BeOne Medicines Ltd. — Director's Dealing 2025

Nov 13, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: BeOne Medicines Ltd. (ONC)
CIK: 0001651308
Period of Report: 2025-11-11

Reporting Person: OYLER JOHN (Director, Chief Executive Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-11-11	Ordinary Shares	G	151320	—	Disposed	7299574	Direct
2025-11-12	Ordinary Shares	G	858533	—	Disposed	6441041	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares	481533	Indirect
Ordinary Shares	7722480	Indirect
Ordinary Shares	28204115	Indirect
Ordinary Shares	9545000	Indirect
Ordinary Shares	102188	Indirect

Footnotes

F1: Bona fide gift of shares to a private foundation which is exempt from Section 16(b) of the Securities Exchange Act pursuant to Rule 16b-5.

F2: These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

F3: These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F4: These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interest owned by a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F5: These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

F6: These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's minor child, for which the Reporting Person disclaims beneficial ownership.