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BlackRock Health Sciences Trust

Regulatory Filings May 23, 2017

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N-Q 1 d369527dnq.htm BLACKROCK HEALTH SCIENCES TRUST BlackRock Health Sciences Trust

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED

MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number: 811-21702

Name of Fund: BlackRock Health Sciences Trust (BME)

Fund Address: 100 Bellevue Parkway, Wilmington, DE 19809

Name and address of agent for service: John M. Perlowski, Chief Executive Officer, BlackRock Health Sciences Trust,

55 East 52 nd Street, New York, NY 10055

Registrant’s telephone number, including area code: (800) 882-0052, Option 4

Date of fiscal year end: 12/31/2017

Date of reporting period: 03/31/2017

Item 1 – Schedule of Investments

Schedule of Investments March 31, 2017 (Unaudited)
(Percentages shown are based on Net Assets)
Common Stocks Value
Biotechnology — 24.6%
AbbVie, Inc. (a) 38,586 $ 2,514,264
Acceleron Pharma, Inc. (a)(b) 44,300 1,172,621
Acerta Pharma BV, Series B (Acquired 2/01/16, cost $986,402) (b)(c) 17,146,440 1,455,733
Agios Pharmaceuticals, Inc. (a)(b) 9,600 560,640
Alder Biopharmaceuticals, Inc. (b) 5,829 121,243
Alkermes PLC (a)(b) 28,000 1,638,000
Alnylam Pharmaceuticals, Inc. (a)(b) 14,000 717,500
Amgen, Inc. (a) 71,322 11,701,801
Aquinox Pharmaceuticals, Inc. (a)(b) 22,383 373,572
Audentes Therapeutics, Inc. (b) 10,083 171,814
Avexis, Inc. (a)(b) 22,752 1,729,835
Biogen, Inc. (a)(b) 23,348 6,383,810
BioMarin Pharmaceutical, Inc. (a)(b) 16,000 1,404,480
Bioverativ, Inc. (a)(b) 11,674 635,766
Celgene Corp. (a)(b) 97,986 12,192,391
Galapagos NV — ADR (a)(b) 4,200 361,998
Genomic Health, Inc. (a)(b) 16,500 519,585
Gilead Sciences, Inc. (a) 67,200 4,564,224
Global Blood Therapeutics, Inc. (a)(b) 16,088 592,843
Halozyme Therapeutics, Inc. (a)(b) 49,200 637,632
Incyte Corp. (a)(b) 20,500 2,740,235
Karyopharm Therapeutics, Inc. (a)(b) 6,500 83,460
Lion Biotechnologies, Inc. (b) 62,723 467,286
Myovant Sciences Ltd. (b) 29,453 345,778
Neurocrine Biosciences, Inc. (a)(b) 19,562 847,035
Otonomy, Inc. (b) 9,400 115,150
Prothena Corp. PLC (b) 2,244 125,193
PTC Therapeutics, Inc. (a)(b) 15,700 154,488
Regeneron Pharmaceuticals, Inc. (a)(b) 9,058 3,510,066
REGENXBIO, Inc. (b) 36,250 699,625
Sage Therapeutics, Inc. (a)(b) 15,752 1,119,495
Sarepta Therapeutics, Inc. (a)(b) 37,450 1,108,520
Seattle Genetics, Inc. (a)(b) 22,767 1,431,134
Spark Therapeutics, Inc. (a)(b) 4,600 245,364
Syndax Pharmaceuticals, Inc. (b) 52,584 721,452
TESARO, Inc. (a)(b) 18,431 2,835,978
Ultragenyx Pharmaceutical, Inc. (a)(b) 8,300 562,574
Vertex Pharmaceuticals, Inc. (a)(b) 60,905 6,659,962
73,222,547
Diversified Consumer Services — 0.4%
Service Corp. International 42,000 1,296,960
Health Care Equipment & Supplies — 21.8%
Abbott Laboratories (a) 117,900 5,235,939
Baxter International, Inc. (a) 140,900 7,307,074
Becton Dickinson and Co. (a) 21,533 3,950,014
Boston Scientific Corp. (a)(b) 346,700 8,622,429
CR Bard, Inc. (a) 25,453 6,326,089
Edwards Lifesciences Corp. (a)(b) 15,900 1,495,713
Hologic, Inc. (a)(b) 76,600 3,259,330
Intuitive Surgical, Inc. (a)(b) 5,700 4,368,879
Common Stocks Value
Health Care Equipment & Supplies (continued)
iRhythm Technologies, Inc. (b) 4,883 $ 183,601
Masimo Corp. (a)(b) 22,200 2,070,372
Medtronic PLC (a) 169,800 13,679,088
Stryker Corp. 64,900 8,544,085
65,042,613
Health Care Providers & Services — 27.9%
Aetna, Inc. (a) 44,311 5,651,868
Amedisys, Inc. (b) 56,860 2,904,977
AmerisourceBergen Corp. (a) 15,000 1,327,500
Anthem, Inc. (a) 50,300 8,318,614
Cardinal Health, Inc. (a) 36,830 3,003,488
Centene Corp. (b) 35,700 2,543,982
Cigna Corp. (a) 44,700 6,548,103
DaVita, Inc. (a)(b) 64,994 4,417,642
Express Scripts Holding Co. (a)(b) 18,500 1,219,335
HCA Holdings, Inc. (a)(b) 44,794 3,986,218
HealthEquity, Inc. (a)(b) 12,600 534,870
Humana, Inc. (a) 38,000 7,833,320
McKesson Corp. (a) 29,600 4,388,496
Quest Diagnostics, Inc. (a) 55,600 5,459,364
Teladoc, Inc. (a)(b) 21,200 530,000
UnitedHealth Group, Inc. (a) 130,802 21,452,836
Universal Health Services, Inc., Class B (a) 18,900 2,352,105
WellCare Health Plans, Inc. (a)(b) 6,300 883,323
83,356,041
Life Sciences Tools & Services — 2.0%
Agilent Technologies, Inc. (a) 37,300 1,972,051
Thermo Fisher Scientific, Inc. (a) 25,100 3,855,360
5,827,411
Pharmaceuticals — 21.3%
Allergan PLC (a) 36,085 8,621,428
AstraZeneca PLC 52,976 3,257,331
Bristol-Myers Squibb Co. (a) 94,162 5,120,530
Chugai Pharmaceutical Co. Ltd. 7,900 271,944
Dermira, Inc. (a)(b) 22,100 753,831
Eli Lilly & Co. (a) 75,800 6,375,538
GlaxoSmithKline PLC 66,800 1,388,965
Intra-Cellular Therapies, Inc. (b) 13,701 222,641
Jazz Pharmaceuticals PLC (a)(b) 11,100 1,610,943
Johnson & Johnson (a) 61,870 7,705,910
Merck & Co., Inc. (a) 108,000 6,862,320
Merck KGaA 26,200 2,985,584
Mylan NV (a)(b) 64,400 2,510,956
Novartis AG — ADR 9,600 712,992
Pacira Pharmaceuticals, Inc. (a)(b) 5,100 232,560
Pfizer, Inc. (a) 359,398 12,295,006
Portfolio Abbreviations — ADR American Depositary Receipt EUR Euro
CVR Contingent Value Rights GBP British Pound

MARCH 31, 2017 1

Schedule of Investments (continued) BlackRock Health Sciences Trust (BME)

Common Stocks Value
Pharmaceuticals (continued)
Zoetis, Inc. (a) 46,500 $ 2,481,705
63,410,184
Total Common Stocks — 98.0% 292,155,756
Preferred Stocks
Biotechnology — 0.2%
Ovid Therapeutics, Inc. (Acquired 8/7/15, Cost $503,166), 0.00% (b)(c) 80,765 545,164
Rights — 0.0%
Biotechnology — 0.0%
Dyax Corp. — CVR (b) 61,727 141,355
Total Long-Term Investments (Cost — $206,591,314) — 98.2% 292,842,275
Short-Term Securities — BlackRock Liquidity Funds, T-Fund, Institutional Class, 0.60% (d)(e) Value — $ 5,850,857
Total Short-Term Securities (Cost — $5,850,857) — 1.9% 5,850,857
Total Investments Before Options
Written (Cost — $212,442,171*) — 100.1% 298,693,132
Options Written
(Premiums Received — $2,659,620) — (0.7)% (2,146,847 )
Total Investments Net of Options Written — 99.4% 296,546,285
Other Assets Less Liabilities — 0.6% 1,687,271
Net Assets — 100.0% $ 298,233,556

Notes to Schedule of Investments

  • As of March 31, 2017, gross unrealized appreciation and depreciation based on cost for federal income tax purposes were as follows:
Tax cost $
Gross unrealized appreciation $ 86,973,569
Gross unrealized depreciation (2,295,005 )
Net unrealized appreciation $ 84,678,564

(a) All or a portion of security has been pledged and/or segregated as collateral in connection with outstanding exchange-traded options written.

(b) Non-income producing security.

(c) Restricted securities as to resale, excluding 144A securities. As of period end, the Trust held restricted securities with a current value of $2,000,897 and an original cost of $1,489,568 which was 0.7% of its net assets.

(d) Current yield as of period end.

(e) During the period ended March 31, 2017, investments in issuers considered to be affiliates of the Trust for purposes of Section 2(a)(3) of the Investment Company Act of 1940, as amended, were as follows:

Affiliates — BlackRock Liquidity Funds, T-Fund, Institutional Class 8,611,967 (2,761,110 ) 5,850,857 Value at March 31, 2017 — $ 5,850,857 Income — $ 8,475 Realized Gain — — —
SL Liquidity Series, LLC, Money Market Series 126,889 (126,889 ) — — 1,580 1 $ 18 —
Total $ 5,850,857 $ 10,055 $ 18 —

1 Represents securities lending income earned from the reinvestment of cash collateral from loaned securities, net of fees and collateral investment expenses, and other payments to and from borrowers of securities.

2 MARCH 31, 2017

Schedule of Investments (continued) BlackRock Health Sciences Trust (BME)

• For Trust compliance purposes, the Trust’s industry classifications refer to one or more of the industry sub-classifications used by one or more widely recognized market indexes or ratings group indexes, and/or as defined by the investment adviser. These definitions may not apply for purposes of this report, which may combine industry sub-classifications for reporting ease.

Derivative Financial Instruments Outstanding as of Period End

Exchange-Traded Options Written — Description Put/ Call Expiration Date Strike Price Contracts Value
Boston Scientific Corp. Call 4/03/17 USD 23.90 83 $ (8,076 )
Abbott Laboratories Call 4/07/17 USD 45.50 109 (436 )
AbbVie, Inc. Call 4/07/17 USD 63.50 74 (13,283 )
AmerisourceBergen Corp. Call 4/07/17 USD 92.00 31 (930 )
Baxter International, Inc. Call 4/07/17 USD 50.50 83 (12,575 )
Biogen, Inc. Call 4/07/17 USD 300.00 57 (3,135 )
Cigna Corp. Call 4/07/17 USD 152.50 47 (8,554 )
Eli Lilly & Co. Call 4/07/17 USD 83.00 170 (27,370 )
Gilead Sciences, Inc. Call 4/07/17 USD 70.00 58 (406 )
HCA Holdings, Inc. Call 4/07/17 USD 86.00 48 (16,080 )
Humana, Inc. Call 4/07/17 USD 207.50 15 (2,550 )
McKesson Corp. Call 4/07/17 USD 155.00 99 (1,485 )
Regeneron Pharmaceuticals, Inc. Call 4/07/17 USD 365.00 16 (36,880 )
UnitedHealth Group, Inc. Call 4/07/17 USD 162.50 100 (22,900 )
UnitedHealth Group, Inc. Call 4/07/17 USD 170.00 70 (945 )
Vertex Pharmaceuticals, Inc. Call 4/07/17 USD 95.00 63 (89,775 )
Celgene Corp. Call 4/13/17 USD 127.00 38 (2,717 )
Humana, Inc. Call 4/13/17 USD 220.00 29 (3,118 )
Masimo Corp. Call 4/13/17 USD 72.00 32 (68,032 )
Medtronic PLC Call 4/13/17 USD 83.00 102 (969 )
Merck & Co., Inc. Call 4/13/17 USD 66.00 114 (1,368 )
Pfizer, Inc. Call 4/13/17 USD 34.00 30 (1,305 )
Pfizer, Inc. Call 4/13/17 USD 34.50 24 (432 )
UnitedHealth Group, Inc. Call 4/13/17 USD 170.00 101 (2,020 )
Abbott Laboratories Call 4/21/17 USD 46.00 190 (2,945 )
Acceleron Pharma, Inc. Call 4/21/17 USD 30.00 151 (5,285 )
Agilent Technologies, Inc. Call 4/21/17 USD 55.00 65 (1,463 )
Agios Pharmaceuticals, Inc. Call 4/21/17 USD 60.00 33 (5,940 )
Alkermes PLC Call 4/21/17 USD 65.00 49 (3,308 )
Allergan PLC Call 4/21/17 USD 250.00 63 (5,670 )
Alnylam Pharmaceuticals, Inc. Call 4/21/17 USD 65.00 30 (1,050 )
Amgen, Inc. Call 4/21/17 USD 167.47 127 (14,559 )
Amgen, Inc. Call 4/21/17 USD 180.00 34 (204 )
Anthem, Inc. Call 4/21/17 USD 166.00 52 (15,850 )
Aquinox Pharmaceuticals, Inc. Call 4/21/17 USD 20.00 78 (3,120 )
Avexis, Inc. Call 4/21/17 USD 75.00 80 (35,600 )
BioMarin Pharmaceutical, Inc. Call 4/21/17 USD 95.00 56 (3,640 )
Bioverativ, Inc. Call 4/21/17 USD 55.00 40 (6,300 )
Boston Scientific Corp. Call 4/21/17 USD 26.00 514 (3,084 )
Bristol-Myers Squibb Co. Call 4/21/17 USD 57.00 330 (9,570 )
Cardinal Health, Inc. Call 4/21/17 USD 82.00 70 (8,400 )
Celgene Corp. Call 4/21/17 USD 125.00 78 (15,483 )
Cigna Corp. Call 4/21/17 USD 155.00 55 (6,325 )
CR Bard, Inc. Call 4/21/17 USD 250.00 89 (20,470 )
DaVita, Inc. Call 4/21/17 USD 67.50 227 (28,943 )
Galapagos NV — ADR Call 4/21/17 USD 75.00 14 (17,010 )
Genomic Health, Inc. Call 4/21/17 USD 30.00 57 (11,828 )
Global Blood Therapeutics, Inc. Call 4/21/17 USD 40.00 50 (10,750 )
Halozyme Therapeutics, Inc. Call 4/21/17 USD 15.00 150 (3,750 )
HCA Holdings, Inc. Call 4/21/17 USD 90.00 80 (11,000 )
Hologic, Inc. Call 4/21/17 USD 43.00 130 (6,500 )
Humana, Inc. Call 4/21/17 USD 220.00 22 (1,375 )
Incyte Corp. Call 4/21/17 USD 155.00 72 (4,500 )
Intuitive Surgical, Inc. Call 4/21/17 USD 765.00 20 (39,100 )
Johnson & Johnson Call 4/21/17 USD 121.05 108 (44,999 )
Karyopharm Therapeutics, Inc. Call 4/21/17 USD 15.00 22 (990 )
Masimo Corp. Call 4/21/17 USD 95.00 49 (5,512 )

MARCH 31, 2017 3

Schedule of Investments (continued) BlackRock Health Sciences Trust (BME)

Description — Medtronic PLC Call Expiration Date — 4/21/17 USD 82.50 75 Value — $ (1,950 )
Mylan NV Call 4/21/17 USD 45.00 105 (420 )
Neurocrine Biosciences, Inc. Call 4/21/17 USD 45.00 18 (4,410 )
Neurocrine Biosciences, Inc. Call 4/21/17 USD 48.00 52 (10,530 )
Pacira Pharmaceuticals, Inc. Call 4/21/17 USD 50.00 8 (500 )
Pfizer, Inc. Call 4/21/17 USD 33.00 151 (19,857 )
PTC Therapeutics, Inc. Call 4/21/17 USD 23.00 54 (2,970 )
Regeneron Pharmaceuticals, Inc. Call 4/21/17 USD 390.00 15 (13,500 )
Sarepta Therapeutics, Inc. Call 4/21/17 USD 35.00 130 (3,900 )
Seattle Genetics, Inc. Call 4/21/17 USD 70.00 80 (4,600 )
Spark Therapeutics, Inc. Call 4/21/17 USD 60.00 16 (1,120 )
Teladoc, Inc. Call 4/21/17 USD 22.50 74 (21,090 )
TESARO, Inc. Call 4/21/17 USD 160.00 77 (36,960 )
Thermo Fisher Scientific, Inc. Call 4/21/17 USD 158.30 45 (2,917 )
UnitedHealth Group, Inc. Call 4/21/17 USD 170.00 70 (5,845 )
Universal Health Services, Inc., Class B Call 4/21/17 USD 125.00 92 (21,850 )
Vertex Pharmaceuticals, Inc. Call 4/21/17 USD 100.00 129 (129,645 )
WellCare Health Plans, Inc. Call 4/21/17 USD 145.00 22 (1,925 )
Zoetis, Inc. Call 4/21/17 USD 55.00 66 (1,320 )
Abbott Laboratories Call 4/28/17 USD 44.50 113 (8,419 )
AmerisourceBergen Corp. Call 4/28/17 USD 90.00 21 (3,098 )
Amgen, Inc. Call 4/28/17 USD 182.50 79 (2,331 )
Anthem, Inc. Call 4/28/17 USD 167.50 43 (15,158 )
Cardinal Health, Inc. Call 4/28/17 USD 82.50 58 (7,395 )
Celgene Corp. Call 4/28/17 USD 126.00 139 (37,106 )
Celgene Corp. Call 4/28/17 USD 128.00 87 (18,401 )
Cigna Corp. Call 4/28/17 USD 155.00 54 (15,066 )
Edwards Lifesciences Corp. Call 4/28/17 USD 94.00 55 (19,938 )
Express Scripts Holding Co. Call 4/28/17 USD 67.50 64 (7,456 )
HCA Holdings, Inc. Call 4/28/17 USD 87.00 81 (30,780 )
Humana, Inc. Call 4/28/17 USD 210.00 45 (15,412 )
Humana, Inc. Call 4/28/17 USD 220.00 8 (1,060 )
Jazz Pharmaceuticals PLC Call 4/28/17 USD 136.00 25 (26,875 )
Medtronic PLC Call 4/28/17 USD 81.50 292 (22,338 )
Merck & Co., Inc. Call 4/28/17 USD 66.50 114 (9,462 )
Pfizer, Inc. Call 4/28/17 USD 34.50 324 (12,636 )
UnitedHealth Group, Inc. Call 4/28/17 USD 165.00 114 (35,055 )
Zoetis, Inc. Call 4/28/17 USD 55.50 100 (2,750 )
Aetna, Inc. Call 5/01/17 USD 132.50 21 (2,141 )
Becton Dickinson and Co. Call 5/01/17 USD 184.50 75 (19,644 )
Aetna, Inc. Call 5/05/17 USD 129.00 30 (6,945 )
Amgen, Inc. Call 5/05/17 USD 167.50 9 (2,682 )
Baxter International, Inc. Call 5/05/17 USD 52.00 42 (4,389 )
Jazz Pharmaceuticals PLC Call 5/05/17 USD 147.00 25 (10,625 )
Pfizer, Inc. Call 5/05/17 USD 34.50 252 (12,600 )
Anthem, Inc. Call 5/11/17 USD 166.00 52 (22,833 )
AbbVie, Inc. Call 5/12/17 USD 66.00 61 (6,771 )
Gilead Sciences, Inc. Call 5/12/17 USD 70.00 177 (21,683 )
McKesson Corp. Call 5/12/17 USD 155.00 4 (1,050 )
Merck & Co., Inc. Call 5/12/17 USD 63.50 59 (9,410 )
Mylan NV Call 5/12/17 USD 41.00 120 (9,960 )
Pfizer, Inc. Call 5/12/17 USD 34.50 329 (17,602 )
Aetna, Inc. Call 5/19/17 USD 135.00 104 (11,492 )
Agilent Technologies, Inc. Call 5/19/17 USD 52.50 65 (12,838 )
Alkermes PLC Call 5/19/17 USD 65.00 49 (6,248 )
Allergan PLC Call 5/19/17 USD 250.00 63 (23,310 )
Alnylam Pharmaceuticals, Inc. Call 5/19/17 USD 60.00 19 (2,612 )
Anthem, Inc. Call 5/19/17 USD 170.00 29 (10,512 )
Biogen, Inc. Call 5/19/17 USD 275.00 24 (26,040 )
Boston Scientific Corp. Call 5/19/17 USD 25.00 83 (6,765 )
Dermira, Inc. Call 5/19/17 USD 35.00 77 (20,020 )
Eli Lilly & Co. Call 5/19/17 USD 85.00 8 (1,436 )
Hologic, Inc. Call 5/19/17 USD 43.00 140 (17,850 )
Humana, Inc. Call 5/19/17 USD 210.00 14 (8,120 )
Johnson & Johnson Call 5/19/17 USD 121.05 108 (43,587 )

4 MARCH 31, 2017

Schedule of Investments (continued) BlackRock Health Sciences Trust (BME)

Description — Medtronic PLC Call 5/19/17 USD 82.50 125 Value — $ (10,125 )
Merck & Co., Inc. Call 5/19/17 USD 67.50 91 (3,049 )
Pacira Pharmaceuticals, Inc. Call 5/19/17 USD 50.00 9 (1,868 )
Pfizer, Inc. Call 5/19/17 USD 35.00 147 (4,851 )
Quest Diagnostics, Inc. Call 5/19/17 USD 100.00 97 (13,095 )
Sage Therapeutics, Inc. Call 5/19/17 USD 70.00 55 (76,450 )
Ultragenyx Pharmaceutical, Inc. Call 5/19/17 USD 75.00 29 (8,990 )
UnitedHealth Group, Inc. Call 5/19/17 USD 170.00 3 (543 )
Vertex Pharmaceuticals, Inc. Call 5/19/17 USD 110.00 21 (12,180 )
Eli Lilly & Co. Call 6/02/17 USD 84.75 87 (17,965 )
Quest Diagnostics, Inc. Call 6/06/17 USD 98.37 97 (23,183 )
HealthEquity, Inc. Call 6/16/17 USD 50.00 43 (3,010 )
Thermo Fisher Scientific, Inc. Call 6/16/17 USD 160.00 42 (9,555 )
Total $ (1,779,938 )
OTC Options Written — Description Put/ Call Counterparty Expiration Date Strike Price Contracts Value
AstraZeneca PLC Call Morgan Stanley & Co. International PLC 4/07/17 GBP 46.50 13,600 $ (44,716 )
Boston Scientific Corp. Call UBS AG 4/20/17 USD 25.22 28,700 (6,414 )
GlaxoSmithKline PLC Call Deutsche Bank AG 4/25/17 GBP 17.05 22,500 (2,154 )
Merck KGaA Call Deutsche Bank AG 4/26/17 EUR 103.98 7,900 (31,322 )
Centene Corp. Call Citibank N.A. 4/27/17 USD 69.15 12,400 (40,082 )
Baxter International, Inc. Call Royal Bank of Canada 4/28/17 USD 51.25 18,400 (23,016 )
REGENXBIO, Inc. Call Goldman Sachs International 4/28/17 USD 20.50 12,600 (12,618 )
Amedisys, Inc. Call Deutsche Bank AG 5/01/17 USD 51.26 20,000 (34,891 )
AstraZeneca PLC Call Morgan Stanley & Co. International PLC 5/05/17 GBP 50.09 5,000 (5,591 )
Boston Scientific Corp. Call Barclays Bank PLC 5/10/17 USD 25.00 24,600 (17,946 )
Baxter International, Inc. Call Royal Bank of Canada 5/12/17 USD 51.25 18,400 (25,149 )
Syndax Pharmaceuticals, Inc. Call UBS AG 5/12/17 USD 13.78 18,400 (23,758 )
Stryker Corp. Call Barclays Bank PLC 5/22/17 USD 131.75 11,400 (38,457 )
Service Corp. International Call Barclays Bank PLC 5/24/17 USD 30.30 14,700 (19,913 )
Stryker Corp. Call Barclays Bank PLC 6/12/17 USD 132.80 11,400 (40,882 )
Total $ (366,909 )

Fair Value Hierarchy as of Period End

Various inputs are used in determining the fair value of investments and derivative financial instruments. These inputs to valuation techniques are categorized into a fair value hierarchy consisting of three broad levels for financial reporting purposes as follows:

• Level 1 — unadjusted price quotations in active markets/exchanges for identical assets or liabilities that the Trust has the ability to access

• Level 2 — other observable inputs (including, but not limited to, quoted prices for similar assets or liabilities in markets that are active, quoted prices for identical or similar assets or liabilities in markets that are not active, inputs other than quoted prices that are observable for the assets or liabilities (such as interest rates, yield curves, volatilities, prepayment speeds, loss severities, credit risks and default rates) or other market-corroborated inputs)

• Level 3 — unobservable inputs based on the best information available in the circumstances, to the extent observable inputs are not available (including the Trust’s own assumptions used in determining the fair value of investments and derivative financial instruments)

The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements). Accordingly, the degree of judgment exercised in determining fair value is greatest for instruments categorized in Level 3. The inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, for disclosure purposes, the fair value hierarchy classification is determined based on the lowest level input that is significant to the fair value measurement in its entirety. Investments classified within Level 3 have significant unobservable inputs used by the BlackRock Global Valuation Methodologies Committee (the “Global Valuation Committee”) in determining the price for Fair Valued Investments. Level 3 investments include equity or debt issued by privately held companies or funds. There may not be a secondary market, and/or there are a limited number of investors. Level 3 investments may also be adjusted to reflect illiquidity and/or non-transferability, with the amount of such discount estimated by the Global Valuation Committee in the absence of market information.

Changes in valuation techniques may result in transfers into or out of an assigned level within the hierarchy. In accordance with the Trust’s policy, transfers between different levels of the fair value hierarchy are deemed to have occurred as of the beginning of the reporting period. The categorization of a value determined for investments and derivative financial instruments is based on the pricing transparency of the investments and derivative financial instruments and is not necessarily an indication of the risks associated with investing in those securities. For information about the Trust’s policy regarding valuation of investments and derivative financial instruments, refer to the Trust’s most recent financial statements as contained in its annual report.

MARCH 31, 2017 5

Schedule of Investments (continued) BlackRock Health Sciences Trust (BME)

The following tables summarize the Trust’s investments and derivative financial instruments categorized in the disclosure hierarchy:

Level 1 Level 2 Total
Assets:
Investments:
Long-Term Investments:
Common Stocks:
Biotechnology $ 71,766,814 — $ 1,455,733 $ 73,222,547
Diversified Consumer Services 1,296,960 — — 1,296,960
Health Care Equipment & Supplies 65,042,613 — — 65,042,613
Health Care Providers & Services 83,356,041 — — 83,356,041
Life Sciences Tools & Services 5,827,411 — — 5,827,411
Pharmaceuticals 55,506,360 $ 7,903,824 — 63,410,184
Preferred Stocks — — 545,164 545,164
Rights — — 141,355 141,355
Short-Term Securities 5,850,857 — — 5,850,857
Subtotal $ 288,647,056 $ 7,903,824 $ 2,142,252 $ 298,693,132
1 See above Schedule of
Investments for values in each industry.
Derivative Financial Instruments 2
Liabilities:
Equity contracts $ (1,496,152 ) $ (650,695 ) — $ (2,146,847 )
2 Derivative
financial instruments are options written, which are shown at value.
During the period ended March 31, 2017, there were no transfers between levels.
A reconciliation of Level 3 investments is presented
when the Trust had a significant amount of Level 3 investments at the beginning and/or end of the period in relation to net assets. The following table is a reconciliation of Level 3 investments for which significant unobservable inputs were used in
determining fair value:
Common Stocks Preferred Stocks Rights Total
Assets:
Opening Balance, as of December 31, 2016 $ 1,452,303 $ 503,166 $ 68,517 $ 2,023,986
Transfers into Level 3 — — — —
Transfers out of Level 3 — — — —
Accrued discounts/premiums — — — —
Net realized gain — — — —
Net change in unrealized
appreciation/depreciation 1 3,430 41,998 72,838 118,266
Purchases — — — —
Sales — — — —
Closing Balance, as of March 31, 2017 $ 1,455,733 $ 545,164 $ 141,355 $ 2,142,252
Net change in unrealized appreciation/depreciation on investments still held at March 31, 2017 1 $ 3,430 $ 41,998 $ 72,838 $ 118,266
1 Any difference between net change in unrealized appreciation (depreciation) and net change in unrealized appreciation (depreciation) on investments still
held at March 31, 2017 is generally due to investments no longer held or categorized as Level 3 at period end.

6 MARCH 31, 2017

Item 2 – Controls and Procedures
2(a) – The registrant’s principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant’s disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the “1940 Act”)) are effective as of a date within 90 days of the filing of this report based on the evaluation of these controls and
procedures required by Rule 30a-3(b) under the 1940 Act and Rule 13a-15(b) under the Securities Exchange Act of 1934, as amended.
2(b) – There were no changes in the registrant’s internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act) that occurred during the registrant’s last
fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant’s internal control over financial reporting.
Item 3 – Exhibits
Certifications – Attached hereto

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

BlackRock Health Sciences Trust
By: /s/ John M. Perlowski
John M. Perlowski
Chief Executive Officer (principal executive officer) of
BlackRock Health Sciences Trust
Date: May 23, 2017
Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and
on the dates indicated.
By: /s/ John M. Perlowski
John M. Perlowski
Chief Executive Officer (principal executive officer) of
BlackRock Health Sciences Trust
Date: May 23, 2017
By: /s/ Neal J. Andrews
Neal J. Andrews
Chief Financial Officer (principal financial officer) of
BlackRock Health Sciences Trust
Date: May 23, 2017

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