BICYCLE THERAPEUTICS PLC — Director's Dealing 2021

Jul 15, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BICYCLE THERAPEUTICS plc (BCYC)
CIK: 0001761612
Period of Report: 2021-07-12

Reporting Person: Crockett Nigel (Chief Business Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-07-12	Ordinary Shares	M	4331	$11.66	Acquired	4331	Direct
2021-07-12	Ordinary Shares	M	1723	$9.82	Acquired	6054	Direct
2021-07-12	Ordinary Shares	M	974	$15.36	Acquired	7028	Direct
2021-07-12	Ordinary Shares	S	7028	$32.03	Disposed	0	Direct
2021-07-13	Ordinary Shares	M	40426	$11.66	Acquired	40426	Direct
2021-07-13	Ordinary Shares	M	19256	$9.82	Acquired	59682	Direct
2021-07-13	Ordinary Shares	M	13019	$15.36	Acquired	72701	Direct
2021-07-13	Ordinary Shares	S	69580	$32.41	Disposed	3121	Direct
2021-07-13	Ordinary Shares	S	3121	$33.09	Disposed	0	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-07-12	Employee Stock Option (right to buy)	$11.66	M	4331	Disposed	2029-09-26	Ordinary Shares (4331)	Direct
2021-07-12	Employee Stock Option (right to buy)	$9.82	M	1723	Disposed	2030-01-02	Ordinary Shares (1723)	Direct
2021-07-12	Employee Stock Option (right to buy)	$15.36	M	974	Disposed	2030-02-21	Ordinary Shares (974)	Direct
2021-07-13	Employee Stock Option (right to buy)	$11.66	M	40426	Disposed	2029-09-26	Ordinary Shares (40426)	Direct
2021-07-13	Employee Stock Option (right to buy)	$9.82	M	19256	Disposed	2030-01-02	Ordinary Shares (19256)	Direct
2021-07-13	Employee Stock Option (right to buy)	$15.36	M	13019	Disposed	2030-02-21	Ordinary Shares (13019)	Direct

Footnotes

F1: Shares sold pursuant to a Rule 10b5-1 trading plan.

F2: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.00 to $32.26 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4).

F3: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.00 to $32.99 inclusive.

F4: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.00 to $33.50 inclusive.

F5: 25% of the shares underlying this option shall vest on September 26, 2020, and the remaining shall vest in 36 equal monthly installments.

F6: This option shall vest one-fourth (1/4) of the total number of shares under option on January 2, 2021 and the remaining shares in 36 equal monthly installments at the end of each calendar month thereafter.

F7: This option shall vest one-fourth (1/4) of the total number of shares under option on February 21, 2021 and the remaining shares in 36 equal monthly installments at the end of each calendar month thereafter.