BICYCLE THERAPEUTICS PLC — Director's Dealing 2021

Aug 28, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BICYCLE THERAPEUTICS plc (BCYC)
CIK: 0001761612
Period of Report: 2021-08-26

Reporting Person: Kalowski Lee (President and CFO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-08-26	Ordinary Shares	M	550	$8.76	Acquired	550	Direct
2021-08-26	Ordinary Shares	S	550	$35.04	Disposed	0	Direct
2021-08-27	Ordinary Shares	M	7950	$8.73	Acquired	7950	Direct
2021-08-27	Ordinary Shares	S	7950	$35.15	Disposed	0	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-08-26	Stock Option (Right to Buy)	$8.76	M	550	Disposed	2029-03-07	Ordinary Shares (550)	Direct
2021-08-27	Stock Option (Right to Buy)	$8.73	M	7950	Disposed	2029-03-07	Ordinary Shares (7950)	Direct

Footnotes

F1: Shares exercised and sold pursuant to a Rule 10b5-1 trading plan.

F2: This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.374675 to GBP 1.00 as of August 26, 2021.

F3: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.01 to $35.05 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) and (5).

F4: This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.3709 to GBP 1.00 as of August 27, 2021.

F5: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.08 to $35.18 inclusive.

F6: 25% of the shares vested on January 1, 2020, and the remaining vested or shall vest in 36 equal monthly installments.