Episurf — Environmental & Social Information 2016

Feb 15, 2016

Company Announcement February 15, 2016

Episurf Medical and Research Collaborators from the Department of Orthopaedics, Charite, Berlin, Germany, scientific abstract chosen as poster presentation at leading orthopaedic meeting in Barcelona

The scientific abstract "On the attachment of cartilage to HA: Signs of "chondrointegration" Studies on the Episealer mini-prosthesis in the sheep knee," Hanna Schell, Tobias Jung, Leif Ryd* and Georg Duda, Dept. of Orthopedics, Charité, Berlin, Germany and Episurf Medical*, Stockholm, Sweden has been accepted as a poster presentation at the May 2016 European Society of Sport Traumatology, Knee Surgery and Arthroscopy meeting to be held in Barcelona.

The poster will also be added to the ESSKA Academy as educational content after the Congress. This is Episurf Medical's first poster presentation at a leading orthopaedic meeting, underlining the relevance and significance of the research, which is an important part of the foundation of the Episealer® intelligent implant technology. ESSKA's focus is the basic science and clinical practice in Orthopaedics, Traumatology and Sports Medicine

"The findings in this study show that there is a bond between the cartilage and the coating of the implant, a bond that may be permanent. This has not previously been shown and lends, in turn, support to the hypothesis that implantation of an Episealer® devise may stop, or significantly slow down, the process leading to osteoarthritis. At Episurf, we are delighted that the sheep study was accepted for the ESSKA meeting in Barcelona in May 2016. My personal belief is that this is a significant finding with great relevance regarding the longevity of the implant," comments Dr Leif Ryd, Senior Medical Advisor to Episurf Medical.

Echoing Dr Ryd's comment, Rosemary Cunningham Thomas, CEO of Episurf Medical, says that this scientific abstract is another significant milestone for Episurf. The expert review committee undertook a rigorous, points based review process and awarded the abstract a respectable score on the basis of the scientific results. This meeting attracts a large volume of high quality abstract submissions, which makes the outcome for Episurf even more significant.

"We are committed to ongoing scientific investigations to further confirm that Episurf Medical's proprietary Episealer implant design process combined with the hydroxyapatite coating will allay further progressive cartilage degeneration post implantation. We believe this will be borne out as more Episealer® patients reach yearly milestones. The strategy of leading with the hard science, supported by our Epioscopy™ Damage Marking Process and our intelligent, patient specific implant technology, is a potent combination for mainstreaming Episealer® into everyday clinical practice to address the sizable treatment gap that exists

between biologic interventions and partial or full knee prosthesis procedures." says Rosemary Cunningham Thomas, CEO of Episurf Medical.

For more information, please contact:

Rosemary Cunningham Thomas, CEO, Episurf Medical Tel: +46 (0) 70-7655892 Tel: +44 (0) 7803-753603 rosemary@episurf.com

About Episurf Medical

Episurf Medical is endeavoring to bring people with painful joint injuries a more active, healthier life through the availability of minimally invasive and personalized treatment alternatives. Episurf Medical's Episealer® personalized implants and Epiguide® surgical drill guides are in development for treating localized cartilage injury in joints. Episurf Medical's μiFidelity® system will enable implants to be costefficiently tailored to each individual's unique injury for the optimal fit and minimal intervention.

Episurf Medical's head office is in Stockholm, Sweden. Its share (EPIS B) is listed on Nasdaq Stockholm. For more information, go to the company's website: www.episurf.com. The information in this press release is such that Episurf Medical AB is required to disclose in accordance with the Securities Markets Act and/or the Financial Instruments Trading Act.