BeOne Medicines Ltd. — Director's Dealing 2025

Mar 5, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BeiGene, Ltd. (BGNE)
CIK: 0001651308
Period of Report: 2025-03-03

Reporting Person: OYLER JOHN (Director, Chief Executive Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-03-03	Ordinary Shares	M	1220531	$0.50	Acquired	4199364	Direct
2025-03-03	American Depositary Shares	M	101000	$6.50	Acquired	101000	Direct
2025-03-03	American Depositary Shares	S	5956	$240.5314	Disposed	95044	Direct
2025-03-03	American Depositary Shares	S	13816	$241.3782	Disposed	81228	Direct
2025-03-03	American Depositary Shares	S	8192	$242.4601	Disposed	73036	Direct
2025-03-03	American Depositary Shares	S	11195	$243.4414	Disposed	61841	Direct
2025-03-03	American Depositary Shares	S	4910	$244.4546	Disposed	56931	Direct
2025-03-03	American Depositary Shares	S	18386	$244.5579	Disposed	38545	Direct
2025-03-03	American Depositary Shares	S	1090	$245.3554	Disposed	37455	Direct
2025-03-03	American Depositary Shares	S	19232	$245.513	Disposed	18223	Direct
2025-03-03	American Depositary Shares	S	7243	$246.5698	Disposed	10980	Direct
2025-03-03	American Depositary Shares	S	6480	$247.6251	Disposed	4500	Direct
2025-03-03	American Depositary Shares	S	3900	$248.6335	Disposed	600	Direct
2025-03-03	American Depositary Shares	S	600	$249.2484	Disposed	0	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-03-03	Share Option (Right to Buy)	$0.50	M	2533531	Disposed	2025-07-19	Ordinary Shares (2533531)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares	481533	Indirect
Ordinary Shares	7727927	Indirect
Ordinary Shares	28204115	Indirect
Ordinary Shares	9545000	Indirect
Ordinary Shares	102188	Indirect

Footnotes

F1: These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

F2: These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F3: These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interest owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F4: These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

F5: These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's minor child, for which the Reporting Person disclaims beneficial ownership.

F6: Each American Depositary Share represents 13 Ordinary Shares

F7: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F8: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $240.00 to $240.98, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F9: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $241.00 to $241.95, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F10: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $242.00 to $242.9422, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F11: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $243.025 to $244.02, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F12: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $244.17 to $245.12, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F13: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $244.05 to $245.04, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F14: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $245.25 to $245.50, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F15: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $245.05 to $246.02, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F16: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $246.08 to $247.03, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F17: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $247.09 to $248.08, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F18: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $248.09 to $249.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F19: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $249.10 to $249.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F20: These securities vest over a five-year period as follows: 20% on July 19, 2016, and the remaining in 48 successive equal monthly installments, subject to continued service.