CSL Ltd. — Investor Presentation 2020

Apr 8, 2020

For immediate release

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9 April 2020

Company Update on COVID-19

Melbourne, Australia – CSL Limited (ASX:CSL; USOTC:CSLLY)

Please find attached an update on CSL’s operations in light of the COVID-19 pandemic.

A briefing will be presented via a webcast at 9am AEST on Thursday 9 April 2020. The briefing will be webcast on the Company website at www.csl.com in the ‘Investors/Presentations’ section. Investors are encouraged to access the website a short time ahead of the briefing commencing in order to register.

An archived copy of the webcast will be uploaded to the website later that day.

Authorised by Fiona Mead Company Secretary

For further information, please contact:

Investors: Media: Mark Dehring Jemimah Brennan Head of Investor Relations Head of Communications, Asia Pacific CSL Limited CSL Limited Telephone: +613 9389 3407 Mobile +61 412 635 483 Email: mark.dehring@csl.com.au Email: jemimah.brennan@csl.com.au

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9 April, 2020 Paul Perreault, CEO Andrew Cuthbertson, Chief Scientific Officer David Lamont, CFO Paul McKenzie, Chief Operating Officer

COVID-19 INVESTOR UPDATE

CSL LIMITED

LEGAL NOTICE

Forward looking statements

The materials in this presentation speak only as of the date of these materials, and include forward looking statements about CSL Limited and its related bodies corporate (CSL) financial results and estimates, business prospects and products in research, all of which involve substantial risks and uncertainties, many of which are outside the control of, and are unknown to, CSL. You can identify these forward looking statements by the fact that they use words such as “anticipate,” “estimate,” “expect,” “project,” “intend,” “plan,” “believe,” “target,” “may,” “assume,” and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. Factors that could cause actual results to differ materially include: the success of research and development activities, decisions by regulatory authorities regarding approval of our products as well as their decisions regarding label claims; competitive developments affecting our products; the ability to successfully market new and existing products; difficulties or delays in manufacturing; trade buying patterns and fluctuations in interest and currency exchange rates; legislation or regulations that affect product production, distribution, pricing, reimbursement, access or tax; acquisitions or divestitures; research collaborations; litigation or government investigations, and CSL’s ability to protect its patents and other intellectual property. CSL Group is also involved in multiple litigations in the ordinary course of business. The statements being made in this presentation do not constitute an offer to sell, or solicitation of an offer to buy, any securities of CSL. No representation, warranty or assurance (express or implied) is given or made in relation to any forward looking statement by any person (including CSL). In particular, no representation, warranty or assurance (express or implied) is given in relation to any underlying assumption or that any forward looking statement will be achieved. Actual future events may vary materially from the forward looking statements and the assumptions on which the forward looking statements are based.

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Subject to any continuing obligations under applicable law or any relevant listing rules of the Australian Securities Exchange, CSL disclaims any obligation or undertaking to disseminate any updates or revisions to any forward looking statements in these materials to reflect any change in expectations in relation to any forward looking statements or any change in events, conditions or circumstances on which any such statement is based. Nothing in these materials shall under any circumstances create an implication that there has been no change in the affairs of CSL since the date of these materials.

Trademarks

Except where otherwise noted, brand names designated by a ™ or ® throughout this presentation are trademarks either owned by and/or licensed to CSL.

2 | Driven by Our Promise[™]

COVID-19

Overview

• Primary objective is to ensure safety and wellbeing of our staff, donors and continuity of supply of medicines to patients

• Expertise, technologies, equipment and materials are being provided to support the response to COVID-19

• Providing additional southern hemisphere influenza vaccine doses to Australia

• Business continuity plans implemented at all sites

Evolving Pandemic

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3 | Driven by Our Promise[™]

COVID-19

Employees

• Health and welfare of staff are of primary importance to CSL

• Wherever possible, staff are strongly encouraged to work remotely

• Facilities are ‘critical infrastructure/essential facilities’ and excluded from most government shutdown processes

• On-boarding of critical staff positions accelerated

• International and domestic travel limited to business critical

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26,000+

Employees around the world

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60+

Countries of operations around the world

4 | Driven by Our Promise[™]

Plasma Collections

Challenge

• Plasma collections expected to be impacted

Mitigation

• Collection centres designated ‘essential critical infrastructure’

• ‘Safe passage’ letters provided to staff, donors and key vendors

• FDA initiatives to release plasma earlier in the cycle

• Potential to accelerate plasma collections post crisis

• New donors expected to arise following economic downturn

• Long manufacturing cycle. Today’s collections underpin sales next fiscal year

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Protecting Staff and Donors

Actions

• Pre-assessment of potential donors

• Re-direction of donors to sister centers if needed

• Plasma designed social distancing

• Enhanced cleaning & disinfectant procedures

5 | Driven by Our Promise[™]

COVID-19

Plasma Collection Centres

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6 | Driven by Our Promise[™]

COVID-19

Commercial

• Products are life saving or life extending, usually non-discretionary

• Demand is consistent with plan:

• Requests for IVIG elevated

• Strong demand for influenza vaccines

• Currently no ‘stock-outs’ – no interruption to the supply chain

• Alternative delivery mechanisms utilised as needed

• China:

• Wuhan facility operations recommenced

• Additional efforts to continue import supply of albumin (ie. air instead of sea freight)

7 | Driven by Our Promise[™]

CSL

Core R&D Capabilities

• Globally integrated R&D network

• World class expertise in immunological science, vaccinology and protein therapeutics

• Extensive Hyperimmune product development and manufacturing capabilities

• Scaled recombinant protein-based vaccine development and manufacturing

• Recombinant protein rMAb therapeutics development and manufacturing

• MF59 proprietary adjuvant technology and manufacturing

8 | Driven by Our Promise[™]

Focused COVID-19 Response

Prevention

Treatment

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s e v e r i t y

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Population General public At-risk healthcare workers and infected patients Therapeutic * Vaccines * Hyperimmunes * Monoclonal Options antibodies Polyclonal antibodies CSL Assets & Adjuvant technology Process development CSL312; CSL324 Capabilities Scaled manufacturing Scaled manufacturing IL6; C1inhibitor Collaborators University of Hyperimmune: Alliance Academic clinical with Takeda and others Queensland/CEPI researchers Polyclonal: Sab Therapeutics

• [CSL platform]

9 | Driven by Our Promise[™]

COVID-19 Summary

• Plasma collections presents a challenge

• Various initiatives expected to mitigate impact

• Actively pursuing COVID-19 response consistent with core R&D and manufacturing capabilities

• Modest delays expected in capital projects and clinical trials

• Potential to accelerate activity post crisis to ensure no material change to original plan

Plasma Collection

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Clinical Trials

• Strong capital position

• Est. ~$1.1bn available liquidity

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• Profit guidance for FY20 reaffirmed

Profit Guidance

• ~$2,110m to $2,170m @CC[2,3]

• 1 For forward looking statements, refer to Legal Notice on page 2

• 2 Constant Currency (CC) removes the impact of exchange rates movements to facilitate comparability.

• 3 Full year FX impact expected to be $100 million unfavourable

• assuming exchange rates remain steady for the remainder of the financial year

10 | Driven by Our Promise[™]

CSL Limited Contact

Bernard Ronchi Senior Manager Investor Relations  +61 3 9389 3470

• Bernard.Ronchi@csl.com.au

Mark Dehring

VP Investor Relations

• +61 3 9389 3407

• mark.dehring@csl.com.au

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