BICYCLE THERAPEUTICS PLC — Director's Dealing 2021

Aug 31, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BICYCLE THERAPEUTICS plc (BCYC)
CIK: 0001761612
Period of Report: 2021-08-27

Reporting Person: Lee Kevin (Director, Chief Executive Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-08-27	Ordinary Shares	M	1808	$14.00	Acquired	246893	Direct
2021-08-27	Ordinary Shares	S	1808	$36.02	Disposed	245085	Direct
2021-08-31	Ordinary Shares	M	10420	$14.00	Acquired	255505	Direct
2021-08-31	Ordinary Shares	S	9953	$36.23	Disposed	245552	Direct
2021-08-31	Ordinary Shares	S	1272	$37.08	Disposed	244280	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-08-27	Stock Option (right to buy)	$14.00	M	1808	Disposed	2029-06-28	Ordinary Shares (1808)	Direct
2021-08-31	Stock Option (right to buy)	$14.00	M	10420	Disposed	2029-06-28	Ordinary Shares (10420)	Direct

Footnotes

F1: Shares sold pursuant to a Rule 10b5-1 trading plan.

F2: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $36.00 to $36.20 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4).

F3: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $36.00 to $36.86 inclusive.

F4: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.00 to $37.58 inclusive.

F5: This option shall vest in 36 equal monthly installments at the end of each calendar month following the date of the grant.