13,442 | 2,810 |
| — Cash and cash equivalents at beginning of period | 699,326 | 422,580 |
| Cash and cash equivalents at end of the period | 463,913 | 333,404 |