BICYCLE THERAPEUTICS PLC — Director's Dealing 2021

Apr 9, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BICYCLE THERAPEUTICS plc (BCYC)
CIK: 0001761612
Period of Report: 2021-04-08

Reporting Person: Legault Pierre (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-04-08	Ordinary Shares	M	24838	$8.74	Acquired	24838	Direct
2021-04-08	Ordinary Shares	S	12500	$32.00	Disposed	12338	Direct
2021-04-08	Ordinary Shares	S	12099	$31.40	Disposed	239	Direct
2021-04-08	Ordinary Shares	S	239	$32.13	Disposed	0	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-04-08	Stock Option (Right to Buy)	$8.74	M	24838	Disposed	2029-04-25	Ordinary Shares (24838)	Direct

Footnotes

F1: This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.37265 to GBP 1.00 as of April 8, 2021.

F2: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.00 to
$31.98 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and
Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) and (4).

F4: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.09 to $32.16 inclusive.

F5: This option shall vest in 36 equal monthly installments and shall be fully vested on March 15, 2022.