BeOne Medicines Ltd. — Director's Dealing 2025

Mar 8, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BeiGene, Ltd. (BGNE)
CIK: 0001651308
Period of Report: 2025-03-05

Reporting Person: OYLER JOHN (Director, Chief Executive Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-03-05	Ordinary Shares	A	201084	—	Acquired	4405895	Direct
2025-03-06	Ordinary Shares	M	486161	$0.50	Acquired	4892056	Direct
2025-03-06	American Depositary Shares	M	40109	$6.50	Acquired	40109	Direct
2025-03-06	American Depositary Shares	S	3500	$256.9142	Disposed	36609	Direct
2025-03-06	American Depositary Shares	S	13598	$257.9202	Disposed	23011	Direct
2025-03-06	American Depositary Shares	S	8200	$258.9114	Disposed	14811	Direct
2025-03-06	American Depositary Shares	S	6705	$259.7742	Disposed	8106	Direct
2025-03-06	American Depositary Shares	S	2906	$261.0794	Disposed	5200	Direct
2025-03-06	American Depositary Shares	S	3400	$262.0294	Disposed	1800	Direct
2025-03-06	American Depositary Shares	S	1700	$262.9688	Disposed	100	Direct
2025-03-06	American Depositary Shares	S	100	$264.27	Disposed	0	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-03-06	Share Option (Right to Buy)	$0.50	M	1007578	Disposed	2025-07-19	Ordinary Shares (1007578)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares	481533	Indirect
Ordinary Shares	7722480	Indirect
Ordinary Shares	28204115	Indirect
Ordinary Shares	9545000	Indirect
Ordinary Shares	102188	Indirect

Footnotes

F1: Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2027, subject to the Reporting
Person continuing to provide service to the Company through such vesting date. Unvested shares are subject to accelerated vesting upon change of control or certain termination events.

F2: These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

F3: These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F4: These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interest owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F5: These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

F6: These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's minor child, for which the Reporting Person disclaims beneficial ownership.

F7: Each American Depositary Share represents 13 Ordinary Shares

F8: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F9: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $256.28 to $257.19, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F10: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $257.41 to $258.39, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F11: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $258.44 to $259.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F12: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $259.44 to $260.43, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F13: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $260.50 to $261.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F14: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $261.56 to $262.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F15: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $262.81 to $263.37, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F16: These securities vest over a five-year period as follows: 20% on July 19, 2016, and the remaining in 48 successive equal monthly installments, subject to continued service.