CHITOGENX INC — Proxy Solicitation & Information Statement 2021

May 21, 2021

May 21, 2021

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1500 Robert-Bourassa Blvd., 7th Floor Montreal QC, H3A 3S8 www.computershare.com

To: All Canadian Securities Regulatory Authorities

Subject: ORTHO REGENERATIVE TECHNOLOGIES INC.

Dear Sir/Madam:

We advise of the following with respect to the upcoming Meeting of Security Holders for the subject Issuer:

Meeting Type : Annual General and Special Meeting Record Date for Notice of Meeting : June 15, 2021 Record Date for Voting (if applicable) : June 15, 2021 Beneficial Ownership Determination Date : June 15, 2021 Meeting Date : July 21, 2021 Meeting Location (if available) : Montreal, QC Issuer sending proxy related materials directly to NOBO: No Issuer paying for delivery to OBO: Yes Notice and Access (NAA) Requirements: NAA for Beneficial Holders No NAA for Registered Holders No

Voting Security Details: Description CUSIP Number ISIN CLASS A SHARES 68752F103 CA68752F1036

Sincerely,

Computershare

Agent for ORTHO REGENERATIVE TECHNOLOGIES INC.