BICYCLE THERAPEUTICS PLC — Director's Dealing 2021

Jul 15, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BICYCLE THERAPEUTICS plc (BCYC)
CIK: 0001761612
Period of Report: 2021-07-12

Reporting Person: Lee Kevin (Director, Chief Executive Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-07-12	Ordinary Shares	M	1936	$14.00	Acquired	256670	Direct
2021-07-12	Ordinary Shares	S	1936	$32.04	Disposed	254734	Direct
2021-07-13	Ordinary Shares	M	35446	$14.00	Acquired	290180	Direct
2021-07-13	Ordinary Shares	S	21979	$32.42	Disposed	268201	Direct
2021-07-13	Ordinary Shares	S	5788	$33.09	Disposed	262413	Direct
2021-07-13	Ordinary Shares	S	11194	$34.00	Disposed	251219	Direct
2021-07-14	Ordinary Shares	M	8331	$14.00	Acquired	259550	Direct
2021-07-14	Ordinary Shares	S	2642	$32.93	Disposed	256908	Direct
2021-07-14	Ordinary Shares	S	2686	$33.85	Disposed	254222	Direct
2021-07-14	Ordinary Shares	S	9084	$34.89	Disposed	245138	Direct
2021-07-14	Ordinary Shares	S	53	$35.16	Disposed	245085	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-07-12	Stock Option (right to buy)	$14.00	M	1936	Disposed	2029-06-28	Ordinary Shares (1936)	Direct
2021-07-13	Stock Option (right to buy)	$14.00	M	35446	Disposed	2029-06-28	Ordinary Shares (35446)	Direct
2021-07-14	Stock Option (right to buy)	$14.00	M	8331	Disposed	2029-06-28	Ordinary Shares (8331)	Direct

Footnotes

F1: Shares sold pursuant to a Rule 10b5-1 trading plan.

F2: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.00 to
$32.26 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and
Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnotes (2), (3), (4), (5), (6) and (7).

F3: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.00 to $32.98 inclusive.

F4: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.00 to $33.50 inclusive.

F5: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.15 to $33.14 inclusive.

F6: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.15 to $34.12 inclusive.

F7: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.16 to $35.11 inclusive.

F8: This option shall vest in 36 equal monthly installments at the end of each calendar month following the date of the grant.