CODEXIS, INC. — Director's Dealing 2025

Jun 16, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: CODEXIS, INC. (CDXS)
CIK: 0001200375
Period of Report: 2025-06-12

Reporting Person: Opaleye Management Inc. (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-06-12	Common Stock, par value $0.001 per share	P	100000	$2.25	Acquired	12100000	Indirect
2025-06-13	Common Stock, par value $0.001 per share	P	99102	$2.23	Acquired	12199102	Indirect
2025-06-16	Common Stock, par value $0.001 per share	P	50898	$2.24	Acquired	12250000	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock, par value $0.001 per share	250000	Indirect

Footnotes

F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

F3: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.