Cocrystal Pharma, Inc. — Director's Dealing 2025

Nov 28, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Cocrystal Pharma, Inc. (COCP)
CIK: 0001412486
Period of Report: 2025-11-26

Reporting Person: FROST PHILLIP MD ET AL (Director, 10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-11-26	Common Stock	P	1500	$1.00	Acquired	1701051	Indirect
2025-11-26	Common Stock	P	2500	$0.99	Acquired	1703551	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	27100	Direct

Footnotes

F1: These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2: Includes shares of common stock issuable upon vesting of restricted stock units.