CODEXIS, INC. — Director's Dealing 2025

Dec 15, 2025

SEC Form 4/A — Form 4/A

Issuer: CODEXIS, INC. (CDXS)
CIK: 0001200375
Period of Report: 2025-11-26

Reporting Person: Opaleye Management Inc. (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-11-26	Common Stock, par value $0.001 per share	S	148318	$1.7413	Disposed	10305000	Indirect
2025-11-26	Common Stock, par value $0.001 per share	S	5000	$1.7413	Disposed	191012	Indirect
2025-11-28	Common Stock, par value $0.001 per share	S	105000	$1.75	Disposed	10200000	Indirect
2025-11-28	Common Stock, par value $0.001 per share	S	2490	$1.75	Disposed	188522	Indirect
2025-12-01	Common Stock, par value $0.001 per share	S	245000	$1.6675	Disposed	9955000	Indirect
2025-12-01	Common Stock, par value $0.001 per share	S	8533	$1.6675	Disposed	179989	Indirect

Footnotes

F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

F3: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.7316 - $1.75699 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F4: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.73 - $1.7715 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F5: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.65 - $1.7101 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.