Bavarian Nordic

Annual Report (ESEF) • Mar 2, 2023

BAVA - 2022 Bavarian Nordic A/SPhillip Heymans Alle3DK-2900Hellerupwww.bavarian-nordic.com162711872138006JCDVYIN6INP512022-01-012022-12-312021-01-012021-12-31bavarian-nordic.combavarian-nordic.combavarian-nordic.comwww.bavarian-nordic.com/corporategovernanceCopenhagen2023-03-03Årsrapport33767552EasyXVestervoldgade 8, 1th.1560 København VxWizard version 1.1.1177.5, by EasyX Aps. www.easyx.euRevisionspåtegningGrundlag for konklusionKonklusionDeloitte Statsautoriseret RevisionspartnerselskabDeloitte Statsautoriseret Revisionspartnerselskab33963556Kirsten Aaskov MikkelsenState Authorised Public AccountantState Authorised Public Accountantmne21358Eskild Nørregaard JakobsenState Authorised Public AccountantState Authorised Public Accountantmne1168133963556Deloitte Statsautoriseret RevisionspartnerselskabDeloitte Statsautoriseret 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An open world through vaccines Annual Report 2022 Bavarian Nordic Annual Report 2022 2 Our purpose An open world through vaccines Providing us comfort and security Making the world a safer and better place At Bavarian Nordic, we are working to save and improve lives by unlocking the power of the immune system No matter who we are or where we live Vaccines are an integral part of our lives Bavarian Nordic Annual Report 2022 3 Our DNA in Bavarian Nordic Protecting lives every day is an essential part of our DNA in Bavarian Nordic, and we aspire to develop vaccines that address unmet medical needs for the greater good of the global society. By improving access to new and better vaccines for the most vulnerable people, we play an important role in the vaccine industry that is transforming the lives of individuals, helping to boost the economies of low- as well as high-income countries, and making the world a safer and better place. Bavarian Nordic Annual Report 2022 4 Contents Our response to the global mpox outbreak Our strategy and business Introduction 6 7 9 Bavarian Nordic at a glance Products and markets 2022 in numbers 13 19 → → 11 2022 highlights 13 Our response to the global mpox outbreak 15 A message from the Chair 16 Letter from the CEO Sustainability 33 Protecting our tomorrow 34 Climate-related financial disclosures 35 ESG key figures Financial Review 52 Financial review 53 Sales performance 55 Income statement 58 Balance sheet Our strategy and business 19 Our strategy Corporate information 37 Corporate governance 20 Progress in 2022 21 Key 2023 priorities 22 Outlook for 2023 25 Research and development Financial statements 61 Consolidated financial statements 40 Risk management 44 Shareholder information 46 Board of Directors 68 Notes 117 Financial statements of the parent company 122 Notes 49 Executive Management 136 Statement by management on the Annual Report 137 Independent auditor’s reports Read our Sustainability Report 2022 Read our Remuneration Report 2022 Read our Corporate Governance Report 2022 → → → Bavarian Nordic Annual Report 2022 5 Introduction In February 2023, we announced the acquisition of a portfolio of marketed and development- stage vaccines from Emergent BioSolutions, including manufac- turing and R&D facilities. → Bavarian Nordic at a glance → Products and markets → 2022 in numbers By the reporting date, the acqui- sition is still subject to closing, pending approval from the authorities and the acquired assets are not presented as part of our business. → 2022 highlights → Our response to the global mpox outbreak → A message from the Chair → Letter from the CEO Read more about the acquisition on page 23 → Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 6 Commercial products with leading market positions: Rabies, TBE, Ebola, Smallpox, Mpox At a glance Bavarian Nordic is a fully integrated vaccines 5 3 2 company focused on R&D innovation, manufacturing and commercialization of life-saving vaccines. Inlicensed products: Hepatitis B, Cholera, Japanese encephalitis Global commercial operations with own salesforce and distribution in strategic markets End-to-end Listed on NASDAQ OMX Copenhagen C25 (BAVA.CO) and ADR (BVNRY) More than 1,000 employees worldwide Late stage pipeline candidates: RSV, manufacturing at highest quality standards COVID-19 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 7 Products and markets Information for patients and healthcare professionals We have established a diverse portfolio of in-house developed and acquired products addressing infectious diseases across the globe, and through our partnerships with governments and international organizations, we are working to increase the availability of important vaccines to improve public health. Throughout 2022, we have continued to expand our digital services for patients and healthcare professionals, providing access to information about our disease areas and prod- ucts. We will continue to launch our websites in more countries in 2023. Consumer website with relevant disease infor- mation. Currently available in English, German, Danish, Swedish, Finnish and Estonian. Marketed vaccines Public health and preparedness Endemic diseases Travel vaccines Own products Smallpox → www.loweringtherisk.com Mpox An online resource for healthcare professionals with in-depth knowledge about our vaccines and the diseases they are addressing. Currently available in the US, Germany, Switzerland, Sweden, Finland and Estonia. Ebola Rabies Tick-borne encephalitis → In-licensed products Hepatitis B www.bnvaccines.com Cholera Japanese encephalitis Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 8 JYNNEOS® Mpox and smallpox vaccine Rabipur® / RabAvert® Rabies vaccine Encepur® Tick-borne encephalitis vaccine Marketing and distribution agreements Although smallpox was eradicated more than 40 years ago, vaccines and therapeutics are still in demand from governments who prioritize their biological preparedness. Through a two-decade long partnership with the US government, we have developed a non-replicating smallpox vaccine on our MVA-BN platform technology, which has been approved in the US, Canada and EU. The vaccine is also approved for mpox. In response to the global mpox outbreak in 2022, we have supplied the vaccine to more than 70 countries, including coun- tries where the vaccine did not have regulatory approval, but was accepted under national emer- gency provisions. Although the prevalence of rabies in Western countries has significantly diminished through vaccination campaigns of domesticated animals and even among wild-life animals, the risk is still present and post-exposure vaccination remains the only effective treatment. In other parts of the World, the risk of rabies is considered significantly higher, particularly in Asia and Africa, and pre-exposure vaccination are often recommended for travelers to these regions. Tick-borne encephalitis (TBE) is prevalent in central, eastern and northern Europe and the geographic range of the virus appears to have expanded to new areas, likely due to a complex combination of changes in diagnosis and surveillance, human activities and socioeconomic factors, and ecology and climate. We have entered agreements with Valneva and Dynavax to market and distribute their vaccines in selected markets. With Valneva, we have a mutual agreement, whereby Valneva also markets our rabies and tick-borne encephalitis vaccines in certain markets. IXIARO® Our vaccine is available in 14 European countries where we are market challenger in key markets with Germany representing our largest single- market. Valneva’s vaccine against Japanese encephalitis, which we market and distribute in Germany and Switzerland. Our vaccine is available in 20 countries and has a global market-leading position with the U.S. being our largest single-market, primarily due to the need for post-exposure vaccinations. DUKORAL® Valneva’s vaccine against cholera, which we market and distribute in Germany and Switzerland. Mvabea® Ebola vaccine developed on our MVA-BN platform technology. Licensed to Janssen (Johnson & Johnson) in 2014 and now part of their two-dose vaccine regimen (Zabdeno® + Mvabea®) approved by the EC in 2020. We continue to be manufacturer of the vaccine. JYNNEOS is the U.S. brand name. The vaccine is marketed as IMVAMUNE® in Canada and IMVANEX® in EU. HEPLISAV-B® Dynavax’ hepatitis-B vaccine, which we market and distribute in Germany. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 9 Revenue 2018-2022 2022 in numbers DKK million 2022 2021 2020 2019 2018 3,151 We delivered significantly stronger than expected financial results in 2022, even after eight guidance upgrades during the year, primarily resulting from numerous supply contracts for our mpox vaccine, but also due to a higher demand for our rabies vaccine. 1,898 1,852 662 Revenue EBITDA Cash and cash equivalents at year-end (mDKK) (mDKK) (mDKK) 501 1,741 3,151 328 EBITDA 2018-2022 DKK million 2022 2021 2020 2019 2018 328 75 Compared to original guided revenue of 1,100 - 1,400 mDKK Compared to original guided EBITDA of (1,300 - 1,000) mDKK Compared to original guided cash position of DKK 1,000 - 1,200 mDKK See also the financial review on page 52 → 740 (271) (313) * The guidance assumed a bank debt level at year-end of DKK 600 million, however remaining bank debt was repaid during the fourth quarter and no new debt agreements were implemented. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 10 Group key figures 2018-2022 DKK million 2022 2021 2020 2019 2018 DKK million Financial Ratios1) 2022 2021 2020 2019 2018 Income statement Revenue 3,151 1,450 213 1,898 1,328 192 1,852 1,195 286 341 662 355 501 255 EBITDA 328 75 740 5.1 (271) (10.7) 57.6 171 (313) (11.2) 67.5 127 Production costs Earnings (basic) per share of DKK 10 Net asset value per share Share price at year-end (4.9) (7.4) Sales and distribution costs Research and development costs Administrative costs 53 34 101.1 104.7 83.7 187 2.2 1,183 376 399 409 386 180 213 269 293 278 173 Share price/Net asset value per share 2.1 2.6 3.0 1.9 Income before interest and tax (EBIT) Financial items, net (71) (314) (141) (454) (465) 380 (98) 282 (328) (16) (345) (347) (355) (2) Number of outstanding shares at year-end (thousand units) 70,735 58% 70,468 61% 58,450 32,389 32,311 71% (261) (332) (347) Equity share 56% 26% Income before company tax Net result for the year (357) (362) Number of employees, converted to full-time, at year-end 278 975 759 690 491 419 Balance sheet Total non-current assets Total current assets Total assets 1) Earnings per share (EPS) is calculated in accordance with IAS 33 "Earning per share". Other financial ratios have been calculated in accordance with the guidelines from the Danish Society of Financial Analysts. 7,907 4,485 12,391 7,150 7,336 4,754 12,089 7,375 6,378 2,381 8,759 4,894 2,912 952 6,392 655 553 2,508 3,061 2,181 398 Reconciliation of EBITDA 7,047 1,865 3,134 2,047 Income before interest and tax (EBIT) Depreciation and amortization (note 9) Impairment losses (note 9) EBITDA (71) 399 - (314) 388 1 380 344 16 (328) 57 (355) 42 Equity Non-current liabilities Current liabilities 2,954 2,287 2,806 1,909 - - 483 328 75 740 (271) (313) Cash Flow Statement Securities, cash and cash equivalents Cash flow from operating activities Cash flow from investment activities – Investment in intangible assets – Investment in property, plant and equipment – Net investment in securities 2,845 220 3,717 (359) 1,670 572 472 (276) (810) (2,311) (360) 1,861 1,115 2,317 (289) 17 (877) (1,020) (361) 674 (2,877) (575) (1,912) (484) (223) (1,202) 1,335 (10) (202) 229 (483) (1,779) 3,536 Cash flow from financing activities 636 246 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 11 2022 highlights Mpox / smallpox • In response to the global mpox outbreak, we entered numerous agreements with governments and organizations to supply our vaccine in 2022 and beyond. • The European Commission approved an extension of the marketing authorization for our smallpox vaccine to include mpox and disease caused by vaccinia virus. • Through these agreements, we have expanded the access to our vaccine to more than 70 coun- tries worldwide and supplied approximately 4 million doses in 2022. • The U.S. government exercised the first options valued at USD 119 million under the USD 299 million contract to supply a freeze-dried version of the mpox/smallpox vaccine. • To meet the demand, we scaled up our manu- facturing capacity at our own manufacturing site and through our partnership with the US based contract manufacturer, Grand River. Read more about our response to the global mpox outbreak on page → 13 • We entered into a 10-year supply contract with Canada valued up to USD 470 million, thereby continuing our 15-year long partnership to improve the country’s preparedness. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 12 2022 highlights — continued RSV Other developments COVID-19 • We initiated a Phase 3 clinical trial of our COVID-19 booster vaccine candidate, ABNCoV2 in 4,000 subjects across USA, Belgium and Denmark. • We initiated a global Phase 3 clinical trial of our MVA-BN RSV vaccine candidate for respiratory syncytial virus (RSV) in older adults. Enroll- ment of the planned 20,000 subjects was completed in December 2022. • We entered an agreement valued up to USD 83 million with the U.S. Department of Defense to further advance our MVA-BN-based vaccine candidate against Western, Eastern and Venezuelan equine encepha- litis virus. • Additional positive data from the Phase 2 study were reported during the year, including six-month follow up data which demonstrated durable antibody levels across variants of concern. • MVA-BN RSV was granted Breakthrough Therapy Designation by the FDA as well as access to the PRIME scheme by the EMA – both desig- nations are intended to expedite the development and regulatory review of the product candidate. • Our commercial product portfolio was expanded through agreements with Valneva and Dynavax to market and distribute their travel vaccines in selected European markets. • An additional bulk manufacturing line at our site in Denmark was completed to support transfer of Rabipur/RabAvert and Encepur to our own manufacturing facility. • We entered a license and supply agreement with Nuance Pharma on the commercialization of MVA-BN RSV in China and selected Asian markets. • Our fill and finish facility was approved by the FDA and EMA for the final drug production of the mpox / smallpox vaccine. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 13 Our response to the global mpox outbreak However, we also had limited bulk vaccine in stock, A new, global health crisis emerged in 2022. Initially, like several times before in recent years, sporadic cases of human mpox were reported in Europe among returned travelers from areas in Africa where the disease is endemic. Also, like in previous cases, we were contacted by health authorities to assist with supplies of our smallpox vaccine for healthcare workers and close contacts. which allowed us to rapidly initiate the final drug production (fill and finish) of the vaccine as demand rose during the first months of the outbreak. While our manufacturing lines were reserved for other purposes, and some parts even shut down due to a planned expansion, we acted swiftly and reprior- itized our plans to enable scale-up of mpox vaccine production. Later in the year, we were also able to re-initiate manufacturing of the bulk vaccine to ensure the continued supply during 2022 and beyond. However, it quickly became clear, that this outbreak was not following the same pattern of previous years. Unrelated cases were reported across several countries, and numbers rose rapidly. By the end of May, more than 600 cases were reported across nearly 30 countries and by year-end, this figure had increased to more than 84,000 cases in over 100 countries. virus caused the World Health Organization (WHO) to declare it a Public Health Emergency of International Concern (PHEIC) – a declaration only used six times before, of which only two concerned outbreaks with global impact (Swine Flu and COVID-19), thus under- lining the seriousness of the situation. Through numerous agreements with governments and organizations, we have distributed more than 4 million doses of the mpox vaccine during 2022, providing access for more than 70 countries world- wide. This work continues into 2023, as we remain committed to ensuring supply of the vaccine to our customers. We will also continue the dialogue with governments on planning of their future prepared- ness against mpox and other orthopox viruses. As the sole manufacturer of an approved mpox vaccine, we were contacted by authorities from dozens of countries, inquiring about the vaccine. Only limited supplies were readily available, as no commercial market had previously existed beyond the sales to a few government stockpiles for their biological preparedness against a related, but far more dangerous virus: smallpox. Facing this unexpected event with no prior expe- rience to draw from, health authorities around the globe were challenged to implement measures while still trying to understand the epidemiology of this disease and how this outbreak was evolving. The sudden emergence and widespread incidence of the Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 14 The mpox vaccine Our mpox vaccine, marketed as JYNNEOS® (US), IMVAMUNE® (Canada) and IMVANEX® (EU), is based on our proprietary technology, MVA-BN®. Medicines Agency (EMA), we worked with the authorities to expedite a review of data to support an extension of the current approval of IMVANEX to include mpox. A positive opinion was adopted by EMA’s Committee for Medicinal Products for Human Use (CHMP) in July 2022 and shortly after, the Euro- pean Commission formally gave its approval, which is valid in all European Union Member States as well as in Iceland, Liechtenstein, and Norway. interactions, and we have conducted symposia on mpox and presented clinical data on our vaccine at international scientific congresses. The mpox outbreak has not only contributed to improved understanding about the disease and its epidemiology, but the widespread use of our vaccine has also provided important data on its use in a real-life setting. During the fall of 2022, the first effectiveness data were reported from national authorities and as more and more people have been vaccinated, more robust data have been presented and continue to accumulate. Originally, we began the development of MVA-BN as a non-replicating smallpox vaccine suitable for immune-compromised people who are not recom- mended vaccination with traditional replicating vaccines. This development has been supported by the US government, through a series of devel- opment contracts since 2003. These contracts later evolved into procurement contracts, and we started delivering the vaccine in the current liquid-frozen formulation to the US in 2010 under an emergency use provision until approval by the U.S. Food and Drug Administration (FDA) in 2019, which included the mpox indication. In recent years, we have been contracted by the US government to manufacture bulk vaccine with the purpose of supplying a freeze- dried formulation of the vaccine with a longer shelf life. The freeze-dried version has completed the clinical development and activities are ongoing to prepare for submission of a supplement BLA to the FDA for this formulation. Real-life effectiveness of the mpox vaccine The approval of MVA-BN was based on a compre- hensive non-clinical and clinical program encom- passing more than 7,000 subjects. The vaccine’s effectiveness was inferred from efficacy data from animal challenge studies and from a clinical trial which demonstrated a comparable immune response to ACAM2000, the US approved, replicating smallpox vaccine. Since 2008, we also have a long-standing partnership with the Canadian government on supplying the vaccine for both public health preparedness and for the national defense. In 2022, this collaboration was extended with a 10-year procurement agreement. Across several studies, the effectiveness of the vaccine after a single dose was shown to be consistently around 80% and data have confirmed the strong safety profile1,2. We have supported and continue to support multiple research groups working on the real-life evaluation of MVA-BN, and are also supporting two investigator-initiated trials, one studying the effectiveness of pre-exposure vaccination with MVA-BN in non-endemic countries and one determining whether MVA-BN can reduce mpox burden of illness in exposed household contacts of confirmed cases in endemic countries. Expedited approvals for faster and broader access to the vaccine While MVA-BN had already been approved for mpox in the U.S. and Canada, the approval in the EU only covered smallpox. Thus, in the initial mpox outbreak phase, countries within EU, but also outside, were providing the vaccines under local exemptions, such as emergency use provisions. Upon recommenda- tion from the Emergency Task Force of the European The 2022 outbreak was unprecedented and only limited knowledge of mpox and MVA-BN existed in the scientific community. To help increase awareness and knowledge, we have engaged with supranational institutions, government authorities and health care professionals through numerous 1 2 Effectiveness of a single-dose Modified Vaccinia Ankara in Human Monkeypox: an observational study, R.Arbel et. al, 2022. https://doi.org/10.21203/rs.3.rs-1976861/v2 Effectiveness of one dose of MVA-BN smallpox vaccine against monkeypox in England using the case-coverage method, Bertran M. et al., 2022. https://doi.org/10.1101/2022.12.13.22282654 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 15 A message from the Chair Dear Shareholder, global commercial organization, which has driven our organizational growth to more than 1,000 employees today. Three years ago, we embarked on a new journey. Through a strategic acquisition, we endeavored to transform Bavarian Nordic into a commercial vaccine company with a global footprint. Leveraging our strong heritage in vaccine research, development and manufacturing, we added a commercial organization and expanded our presence to key markets with a growing portfolio of life-saving vaccines. This was a bold move, but also the right one for our company to ensure continued growth and long-term value-creation. Our employees have enabled the success of Bavarian Nordic, and my thanks goes out to each one of you. With all the great achievements, we have accomplished over the past 15 years, I am proud, but also confident to hand over my respon- sibilities to Luc Debruyne, former President Global Vaccines at GSK, pending election at the annual general meeting and constitution of the Board in March 2023. The diversification of our product portfolio has provided resilience to the challenges imposed by the market such as COVID-19. However, these chal- lenges also created a new demand, and with that an unprecedented global awareness of vaccines and their role in improving public health and enabling an open world. solidified the company, further enabling our efforts to develop new life-saving vaccines and growing the company. After 15 years of serving on the Board of Directors, more than half of which I have had the distin- guished pleasure to chair the board, I will step down at the annual general meeting in 2023. During my tenure, Bavarian Nordic has undergone a significant transformation, and has become an established player in the vaccine market with a diverse portfolio of in-house developed and acquired products. The pipeline has matured, and we have significantly expanded our footprint, through several manu- facturing expansions and the establishment of a I would also like to thank my fellow board members and the executive management team for a great collaboration throughout the years, and not least their dedication and hard work to continuously drive Bavarian Nordic forward towards ambitious targets. In 2022, we were called upon by governments from around the world to supply our mpox vaccine to help fight the global outbreak. For Bavarian Nordic and our employees, this has been a highly rewarding experience. Firstly, the huge impact of our work and our contribution to protecting and saving lives have made us immensely proud, and secondly, it has Finally, I would like to thank our shareholders for the trust you have shown me and the rest of the board over the years. It has been a privilege to lead the journey so far, and I wish both you and the Company a prosperous future. Gerard van Odijk Chair of the Board of Directors Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 16 Letter from the CEO Prepared for the unexpected 2022 will go over in history as yet another year where things turned out completely different than we had anticipated for Bavarian Nordic. The outbreak of mpox, was a first of its kind and took the world by surprise, as no one was expecting an outbreak of this magnitude and there was little experience in managing the disease. Even after COVID-19, with all the lessons learned – or maybe re-learned from pandemics in the past – the public health system around the globe was still caught by surprise with the outbreak. One thing, however, fundamentally differed from the past: a vaccine had already been developed and licensed. Paul Chaplin President and CEO Only six times over the past decade, the WHO has declared a Public Health Emergency of International Concern (PHEIC). The global mpox outbreak repre- sents the most recent example and Ebola has twice been declared a PHEIC. At Bavarian Nordic, we have made significant contributions to the fight against both diseases. We partnered with Janssen in 2014 to further develop and manufacture an Ebola vaccine, which has been deployed several times to affected areas in West Africa, and which gained regulatory approval in 2020. And for mpox, we had already developed the smallpox vaccine, which was initially approved in the EU and Canada in 2013, and in the US in 2019 where mpox was added to the label. meet the increasing demand. Since then, we have worked tirelessly to manufacture and distribute our vaccine to countries all over the world. The same vaccine, which historically has been stock- piled in the less likely event of the re-emergence of smallpox, was suddenly used in real-life and became the preferred option for the prevention of mpox in millions of people. The call for our vaccine and our ability to deliver can largely be ascribed to the leadership and foresight of the US govern- ment to improve the public health preparedness. For two decades, we have partnered with them not only to develop our MVA-BN technology as a safer, non-replicating smallpox vaccine, but also to establish manufacturing to ensure supply of the vaccine, which has formed part of the US stockpile since 2010. Having an approved vaccine significantly reduced the time to action, and we swiftly changed our priorities to scale up manufacturing to be able to Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 17 the rabies market, particularly in the US where we achieved record sales since RabAvert was licensed. gent BioSolutions to acquire their travel vaccine portfolio of two marketed travel vaccines and one in late-stage development along with the manufac- turing, research and development and sales capabil- ities to support this expansion, which will establish us as a global leader in travel vaccines. This transac- tion is now just awaiting customary closing condi- tions to be satisfied before it is complete. development, however the regulatory require- ments for COVID-19 vaccines have been subject to change, also affecting the timely initiation of our Phase 3 study of ABNCoV2, which was delayed into September 2022. Enrollment is continuing into 2023 and we expect to report topline results for the study in mid-2023. “We have worked tirelessly to The global demand for mpox vaccines stretches into 2023 and even beyond. While many one-off orders were secured for delivery in 2022 and 2023, we also strengthened our relations with existing and new customers, resulting in longer-term commitments. In addition to our long-standing US partner, BARDA, we have also extended our contracts with Canada, and have established important partnerships with the EU’s Health Emergency Preparedness and Response Authority (HERA) and the Pan American Health Organization (PAHO), which have been instrumental in expanding access to the mpox vaccine worldwide. manufacture and distribute our mpox One of the core strengths of Bavarian Nordic, and of our employees, is the ability to always act swiftly to change. This is how we have steered through oppor- tunities and challenges many times in the past and a key attribute to the success we have experienced over time. Even now, as we have reached more than 1,000 employees, we remain agile to ensure we can harvest opportunities as they arise, however, not least we remain inspired by being able to make a change in people’s lives through innovation of novel vaccines. In December 2022, we successfully completed the planned enrollment of 20,000 subjects in the Phase 3 study of our RSV vaccine. Results from the study are expected by mid-year 2023, potentially supporting approval of the vaccine for older adults in 2025. By then, we would expect a higher uptake, as the market will only start developing later in 2023, where the first RSV vaccines are expected to be approved. Our vaccine could enter as fourth in a market that is predicted to be on par with the flu vaccine market and with room for several players. During 2022, we entered a license and supply agree- ment with Nuance Pharma to commercialize the RSV vaccine in China and selected Asian markets, where we still have a first-in-market potential. vaccine to countries all over the world.” We have built a resilient business model based on a diverse product portfolio that addresses both the private travel segment and public health prepared- ness. It is our objective to grow these segments, while also expanding our portfolio through the advancement of our pipeline and a selective M&A approach. Through this combination, we aim to fulfil our ambition to achieve annual group sales greater than USD 1 billion and secure Bavarian Nordic as one of the largest pure play vaccine companies by 2025. 2022 was never meant to be about mpox. We were looking into a year with the continued after-ef- fects of COVID-19, particularly on our travel vaccine franchise, which saw a significant decline during the pandemic. Combined with our significant invest- ments in R&D to initiate two Phase 3 trials, we had forecasted a significant loss for the year. However, as things turned out, we ended up delivering an all-time high revenue and a positive EBITDA, supported by the unprecedented demand for our mpox vaccine, but also a strong performance in Paul Chaplin President and CEO COVID-19 remains high on the agenda with the global authorities, although the market is transi- tioning to a private market, like flu vaccines. Contin- uously advancements are seen in the global vaccine In February 2023, we took a significant step forward in this endeavor through an agreement with Emer- Bavarian Nordic Annual Report 2022 18 Our strategy and business → Our strategy → Progress in 2022 → Key 2023 priorities → Outlook for 2023 → Research and development Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 19 Our strategy To drive forward this ambition, we have In 2020, we launched an ambitious five-year strategy. Building on our core strengths in vaccine research, development, and manufacturing, we clear and focused priorities: accelerated our growth through a strategic product acquisition and expansion of our organization to include a full, global commercial infrastructure, thus becoming a full-fledged vaccine company with an aspiration to become one of the largest pure play vaccine companies by 2025 and deliver annual revenues of more than USD 1 billion. Market excellence Secure profitable growth from current business Advance pipeline Mature and expand in-house R&D projects 2025 one of the largest pure play vaccine companies Strategic and selective M&A Increasing revenue through acquisitions Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 20 Progress in 2022 Our significant role as a vaccine supplier during the global mpox outbreak demanded a shift in priorities in 2022, primarily affecting our manufacturing, but also other parts of our organization. Nevertheless, we managed to keep up the planned progress in our pipeline by advancing two pipeline programs into Phase 3 trials, both with significant potential to contribute to our long-term growth. Markets Pipeline Strategic and selective M&A Sustainability After a challenging year in 2021, where the travel vaccine market remained significantly hit by the COVID-19 pandemic, global travel picked up again and vaccine sales rebounded in 2022. While sales in the travel segment did not reach pre-COVID-19 levels, the quarter-by-quarter performance showed a clear growth trend that is expected to continue into 2023. Importantly, we succeeded in defending our market shares in key markets. The US domestic rabies business has been more resilient during COVID-19 and showed a historically high perfor- mance through 2022. Along with the mpox oppor- tunity that arose during the year due to the global outbreak, which resulted in a significant and unex- pected revenue stream, as well as the addition of new products to our portfolio through partnerships, our core vaccine business performed better than anticipated, resulting in all-time high revenues. Our primary achievement in research and devel- opment in 2022 was the advancement of two key pipeline programs into Phase 3 trials. The RSV Phase 3 study was initiated in April and reached its enrollment target of 20,000 subjects on time in December 2022.The start of the Phase 3 study for our COVID-19 booster vaccine candidate experienced delays, due to late additional regulatory demands that have pushed the enrollment completion into 2023. We also received additional funding from the US government to further advance a program for an equine encephalitis vaccine. Growth through acquisitions has become an inherent part of our strategy. We apply a selective approach whereby we seek to expand our commer- cial portfolio with products that complement our existing business and with synergies to our existing manufacturing and commercial operations. During 2022, we have continued to explore M&A opportu- nities, resulting in a process for the acquisition of a portfolio of marketed and development-stage travel vaccines from Emergent BioSolutions, which was announced in February 2023 and now just awaiting customary closing conditions to be satisfied before it is completed. Driven by our purpose to save and improve lives by unlocking the power of the immune system, our success depends on our ability to grow Bavarian Nordic and keep delivering novel vaccines that truly set a mark on global health. In doing so, we also increase our environmental and social footprint on the surrounding world, among others. During 2022, we have significantly enhanced our commitment to the global sustainability agenda and by integrating sustainability targets into our overall objectives, as well as into our remuneration principles, we have ensured accountability for our actions. Read more on our sustainability performance on page 33 → Read more on the acquisition on page 23 → → Sustainability Report Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 21 Advance pipeline Key 2023 priorities Mature and expand in-house R&D projects Strategic focus 2023 priorities The positive market trends from 2022 for our core vaccine business are expected to continue into 2023 and together with increased deliveries of mpox vaccines (based on orders secured in 2022), we expect yet another record-breaking year for Bavarian Nordic. Importantly, both Phase 3 trials Launch of RSV vaccine for older adults through partnerships. Report topline Phase 3 data, assuming statistical threshold has been met. Continue manufacturing activities to prepare for commercial launch of the product. Support the clinical development towards licensure of the vaccine in China with our partner Nuance. (RSV and COVID-19) are expected to deliver topline results during the year and throughout the organization, we are focused on activities that will support market launch of the products in the years to come. Launch of COVID-19 booster vaccine. Complete Phase 3 enrollment and report topline data. Continue manufacturing activities to prepare for a regulatory submission. Approval of freeze-dried version of mpox/smallpox vaccine. Complete transfer of freeze-dried manufacturing process to Bavarian Nordic, including final preparations for submission of a supplement BLA to the FDA. Market excellence Sustainability Secure profitable growth from current business Strategic focus Rabies and TBE 2023 priorities Strategic focus 2023 priorities Reduce our environmental footprint Implement energy-saving measures at our manufacturing facility to reduce natural gas consumption thereby also reducing emissions. Defend and gain market shares for Rabipur/RabAvert and Encepur in key markets (US and Germany). Waste recycling rate >50%. Ensure a good customer service with continuous supply of both products. A healthy, engaging and diverse workplace Employee turnover equal to or lower than global industry standards. Maintain gender equality among leaders. Mpox Deliver on secured orders, supported by own manufacturing and US-based CMO and continue dialogue with governments to secure preparedness. Accident rate ≤ last 3-year average. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 22 Outlook for 2023 The financial expectations for 2023 outlined below do not include the impact of the acquisition of the travel vaccine portfolio from Emergent BioSolutions announced in February 2023. The acquisition is pending final closing, upon which the Company will update its 2023 outlook. See also page 23. Key assumptions 2023 financial Revenue vaccine in China under our agreement with Nuance Pharma. No other RSV income assumed in 2023. • Capitalization of ABNCoV2 development costs: approximately DKK 300 million. outlook The revenue guidance reflects the following assumptions: • Milestone payments to AdaptVac of approximately DKK 300 million; pending successful outcome of the Phase 3 study and regulatory submissions. Revenue, DKK million • Smallpox/mpox vaccines: only confirmed orders have been included and amounts to approxi- mately DKK 4,400 million. Research and development costs • Total investments in research and development amount to approximately DKK 1,900 million, including ABNCoV2 capitalized costs of approxi- mately DKK 300 million. ~6,000 • Other tangible investments: approximately DKK 250 million. • Both the rabies and the TBE businesses are expected to grow with more markets expected to return to pre-COVID levels. • Non-capitalized research and development costs amount to approximately DKK 1,600 million of which the RSV project accounts for approximately DKK 1,000 million. • Net working capital is expected to increase by approximately DKK 1,500 million due to planned inventory buildup during tech-transfer of manu- facturing from GSK and due to increased sales. • Ebola revenue will only be included based on actual orders. No revenue included in the guidance. EBITDA, DKK million • Milestone payments of DKK 195 million in total, which will be triggered by the expected start of Phase 1 and Phase 3 clinical trials of the RSV Investments • Capitalization of tech-transfer activities for acquired vaccines: approximately DKK 100 million The outlook is based on the following assumptions on currency exchange rates of DKK 7.00 per 1 USD and DKK 7.45 per 1 EUR. ~2,200 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 23 Strategic acquisition of travel vaccine portfolio In February 2023, we announced an agreement with Emergent BioSolutions to acquire their travel vaccine portfolio, which includes two marketed vaccines for the prevention of typhoid fever and cholera and a Phase 3 vaccine candidate in development for the prevention of Chikungunya virus, all products that will expand and diversify our portfolio and establish us as a global leader in travel vaccines. The agreement also includes a vaccine manufac- turing facility in Switzerland, an R&D site in Cali- fornia, and a specialty sales force in both EU and US markets, in total encompassing approximately 280 employees. commercial synergies to our existing business by enhancing our US presence and increasing scale in European markets, where we are not present today. market. Chikungunya represents a significant market opportunity, as there are no approved vaccines for the prevention of the disease, which is spread to humans by infected mosquitoes. The disease can cause severely debilitating joint pain and is preva- lent in many tropic and subtropic regions visited by Western travelers. markets for the commercial products which are underprioritized today and with a large upside from the Chikungunya program. In addition to the manufacturing of the acquired vaccines, the Swiss facility will add to our overall capacity and together with our existing facilities provide expanded future flexibility and optionality. Operations at the facility will remain uninterrupted during the take-over, which is also the case for the R&D facility in San Diego, US, which is focused on bringing the Chikungunya vaccine candidate to the A brief overview of the acquisition Total acquisition price of up to USD 380 million, including USD 270 million in an upfront payment and up to USD 110 million in future conditional milestone payments, subject to the successful development of the Chikungunya vaccine (USD 80 million) and sales performance of the marketed vaccines (USD 30 million). This acquisition is aligned with our strategy to expand our commercial footprint through organic growth and launch of new products from our own R&D pipeline, combined with a selective M&A approach. The addition of two market-leading, and revenue-generating vaccines provides clear Building on our successful experience from the takeover and integration of two vaccines from GSK in 2020, we see this acquisition as a low-risk trans- action with a significant potential to grow existing Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 24 Financial implications in 2023 of the travel vaccine portfolio acquisition from Emergent BioSolutions The acquired business is expected to add approx- imately DKK 200 million to revenue and a loss of approximately DKK 400 million to EBITDA, not included in the current company financial guidance for 2023. The expected loss is due to investments in the Manufacturing facility R&D Commercial operations Chikungunya Phase 3 program and inclusion of necessary one-off integration costs. The financial impact from the acquired business is pending final closing of the transaction and the timing thereof after which the Company will update its full-year guidance. capabilities Cell-culture based facility in Bern, Switzerland San Diego, CA. USA EU and US specialty sales force ~280 employees 2 marketed vaccines Phase 3 vaccine candidate Vivotif® typhoid vaccine Vaxchora® cholera vaccine CHIKV VLP vaccine candidate targeting Chikungunya Approved in >25 markets in US/EU Potential launch in 2025 325 mUSD 500 mUSD estimated annual market size estimated annual market size Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 25 Research and development Solid progress was made in our pipeline during 2022, where we advanced two programs into Phase 3 clinical trials. Both programs are expected to deliver topline results in 2023 and they both hold the potential to significantly contribute to our growth strategy and save lives. Additionally, our program for an equine encephalitis vaccine was re-introduced into the pipeline after reaching an agreement with the U.S. Department of Defense, who will fund the further development of the vaccine. Our clinical pipeline A detailed description of the pipeline programs, including results from clinical trials, is disclosed in company announcements and in the pipeline section on our website: → www.bavarian-nordic.com Indication Product candidate Phase 1 Phase 2 Phase 3 MVA-BN RSV Phase 3 enrollment completed. Topline results expected mid-2023 Addressing a large unmet medical need in respiratory disease in the older population RSV → Read more on page 26 ABNCoV2 Phase 3 enrolling with expected completion and topline results in mid-2023. Next-generation COVID-19 booster vaccine candidate designed for broad protection without need for variant-specific adaptation. SARS-CoV-2 → Read more on page 28 MVA-BN WEV TAEK-VAC Phase 1 completed. Phase 2 planned in 2024 US-funded development program to develop a vaccine against variants of mosquito-borne equine encephalitis. Equine encephalitis Immuno-oncology → Read more on page 30 Phase 1 ongoing Targeted immunotherapy designed to arm the body’s own immune system to seek and destroy cancer cells. → Read more on page 31 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 26 RSV Our vaccine candidate has been designed to provide broad protection against respiratory syncytial virus (RSV). The high level of protection demonstrated in a human challenge trial provides us confidence that the vaccine has significant potential in the future market for RSV vaccines. MVA-BN RSV is being developed for prevention of RSV in older adults. The vaccine candidate is based on our proprietary vaccine platform technology, MVA-BN, and incorporates five distinct RSV antigens to stimulate a broad immune response against both RSV subtypes (A and B). In a clinical Phase 2 double- blinded, placebo-controlled human challenge trial, a significant reduction in viral load was reported in vaccinated subjects versus placebo and MVA-BN RSV demonstrated a vaccine efficacy of up to 88.5% when active RSV infection was confirmed by cell culture3. Clinical trials to-date have furthermore shown MVA-BN RSV to have an acceptable safety profile as previously observed for MVA-BN or other recombi- nant MVA-BN based vaccines. Based on the preliminary clinical evidence, indi- cating that the vaccine may demonstrate a substan- tial improvement over available therapy on a clinically significant endpoint, MVA-BN RSV received special designations from U.S. and EU regulatory authorities in 2022, intended to expedite the development and regulatory review of the product candidate. In February, the U.S. Food and Drug Administration (FDA) granted MVA-BN RSV Break- through Therapy Designation for the prevention of RSV in older adults, and in June, the European Medi- cines Agency (EMA) granted access to its priority medicines (PRIME) scheme for MVA-BN RSV in active immunization for the prevention of LRTD caused RSV in adults ≥60 years of age. We have previously reported results from a Phase 2 trial of MVA-BN RSV in 421 subjects aged 55 years and older, demonstrating that the vaccine was well-tolerated and induced both broad and durable antibody and T-cell responses against RSV, as well as mucosal immune responses that may be impor- tant for protection against RSV. The Phase 2 program in older adults included a revaccination of subjects after one year, following which the immune responses were rapidly and significantly increased, notably in subjects with the weakest immunity prior to the booster vaccination4. MVA-BN® RSV Completed Partnership in place for China As part of the strategy to commercialize the vaccine globally, we entered into a regional license and supply agreement with Nuance Pharma in the first quarter of 2022 on the development and commer- vaccine candidate with competitive Phase 2 efficacy data in older adults enrollment of 20,000 subjects in global Phase 3 study, data and selected Asian markets expected mid-2023 3 4 https://www.medrxiv.org/content/10.1101/2022.12.02.22283030v1.full.pdf Jordan E. et al. 2010. J. Infect, Dis. 28:223(6). 1062-1072 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 27 cialization of MVA-BN RSV for adults in China and selected Asian markets. The milestone-based agreement has a total value of up to USD 225 million in addition to tiered, double-digit royalties. Nuance Pharma obtains rights to commercialize MVA-BN RSV in Chinese Mainland, Hong Kong, Macau, Taiwan, South Korea and Southeast Asia and will be respon- sible for all material costs, including development and regulatory. Nuance Pharma is planning the initiation of a Phase 3 trial of MVA-BN RSV in 2023. About RSV RSV is a common virus that usually causes mild, cold-like symptoms, but in serious cases can lead to severe lung infections, including bronchiolitis and pneumonia, which ultimately can lead to death. By the age of 2 years, most infants have experi- enced their first RSV infection, followed by frequent reinfections throughout life, because RSV infections do not induce a sustainable, long-lasting protective immunity. In April 2022, we initiated a global, randomized, double-blind Phase clinical study of MVA-BN RSV in adults ≥60 years of age. The primary objective of the study will assess the efficacy of the vaccine candidate against lower-respiratory tract disease (LTRD) caused by RSV compared to placebo. In December 2022, we reached the planned enrollment of 20,000 subjects in the study. Topline results from the study are anticipated in mid-2023. Infants, older adults and immunocompromised individuals are most susceptible to serious compli- cations from infection with RSV. An estimated 5.2 million cases of RSV occurred in high-income countries among adults aged ≥60 years in 2019, leading to 470,000 hospitalizations and 33,000 in-hospital deaths5, thus representing a significant burden to the healthcare system. Currently there is no approved vaccine against RSV. 5 Savic, M.; Penders, Y.; Shi, T.; Branche, A.; Pirçon, J.-Y. Respiratory syncytial virus disease burden in adults aged 60years and older in high-in- come countries: A systematic literature review and meta-analysis. Influenza Other Respir Viruses 2023, 17, e13031. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 28 COVID-19 ABNCoV2 is a virus-like particle (VLP)-based vaccine candidate in development as a universal booster vaccine for COVID-19. The goal is to create a longer- lasting vaccine protection with broader efficacy that obviates the need for continuously adapting to new variants of the SARS-CoV-2 virus. We have licensed the vaccine candidate from AdaptVac. adenovirus-based vaccines) was able to demon- strate a strong boosting effect, increasing the existing levels of SARS-CoV-2 neutralizing antibodies against both the Wuhan variant and variants of concern (Alpha, Beta, Delta) to levels reported to be highly efficacious (>90%) against SARS-CoV-26. A post-pandemic market for COVID-19 vaccines is shaping up. Broad and durable protection are key differentiators for a commercially viable vaccine and based on clinical results demonstrated thus far, our vaccine candidate is well-positioned to take a share of the future market. During 2022, we reported additional results from the ABNCoV2 Phase 2 clinical program: We have concluded the Phase 2 clinical devel- opment of ABNCoV2 with results confirming the vaccine candidate’s ability to boost neutralizing antibodies to levels reported to be highly efficacious against SARS-CoV-2, both when used for primary vaccination and when used as a booster in subjects previously vaccinated with mRNA- or adenovi- rus-based vaccines. A global Phase 3 trial of the vaccine candidate was initiated in 2022 with antici- pated results in 2023. • In February, we reported results from a seroposi- tive group (n=66) receiving a lower booster dose (50 μg) of ABNCoV2 and a seronegative group (n=28) receiving two doses of ABNCoV2 (100 μg) four weeks apart. In both groups, high levels of neutralizing antibodies against SARS-CoV-2 were observed. • In May, we reported further data from the sero- positive groups, showing that vaccination with either 50 μg or 100 μg of ABNCoV2 induced a significant boost to the neutralizing antibodies against the Omicron variant in the majority of subjects (87%). Phase 2 – additional results reported during 2022 Primary results from the Phase 2 clinical program were reported in 2021, showing that vaccination with 100ug ABNCoV2 in 103 seropositive subjects (previously vaccinated with approved mRNA- or ABNCoV2, a Phase 2 data Phase 3 ongoing with read-out in 2023 VLP-based, demonstrated durable and broad antibody responses against variants of concern non-adjuvanted COVID-19 booster vaccine candidate 6 P. B. Gilbert et al., Science 10.1126/science.abm3425 (2021) Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 29 • In October, we reported follow-up results, demonstrating that six months post the booster vaccination with ABNCoV2, the neutralization antibody titers against Wuhan and the Omicron variant remained high and at levels associated with a greater than 90% efficacy. Six months post vaccination, neutralization titers were six times higher than pre-boost titers against Wuhan and nearly 10 times higher than the pre-boost titers for Omicron BA.1. This represented less than a 50% decline in the peak neutralizing titers after six months. Compared to the data published for mRNA vaccines7,8,9, the antibody decay appears less sharp, indicating a potentially longer duration of protection across variants of concern. Phase 3 initiated – data expected in 2023 In September 2022, we initiated a double-blind, controlled Phase 3 clinical trial of ABNCoV2 in 4,000 adult subjects who either previously completed primary vaccination or have already received one booster dose of a licensed COVID-19 vaccine. One cohort is evaluating the safety and tolerability of the vaccine in 3,000 subjects receiving a single 100 µg dose of ABNCoV2 (US sites). A second cohort of 1,000 subjects, who are randomized to receive either a single 100 µg dose of ABNCoV2, or a single 30 µg adult booster dose of Comirnaty (Denmark and Belgium sites) The primary endpoint of the trial is to assess non-inferiority of ABNCoV2 compared to Comirnaty® in terms of neutralizing antibodies against the SARS-CoV-2 (Wuhan wild type). Other variants of concern will be assessed as secondary endpoints. The vaccine was generally well-tolerated, with no related serious adverse events reported and no relevant difference in the safety profile between subjects receiving either 50 μg or 100 μg of ABNCoV2. Initial trial results are expected in mid-2023. The Phase 3 development of ABNCoV2 is largely funded through an agreement with the Danish State. 7 8 9 Bellusci et al. Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and BA.3 following third mRNA vaccination Forgacs et al. The Effect of Waning on Antibody Levels and Memory B Cell Recall following SARS-CoV-2 Infection or Vaccination Qu et al. Durability of Booster mRNA Vaccine against SARS-CoV-2 BA.2.12.1, BA.4, and BA.5 Subvariants (letter) Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 30 MVA-BN WEV is a multi-valent vaccine candidate developed under contracts with the US government to address the unmet medical need for a vaccine against western, eastern and Venezuelan equine encephalitis viruses, which are rare, but potentially deadly viruses transmitted to humans by mosquitos. more, the agreement includes options valued at USD 28 million to support Phase 3 preparations. Equine encephalitis About equine encephalitis viruses Continuing our long-standing collaboration with the US government on public health preparedness, our MVA-BN vaccine platform technology has been selected for the development of a vaccine against the rare, but potentially deadly mosquito-borne viruses: western, eastern and Venezuelan equine encephalitis virus. Western, Eastern and Venezuelan equine enceph- alitis viruses belong to the family alphavirus, and are transmitted through mosquitos, as well as birds and some mammals. While the viruses vary in infection rates and severity of disease, all three pathogens are associated with risks of flu-like symptoms, potential central nervous disorders, and death. All three viruses are considered as potential biological threats, having been investigated as potential biological weapons at various times in the past century. The viruses belong to the U.S. list of prioritized pathogens amongst other agents, like smallpox, anthrax and other lethal diseases, which are covered by the current vaccination policy for U.S. military personnel being deployed around the globe. However, there are currently no approved vaccines for human use against any of the equine encephalitis viruses. The first contract valued up to USD 36 million was awarded by the U.S. Department of Defense (DoD) in 2018 and included the demonstration of protective efficacy in animals and a Phase 1 first-in-human trial of MVA-BN WEV. Results from this trial were reported in 2020, showing that the vaccine was well tolerated and immunogenic across all dose groups. Neutralizing antibody responses were observed against Venezuelan equine encephalitis virus in all dose groups, with peak levels reached after the second vaccination. Recent data has confirmed neutralizing antibody responses also against western and eastern equine encephalitis viruses that were durable throughout the six-months follow up period. In December 2022, we entered a new agreement valued up to USD 83 million with DoD for the advanced development of MVA-BN WEV. The base agreement of USD 55 million has been secured for the period 2023-2026 and covers the costs for a clinical Phase 2 dose finding study of MVA-BN WEV, further non-clinical studies, process development and manufacturing of clinical trial material. Further- In recent years, the U.S. has seen a rise in human cases of eastern equine encephalitis, particularly in the southern and northeastern parts of the country, correlating with increased observations of mosquitos carrying the virus in these regions. According to the U.S Centers for Disease Control and Prevention (CDC), 38 cases were reported in 2019, compared to an annual average of 7 cases over the past decade. On average, more than 4 of 10 infected individuals die after contracting the virus . MVA-BN® WEV has completed Phase 1 clinical development demonstrating potential for broad, and long-term protection Development funded by the U.S. Department of Defense Phase 2 planned for 2024 10 https://clinicaltrials.gov/ct2/show/NCT04131595 11 https://www.cdc.gov/easternequineencephalitis/statistics-maps/index.html Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 31 Immuno-oncology While infectious disease vaccine remains our primary focus, we have continuously worked to advance our science through the discovery of novel immunotherapy candidates with potential to transform oncology treatments. TAEK-VAC represents a next generation immuno-on- cology candidate, which leverages our MVA-BN plat- form technology, purposed to arm the body’s own immune system to seek and destroy cancer cells. A Phase 1 open label trial of intravenous admin- istration of the vaccine candidate in patients with advanced HER2 and brachyury-expressing cancers is ongoing. During 2022, the first stage of the study was completed, confirming the dose for stage 2, which has now opened for enrollment. In this stage, two cohorts will initially enroll patients with either chordoma (TAEK-VAC given as monotherapy) or HER2-positive breast cancer (TAEK-VAC in combina- tion treatment with trastuzumab). Once safety of the combination treatment has been established in the second cohort, two further combination treatment cohorts will be opened for recruitment. Providing the body with as many tools as possible significantly increases its chances to eradicate the disease. This tactic includes: priming antigen-spe- cific T-cell activation; inducing T-cell expansion, migration and invasion into tumor sites; modifying tumor microenvironments to allow T-cell func- tion and killing; induction of natural killer cells to account for tumor cells that cannot be recognized by T-cells; and overcoming T-cell inhibitory (checkpoint) signals. Bavarian Nordic Annual Report 2022 32 Sustainability → Protecting our tomorrow → Climate-related financial disclosures → ESG key figures Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 33 Protecting our tomorrow Protecting lives is our core business, and 2022 was truly a year of proof of our ability to make an impact on public health, which was demonstrated by our efforts to secure access to our mpox vaccine glob- ally. With several pipeline candidates in late-stage development, which could potentially be approved in a few years, we aim to launch more vaccines that address significant unmet medical needs Our progress on sustainability is reported in our sustaina- bility report, which covers our reporting obligations cf. sections 99a, 99b, and 107d of the Danish Financial Statements Act and Article 8 of the EU Taxonomy Regulation. In the endeavor, we remain aware of our responsi- bility to the global community beyond public health, and during 2022, we have continued to advance our efforts secure a sustainable and responsible busi- ness in the future. This commitment is reflected in a strengthened accountability for our actions, through the incorporation of relevant environmental, social and governance (ESG) targets into the remuneration principles for the Executive Management and the organization as a whole. → Read our Sustainability Report Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 34 Climate-related financial disclosures In 2022, we mapped our key risks and opportunities arising from climate change. We conducted our first scenario analysis based on the recommendations from the Task Force on Climate-Related Financial Disclosures (TCFD). Our assessment did not reveal significant financial or operational risks to our business in the short- to medium term. Going forward, we will assess climate-related risks and opportunities against the selected scenarios as part of our annual enterprise risk management process. Recommendation Our disclosure in brief The initial assessment, which we conducted in 2022, did not reveal any significant near- term risks or opportunities when testing against the selected climate-related scenarios. Going forward, the assessment will be integrated in our annual review of the business strategy and in our Enterprise Risk Management (ERM) process and resilience plans will be developed as needed. Strategy Disclose the actual and potential impacts of climate-related risks and opportunities on the organization’s businesses, strategy, and financial Specifically, we assessed climate-related risks and opportunities against two physical and two tran- sition scenarios under different timeframes, and current and planned actions to mitigate risks and leverage opportunities have been identified. The TCFD recommendations provide a framework for disclosure of the governance, strategy, risk management and metrics and targets used in the assessment of the company’s climate-related risks and opportunities. Our compliance with the recom- mendations is outlined in the table below. planning where such information is material. To integrate the identification and management of climate hazards and/or the risks posed by the transition to a low-carbon economy into our existing systems and processes, we have integrated climate assessments into our Enterprise Risk Management (ERM) process, which is coordinated by the Finance department and reported to the Finance Risk and Audit Committee. Each risk has a defined risk mitigation plan directed by relevant members of the senior leadership team. Risk Management Disclose how the organization identifies, assesses, and manages climate-related risks. Task Force on Climate-related Financial Disclosures (TCFD) reporting recommendations Recommendation Our disclosure in brief As with the general risk management, we have anchored the responsibility and oversight of environment, social and governance (ESG) issues with the Finance, Risk and Audit Committee in the Board of Directors. Our executive management is responsible for executing the sustainability strategy by setting targets and driving actions in their respective functions. Our ESG Committee, which is chaired by a member of executive management, comprises subject-matter experts from the organization who ensure that activities are aligned and communicated to stakeholders, externally as well as internally. To strengthen accountability for our actions, sustainability is linked to the performance- based remuneration throughout the company, including Executive Management. Governance Disclose the organization’s governance around climate-related risks and opportunities. Relevant climate-related metrics are disclosed in the table on the next page with further details available in our sustainability report. Metrics and Targets Disclose the metrics and targets used to assess and manage relevant climate- related risks and opportunities where such information is material. We have not yet set any targets. However, during 2022, we have established a baseline to enable goal setting for future reductions in energy and emissions. Read more in the Sustainability Report → Read more in the Sustainability Report → Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 35 ESG key figures Unit 2022 2021 2020 2019 2018 Key figures for selected environmental Environmental data1 social and governance areas are provided in accordance with the recommendations set out in “ESG key figures in the annual report” from the Danish Finance Society / CFA Society Denmark, FSR – Danish Auditors, and Nasdaq Copenhagen. CO2e, scope 1 Metric tons 1,765 988 1,422 1,085 1,381 1,175 909 1,178 964 1,398 CO2e, scope 2 Metric tons Energy Consumption Water Consumption GJ m3 53,325 21,772 42,577 17,023 45,110 19,170 34,137 14,770 32,527 11,610 Social data1 Full-Time Workforce Gender Diversity2 FTE 874 59 55 19 8 734 61 56 14 7 607 61 56 9 465 N/A 51 421 N/A 50 % Gender Diversity, Management Employee Turnover Ratio Sickness Absence3 % % 10 13 For the sections regarding environmental and social data in the table below, the data has been subject to an independent auditor’s review in the form of limited assurance. The Independent Auditor’s Assurance Report can be found in our sustainability report. Days per FTE 6 6 6 Governance data4 Gender Diversity, Board Board Meeting Attendance Rate CEO Pay Ratio % % 20 99 22 29 99 16 29 97 16 29 98 15 14 97 Times N/A 1 Data derived from the Company’s sustainability reports 2018-2022. 2 3 4 Data not collected before 2020 Sickness absence does not include offices in the USA. Data derived from the Company’s annual reports 2018-2022, except for CEO pay ratio, which is presented in the 2022 remuneration report. Bavarian Nordic Annual Report 2022 36 Corporate information → Corporate governance → Risk management → Shareholder information → Board of Directors → Executive Management Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 37 Corporate governance Bavarian Nordic remains focused on good corporate governance, having implemented the recommendations from the Committee of Corporate Governance (Komitéen for god Selskabsledelse) for companies listed on the Nasdaq Copenhagen exchange. Management believes that the Company is operated in compliance with guidelines and recommenda- tions that support the Company’s business model and can create value for Bavarian Nordic’s stake- holders. Regularly and at least once a year, Manage- ment monitors adherence to the recommendations on corporate governance in order to ensure the best possible utilization of and compliance with the recommendations and legislation. The Board of Directors The Board is responsible for the overall strategic management and the financial and managerial supervision of Bavarian Nordic, as well as for regular evaluation of the work of the Corporate Manage- ment. In addition, the Board supervises the Company in a general sense and ensures that it is managed in an adequate manner and in accordance with applicable law and the Company’s articles of associ- ation. The Board discharges its duties in accordance with the rules of procedure of the Board, which are reviewed and updated by all members of the Board. At the beginning of 2022, the Board of Directors (“the Board”) consisted of eleven members: seven external members and four employee represent- atives. The external members are elected by the shareholders at the annual general meeting for terms of one year; retiring members are eligible for re-election. The Board elects a chair and deputy chair from among its members. The employee representatives are elected by the employees for a four-year term, which expires in 2025 for the currently elected employees. In accordance with Section 107 b of the Danish Financial Statements Act, Bavarian Nordic has published a statutory report on Corporate Govern- ance for the financial year 2022 on the Company’s website: Board committees Member of the Board since 2010, Erik G. Hansen did not seek re-election at the 2022 annual general meeting, and in August, Elizabeth McKee Anderson, member of the Board since 2017, resigned from her position due to conflicting interests as she assumed a similar role with the board of GSK. Both positions remained vacant during the year. To support the Board in its duties, the Board has established and appointed three subcommittees: a Finance, Risk and Audit Committee, a Nomination and Compensation Committee and a Science, Tech- nology and Investment Committee. The committees, which comprise only shareholder-elected members of the Board are charged with reviewing issues → www.bavarian-nordic.com/corporategovernance Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 38 pertaining to their respective fields that are due to be considered at board meetings. More information about the committees, including the terms of refer- ence which specify the tasks and responsibilities for each of the committees are available on the Compa- ny’s website: mittee’s work, accomplishments and composition. The Chair heads the annual evaluation, which is conducted at least every third year by an external consultant. The process, whether it is facilitated internally or by external consultants, evaluates topics such as board dynamics, board agenda, quality of the material that is submitted to the Board, discussions at the Board meetings, the chair’s leadership of the Board, strategy, Board composition and Board competencies. Typically, the process is further facilitated by each Board member filling out a detailed questionnaire, and the Board members are asked to score to which extent they agree to the individual questions. The results of the ques- tionnaire are then discussed at a subsequent Board meeting, and the individual comments submitted are used in the planning and handling of future Board meetings. The 2022 self-evaluation was facilitated by an external consultant and, in general, key conclusions were positive with a continued satisfaction with the Board’s work as well as the work in the committees. Organizational develop- ment and continued optimization of Board meeting planning and efficiency will continue to be a focus area in 2023. statutory report on Corporate Governance on the Company’s website: sents Executive Management and relevant business functions and who meets regularly to review and assess risks, training, and the levels of compliance. The Finance, Risk and Audit Committee receives regular updates from the Business Ethics Compliance Committee. In 2022, it was decided – in line with the Company’s growth – to appoint a global Chief Compliance Officer who, together with the Business Ethics Compliance Committee, has overall oversight of the Company’s global compliance program. At the same time, it was decided to appoint a US Compli- ance Officer to have specific oversight of the US compliance program. → www.bavarian-nordic.com/corporategovernance Remuneration policy and report → The remuneration of the Board and the Executive Management is governed by the remuneration policy which was updated in 2022 and subsequently approved by the shareholders at the annual general meeting on April 5, 2022. Board committees Diversity in the Board The Board of Directors currently has a representation of one female member elected by the shareholders. On 23 August 2022, the other female member elected by the shareholders at the annual general meeting in April 2022 resigned from the Board. The Board of Directors has since initiated a process to identify one or more new candidates for recommen- dation for election at the annual general meeting in March 2023 and the Board of Directors expects by then to adhere to the guidelines from the Danish Business Authority on equal gender distribution on the Board. In accordance with section 139 b in the Danish Companies Act, Bavarian Nordic has prepared a report on the remuneration of the individual members of the Board and Executive Management in 2022. Business ethics is prioritized on all levels in the organization, and all employees are trained annually in our Code of Conduct, which is also available to external stakeholders via our website. Violations of the Code of Conduct may be reported through the Ethics Hotline (whistleblower scheme), which is also accessible on our website. There were no reports in 2022. → Remuneration Policy → Remuneration Report → Business ethics Code of Conduct Evaluation of the Board The Board and its subcommittees conduct every year a self-evaluation of the Board's and subcom- To ensure corporate oversight of the Company’s global business ethics compliance risks, we have a Business Ethics Compliance Committee who repre- For more details on the work and composition of the Board and its committees, reference is made to the → Ethics Hotline Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 39 Data ethics policy The data ethics policy is based on 8 principles: 1. Our Executive Management is dedicated to ensuring and maintaining a high standard of data ethics See all our policies on: Bavarian Nordic has a data ethics policy to ensure we maintain strong data ethics in our company. The data ethics policy is based on 8 principles and supplements our general procedures and policies for processing (personal) data. → www.bavarian-nordic.com 2. We ensure accountability for data processing In 2022, we have carried out initiatives to support the data ethics principles. We have implemented new procedures as well as improved existing procedures about how we use data. Further, a series of awareness training activities have been carried out for relevant stakeholders to make sure relevant stakeholders know how to use data in compliance with our data ethics policy. 3. We require an appropriate level of data ethics for processing activities carried out by third parties 4. We ensure that the processing activities carried out provide value to the data subjects, and are transparent and secure 5. We train our employees and monitor processing activities We continue to actively work with supporting and implementing the data ethics principles into our way of doing business. 6. We maintain an Ethics Hotline, where violations of data protection laws can be reported by internal and external stakeholders 7. We identify and monitor the use of new technolo- gies for processing of data 8. We carry out internal controls Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 40 Risk management Bavarian Nordic’s business model spans the full value chain from research and development, over production to commercialization and rests on the ability to innovate and commercialize new vaccines. The business model covers partnership business, complex governmental sales and direct sales. By the nature of our business, we are exposed to a variety of risk along our value chain. Bavarian Nordic has a thorough risk management and mitigation process, whereby Bavarian Nordic is managing the risks through risk identification, risk monitoring and risk mitigation. The process is an integrated part of the Bavarian Nordic operational procedures and the management processes. The Finance, Risk and Audit Committee (FRAC) owns and overseas the risk management process and is closely monitoring the risks on a quarterly basis, including selected deep dives on specific risks. The Board of Directors receives regular risk updates from FRAC which is taken into consideration in the Board’s overall decisions about the company strategy. The formal process ensures both bottom-up and top-down identification and handling of risks. In this process key risks are first identified through a bottom-up process including description of the risks and mitigating actions taken to reduce either the likelihood of occurrence or the potential impact. Residual risk after agreed mitigating actions is further mitigated by insurance where this is relevant and possible. All risks have assigned risk owners, normally at the Executive level, and assigned risk-responsible employees who monitors and miti- gates the risks closely. The table below summarizes some of the key risks that are important to Bavarian Nordic’s business including examples of mitigating actions. Risk area Risks Mitigating actions Disruptions to Bavarian Nordic’s supply chain caused by breakdowns in facilities and/or manufacturing issues could have a significant impact on the ability to supply products at the right time and could impact both customer relations and financial performance. • Update and maintain risk assessment for equipment and implement preventive maintenance where necessary Dual sourcing strategies to secure adequate inventory levels Manufacturing and Supply • • Ensure redundant equipment where possible • • Adequate inventory for all core components. Internal quality audits, including mock inspections. • • Shelf-life extension initiatives Disaster recovery plans and backup strategies. To be continued Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 41 Risk area Risks Mitigating actions Risk area Risks Mitigating actions Disruptions, including hacking, malware, or other external attempts to disrupt Bavarian Nordic’s ability to operate, could have a significant impact on the Company’s IT infrastructure and systems, from inability to perform operationally to inability to perform commercial sales or perform R&D. • Constantly having continuity plans updated; Incl. having updated internal processes for data recovery Internal procedures for security monitoring and vulnerability assessment. Plans for micro-segmentation to reduce the impact of attacks Training and awareness campaigns both inside the IT department and within the business. Externally performed maturity assessments test, incl. gap analysis and gap closure plan identification Involvement of third-party cyber security specialist to ensure a constant overview of threats and preventative measures available Perform annual security penetration tests and audits by a third party Bavarian Nordic is constantly developing and maturing processes and systems to support expansion and growth; in-efficient processes or systems could restrict BNs ability to scale up and deliver on the growth potential across products and markets • • • Investment in internal Systems incl ERP and BI systems Constant standardization of processes and quality systems Employee training Cybersecurity Systems and Processes • • • Bavarian Nordic is increasingly using Contract manufacturers (CMOs) and these vendors may be delayed or fail in delivering. Such delays will impact the Company’s ability to deliver and generate revenue or progress development as planned. • • Strong internal Sales and Operations planning and governance Failure to supply from vendors or subcontractors The impact could influence revenue or costs. Continuously demand planning for +24months across products and markets Adequate safety inventory for core products Quality control during technology transfer phase • • • • • • • • The delivery from such contract • Close supply chain control and direct monitoring of key vendors manufacturers is dependent on the ability to transfer the technology used; such transfer may fail or be delayed which could cause delays to Bavarian Nordic’s delivery and revenue. Bavarian Nordic is strategically and Professional vendors selected for supporting the clinical trials; close and constant follow up from Bavarian Nordic Close dialogue with authorities (e.g., FDA and EMA) to secure optimal path to approval and compliance with GMP etc. Strong quality system in place to ensure compliance with standards agreed with and required by authorities. Use of adaptive trial designs to minimize financial risk and impact of failure. Communication with experts and regulators, to discuss regulatory strategy and Development of the future pipeline operationally focused on the development of two phase 3 studies which require significant internal resources, focus and funding. The development of products in the pipeline including clinical trials can be delayed or even abandoned. The product approval phase can be delayed or even fail. All clinical material and production facilities require regulatory approval; such approvals can be delayed or even fail. Bavarian Nordic is dependent on timely delivery of materials for production or R&D; supply chain challenges could delay or hinder BNs revenue or ability to pursue growth opportunities • • All steps in the above approval or clinical phases are associated with risks and can fail. development of recommendation Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 42 Risk area Risks Mitigating actions Risk area Risks Mitigating actions Not complying with laws, incl anti-corruption laws, regulations or any other compliance requirements could damage the Company’s reputation, result in significant fines and impede the Company’s ability to operate. • • • • • Follow and monitor the established internal compliance structure and governance. Internal and external legal resources available. Monitor development in relevant laws and regulations. Allocation of internal resources to secure adaptation of new rules and regulations. Constant monitoring by the Business Ethics Compliance Committee Partnering with other companies and government bodies in the industry is a central element of the Company’s strategy. Loss of partnerships, e.g., due to collaboration issues, failed projects or similar, could have a significant impact on the Company’s reputation and future performance. • • Frequent interactions with partners to build Laws, Regulations and Compliance Partnering and maintain common understanding. Processes in place to resolve potential issues. Increasing demands for transparency and progress on ESG coming from multiple stake- holders as investors, lawmakers, customers, partners and future talents. There is a risk of not living up to the changing and increasing standards that can impact the ability to attract funding, customers, suppliers or new employees Continuous follow, review and assess new and changing requirements and take actions accordingly Set and deliver on targets/selected ESG KPIs that demonstrate Bavarian Nordic’s commit- ment to drive sustainable business and deliver on ESG Not living up to external ESG requirements Bavarian Nordic is competing in markets where prices may be determined by the local supply/demand, including products from competitors that are significantly larger than Bavarian Nordic. If Bavarian Nordic cannot effectively compete in these markets, it will have an adverse impact on future revenue and profit. Pressure from local healthcare politics to reduce costs may impact Bavarian Nordic’s pricing or volume. Geopolitical or macroeconomic changes or health crises, e.g., pandemics, could impact demand, pricing and access to vaccinations. • • Secure an engaged and competent sales, marketing and medical affairs organization. Leverage focus rather than size vis-a-vis competition. Look for and leverage differentiation. Build strong relations through dedication and focus to achieve preferred supplier status. Commercializa- tion and Competition • • Develop systematic and efficient data struc- ture and platform Bavarian Nordic is dependent on the ability to attract and retain talents for many functions. In times of high competition for the right talents or adverse impact on Bavarian Nordic’s image, it could impact the Company’s ability to perform at high standards and compete against other companies. • • • • Perform employer branding • Develop early-stage pipeline of new platforms and vaccines to stay competitive. Attraction Provide training and development. Offer competitive remuneration package. Identifying and develop key talents, incl talent programs and retention of talent and employees Competitors might develop product candidates with higher potential which could reduce the value of Bavarian Nordic’s pipeline and products. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 43 Risk area Risks Mitigating actions Risk area Risks Mitigating actions Significant fluctuations in the DKK/USD and other currencies which Bavarian Nordic is, or could be exposed to, could impact financial positions. Potential disputes with tax authori- ties could result in additional tax payments. • • Aim to create natural hedges by matching income and expenses in USD and EUR. Material net USD exposure is hedged using FX contracts or options. Material net EUR exposure can also be hedged using FX contracts. Frequent monitoring of planned cash flows in other currencies allows for hedging when the risk is identified. Taxes are paid where the Company oper- ates, and intercompany transactions are priced and governed by agreements in compliance with OECD’s transfer pricing guidelines. Proactive work with tax authorities to ensure alignment on tax situation and avoidance of negative surprises. Lack of funds could eventually make it difficult for the Company to pursue the strategy e.g. investments in development and manufacturing facilities. Some development projects require funding from third parties and if this is not available it can result in delays or even termination of the project. • • Ensure solid financial planning Optimize the timing of income from partner agreements. Maintain working capital at appropriate levels to free liquidity. Keep spending and investments at appro- priate levels to stretch the liquidity runway. Ensure constant knowledge about financing options available in the market. Secure access to bank financing if/when needed. Strong relations with key existing or poten- tial investors of development. For ABNCoV2 largely mitigated Currency exposure and tax disputes Lack of funding for general operations or development programs • • • • • • • Currency risks and additional financial risks are further explained in note 23 in the consolidated financial specifically • • statements. • The validity of patents is crucial for the company to secure future revenues and return on the investments made in development. Patents might be challenged by competitors. Dedicated and experienced resources involved in the filing of patent applications to minimize vulnerability to future invalidity actions, and with ability to defend patents if such actions are filed. Intellectual property rights (IP) Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 44 Shareholder information Bavarian Nordic has been listed on the Nasdaq Copenhagen exchange since 1998 under the symbol BAVA. The Company is included in the OMXC25 index and the OMXC Large Cap index. warrants, see note 30 in the consolidated financial statements. Distribution of share capital Ownership 8% 64% At the end of 2022, Bavarian Nordic had approx- imately 112,000 registered shareholders owning 92% of the outstanding shares. The remaining 8% were held by non-registered shareholders. Bavarian Nordic held 0.21% of the share capital as treasury shares, which have been repurchased to meet obli- gations under incentive schemes for the Company's Board and Executive Management. See note 30 in the consolidated financial statements. Non-registered Denmark For US investors, Bavarian Nordic has a sponsored Level 1 American depositary receipt (ADR) program with Deutsche Bank Trust Company Americas acting as the depositary bank. Three ADRs represent one Bavarian Nordic share and the ADR symbol is BVNRY. 15% Europe Share capital The Company’s share capital was DKK 707,353,760 by year-end 2022, comprising 70,735,376 shares with a nominal value of DKK 10 each. Each share carries one vote. The following shareholder had publicly informed Bavarian Nordic that they own five per cent or more of the Company’s shares: 13% During the year, 266,983 new shares were issued as a consequence of warrant exercise by employees during the year, raising proceeds of DKK 38 million. North America ATP Group, Hillerød, Denmark, 10.12% as of December 31, 2022 By December 31, 2022, there were 3,652,007 Share price development outstanding warrants, which entitle warrant holders to subscribe for 3,652,007 shares of DKK 10 each. Thus, the fully diluted share capital amounted to DKK 743,873,830 at year-end, comprising 74,387,383 shares. For further information about outstanding Bavarian Nordic’s shares closed the year at DKK 213.40, corresponding to a 21% decrease over the year, compared to a decrease of 13% in the OMXC25 index and a decrease of 11% in the Nasdaq Biotech- nology (NBI) index. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 45 The year-low was DKK 115.75 on May 9, 2022, and the year-high was DKK 401.70 on August 3, 2022 – based on the daily closing prices of Bavarian Nordic’s shares. An unusually high price volatility could be observed in the international stock market in general and in the Bavarian Nordic share in particular. External factors like the war in Ukraine, high inflation and rapidly rising interest rates caused uncertainties in the market. For our share specifi- cally the mpox outbreak created an unprecedented awareness that had a significant spillover effect on the share price. Investor relations shareholder portal can be accessed via our investor relations website, along with financial reports, company announcements, investor presentations, and more. To register shares by name, shareholders must contact their custodian bank. Financial calendar 2023 March 2, 2023 Annual report Bavarian Nordic maintains an active dialogue with shareholders, analysts, prospective investors and other stakeholders by providing relevant, timely and correct communication about relevant stra- tegic, economic, financial, operational and scientific affairs of the Company. This work is carried out by Management and Investor Relations through frequent interactions with the investor community via participation in investor conferences, meetings and conference calls. March 30, 2023 Annual General Meeting Visit our investor relations website: May 9, 2023 Three-month interim report (Q1) → www.bavarian-nordic.com/investor August 23, 2023 Half-year interim report (Q2) Contact our investor relations team: Through our online shareholder portal, registered shareholders can request admission cards and/ or vote by proxy for the general meetings. The At year-end Bavarian Nordic had a market capitaliza- tion of DKK 15 billion. → November 16, 2023 Nine-month interim report (Q3) investor@bavarian-nordic.com Share price development compared to indices In connection with the publication of financial reports, Management will host a conference call to present the results followed by Q&A for investors and analysts. These events are being webcast live and on-demand through the Company’s website. Bavarian Nordic OMX Copenhagen C25 NASDAQ BIOTECH 150 120 90 Additional information about the annual general meeting will become available on our website no later than 3 weeks before the event. Shareholders who have requested so will receive a notification via e-mail. 60 → www.bavarian-nordic.com/agm 30 Jan ‘22 Feb ‘22 Mar ‘22 Apr ‘22 May ‘22 Jun ‘22 Jul ‘22 Aug ‘22 Sep ‘22 Oct ‘22 Nov ‘22 Dec ‘22 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 46 Board of Directors Gerard van Odijk, MD, Chair Anders Gersel Pedersen, MD, PhD, Deputy chair Former Executive Vice President of Research and Devel- opment of H. Lundbeck A/S. Peter Kürstein, MBA Frank Verwiel, MD, MBA Independent advisor for the pharmaceutical industry and former president and chief executive officer of Teva Pharmaceuticals Europe B.V. Former president and chief executive officer and Chair of Radiometer Medical ApS. Former president and chief executive officer of Aptalis Pharma, Inc. Chair of the board of Ferrosan Medical Devices Holding A/S. Deputy chair of the board of FOSS A/S, Experimen- tarium, and American Chamber of Commerce. Member of the board of N. Foss & Co. A/S and Den Erhvervsdriv- ende Fond Gl. Strand, Dansk BørneAstma Center and Art 2030. Member of the executive board of Mijamax ApS. Chair of the board of Intellia Therapeutics, Inc. Chair of the supervisory board of Hubrecht Organoid Technology. Member of the supervisory board of Centre for Human Drug Research. Member of the board of Genmab A/S, Hansa Biopharma AB and Bond Avillion 2, an entity of Avillion LLP. Chair of the board of Aelis Farma. Special competencies: Extensive strategic, operational and international experience within the pharmaceutical industry. Special competencies: Medical qualifications and extensive executive background within publicly traded and private companies in the international healthcare industry. Mr. Gersel is also the CEO of his private holding company Gerselconsult ApS. Special competencies: Extensive board and manage- ment experience from publicly traded, international healthcare companies. Special competencies: Scientific knowledge and large drug development experience within neuroscience and oncology. Extensive board and management experience from publicly traded, international pharmaceutical and biotech companies. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 47 Anne Louise Eberhard, MSc Law, and BSc Linette Munksgaard Andersen Manager, Customer Service, Shipping and Distribution Thomas Alex Bennekov Anja Gjøl Karen Merete Jensen Sr. App. and Integration Analyst Scientist. QA Specialist. Informatics and Management Accounting Former Senior Executive Vice President and Global Head of Corporate and Institutional Banking of Danske Bank A/S, and former Chief Commercial Officer at Intrum AB. Employee-elected. Employee-elected. Employee-elected. Employee-elected. Member of the board of FLSmidth & Co. A/S and its subsidiary FLSmidth A/S, Oterra A/S and group compa- nies, Knud Højgaards Fond, Den Danske Unicef Fond, and VL 52 ApS. Chair of the board of Finansiel Stabilitet SOV, Moneyflow Group A/S and its subsidiary Money- flow 1 A/S. Member of the executive board of EA Advice ApS. Faculty Member at Copenhagen Business School, Board Educations. Board Shares held in Year of birth Bavarian Nordic First elected Term expires Independent Nationality Gerard van Odijk, chair 2008 2010 2012 2016 2019 2021 2021 2021 2021 2023 2023 2023 2023 2023 2025 2025 2025 2025 No1 No1 Yes Yes Yes No2 No2 No2 No2 Dutch Danish Danish Dutch 1957 1951 1956 1962 1963 1974 1968 1980 1959 28,433 16,959 19,222 2,972 1,371 - Anders Gersel Pedersen, deputy chair Peter Kürstein Special competencies: Extensive finance, risk manage- ment and ESG experience as well as board experience from publicly listed companies. Frank Verwiel Anne Louise Eberhard Danish Danish Danish Danish Danish Linette Munksgaard, employee-elected Thomas Bennekov, employee-elected Anja Gjøl, employee-elected Karen M. Jensen, employee-elected 1,313 - 139 1 2 Gerard van Odijk and Anders Gersel Pedersen are not considered independent under the Danish corporate governance recommendations due to being a member of the board for more than 12 years. Employee-elected members are not considered independent under the Danish corporate governance recommendations Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 48 Meeting Attendance Number of meetings attended by each board member out of the total number of meetings within the member’s term Finance, Risk, and Audit Nomination and Science, Technology, and Investment Committee Board of Directors (C) Committee Compensation Committee Gerard van Odijk (C) Peter Kürstein Elizabeth McKee Anderson1 Anders Gersel Pedersen2 Erik G. Hansen3 (C) (DC) (C) Frank Verwiel4 Anne Louise Eberhard5 (C) Karen M. Jensen, employee-elected Anja Gjøl, employee-elected Thomas Bennekov, employee-elected Linette Munksgaard, employee-elected 1 Elizabeth McKee Anderson left the Board in August 2022 2 Anders G. Pedersen changed membership from the Nom.Com. Committee to the FRAC Committee in May 2022 and became Chair of the STI Committee in November 2022 3 Erik G. Hansen left the Board in April 2022 4 Frank Verwiel changed membership from the FRAC Committee to the STI Committee in June 2022 5 Anne Louise Eberhard became member of the STI Committee in June 2022 C: Chair, DC: Deputy chair Meeting attended Meeting not attended Not a Board member at the time Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 49 Executive Management Paul Chaplin Henrik Juuel Jean-Christophe May President and Chief Executive Officer Executive Vice President, Chief Financial Officer Executive Vice President, Chief Commercial Officer Paul Chaplin, PhD is a British national, born in 1967. He joined Bavarian Nordic in 1999 as director of immunology. Prior to joining the Company, Mr. Chaplin worked for several years both in the UK and Australia developing vaccines against infectious diseases. He was appointed vice president in 2004, and president and chief executive officer in 2014. Henrik Juuel, MSc is a Danish national, born in 1965. He joined Bavarian Nordic in November 2018 from Orexo AB. Prior to Orexo Mr. Juuel has held senior positions at several large and diverse organizations including Group CFO of Virgin Mobile (Central and Eastern Europe), CFO of GN ReSound and NNE Phar- maplan, as well as several senior finance positions at Novo Nordisk Jean-Christophe (JC) May, PharmD, MBA is a French national, born in 1967. He joined Bavarian in 2020 from GlaxoSmithKline (GSK), where he served as vice president and global vaccines commercializa- tion leader and was responsible for global strategic leadership and performance. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 50 Laurence De Moerlooze Anu Helena Kerns Russell Thirsk Executive Vice President, Chief Medical Officer Executive Vice President, People and Organization Executive Vice President, Chief Operating Officer Laurence De Moerlooze, PhD is a Belgian national, born in 1964. She joined Bavarian in 2020 from Takeda Vaccines, where she served as Vice President and Global Program Lead for vaccines against the Zika virus and Norovirus. Before Takeda she worked at GSK for more than 15 years, holding various leading roles in medical affairs and vaccine devel- opment. Anu Helena Kerns, MSc is a Danish national, born in 1972. She joined Bavarian Nordic in 2020 from Novo Nordisk, where she served for 11 years holding various leadership roles with increasing responsi- bilities, including 5 years abroad where she was responsible for establishing a new regional organi- zational structure and driving the HR development and communication strategy. Prior to Novo Nordisk, Ms. Kerns worked for 8 years in the financial sector with employer branding, reputation management, and change communication. Russell Thirsk, MSc is a British national, born in 1968. He joined Bavarian Nordic in April 2022 from GSK Vaccines in Belgium where he served as Head of Operations, a role he assumed after GSK acquired Novartis’ vaccine business, where he served for more than two decades, holding leadership roles of increasing responsibility in vaccine manufacturing operations across various geographies. Bavarian Nordic Annual Report 2022 51 Financial Review → Financial review → Sales performance → Income statement → Balance sheet Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 52 Financial review The financial review is based on the Group’s consolidated financial information for the year ended December 31, 2022, with comparative 2021 figures for the Group in brackets. There is no significant difference in the development of the Group and the Parent Company (except if noted specifically below). In 2022, the Company generated revenues of DKK 3,151 million (DKK 1,898 million) compared to the latest guidance of DKK 2,800 - 3,000 million. The improved revenue is largely resulting from the ship- ment of more mpox vaccines than anticipated in the latest guidance, which reflected some uncertainty related to the timing of deliveries and invoicing towards the end of 2022. Also, a continued strong performance in the rabies business has contributed to the improvement. The income before interest and taxes (EBIT) was a loss of DKK 71 million (loss of DKK 314 million) and EBITDA was an income of DKK 328 million (income of DKK 75 million) compared to the latest guided loss in the interval DKK -200 to 0 million. The higher sale combined with a general cost-conscious approach improved the operating result. Securities, cash, and cash equivalents as of December 31, 2022, amounted to DKK 2,845 million (DKK 3,717 million). The total amount includes a repo loan position of DKK 1,104 million (DKK 500 million); The net cash and cash equivalent position is hence DKK 1,741 (DKK 3,217 million) compared to a guid- ance of > DKK 1,700 million. The guidance assumed a bank debt level at year-end of DKK 600 million, however remaining bank debt was repaid during the fourth quarter and no new debt agreements were implemented. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 53 Sales performance Revenue 2022 DKK million JYNNEOS/IMVAMUNE/IMVANEX Rabipur/RabAvert revenue amounted to DKK 879 million (DKK 506 million) for the year. The 74% growth in revenue versus the prior year was driven by continued and significant market growth in the US and Germany. The US market grew by 32% versus the prior year and RabAvert now has a market share of approximately 69%, slightly above the level seen prior to competition facing a stockout situa- tion during late 2019 and the first half of 2020. The German market grew by 286%, however the market has not yet fully recovered from the COVID-19 pandemic. Rabipur achieved a market share of 95%, slightly above the 2021 level. The majority of revenue (~80%) was derived from Historically, JYNNEOS/IMVAMUNE/IMVANEX has been sold to few governments as part of their biological preparedness against smallpox. However, the 2022 global mpox outbreak created a significant, new demand for the vaccine, which is the only FDA- and EC-approved vaccine against mpox. Germany, where the TBE market saw strong growth in the second half of the year, resulting in an overall growth of 9% in 2022. Encepur sales however declined, due to a temporary stock-out situation during the second half of 2022, also resulting in a minor loss of the 2022 market share, which dropped to 28%. 79 164 Third-party products Other income Revenue from the sale of JYNNEOS/IMVAMUNE/ IMVANEX for the full year was DKK 1,730 million (DKK 734 million) and includes revenues from ongoing contracts with the US government as well as new contracts with various other govern- ments and organizations in response to the global monkeypox outbreak, which has driven the growth versus the prior year. 299 Third-party products Encepur Revenue from the sale of third-party products was DKK 79 million (DKK 0 million), which is related to the sale of DUKORAL and IXIARO (Valneva products assumed in the first quarter of 2022) and HEPLISAV-B (Dynavax product assumed in the second quarter of 2022). Encepur The market for tick-borne encephalitis (TBE) vaccines has made a good recovery during 2022, although it remained below the pre-COVID-19 market. 879 Rabipur/ RabAvert 1,730 JYNNEOS/ IMVAMUNE/ Rabipur/RabAvert Other revenue The rabies vaccine market showed strong signs of recovery, particularly in the US, our largest single market for post-exposure prophylaxis, which has been more resilient during COVID-19. The European market, which is a travelers’ vaccine market, still lags behind, although significant growth was seen in 2022. Other revenue totaled DKK 164 million (DKK 295 million) and included an upfront milestone payment of DKK 83 million from our license and supply agreement with Nuance on our RSV vaccine, DKK 51 million from contract work, and DKK 30 million from the sale of bulk drug substance for the Ebola vaccine to Janssen. Encepur revenue amounted to DKK 299 million (DKK 363 million) for the year, i.e., a decrease of 18% versus the prior year. IMVANEX Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 54 Revenues by quarter mDKK Q1 2022 Q2 2022 117 Q3 2022 578 Q4 2022 1,035 190 FY 2022 1,730 879 FY 2021 734 YOY change 135% JYNNEOS/IMVAMUNE/IMVANEX Rabipur/RabAvert Encepur - 117 69 234 144 38 338 506 74% -18% N/A 62 24 299 363 Third-party products Other revenue 14 11 15 79 - 120 320 4 15 26 164 295 -44% 66% Total 537 1,004 1,290 3,151 1,898 Rabipur/RabAvert sales by quarter Encepur sales by quarter mDKK mDKK 80 98 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 117 69 127 146 144 234 160 338 71 62 138 190 47 24 2021 2022 2021 2022 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 55 Income statement Revenue In the Parent Company revenue was DKK 212 million lower than in the Group as sale of RabAvert in the US and Rabipur and Encepur in Switzerland is handled by the subsidiaries. The internal sale from the Parent Company to the subsidiaries is made under a commissionaire transfer pricing setup. The variance in revenue between Group and Parent Company is influenced by phasing of both external and internal sale. In 2021, the revenue in the Parent Company was DKK 40 million higher than the Group revenue due to inventory build-up at subsidiaries. three quarters of 2022. In 2021 other production costs were also impacted by limited absorption of indirect production costs due to the shutdown but also due to production of RSV Phase 3 clinical trial material, which contributed to a low commercial utilization of the manufacturing capacity. Revenue for the year was DKK 3,151 million (DKK 1,898 million). The sale of JYNNEOS/IMVAMUNE/ IMVANEX mpox/smallpox vaccine amounted to DKK 1,730 million – an increase of DKK 997 million compared to last year, where the majority was related to sale of bulk drug substance batches and liquid-frozen finished products to the U.S. Govern- ment (DKK 644 million). Sale of Rabipur/RabAvert increased by DKK 374 million and reached DKK 879 million, whereas sale of Encepur decreased by DKK 64 million and reached 299 million, partly due to a temporary stock-out situation in some markets. Sale of other products amounted to DKK 108 million (DKK 260 million), primarily related to sale of third-party products of DKK 79 million, whereas the sale in 2021 related to sale of Ebola vaccine to Janssen. 3,151 Revenue mDKK in 2022 The product rights to Rabipur/RabAvert and Encepur are amortized over 20 years, on a straight-line basis, with an annual amortization of DKK 273 million and recognized as production costs. 1,450 Production costs mDKK in 2022 Production costs Sales and distribution costs Production costs amounted to DKK 1,450 million (DKK 1,328 million). Costs related directly to revenue amounted to DKK 665 million (DKK 562 million) of which cost of goods sold totaled DKK 645 million (DKK 540 million). The sales and distribution costs amounted to DKK 213 million (DKK 192 million) split between costs for distribution of products of DKK 37 million (DKK 16 million) and costs for running the commercial organ- ization and activities of DKK 176 million (DKK 176 million). The increase in distribution costs is closely linked to the higher sale of mpox vaccines. 213 Sales and distribution costs mDKK in 2022 Revenue from ongoing contract work amounted to DKK 51 million (DKK 35 million) and included recog- nition of revenue of HPV milestone payment of DKK 16 million, following Janssen’s termination of the development contract. Other production costs totaled DKK 512 million (DKK 493 million) of which net write-downs of inventory amounted to DKK 36 million compared to DKK 172 million in 2021. The bulk manufacturing facility was shut down for a year due to the expansion of the facility for future production of Rabipur/RabAvert and Encepur. The shutdown resulted in a limited absorption of indirect production costs for the first An upfront milestone payment of DKK 83 million was received under our license and supply agree- ment with our RSV partner Nuance. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 56 Research and development costs EBIT/EBITDA Financial expenses were DKK 339 million (DKK 189 The total research and development spending were DKK 1,203 million (DKK 421 million). The amount included research and development spend for funded contract costs of DKK 20 million (DKK 22 million). These costs are recognized as produc- tion costs in the income statement. The amount shown as research and development costs in the income statement totaled DKK 1,183 million (DKK 399 million), see note 6. The increase compared to 2021 was driven by initiation of the RSV Phase 3. Capitalized research and development costs incurred in 2022 related to ABNCoV2 development project amounted to DKK 593 million (DKK 130 million), split between development in progress (note 15) n (DKK 108 million) and commercial scale-up activities at CMO recognized as prepayments (note 21) DKK 303 million (DKK 22 million). Income before interest and tax (EBIT) was a loss of DKK 71 million (loss of DKK 314 million). million) and consisted of unwinding of the discount related to deferred consideration, DKK 103 million (DKK 134 million), currency adjustments on deferred consideration DKK 11 million (DKK 2 million income), interest expense on debt of DKK 17 million (DKK 18 million), negative fair value adjustments on securi- ties of DKK 190 million (net loss of DKK 39 million) and net loss on derivative financial instruments DKK 18 million (DKK 0 million). 1,203 Research and Development spending mDKK in 2022 EBITDA was an income of DKK 328 million (income of DKK 75 million). Amortization of product rights related to Rabipur/RabAvert and Encepur amounted to DKK 273 million (DKK 273 million) whereas depre- ciation and impairment losses on other fixed assets amounted to DKK 126 million (DKK 115 million). 328 EBITDA mDKK in 2022 Financial income and financial expenses Financial income was DKK 79 million (DKK 49 million) and consisted of adjustment of deferred consideration due to change in estimated timing of payments, DKK 54 million (DKK 32 million), interest income on securities of DKK 20 million (DKK 11 million), and a net foreign exchange gain of DKK 5 million (net gain of DKK 4 million). In 2021 the interest on repo transactions amounted to an income of DKK 2 million due to negative interest rates. In 2022 the net interest on repo transactions were DKK 0 million due to increased interest rates during the year. The net value adjustment of deferred consideration was an expense of DKK 60 million (DKK 100 million), consisting of the three components described above. In the Parent financial statements, the financial income was DKK 113 million (DKK 81 million) and included interests on receivables from subsidiaries of DKK 30 million (DKK 23 million). The financial expenses were DKK 341 million (DKK 190 million). Administrative costs Administrative costs totaled DKK 376 million (DKK 293 million), an increase of DKK 83 million compared to last year. The companywide increase in number of employees and activity level during 2022 has also resulted in an increased level of administrative costs. Income before company tax was a loss of DKK 332 million (loss of DKK 454 million). * The deferred consideration for product rights is measured at net present value and the difference between the net present value and the amounts due is recognized in the income statement as a financial expense over the period until expected payment date using the effective interest method. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 57 Tax on income for the year net securities and cash position amounted to DKK 1,741 million (DKK 3,217 million). The Company also maintained unutilized credit lines of DKK 20 million (DKK 243 million) as of such date. RabAvert and Encepur technology transfer project, DKK 130 million (DKK 87 million), and capitalized costs related to the ABNCoV2 development asset, DKK 290 million (DKK 108 million). The net invest- ment in securities was a cash contribution of DKK 674 million (net investment spend of DKK 1,779 million). Tax on the income for the year was an expense of DKK 16 million (DKK 10 million) and related primarily to taxes paid in Bavarian Nordic GmbH and Bavarian Nordic Inc. The parent company had a net loss for the year of DKK 342 million (net loss of DKK 470 million), and a taxable income of DKK 0 million reached by increasing the tax assets. Since further tax assets have been built up during the year and the two Phase 3 studies will continue in 2023, Management assesses that the deferred tax asset should remain at DKK 0 million on the balance sheet. Following the tax position in the parent company the effective tax rate for the Group was negative by 4.8% (negative 2.3%). The Company retains the right to use the tax losses carried forward that was written down in prior years. 575 Cash and cash equivalents mDKK in 2022 Cash flows Cash flow from operating activities totaled a net contribution of DKK 220 million (net spend of DKK 359 million) following the positive EBITDA of DKK 328 million (DKK 75 million). Net change in working capital was negative by DKK 149 million (negative by DKK 469 million) due to a higher level of trade receivables following the higher sale. The increase in inventories is partly offset by higher trade paya- bles as substantial purchases were made from Glax- oSmithKline towards the end of the year to support the production tech transfer activities. Cash flow from financing activities was a contri- bution of DKK 636 million (DKK 3,536 million), split between ABNCoV2 funding from Danish Ministry of Health DKK 400 million (DKK 160 million), increase in repo position DKK 604 million (DKK 500 million) and proceeds from warrant exercise DKK 38 million (DKK 107 million), partly offset by repayment of the European Investment Bank loan of DKK 372 million. During 2021 net proceeds of DKK 2.8 billion was raised through capital increases. 22 Cash flow from operating activities mDKK in 2022 Net result Cash flow spend on investment activities totaled DKK 877 million (DKK 2,877 million) and included DKK 595 million (DKK 372 million) in milestone payments to GlaxoSmithKline and DKK 361 million (DKK 483 million) of investments in property, plant and equipment primarily related to the expansion of the drug substance facility for future production of Rabipur/RabAvert and Encepur. Investment in other intangible assets amounted to DKK 425 million (DKK 203 million) and included the ongoing Rabipur/ The Group reported a net loss for the year of DKK 347 million (net loss of DKK 465 million). The net cash flow for 2022 was negative by DKK 22 million (positive by DKK 301 million). Liquidity and capital resources As of December 31, 2022, the Company had cash and cash equivalents of DKK 575 million (DKK 592 million), held investments in securities of DKK 2,270 million (DKK 3,125 million) and had a repo loan position of DKK 1,104 million (DKK 500 million). The Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 58 Balance sheet The balance sheet total was DKK 12,391 million as of December 31, 2022 (DKK 12,089 million). from DKK 579 million to DKK 196 million. For further details regarding the capitalization see note 16. 22 million) has been recognized as non-current prepayments. As part of the scale-up activity future commercial batches have been produced, totaling costs of DKK 132 million. Since the product is not yet approved, these costs have been recognized as current prepayments and will be reclassified to inventory once product approval is obtained. to GlaxoSmithKline during 2022. The adjustment of the net present value of the deferred consideration, both in terms of change in assumed timing of the future milestone payments and unwinding of the discount, amounted to DKK 53 million (DKK 100 million). Assets Inventories stood at DKK 919 million (DKK 480 million), of which the inventory of Rabipur/RabAvert and Encepur products amounted to DKK 578 million (DKK 305 million) as per December 31, 2022. The positive sale development for Rabipur/RabAvert has resulted in a reversal of write-down by DKK 43 million. A write-down of DKK 78 million was recorded during 2022, primarily related to Encepur. Intangible assets stood at DKK 5,943 million (DKK 5,804 million) with the main asset being the product rights to Rabipur/RabAvert and Encepur of DKK 4,640 million (DKK 4,913 million). The product rights are amortized on a straight-line basis over their expected useful lives of 20 years with an annual amortization of DKK 273 million. The deferred consideration to GlaxoSmithKline does not include the sales milestone of EUR 25 million included in the asset purchase agreement with GlaxoSmithKline as the Company does not assess the sales milestone to be probable as of December 31, 2022. As of December 31, 2022, cash and securities stood at DKK 2,845 million (DKK 3,717 million). Bavarian Nordic’s cash and cash equivalents are primarily invested in deposit accounts with highly rated banks and in short-term Danish government and mortgage bonds. Acquired rights and development in progress related to the development of ABNCoV2 stood at DKK 1,013 million (DKK 734 million). The asset includes the upfront payment to AdaptVac of DKK 30 million, the net present value of probable future sales and development milestones DKK 596 million and capitalization of development costs for running the Phase 2 and Phase 3 study DKK 398 million. For further description of the asset and the accounting policy see note 15. Receivables stood at DKK 720 million (DKK 557 million), of which trade receivables amounted to DKK 523 million (DKK 382 million) and prepayments amounted to DKK 154 million (DKK 109 million). The increase in trade receivables compared to year-end 2021 relates to sale of mpox vaccines. Under the terms of the license and collaboration agreement concluded with AdaptVac in July 2020, the Company is committed to payment of potential future development and sales milestones and tiered royalties. Management assesses that the likeli- hood of future regulatory approval of the ABNVoC2 vaccine is high, hence some of the milestone payments to AdaptVac are expected to become payable. The net present value of the probable mile- stone payments amounts to DKK 591 million (DKK 596 million) and has been recognized as deferred consideration. The adjustment of the net present value of the deferred consideration, both in terms of change in assumed timing of the future milestone Equity After the transfer of the result for the year, equity stood at DKK 7,150 million (DKK 7,375 million). Scale-up activities to prepare for future produc- tion of drug substance for commercial launch of ABNCoV2 is taking place at the contract manufac- turing organization (CMO) which also produced the Phase 3 clinical trial material. Costs related to the scale-up activities are recognized as prepayments and will be recognized as inventory in concurrence with future purchase of products from the CMO. As of December 31, 2022, DKK 193 million (DKK Liabilities The present value of the future milestone payments to GlaxoSmithKline for the acquisition of the product rights has been recognized as deferred consider- ation. Deferred consideration amounted to DKK 2,021 million (DKK 2,551 million), a decrease of DKK 530 million compared to December 31, 2021. Two milestones with a total of DKK 595 million were paid Property, plant and equipment stood at DKK 1,684 million (DKK 1,413 million). The expansion of the drug substance facility for future production of Rabipur/RabAvert and Encepur was completed end of 2022 and reduced the asset under construction Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 59 payments and unwinding of the discount, amounted to DKK 5 million (DKK 0 million). Company has received the upfront payment of DKK 80 million and milestone payments amounting to DKK 480 million. The funding has been recog- nized as prepayment and loan from Government. Management expects to receive the remaining two milestone payments in beginning of 2023. As per December 31, 2022, amortized costs amount to DKK 6 million (DKK 511 thousand). See further description in note 25. At initial recognition of the deferred consideration a corresponding asset of DKK 596 million was recog- nized under the ABNCoV2 development project, see description above under ‘Assets’ and note 24. In August 2021, the Company entered a funding agreement with the Danish Ministry of Health to further advance the development of ABNCoV2. The agreement is valued at up to DKK 800 million and aims to support the completion of the development towards licensure of ABNCoV2 as a booster vaccine. As of December 31, 2022, debt to credit institutions amounted to DKK 1,123 million (DKK 893 million) and included a repo position of DKK 1,104 million (DKK 500 million) and a mortgage loan of DKK 19 million (DKK 21 million). The European Investment Bank loan of DKK 372 million was repaid in October 2022 Under the agreement, Bavarian Nordic is entitled to an upfront payment of DKK 80 million, in addition to payments of up to DKK 720 million, which are contingent upon reaching a number of predefined milestones. All payments are potentially subject to repayment, however only upon successful approval and achievement of a certain level of commercial success. Half of the repayments shall be paid by delivery of vaccines to the Danish Ministry of Health whereas the remaining part of the repayments can be settled in either royalty payments from the sale of the vaccine to other customers or by delivery of further vaccines. As per December 31, 2022, the Bavarian Nordic Annual Report 2022 60 Financial statements → Consolidated financial statements → Notes → Financial statements of the parent company → Notes → Statement by management on the Annual Report → Independent auditor’s reports Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 61 Financial statements – Group Contents Financial statements Notes 18. Inventories Consolidated income statements 1. Significant accounting policies 19. Trade receivables 20. Other receivables 21. Prepayments 22. Other liabilities Consolidated statements of comprehensive income Consolidated statements of cash flow 2. Significant accounting estimates and judgments 3. Revenue Consolidated statements of financial position – Assets Consolidated statements of financial position – Equity and liabilities Consolidated statements of changes in equity 4. Production costs 5. Sales and distribution costs 6. Research and development costs 7. Adminstrative costs 23. Financial risks and financial instruments 24. Deferred consideration 25. Prepayment and loan from Government 26. Debt to credit institutions 8. Staff costs 9. Depreciation, amortization and impairment losses 10. Fees to auditor appointed at the annual general meeting 11. Financial income 27. Lease liabilities 28. Prepayment from customers 29. Related party transactions 12. Financial expenses 30. Share-based payment 13. Tax for the year 31. Contingent liabilities and other contractual obligations 32. Significant events after the balance sheet date 33. Approval of the consolidated financial statements 14. Earnings per share (EPS) 15. Intangible assets 16. Property, plant and equipment 17. Right-of-use-assets Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 62 Consolidated income statements Consolidated statements of comprehensive income For the years ended December 31, 2022 and 2021 For the years ended December 31, 2022 and 2021 DKK thousand Note 2022 2021 DKK thousand Note 2022 2021 Revenue 3 3,150,793 1,449,531 1,701,262 1,897,875 1,327,560 570,315 Net result for the year (347,382) (464,775) Production costs Gross profit 4,8,9 Items that may subsequently be reclassified to the income statement: Exchange rate adjustments on translating foreign operations 7,002 10,081 Sales and distribution costs Research and development costs Administrative costs 5,8 6,8,9 212,932 1,183,092 376,023 191,783 399,159 292,920 883,862 Change in fair value of financial instruments entered into to hedge future cash flows 33,245 (542) Tax on other comprehensive income Other comprehensive income after tax Total comprehensive income 13 - - 7,8,9,10 Total operating costs 1,772,047 40,247 9,539 Income before interest and tax (EBIT) (70,785 (313,547 (307,135 (455,236 Financial income 11 12 78,537 339,363 50,233 191,116 Financial expenses Income before company tax (331,611) (454,430) Revenue DKK million EBITDA DKK million Tax on income for the year 13 15,771 10,345 Net result for the year (347,382) (464,775) Earnings per share (EPS) – DKK Basic earnings per share of DKK 10 Diluted earnings per share of DKK 10 2022 2021 3,151 2022 2021 328 75 14 14 (4.9) (4.9) (7.4) (7.4) 1,898 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 63 Consolidated statements of cash flow For the years ended December 31, 2022 and 2021 DKK thousand Note 2022 2021 DKK thousand Note 2022 2021 Net result for the year (347,382) (464,775) Investments in product rights Investments in other intangible assets Investments in property, plant and equipment Investments in financial assets Investments in securities 15, 24 15 (594,920) (425,411) (361,244) (169,460) (371,849) (203,475) (483,127) (39,041) Adjustment for non-cash items: Financial income 16 11 12 (78,537) 339,363 15,771 (50,233) 191,116 10,345 Financial expenses (414,613) (2,115,796) 1,088,243 336,342 Tax on income for the year Depreciation, amortization and impairment Share-based payment Disposal of securities 9 399,247 49,284 388,310 56,857 30 Cash flow from investment activities (877,405) (2,876,946) Changes in inventories Changes in receivables Changes in current liabilities (439,029) (133,167) 423,407 41,039 (364,393) (146,007) Payment on loans 26 26 27 (374,339) 1,003,661 (21,981) 37,918 - (2,173) 660,000 (19,507) 107,183 Proceeds from loans Repayment of lease liabilities Proceeds from warrant programs exercised Proceeds from capital increase Costs related to issue of new shares Purchase of treasury shares Cash flow from operations (operating activities) 228,957 (337,741) 2,856,596 (57,438) (8,581) (111) Received financial income Paid financial expenses Paid company taxes 18,552 (24,244) (3,212) 6,198 (24,383) (2,574) (9,328) Cash flow from financing activities Cash flow of the year 635,820 3,536,080 Cash flow from operating activities 220,053 (358,500) (21,532) 300,634 Cash and cash equivalents as of January 1 591,820 5,119 285,487 5,699 Currency adjustments Cash and cash equivalents as of December 31 575,407 591,820 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 64 Consolidated statements of financial position – Assets December 31, 2022 and 2021 DKK thousand Note 2022 2021 DKK thousand Note 2022 2021 Non-current assets Current assets Inventories Product rights 4,639,895 1,013,484 14,768 4,912,830 733,770 18 919,072 480,043 Acquired rights and development in progress Software Trade receivables Other receivables Prepayments 19 20 21 523,145 43,263 381,624 66,517 22,985 Intangible assets in progress Intangible assets 274,490 134,371 153,934 720,342 108,840 556,981 15 5,942,637 5,803,956 Receivables Land and buildings 630,138 24,765 345,953 10,011 Securities 23 2,269,759 575,407 3,124,795 591,820 Leasehold improvements Cash and cash equivalents Securities, cash and cash equivalents Plant and machinery 321,745 511,195 196,130 254,530 223,467 578,707 1,412,668 2,845,166 3,716,615 Fixtures and fittings, other plant and equipment Assets under construction Total current assets Total assets 4,484,580 4,753,639 Property, plant and equipment 16 1,683,973 12,391,246 12,089,269 Right-of-use assets 17 67,433 75,843 Other receivables Prepayments 20 21 5,086 207,537 212,623 4,778 38,385 43,163 Financial assets Total non-current assets 7,906,666 7,335,630 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 65 Consolidated statements of financial position – Equity and liabilities December 31, 2022 and 2021 DKK thousand Note 2022 2021 Equity Share capital Treasury shares Retained earnings Other reserves 707,354 (1,463) 704,684 (1,112) 6,300,575 143,521 6,588,908 82,187 Equity 7,149,987 7,374,667 Liabilities Deferred consideration Prepayment and loan from Government Debt to credit institutions Lease liabilities 24 25 26 27 2,324,657 566,420 17,008 2,569,090 160,511 18,896 45,834 57,547 Non-current liabilities 2,953,919 2,806,044 Deferred consideration Debt to credit institutions Lease liabilities 24 26 27 28 287,436 1,105,583 24,487 - 577,667 874,373 21,266 16,904 263,611 3,743 Prepayment from customers Trade payables 605,928 6,337 Company tax Other liabilities 22 257,569 150,994 Current liabilities 2,287,340 1,908,558 5,241,259 4,714,602 12,391,246 12,089,269 Total liabilities Total equity and liabilities Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 66 Consolidated statements of changes in equity December 31, 2022 Reserves for Reserves for currency adjustment fair value Share capital Treasury shares Retained earnings of financial Share-based instruments The share capital comprises a total of 70,735,376 shares of DKK 10 as of December 31, 2022 (70,468,393 shares). The shares are not divided into share classes, and each share carries one vote. Treasury shares In May 2022, the Board of Directors decided to launch a share buy-back program, under which the Company bought back 71,562 of its own shares (31,747 shares in 2021). The purpose of the share buy-back program was to meet the Company's obligations arising from the share-based incentive program for the Executive Management and the Board of Directors. Under the share-based incentive program, payment of half of the achieved bonus for 2021 for members of the Executive Management are converted to restricted stock units for a value corresponding to half of the achieved bonus. The restricted stock units will be released to the Exec- utive Management 3 years after grant. This to further increase the long-term shared interests between the Executive Management and the Company's share- holders. The Board of Directors is granted restricted stock units corresponding to 50% of the annual fee (excl. committee fee). The vesting period for those restricted stock units is also 3 years. Treasury shares represent 0.16% (0.18%) of the total share capital. For further information about share based payment see note 30. DKK thousand payment Equity Equity as of January 1, 2022 704,684 (1,112) 6,588,908 (347,382) - (30,559 (1,351) 114,097 7,374,667 Comprehensive income for the year Net result for the year - - - - - - - - - (347,382) 7,002 Other comprehensive income Exchange rate adjustments on translating foreign operations 7,002 Change in fair value of financial instruments entered into to hedge future cash flows - - - - 33,245 33,245 - 33,245 Total comprehensive income for the year - - (347,382) 7,002 - (307,135 Transactions with owners Share-based payment - - - 46,145 17,898 - - - - - - - - - - - - - - - - - 53,976 53,976 Warrant programs exercised 2,670 - (10,897) 37,918 Warrant programs expired - - - (17,898) - - Capital increase through private placement Costs related to issue of new shares Purchase of treasury shares - - - - (111) - - (111) (9,328) - - - (716) 365 (351) (8,612) 3,729 59,049 Transfer regarding restricted stock units Total transactions with owners (4,094) 21,087 2,670 82,455 Equity as of December 31, 2022 707,354 (1,463) 6,300,575 (23,557) 31,894 135,184 7,149,987 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 67 Consolidated statements of changes in equity December 31, 2021 Reserves for Reserves for currency adjustment fair value Share capital Treasury shares Retained earnings of financial Share-based instruments The share capital comprises a total of 70,468,393 shares of DKK 10 as of December 31, 2021 (58,450,112 shares). The shares are not divided into share classes, and each share carries one vote. Rules on changing Articles of Association Changing the Articles of Association requires that the resolution passes by at least 2/3 of the votes as well as 2/3 of the voting capital represented. DKK thousand payment Equity Equity as of January 1, 2021 584,501 (1,077) 4,246,359 (464,775) - (40,640) (809) 106,019 4,894,353 Comprehensive income for the year Net result for the year - - - - - - - - - (464,775) 10,081 Other comprehensive income Exchange rate adjustments on translating foreign operations 10,081 Change in fair value of financial instruments entered into to hedge future cash flows - - - - (542) (542) - (542) Total comprehensive income for the year - - (464,775) 10,081 - (455,236 Transactions with owners Share-based payment - - - 126,729 695 - - - - - - - - - - - - - - - - - - 38,584 (24,492) (695) - 38,584 107,183 - Warrant programs exercised 4,946 - Warrant programs expired - - - Capital increase through private placement Costs related to issue of new shares Purchase of treasury shares 115,237 2,741,359 (57,438) (8,263) 4,242 2,856,596 (57,438) (8,580) - - - - - (317) 282 - - Transfer regarding restricted stock units Restricted stock units converted to cash bonus at exercise Total transactions with owners - - (4,524) (795) 8,078 - (795) 120,183 (35) 2,807,324 2,935,550 Equity as of December 31, 2021 704,684 (1,112) 6,588,908 (30,559 (1,351) 114,097 7,374,667 Transactions on the share capital DKK thousand 2022 2021 2020 2019 2018 Share capital as of January 1 Issue of new shares 704,684 2,670 584,501 120,183 704,684 323,891 260,610 584,501 323,106 785 322,451 655 Share capital as of December 31 707,354 323,891 323,106 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 68 Note 1 Significant accounting policies Implementation of new and revised standards and interpretations Management has assessed the impact of new or amended and revised accounting standards and interpretations (IFRSs) issued by the IASB and IFRSs endorsed by the European Union effective on or after January 1, 2022. It is assessed that application of amendments effective from January 1, 2022 has not had a material impact on the consolidated financial state- ments for 2022. Furthermore, Management does not anticipate any significant impact on future periods from the adoption of these amendments. The specific disclosures required by IFRS are provided in the Consolidated Financial Statements unless the information is considered immaterial to the users of the financial statements. Intra-group income and expenses together with all intra-group profits, receivables and payables are eliminated on consolidation. In the preparation of the consolidated financial statements, the book value of shares in subsidiaries held by the parent company is set off against the equity of the subsidiaries. Basis of preparation The consolidated financial statements for Bavarian Nordic have been prepared in accordance with the International Financial Reporting Standards (IFRS) as adopted by the EU and Danish disclosure requirements for the consolidated financial statements of listed companies. Danish disclosure requirements for the presentation of consolidated financial statements are imposed by the Statutory Order on Adoption of IFRS issued under the Danish Financial Statements Act. The accounting policies are unchanged from last year except for changes due to implementation of new and revised standards that were effective January 1, 2022. The consolidated financial statements are presented in Danish kroner (DKK), which is the functional currency of the parent company. The consolidated financial statements are presented on a historical cost basis, apart from derivative financial instruments, securities and liability relating to phantom shares, which are measured at fair value. The accounting policies have been consistently applied for the financial year and for the comparative figures except for implementation of new standards and amendments, see further below. In the narrative sections of the consolidated financial statements comparative figures for 2021 are shown in brackets. Accounting policies The accounting policies for specific line items are described in the notes to the financial statements. Set out below is a description of the accounting policies for the basis of consolidation, foreign currency translation and the cash flow statement. Foreign currency translation On initial recognition, transactions denominated in currencies other than the Group’s functional currency are translated at the exchange rate ruling at the trans- action date. Receivables, payables and other monetary items denominated in foreign currencies that have not been settled at the balance sheet date are translated at the exchange rates at the balance sheet date. Exchange differences between the exchange rate at the date of the transaction and the exchange rate at the date of payment or the balance sheet date, respec- tively, are recognized in the income statement under financials. Property, plant and equipment and intan- gible assets, inventories and other nonmonetary assets acquired in foreign currency and measured based on historical cost are translated at the exchange rates at the transaction date. On recognition in the consolidated financial state- ments of subsidiaries whose financial statements are presented in a functional currency other than Danish kroner (DKK), the income statements are translated at the average exchange rates of the respective months. Recognition and measurement Income is recognized in the income statement when generated. Assets and liabilities are recognized in the balance sheet when it is probable that any future economic benefit will flow to or from the Group and the value can be reliably measured. On initial recog- nition, assets and liabilities are measured at cost. Subsequently, assets and liabilities are measured as described in the description of the accounting policies in the respective notes to the financial statements. Standards and interpretations not yet in force At the date of publication of the consolidated financial statements, a number of new and amended standards and interpretations have not yet entered into force or have not yet been adopted by the EU. Therefore, they are not incorporated in the consolidated financial state- ments. None of the new or amended standards and interpre- tations are expected to have a material impact on the consolidated financial statements. Basis of consolidation The consolidated financial statements include Bavarian Nordic A/S and the subsidiaries in which the Group holds more than 50% of the voting rights or otherwise has control. Applying materiality The consolidated financial statements are a result of processing large numbers of transactions and aggre- gating those transactions into classes according to their nature or function. The transactions are presented in classes of similar items in the consolidated financial statements. If a line item is not individually material, it is aggregated with other items of a similar nature in the consolidated financial statements or in the notes. Principles of consolidation The consolidated financial statements are prepared on the basis of the financial statements of the parent company and the individual subsidiaries, and these are prepared in accordance with the Group’s accounting policies and for the same accounting period. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 69 Note 1 Significant accounting policies (continued) Balance sheet items are translated at the exchange rates at the balance sheet date. Exchange differences arising on the translation of foreign subsidiaries’ opening balance sheet items to the exchange rates at the balance sheet date and on the translation of the income statements from average exchange rates of the respective months to exchange rates at the balance sheet date are recognized as other comprehensive income. In the cash flows from operating activities, net profit for the year is adjusted for non-cash operating items and changes in working capital. Cash flows from investing activities include cash flows from the purchase and sale of intangible assets, prop- erty, plant and equipment, investments and securities. Cash flows from financing activities include cash flows from the raising and payment of loans and capital increases. Additionally, cash flows from assets held under finance leases are recognized by way of lease payments made. that are considered to match the content of those line items. For line items not considered to be covered by line items defined in the taxonomy, entity-specific extensions to the taxonomy have been incorporated. Except for subtotals, these extensions are anchored to standard elements of the ESEF taxonomy. Consistently with the requirements of the ESEF Regu- lation, the annual report approved by Management is comprised of a ZIP file bava-2022-12-31-en.zip, which includes an XHTML file that may be opened using standard web browsers, and a number of technical XBRL files enabling mechanical retrieval of the XBRL data incorporated. Segment reporting The Group does not prepare segment reporting inter- nally and therefore only reports one operating segment externally. Geographic spilt of revenue and revenue from major customers is disclosed in note 3 to the consolidated financial statements. Geographic location of noncurrent assets is disclosed in note 15 and 16 to the consolidated financial statements. Reporting under the ESEF Regulation The Commission Delegated Regulation (EU) 2019/815 on the European Single Electronic Format (ESEF Regulation) requires the use of a particular electronic reporting format for annual reports of listed companies in the EU. More specifically, the ESEF Regulation requires the annual report to be prepared in XHTML format with iXBRL tagging of the consolidated financial statements including notes. The Company’s iXBRL tagging has been made using the ESEF taxonomy disclosed in the annexes to the ESEF Regulation and developed based on the IFRS taxonomy published by the IFRS Foundation. The 2021 version of the ESEF taxonomy has been used in the annual report for 2022. The line items in the consolidated financial statements are XBRL-tagged to the elements of the ESEF taxonomy Net asset value per share: Equity Number of shares at year-end Share price/Net asset value per share: Market price per share Net asset value per share Equity share, %: Equity x 100 Total assets Earnings per share and diluted earnings per share are calculated in accordance with IAS 33 “Earnings per share” and specified in note 14. Cash flow statement The cash flow statement is prepared in accordance with the indirect method on the basis of the Group’s net result for the year. The statement shows the Group’s cash flows broken down into operating, investing and financing activities, cash and cash equivalents at year end and the impact of the calculated cash flows on the Group’s cash and cash equivalents. Cash flows in foreign currencies are translated into Danish kroner (DKK) at the exchange rate on the trans- action date. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 70 Note 2 Significant accounting estimates and judgments Note 3 Revenue Significant accounting estimates In the preparation of the consolidated financial state- ments, Management makes a number of accounting estimates, which form the basis for the presentation, recognition and measurement of the Group's assets and liabilities. The recognition and measurement of assets and liabil- ities often depend on future events that are somewhat uncertain. In that connection, it is necessary to assume a course of events that reflects Management’s assess- ment of the most probable course of events. The key accounting estimates identified are those that have a significant risk of resulting in a material adjust- ment to the measurement of assets and liabilities in Accounting policies Sale of goods Revenue from sale of goods is recognized when Bavarian Nordic has transferred control of products sold to the buyer and it is probable that Bavarian Nordic will collect the consideration to which it is entitled for transferring the products. Control of the products is transferred at a point in time, typically on delivery. The amount of sales to be recognized is based on the consideration Bavarian Nordic expects to receive in exchange for its goods. When sales are recognized, Bavarian Nordic also records estimates for a variety of sales deductions, including product returns as well as rebates and discounts to government agencies, whole- salers, health insurance companies, managed health- care organisations and retail customers. Revenue is measured net of value added tax, duties, etc. collected on behalf of a third party. Where contracts contain customer acceptance criteria, Bavarian Nordic recognizes sales when the acceptance criteria are satisfied. Where absolute amounts are known, the rebates are recognized as other liabilities. Wholesaler charge-backs are netted against trade receivable balances. The pricing mechanisms in the US market and the different kind of rebates are described below. the following reporting period. Management bases its estimates on historical experience and various other assumptions that are held to be reasonable under the circumstances. The estimates and underlying assump- tions are reviewed on an ongoing basis. If necessary, changes are recognised in the period in which the estimate is revised. Management considers the key accounting estimates to be reasonable and appropriate based on currently available information. The actual amounts may differ from the amounts estimated as more detailed information becomes available. Management has made the following accounting esti- mates which significantly affect the amounts recog- nized in the consolidated financial statements: customers in the US include private payers, Group Purchasing Organizations (GPOs) and government payers. GPOs play a role in negotiating price conces- sions with drug manufacturers for the commercial channels, and determine which drugs are offered as preferred options on their drug lists. US Medicaid & Medicare rebates Medicaid & Medicare are government insurance programmes. Medicaid and Medicare rebates have been estimated using a combination of historical expe- rience, product and population growth, price increases, and the impact of contracting strategies. The calcula- tion also involves interpretation of relevant regulations that are subject to changes in interpretative guidance from government authorities. Bavarian Nordic adjusts the provision periodically to reflect actual sales perfor- mance. Accounting policy Key accounting estimates and judgements Note Revenue Estimate of US sales deductions and provisions for sales rebates 3 Intangible assets Estimate regarding impairment of assets; assessment whether future sales 15 and development milestones have become probably; assessment whether development costs should be expensed or capitalized Inventories Estimate of indirect production costs capitalized and inventory write-down 18 Wholesaler charge-backs Wholesaler charge-backs relate to contractual arrange- ments between Bavarian Nordic and indirect customers whereby products are sold at contract prices lower than the list price originally charged to wholesalers. A wholesaler charge-back represents the difference between the invoice price to the wholesaler and the indirect customer’s contract price. Accruals are calcu- lated for estimated charge-backs using a combination of factors such as historical experience, current whole- saler inventory levels, contract terms and the value of claims received but not yet processed. Pricing mechanisms in the US market In the US, sales rebates are paid in connection with government and commercial programmes. Key Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 71 Note 3 Revenue (continued) Accounting policies (continued) Significant accounting estimates Provisions for sales deductions Sales discounts and rebates are predominantly issued in the US in connection with the US Federal and State Government Healthcare programs, namely Medicare and Medicaid, and commercial rebates. The estimate of sales discounts and rebates is based on a calculation which includes a combination of historical utilization data, combined with expectations in relation to the development in sales and utilization. Further- more, specific circumstances regarding the different programs are considered. The obligations concerning sales discounts and rebates are incurred at the time the sale is recorded. However, the actual discount or rebate related to a specific sale may be invoiced later. Bavarian Nordic considers the provisions established for sales discounts and rebates to be reasonable and appropriate based on currently available information. However, the actual amount of discounts and rebates may differ from the amounts estimated as more detailed information becomes available. Partner contracts Whether a component of a multiple element contract has value to the partner on a stand-alone basis is based on an assessment of specific facts and circumstances and is associated with judgement. This applies also to the assessment of whether a license transfers rights associated with ownership of an intangible asset. Furthermore, allocation of the total consideration of a contract to separately identifiable components requires considerable estimates and judgement to be made by Management. At inception and throughout the life of a contract Management is performing an analysis of the agree- ment with its partners based on available facts and circumstances at each assessment date such as histor- ical experience and knowledge from the market to the extent obtainable. This includes also an understanding of the purpose of the deliverables under the contract and the negotiation taken place prior to concluding the contract. Other discounts and sales returns Other discounts are provided to wholesalers, hospi- tals, pharmacies, etc. They are usually linked to sales volume or provided as cash discounts. Accruals are calculated based on historical data and recorded as a reduction in gross sales at the time the related sales are recorded. Sales returns are related to damaged or expired products. Agreements with commercial partners generally include non-refundable upfront license and collabora- tion fees, milestone payments, the receipt of which is dependent upon the achievement of certain clinical, regulatory or commercial milestones, as well as royal- ties on product sales of licensed products, if and when such product sales occur, and revenue from the supply of products. For these agreements that include multiple elements, total contract consideration is attributed to separately identifiable components on a reliable basis that reasonably reflects the selling prices that might be expected to be achieved in stand-alone transactions provided that each component has value to the partner on a stand-alone basis. The allocated consideration is recognized as revenue in accordance with the principles described above. Sale of services and licenses Furthermore, revenue comprises the fair value of the consideration received or receivable for income derived from development services where revenue is measured at the expected net sales price. Sales of licenses that transfer the rights associated with ownership of intellectual property are recognized at a point in time when control is transferred. Revenue from development services and licenses that do not transfer the right of ownership to intellectual property are recognized over time in line with the execution and delivery of the work. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 72 Note 3 Revenue (continued) Other product sale for 2022 consist of the following: • Sale of Mvabea (Ebola vaccine) to Janssen. • Sale of Dukoral and Ixiaro licensed from Valneva • Sale of Heplisav-B licensed from Dynavax In 2022 revenue achieved on the Danish market amounted to DKK 19.3 million (DKK 0 million). In 2022 no customer represented more than 10% of total revenue. In 2021 the following customers represented more than 10% of total revenue: • Biomedical Advanced Research and Development Authority (BARDA), USA, DKK 675.3 million. • Janssen Pharmaceutica NV, Belgium, DKK 260.2 million. DKK thousand 2022 2021 MVA-BN smallpox vaccine sale 1,730,472 733,593 Rabipur/RabAvert 879,341 505,769 Encepur 298,736 363,054 Other product sale 108,496 260,225 Sale of goods 3,017,045 1,862,641 Milestone payments 83,048 - Contract work 50,700 35,234 Sale of services 133,748 35,234 Revenue 3,150,793 1,897,875 Total revenue includes: Fair value adjustment concerning financial instruments entered into to hedge revenue - (7,072) Geographic split of revenue: USA 841,527 1,066,800 Germany 650,208 258,288 Belgium 335,399 264,410 France 268,186 26,088 Canada 197,283 10,516 United Kingdom 169,203 16,975 Hong Kong 115,599 - Saudi Arabia 100,442 - Australia 97,655 2,504 Switzerland 70,986 24,142 Other geographic markets 304,305 228,152 Revenue 3,150,793 1,897,875 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 73 Note 3 Revenue (continued) Accounting for contract with Biomedical Advanced Research and Development Authority (BARDA) In April 2020, BARDA placed a new order for the manu- facturing and supply of JYNNEOS®, at a total value of USD 202 million. The contract expansion covered manu- facturing of 35 bulk drug substance (BDS) batches and the supply of up to 1.4 million doses of liquid-frozen JYNNEOS®. At year-end 2022 only 6 BDS batches remain to be manufactured and invoiced. In June and July 2022, BARDA ordered in total 5,500,000 doses of liquid-frozen JYNNEOS®, for delivery in 2022 and 2023. When BDS batches are invoiced to BARDA the BDS batches remain in the Company's physical possession until filling as final product. The filling takes place either at the Company's facility in Kvistgaard or at CMO's (a bill-and-hold arrangement). Revenue is recog- nized once the BDS are releasable according to contract with BARDA. Payment is due within 30 days after invoicing. of MVA-BN® RSV in China, which will be conducted separately from the Company’s own Phase 3 trial planned for initiation later in the first half of 2022 to support a U.S. Biologics License Application. Under the terms of the agreement, Bavarian Nordic has received an upfront payment of USD 12.5 million and is eligible to receive future milestone payments of up to USD 212.5 million that are triggered upon achieve- ment of certain clinical, regulatory, and commercial milestones, in addition to tiered, double-digit royalties on future net sales. The received upfront payment has been recognized as revenue. The future milestone payments will be recognized as revenue once the mile- stones are achieved. Nuance Pharma will assume all costs and responsibility for the clinical development, regulatory filings, and commercialization of the vaccine in territories covered by the agreement. Subject to Chinese regulatory authority (National Medical Products Administration, NMPA) approval, Phase 1 and Phase 3 trials are planned for the vaccine approval in China. Accounting for license and collaboration agree- ments with Nuance Pharma In March 2022, Bavarian Nordic entered into an exclusive license and supply agreement with Nuance Pharma, on the development and commercialization of MVA-BN® RSV against respiratory syncytial virus (RSV) in adults in Chinese Mainland, Hong Kong, Macau, Taiwan, South Korea and certain Southeast Asian countries. The agreement entails clinical development, including a Phase 3 trial to support regulatory approval Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 74 Note 4 Production costs DKK thousand 2022 2021 Cost of goods sold 644,683 539,789 Contract costs 19,889 21,959 Other production costs 512,024 492,877 Amortization of product rights 272,935 272,935 Production costs 1,449,531 1,327,560 Note 5 Sales and distribution costs Accounting policies Sales and distribution costs comprise costs incurred for the sale and distribution of products sold during the year. This includes costs incurred for sales campaigns, training and administration of the sales force and for direct distribution, marketing and promotion. Also included are salaries and other costs for the sales, distribution and marketing functions, loss allowance for expected credit losses, amortization, depreciation and other indirect costs. Other production costs amounted to DKK 512.0 million (DKK 492.9 million), of which net write-downs of inven- tory amounted to DKK 35.5 million compared to DKK 171.6 million in 2021. Development in write-downs is further described in note 18. The bulk manufacturing facility has been shutdown for a year due to the expansion of the facility for future production of Rabipur/RabAvert and Encepur. The shutdown resulted in a limited absorption of indirect production costs for the first 3 quarters of 2022. In 2021 other production costs were also impacted by limited absorption of indirect production costs due to the shut- down in fourth quarter but also due to production of RSV Phase 3 clinical trial material, which contributed to a low commercial utilization of the manufacturing capacity. The product rights to Rabipur/RabAvert and Encepur are amortized over 20 years with an annual amortization of DKK 272.9 million. Accounting policies Production costs consist of costs incurred in gener- ating the revenue for the year. Costs for raw materials, consumables, production staff and a proportion of production overheads, including maintenance, amorti- zation, depreciation and impairment of intangible and tangible assets used in production as well as operation, administration and management of the production facility are recognized as production costs. Amortization of acquired product rights are recognized as production costs. In addition, the costs related to excess capacity and write-down to net realisable value of goods on stock are recognized. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 75 Note 6 Research and development costs 2022 2021 DKK thousand Research and development costs incurred this year 1,202,981 421,118 Of which: Contract costs recognized as production costs (note 4) (19,889) (21,959) Research and development costs recognized in the income statement 1,183,092 399,159 Note 7 Adminstrative costs Accounting policies Administrative costs include costs of Group Manage- ment, staff functions, administrative personnel, office costs, rent, short-term lease payments and depreciation not relating specifically to production, research and development or sales and distribution. Fair value adjustment concerning financial instruments entered into to hedge research and development costs 30,201 - Accounting policies Research and development costs include salaries and costs directly attributable to the Group’s research and development projects, less government grants. Further- more, salaries and costs supporting direct research and development, including costs of patents, rent, leasing and depreciation attributable to laboratories, and external scientific consultancy services, are recognized under research and development costs. No indirect or general overhead costs that are not directly attributable to research and development activities are included in the disclosure of research and development expenses recognized in the income statement. Research costs are expensed in the year they occur. Development costs are generally expensed in the year they occur. In line with industry custom, capitaliza- tion of development costs does not begin until it is deemed realistic that the product can be completed and marketed and it is highly likely that a marketing authorization will be received. In addition, there must be sufficient certainty that the future earnings to the Under the Group’s accounting policies development costs are generally expensed in the year they occur. During the development of ABNCoV2, the Group has, however, started capitalization of directly related development cost at commencement of the phase 2 studies as – unlike most other development candidates - the feasibility of developing a final vaccine and obtain regulatory approval is considered likely, because the development of other COVID-19 vaccine candidates based on the same antigen has been successful. Furthermore, the Group has ensured significant finance of the development through the funding obtained from Danish Ministry of Health and a minimum demand agreed in the agreement with the Danish Ministry of Health. See further description in note 15. Research and development costs include expenses for external clinical research organizations, or CRO's, of DKK 874.9 million (DKK 160.5 million). Group will cover not only production costs, direct distri- bution and administrative costs, but also the develop- ment costs. Contract research and development costs incurred to achieve revenue are included in "Research and devel- opment costs incurred this year" in the below tabel and then transferred under "Contract costs recognized as production costs" to be recognized as production costs. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 76 Note 8 Staff costs 2022 2021 DKK thousand Wages and salaries 664,791 535,670 Contribution based pension 52,635 44,114 Social security expenses 24,861 21,431 Other staff expenses 48,373 34,510 Share-based payment, see specification in note 30 49,284 57,652 Staff costs 839,944 693,377 Staff expenses are distributed as follows: Production costs 333,547 259,719 Sales and distribution costs 89,304 70,727 Research and development costs 198,838 178,439 Administrative costs 168,259 137,332 Capitalized salaries 49,996 47,160 Staff costs 839,944 693,377 Average number of employees converted to full-time 874 734 Number of employees as of December 31 converted to full-time 975 759 The Group only has defined contribution plans and pays regular fixed contributions to independent pension funds and insurance companies. 2022 2021 DKK thousand Staff costs include the following costs: Board of Directors: Remuneration 5,475 5,202 Share-based payment 1,750 1,950 Remuneration to Board of Directors 7,225 7,152 Executive Management: Salary 9,873 8,661 Paid bonus 2,068 3,956 Other employee benefits 692 678 Contribution based pension 1,367 2,048 Share-based payment 13,485 9,035 Corporate Management 27,485 24,378 Salary 11,527 11,630 Paid bonus 2,947 2,946 Other employee benefits 1,362 1,237 Contribution based pension 1,472 1,430 Share-based payment 8,756 7,193 Salary and benefits in notice period 7,851 7,378 Other Executive Management 33,915 31,814 Remuneration to Executive Management 61,400 56,192 Total Management remuneration 68,625 63,344 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 77 Note 8 Staff costs (continued) Note 9 Depreciation, amortization and impairment losses 2022 2021 DKK thousand Depreciation and amortization included in: Production costs 352,554 348,243 Sales and distribution costs 73 34 Research and development costs 6,403 4,718 Administrative costs 40,217 34,697 Depreciation and amortization 399,247 387,692 Hereof loss from disposed fixed assets 1,175 5,259 Impairment losses included in: Production costs - 618 Impairment losses - 618 CEO and President of the Company Paul Chaplin and CFO Henrik Juuel constitute the Corporate Management in the Parent Company. COO Russell Thirsk, CPO Anu Kerns, CCO JC May and CMO Laurence De Moerlooze constitute the Other Executive Management. Restricted stock units In March 2022 Corporate Management was granted 12,682 restricted stock units (excl. matching shares) (8,833 restricted stock units) at a value of DKK 2.1 million (DKK 2.0 million) at grant. Other Executive Management was granted 9,896 restricted stock units (excl. matching shares) (7,580 restricted stock units) corresponding to a value of DKK 1.6 million (DKK 1.7 million) at grant. In April 2022 CEO Paul Chaplin was granted 17,109 restricted stock units (excl. matching shares) as a part of the reten- tion agreement at a value of DKK 2.7 million. In April 2022 COO Russell Thirsk was granted 4,446 restricted stock units (excl. matching shares) as a sign-on bonus at a value of DKK 0.7 million. In April 2022, the members of the Board of Directors were granted in total 11,795 restricted stock units (7,127 restricted stock units) corresponding to 50% of their fixed fee amounting to DKK 1.8 million (DKK 2.0 million). For further description of restricted stock units see note 30. Warrants In December 2022 Corporate Management was granted 126,487 warrants (137,030 warrants) with a fair value of DKK 9.9 million (DKK 10.4 million). Other Executive Management was granted 122,300 warrants (108,788 warrants) with a fair value of DKK 9.6 million (DKK 8.3 million). Fair value calculated based on Black-Scholes, cf. note 30. Incentive programs for the Executive Management and other employees are disclosed in note 30. Members of the Executive Management have contracts of employment containing standard terms for members of the Executive Management of Danish listed compa- nies, including the periods of notice that both parties are required to give and competition clauses. If a contract of employment of a member of the Executive Management is terminated by the Company without misconduct on the part of such member, the member of the Executive Management is entitled to compensation, which, depending on the circumstances, may amount to a maximum of 8-18 months' remuneration. In the event of a change of control the compensation can amount to 24 months' remuneration. The product rights to Rabipur/RabAvert and Encepur are amortized over 20 years with an annual amortization of DKK 272.9 million. The amortization is recognized as part of cost of goods sold under production costs. The product rights was acquired from GlaxoSmithKline as per December 31, 2019. See further description in note 15. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 78 Note 10 Fees to auditor appointed at the annual general meeting 2022 2021 DKK thousand Audit of financial statements 2,208 2,173 Other assurance services 176 160 Tax advisory 501 720 Other services 143 213 Fees 3,028 3,266 The fee for non-audit services provided to the Group by Deloitte Statsautoriseret Revisionspartnerselskab, Denmark, amounted to DKK 0.3 million (DKK 0.6 million) and consisted of assurance work related to the assistance with compliance reviews, and other accounting and tax advisory services. Note 11 Financial income 2022 2021 DKK thousand Financial income from bank and deposit contracts 26 1,739 Interest income from financial assets measured at amortized cost 26 1,739 Financial income from securities 19,543 11,045 Adjustment of deferred consideration due to change in estimated timing of payments 54,390 32,185 Currency adjustment deferred consideration - 1,677 Net foreign exchange gains 4,578 3,587 Financial income 78,537 50,233 Accounting policies Interest income is recognized in the income statement at the amounts relating to the financial year. Financial income also includes net positive value adjustments of financial instruments and securities, adjustment of the net present value of provisions and net currency gains. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 79 Note 12 Financial expenses 2022 2021 DKK thousand Interest expenses on debt 16,640 18,487 Interest expenses on financial liabilities measured at amortized cost 16,640 18,487 Fair value adjustments on securities 190,301 39,056 Unwinding of the discount related to deferred consideration 103,049 133,573 Currency adjustment deferred consideration 11,597 - Net loss on derivative financial instruments at fair value through the income statement 17,776 - Financial expenses 339,363 191,116 Accounting policies Interest expenses are recognized in the income state- ment at the amounts relating to the financial year. Financial expenses also include adjustment of net present value of the deferred consideration, cf. note 24, negative value adjustments of financial instruments and securities and net currency losses. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 80 Note 13 Tax for the year 2022 2021 DKK thousand Tax recognized in the income statement Current tax on profit for the year 15,738 8,923 Adjustments to current tax for previous years 33 1,422 Current tax 15,771 10,345 Deferred tax - - Tax for the year recognized in the income statement 15,771 10,345 Tax on income for the year is explained as follows: Income before company tax (331,611) (454,430) Calculated tax (22.0%) on income before company tax (72,954) (99,975) Tax effect on: Different tax percentage in foreign subsidiaries 572 168 Non-recognized deferred tax asset on current year losses in foreign subsidiaries (1,953) 32,072 Income ()/expenses that are not taxable/deductible for tax purposes (4,443) 2,249 Special tax credit (46,946) (16,898) Change in unrealized intra-group profits (25,099) 30,258 Change in non-recognized tax asset 166,561 63,762 Adjustments to previous years non-recognized tax asset - (2,713) Adjustments to current tax for previous years 33 1,422 Tax on income for the year 15,771 10,345 Tax recognized in other comprehensive income Tax on change in fair value of financial instruments entered into to hedge future cash flows Tax recognized in equity Tax on share based payment Tax on income is an expense of DKK 15.8 million (DKK 10.3 million), corresponding to an effective nega- tive tax rate of negative 4.8% (negative 2.3%). The parent company’s taxable income for 2022 is zero. Tax expensed in 2022 relates mainly to Bavarian Nordic GmbH and Bavarian Nordic, Inc. 'Income()/expenses that are not taxable/deductible for tax purposes' primarily relates to the 30% step up deduction on research and development costs according to Section 8B of the Danish Tax Assessment Act. Deferred tax is measured using the balance sheet liability method on all temporary differences between accounting values and tax values. Deferred tax liabili- ties arising from temporary tax differences are recog- nized in the balance sheet as a liability. Deferred tax assets arising from temporary deductible differences and tax losses carried forward are recog- nized when it is probable that they can be realized by offsetting them against taxable temporary differences or future taxable profits. At each balance sheet date, it is assessed whether it is probable that there will be sufficient future taxable income for the deferred tax asset to be utilized. Deferred income tax is provided on temporary taxable differences arising on investments in subsidiaries, unless the parent company is able to control the timing when the deferred tax is to be realized and it is likely that the deferred tax will not be realized within the foreseeable future. Deferred tax is calculated at the tax rates applicable on the balance sheet date for the income years in which the tax asset is expected to be utilized. Accounting policies Income tax for the year comprises current tax and deferred tax for the year. The part relating to the profit for the year is recognized in the income statement, and the part attributable to items in the comprehensive income is recognized in the comprehensive income statement. The tax effect of costs that have been recognized directly in equity is recognized in equity under the rele- vant items. Current tax receivable is recognized in the balance sheet under current asset. Current tax payable is recognized in the balance sheet under current liabilities. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 81 Note 13 Tax for the year (continued) 2021 Recognized January 1, in the income Recognized December 31, in the income 31, DKK thousand 2021 statement in equity 2021 Product rights (94,360) 83,939 - (10,421) Other intangible assets 377 (377) - - Property, plant and equipment 38,342 22,158 - 60,500 Right-of-use assets 373 (3) - 370 Development projects for sale 32,446 - - 32,446 Accrued project costs (181) 181 - - Receivables 18 19 - 37 Provisions 17,930 (17,930) - - Financial instruments 178 - 119 297 Share-based payment 15,397 6,726 5,871 27,994 Tax losses carried forward 362,209 (693) - 361,516 Not recognized tax asset (372,729) (94,020) (5,990) (472,739) Recognized deferred tax assets - - - - 2022 Adjustment Recognized January 1, to previous Recognized December DKK thousand 2022 year statement in equity 2022 Product rights (10,421) - 73,302 - 62,881 Acquired rights and development in progress - - (2,659) - (2,659) Property, plant and equipment 60,500 4,184 23,440 - 88,124 Right-of-use assets 370 - (83) - 287 Development projects for sale 32,446 - - - 32,446 Unrealized intra-group profits - (46,364) 25,099 - (21,265) Receivables 37 - 154 - 191 Financial instruments 297 - - (7,314) (7,017) Share-based payment 27,994 - 5,282 (5,871) 27,405 Tax losses carried forward 361,516 66,843 42,026 - 470,385 Not recognized tax asset (472,739) (24,663) (166,561) 13,185 (650,778) Recognized deferred tax assets - - - - - Deferred tax Recognized deferred tax assets relate to temporary differences between the tax base and accounting carrying amount and tax losses carried forward. Deferred tax assets arising from temporary deductible differences and tax losses carried forward are recog- nized to the extent they are expected to be offset against future taxable income. Recognized tax losses carried forward relate to Bavarian Nordic A/S and the two Danish subsidiaries Aktieselskabet af 1. juni 2011 I and Aktieselskabet af 1. juni 2011 II. The tax value of non-recognized tax losses carried forward in Bavarian Nordic A/S and the two Danish subsidiaries amounts to DKK 470.4 million (DKK 361.5 million), whereas the tax value of non-recognized temporary deductible differences amounts to DKK 180.4 million (DKK 111.2 million). Tax rate used for Danish entities is 22%. The Company's right to use the tax losses carried forward is not time-limited. Change in non-recognized deferred tax asset also includes deferred tax on intercompany transactions between Bavarian Nordic A/S and Bavarian Nordic, Inc. and Bavarian Nordic Switzerland AG under the Distri- bution Agreements for sale of Encepur and Rabipur/ RabAvert in US and Switzerland, DKK 25.1 million (DKK 30.3 million). Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 82 Note 14 Earnings per share (EPS) 2022 2021 DKK thousand Net result for the year (347,382) (464,775) Earnings per share of DKK 10 (4.9) (7.4) Diluted earnings per share of DKK 10 (4.9) (7.4) The weighted average number of ordinary shares for the purpose of diluted earning per share reconciles to the weighted average number of ordinary shares used in the calculation of basic earnings per share as follows: Weighted average number of ordinary shares (thousand units) 70,548 63,213 Weighted average number of treasury shares (thousand units) (129) (109) Weighted average number of outstanding ordinary shares used in the calculation of basic earnings per share (thousand units) 70,419 63,104 Average dilutive effect of outstanding warrants under incentive schemes - - Weighted average number of outstanding ordinary shares used in the calculation of diluted earnings per share (thousand units) 70,419 63,104 Outstanding warrants that may have an effect on the calculation of diluted earnings per share in the future. 2022-programs 1,013,923 - 2021-program 655,774 706,469 2020-programs 1,142,109 1,207,003 2019-program 599,493 625,984 2018-program 240,708 515,684 2017-programs - 223,683 2016-program - 77,661 Outstanding warrants, cf. note 30 3,652,007 3,356,484 Accounting policies Earnings per share is calculated as the profit or loss for the year compared to the weighted average of the issued shares in the financial year. The basis for the calculation of diluted earnings per share is the weight- ed-average number of ordinary shares in the financial year adjusted for the dilutive effects of warrants. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 83 Note 15 Intangible assets Accounting policies Intangible assets are measured at historic cost less accumulated amortization and impairment losses. Cost of acquired product rights are measured at cash consid- eration and present value of any deferred payments for those rights. Furthermore costs of acquired product rights include transaction costs that are directly attribut- able to the acqusition. Internal development projects that meet the require- ments for recognition as intangible assets are measured at direct cost relating to the development projects. Amortization is provided on a straight-line basis over the useful economic lives of the assets. The useful lives of acquired product rights are estimated to be 20 years and software is estimated to be 3-5 years. Amortization of acquired product rights is recognized as part of cost of goods sold under production costs. Significant accounting estimates Product rights When determining the amortization period for acquired product rights, Management need to make an assessment of expected useful economic life. In the assessment Management take among other things the following components into consideration: The maturity of the products acquired, development in the market the acquired products are targeting, the current competitors, clinical development of new competing products and entry barriers to the market due to advanced production technology. Straight-line amortization reflects the use and impairment of the product rights. Management continuously updates the valuation model used when acquiring the product rights from GlaxoSmithKline to assess the value creation expected from the acquisition. The latest update of the valuation model shows a value above the net present value of the purchase price, hence there is no indications of impair- ment. As per December 31, 2022 Management still judge that the sales milestone of EUR 25 million included in Asset Purchase Agreement is not probable and therefore the present value has not been added to the cost of the product rights. Significant accounting judgments Management has made the following accounting judg- ment which significantly affect the amounts recognized in the consolidated financial statements: Phase 3 clinical trial in September 2022 and initial results are expected to be ready in mid-2023. In 2021 the Group ensured significant finance of the development through the funding obtained from the Danish Ministry of Health and a minimum demand agreed in the agreement with the Danish Ministry of Health. In the winter of 2022/2023, we have seen a high number of COVID-19 infections. It is evident though, that booster vaccinations have been necessary to control the pandemic. Management assesses that the booster vacci- nations will continue to be required, at least for vulner- able groups as is the case for example with the flu market, where annual booster vaccinations are given. Hence, with the development of ABNCoV2 as a universal booster vaccine with a better value proposition compared to the already approved vaccines, Manage- ment expects that the Company can take a reasonable share of the future COVID-19 vaccine market, initially targeting governments, but over time moving towards a more traditional market for private vaccinations. Acquired rights and development in progress Under the Group’s accounting policies and in accordance with common industry practice, development costs are generally expensed in the year they occur. During the development of ABNCoV2, the Group has, however, started capitalization of directly related development cost at commencement of the Phase 2 and 3 studies as – unlike most other development candidates - the feasibility of developing a final vaccine and obtain regu- latory approval is considered highly likely. The Phase 1 and Phase 2 clinical trial showed positive results in 2021- 22, further supported by positive six-month follow-up analysis for the Phase 2 clinical trial in October 2022. The follow-up analysis demonstrated that six months post the booster vaccination with ABNCoV2, the neutral- ization antibody titers against Wuhan and the Omicron variant remained high and at levels associated with a greater than 90% efficacy. The Group initiated the global Impairment The carrying amounts of intangible assets carried at cost or amortized cost are tested at least annually to deter- mine whether there are indications of any impairment in excess of that expressed in normal amortization. If that is the case, the asset is written down to the recov- erable amount, which is the higher of its fair value less costs to sell and its value in use. Impairment losses on intangible assets are recognized under the same line item as amortization of the assets. For development projects in progress, the recoverable amount is assessed annually, regardless of whether any indications of impairment have been found. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 84 Note 15 Intangible assets (continued) Product rights December 31, 2019 the Company acquired the product rights to two commercial products owned by Glax- oSmithKline - Rabipur/RabAvert and Encepur. The products have been on the market for more than 20 years. There is no need to further develop the prod- ucts. Management assesses that it will require up to 10 years of clinical development for competitors to bring a new competing product to the market likewise the production process required to produce these products is highly complex. Based on these factors Management assesses that the acquired product rights should be amortized over 20 years. The acquisition price for the two product rights consists of the upfront payment and the present value of the milestone payments included in the Asset Purchase Agreement with GlaxoSmithKline. The milestone payments relate to transfer and re-registration of marketing authorizations, technology transfer of different steps of the production and packaging activi- ties as well as a milestone payment when all services agreed to be rendered has been completed. The Asset Purchase Agreement specifies the above milestone payments for each product. In total EUR 470 million. The Asset Purchase Agreement also includes a sales mile- stone of EUR 25 million. The sales milestone is related to the total revenue of the two products. Manage- ment deems it unlikely that the sales milestone will be trickered, hence the sales milestone has not been recognized as part of the asset nor the deferred consid- eration as per December 31, 2021. 2022 Acquired Other rights and intangible Product development assets in DKK thousand rights in progress Software progress Total Costs as of January 1, 2022 5,458,700 733,770 100,385 134,371 6,427,226 Additions - 279,714 3,006 142,691 425,411 Transfer - - 2,572 (2,572) - Exchange rate adjustments - - 131 - 131 Cost as of December 31, 2022 5,458,700 1,013,484 106,094 274,490 6,852,768 Amortization as of January 1, 2022 545,870 - 77,400 - 623,270 Amortization 272,935 - 13,908 - 286,843 Exchange rate adjustments - - 18 - 18 Amortization as of December 31, 2022 818,805 - 91,326 - 910,131 Carrying amount as of December 31, 2022 4,639,895 1,013,484 14,768 274,490 5,942,637 Geographical split of intangible assets – 2022 Denmark 5,941,664 USA 973 Total intangible assets 5,942,637 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 85 Note 15 Intangible assets (continued) Deferred consideration for the acquired product rights are described in note 24. COVID-19 vaccine was high, hence milestone payments to AdaptVac were expected to become payable. Based on current regulatory plans and expectations for future revenue from sale of the COVID-vacine all sales mile- stones and part of the development milestones were assumed probable. At initial recognition in December 2021 the net present value of the probable milestone payments was calculated amounting to DKK 596 million, and was recognized as part of the "Acquired rights and development in progress". A corresponding liability was been recognized as deferred consideration (note 24). Acquired rights and development in progress In July 2020, the Company concluded a license and collaboration agreement with AdaptVac. The license agreement provides Bavarian Nordic the global commercialization rights to a COVID-19 vaccine candi- date based on AdaptVac’s technology. Under the terms of the agreement AdaptVac has been responsible for running a Phase 1/2 open label, dose-escalation trial sponsored by Radhould University Medical Center. The Company has assumed the responsibility for the further clinical development and manufacturing. At commence- ment of the positive Phase 2 trial the Company started capitalization of directly related development cost as the feasibility of developing a final vaccine and obtain regulatory approval is considered highly likely, see further description under "Significant accounting judge- ments". The Company made an upfront payment of EUR 4 million to AdaptVac in 2020 when the license agree- ment was signed. The upfront payment was capitalized and recognized as "Acquired rights and development in progress". The Company has also committed to payment of potential future development and sales milestones and tiered royalties. At year-end 2020 Management assessed that those milestone payments were not probable since no in-human studies had completed, hence milestone payments were not recog- nized as an asset and a liability as per December 31, 2020. Based on the positive clinical results during 2021 Management assessed at year-end 2021 that the like- lihood of future regulatory approval of the Company's Intangible assets in progress Rabipur/RabAvert and Encepur are currently manu- factured by GlaxoSmithKline and the basis of the technology transfer to Bavarian Nordic is an as-is transfer of the current manufacturing process. This transfer will be a staged process, starting with pack- aging then filling and ending with the transfer of bulk manufacturing. The Company will incur material costs in terms of internal labour and consultancy to handle the technology transfer and gain crucial knowledge about the manufacturing process. These costs will be capitalized as an intangible asset. As per December 31, 2022 the capitalized costs amounts to DKK 255.3 million (DKK 125.2 million), recognized as intangible assets in progress. As part of the development plan for ABNCoV2 the filling process at Kvistgaard need to be scaled up to handle production for commercial launch. Cost related to the scale up activities are recognized as part of intangible assets in progress with an amount of DKK 14.2 million (DKK 3.6 million). Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 86 Note 15 Intangible assets (continued) 2021 Acquired Other rights and intangible Product development assets in DKK thousand rights in progress Software progress Total Costs as of January 1, 2021 5,458,700 29,813 87,587 57,543 5,633,643 Additions - 703,957 145 96,160 800,262 Transfer - - 18,921 (18,921) - Transfer to/from property, plant and equipment - - - (559) (559) Disposals - - (6,280) - (6,280) Exchange rate adjustments - - 12 148 160 Cost as of December 31, 2021 5,458,700 733,770 100,385 134,371 6,427,226 Amortization as of January 1, 2021 272,935 - 69,956 - 342,891 Amortization 272,935 - 13,681 - 286,616 Disposals - - (6,257) - (6,257) Exchange rate adjustments - - 20 - 20 Amortization as of December 31, 2021 545,870 - 77,400 - 623,270 Carrying amount as of December 31, 2021 4,912,830 733,770 22,985 134,371 5,803,956 Geographical split of intangible assets – 2021 Denmark 5,802,332 Germany 6 USA 1,618 Total intangible assets 5,803,956 Other intable assets in progress relates to IT invest- ments. Other intangible assets in progress include investments in software. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 87 Note 16 Property, plant and equipment Accounting policies Property, plant and equipment include land and build- ings, production equipment, leasehold improvements, office and IT equipment and laboratory equipment and is measured at cost less accumulated depreciation and impairment losses. Cost includes the costs directly attributable to the purchase of the asset, until the asset is ready for use. For assets constructed by the Group cost includes mate- rials, components, third-party suppliers and labour. Borrowing costs directly attributable to the construction of property, plant and equipment are included in cost. Other borrowing costs are recognized in the income statement. Depreciation is charged over the expected economic lives of the assets, and the depreciation methods, expected lives and residual values are reassessed indi- vidually for the assets at the end of each financial year. Assets are depreciated on a straightline basis over their estimated useful lives as follows: Buildings 10–20 years Installations 5–15 years Leasehold improvements 5 years Office and IT equipment 3–5 years Laboratory equipment 5–10 years Production equipment 3–15 years Management reviews the estimated useful lives of material property, plant and equipment at the end of each financial year. Impairment The carrying amounts of property, plant and equipment carried at cost or amortized cost are tested annually to determine whether there are indications of any impair- ment in excess of that expressed in normal deprecia- tion. If that is the case, the asset is written down to the recoverable amount, which is the higher of its fair value less costs to sell and its value in use. Impairment losses on property, plant and equipment are recognized under the same line item as depreciation of the assets. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 88 Note 16 Property, plant and equipment (continued) 2022 Other fixtures and fittings, other Land and Leasehold Plant and plant and Assets under DKK thousand buildings improvement machinery equipment construction Total Costs as of January 1, 2022 546,771 22,288 424,291 312,179 578,707 1,884,236 Additions 73,768 6,147 26,023 146,421 108,885 361,244 Transfer 238,004 11,802 73,919 167,745 (491,470) - Disposals - - (9,864) (428) - (10,292) Exchange rate adjustments - - - 119 8 127 Cost as of December 31, 2022 858,543 40,237 514,369 626,036 196,130 2,235,315 Depreciation and impairment losses as of January 1, 2022 200,818 12,277 169,761 88,712 - 471,568 Depreciation 27,587 3,196 31,061 26,360 - 88,204 Disposals - - (8,198) (301) - (8,499) Exchange rate adjustments - (1) - 70 - 69 Depreciation and impairment losses as of December 31, 2022 228,405 15,472 192,624 114,841 - 551,342 The expansion of the drug substance facility for future production of Rabipur/RabAvert and Encepur completed end of 2022. The Company has not incurred any borrowing costs directly attributable to the construction of the fill finish manufacturing facility, hence no borrowing costs have been capitalized. Mortgage loans of DKK 18.9 million are secured by mortgages totaling DKK 50.0 million on the property Bøgeskovvej 9/Hejreskovvej 10A, Kvistgaard. In addi- tion, as of December 31, 2022, mortgage deeds for a total of DKK 75.0 million have been issued. The carrying amount of assets mortgaged in security of mortgage loans is DKK 951.8 million (land and buildings: DKK 630.1 million; plant and machinery: DKK 321.7 million). Carrying amount as of December 31, 2022 630,138 24,765 321,745 511,195 196,130 1,683,973 Geographical split of property, plant and equipment – 2022 Denmark 1,626,673 Germany 56,564 USA 463 Switzerland 273 Total property, plant and equipment 1,683,973 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 89 Note 16 Property, plant and equipment (continued) 2021 Other fixtures and fittings, other Land and Leasehold Plant and plant and Assets under DKK thousand buildings improvement machinery equipment construction Total Costs as of January 1, 2021 548,291 14,404 485,024 294,418 213,309 1,555,446 Additions 2,516 597 5,717 11,871 461,867 482,568 Transfer 6,911 7,811 73,155 9,148 (97,025) - Transfer from intangible assets - - - - 559 559 Disposals (10,946) (518) (139,605) (3,369) - (154,438) Exchange rate adjustments (1) (6) - 111 (3) 101 Cost as of December 31, 2021 546,771 22,288 424,291 312,179 578,707 1,884,236 Depreciation and impairment losses as of January 1,2021 182,059 10,691 280,360 71,180 - 544,290 Depreciation 25,695 2,104 27,572 20,420 - 75,791 Impairment losses - - 278 340 - 618 Disposals (6,936) (518) (138,449) (3,300) - (149,203) Exchange rate adjustments - - - 72 - 72 Depreciation and impairment losses as of December 31, 2021 200,818 12,277 169,761 88,712 - 471,568 Assets under construction relates mainly the ongoing expansion of the drug substance facility for future production of Rabipur/RabAvert and Encepur (DKK 479 million). The fill and finish manufacturing facility completed in 2021 and the depreciation of the fill and finish building and equipment commenced. Mortgage loans of DKK 21.1 million are secured by mortgages totaling DKK 50.0 million on the property Bøgeskovvej 9/Hejreskovvej 10A, Kvistgaard. In addi- tion, as of December 31, 2021, mortgage deeds for a total of DKK 75.0 million have been issued. The carrying amount of assets mortgaged in security of mortgage loans is DKK 600.5 million (land and buildings: DKK 346.0 million; plant and machinery: DKK 254.5 million). Carrying amount as of December 31, 2021 345,953 10,011 254,530 223,467 578,707 1,412,668 Geographical split of property, plant and equipment – 2021 Denmark 1,369,996 Germany 41,775 USA 577 Switzerland 320 Total property, plant and equipment 1,412,668 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 90 Note 17 Right-of-use-assets Accounting policies The right-of-use assets comprise the initial measure- ment of the corresponding lease liability. Right-of-use assets are subsequently measured at cost less accumu- lated depreciation and impairment losses. All operating leases with a lease term of more than 12 months are recognized on the balance sheet as right- of-use-assets. For leases with a lease term of less than 12 months the lease payments are recognized as an operating expense on a straight-line basis over the term of the lease. The right-of-use-assets are measured at the present value of all future lease payments. When assessing the lease term, any extension or termination options are included in the assessment. The options are included in determining the lease term, if exercise is reason- ably certain. When determining the discount rates used to calculate the net present value of future lease payments, an incremental country specific borrowing rate is used, based on a government bond plus the Group’s credit margin, ranging from 2.5% to 3.0%. A single discount rate is used for a portfolio of lease assets with reasonable similar characteristics. Initial direct costs are not included in measurement of the right-of-use-assets. Non-lease components are not separated from lease components. 2022 Rent Car DKK thousand facility leasing Equipment Total Right-of-use assets as of January 1, 2022 73,026 1,742 1,075 75,843 Additions 917 8,671 - 9,588 Modifications 5,326 986 - 6,312 Disposals (2,412) - - (2,412) Depreciations (19,475) (3,050) (500) (23,025) Reversal depreciations 909 - - 909 Exchange rate adjustments 176 43 (1) 218 Right-of-use assets as of December 31, 2022 58,467 8,392 574 67,433 2021 Rent Car DKK thousand facility leasing Equipment Total Right-of-use assets as of January 1, 2021 68,931 2,312 744 71,987 Additions - 902 768 1,670 Modifications 22,036 (46) 38 22,028 Depreciations (18,071) (1,480) (475) (20,026) Exchange rate adjustments 130 54 - 184 Right-of-use assets as of December 31, 2021 73,026 1,742 1,075 75,843 Impact from change in lease terms, lease payments or modification of the lease contract is further described in note 27. Right-of-use assets are depreciated over the shorter period of lease term and useful life of the underlying asset. The depreciation starts at the commencement date of the lease. IAS 36 is applied to determine whether a right-of-use asset is impaired and any iden- tified impariment losses are accounted for as described in note 15. DKK thousand 2022 2021 Amounts included in the income statement Interest expense leases 1,888 1,976 Depreciation recognized on right-of-use assets 23,025 20,026 Cost recognized for short term leases (less than 12 months) 267 427 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 91 Note 18 Inventories 2022 2021 DKK thousand Raw materials and supply materials 206,211 80,243 Work in progress 641,183 79,904 Manufactured goods and commodities 234,097 492,837 Write-down on inventory (162,419) (172,941) Inventories 919,072 480,043 Write-down on inventory as of January 1 (172,941) (63,537) Write-down for the year (78,101) (171,643) Use of write-down 46,031 62,239 Reversal of write-down 42,592 - Write-down on inventory as of December 31 (162,419) (172,941) Cost of goods sold amounts to, cf. note 4 644,683 539,789 The inventory of Encepur and Rabipur/RabAvert prod- ucts amounted to DKK 577.9 million (DKK 305.4 million) as per December 31, 2022 incl. write-down. Write-down for the year amounted to DKK 78.1 million and mainly relates to Encepur products which have been challenged with delays at CMO's. The delays led to issues with seasonality and too low shelf life. Use of write-down in 2022 of DKK 46 million relates to scrap of old Encepur batches fully written down last year. Reversal of write-down of DKK 42.6 million mainly relates to Rabipur/RabAvert products since actual sales exceeded expected sales for the year. administration and management. The net realisable value is the estimated sales price in the ordinary course of business less relevant sales costs determined on the basis of marketability, obsolescence and changes in the expected sales price. Significant accounting estimates Production overheads are measured on the basis of actual costs. The basis of the actual costs is reassessed regularly to ensure that they are adjusted for changes in the utilization of production capacity, production changes and other relevant factors. Biological living material is used, and the measurements and assump- tions for the estimates made may be incomplete or inaccurate, and unexpected events or circumstances may occur, which may cause the actual outcomes to later deviate from these estimates. It may be necessary to change previous estimates as a result of changes in the assumptions on which the estimates were based or due to new information or subsequent events, for which certainty could not be achieved in the earlier estimates. Estimates that are material to the financial reporting are made in the determination of any impairment of inventories as a result of 'out-of-specification' products, expiry of products and sales risk. Accounting policies Inventories except for raw materials are measured at the lower of cost using the weighted average cost formula method less write-downs for obsolescence and net realisable value. Raw materials are measured at cost based on the FIFO method. For raw materials, cost is determined as direct acquisition costs incurred. The cost of finished goods produced in-house and work in progress includes raw materials, consumables, filling cost, QC testing and direct payroll costs plus indirect costs of production. Indirect costs of production include indirect materials and labour as well as maintenance of and depreciation on the machinery used in production processes, factory buildings and equipment used and cost of production Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 92 Note 19 Trade receivables Credit risk Bavarian Nordic’s customers are predominantly public authorities and renowned wholesalers and therefore the credit risk is very low. There are overdue receiv- ables as of December 31, 2022 DKK 40 million (DKK 7 million). As of December 31, 2022 a loss allowance of DKK 870 thousand (DKK 166 thousand) has been recog- nized. The Group has applied the simplified approach to measure the expected credit loss and a lifetime expected loss allowance for all trade receivables.The allowance is an estimate based on shared credit risk characteristics and the days past due. At the time of revenue recognition, Bavarian Nordic assesses the full lifetime expected credit losses. In addition, undue and due receivables are analyzed in an ongoing process. Based on the credit assessment, receivables analysis, historical experience and industry experience, it is estimated whether the receivables are recoverable or write-downs are needed. Bavarian Nordic monitor the credit exposure on all customers, both new and existing. The payment conditions for the customers, including credit periods and any payment of interest in case of non-payment, vary, but are always based on industry practice in the relevant market. The weighted average credit period is approximately 60 days for the sales of Encepur and Rabipur/RabAvert. The table details the risk profile for trade receivables. 2022 2021 DKK thousand Trade receivables from smallpox vaccine sale 329,897 78,218 Trade receivables from Encepur and Rabipur/RabAvert 167,332 162,546 Trade receivables from other product sale - 137,731 Trade receivables from contract work 25,916 3,129 Trade receivables 523,145 381,624 2022 Gross Net carrying Loss carrying DKK thousand amount allowance amount Trade receivables Not past due date 484,110 - 484,110 Overdue by 0-3 months 39,435 (823) 38,612 Overdue by 3-6 months 470 (47) 423 Trade receivables 524,015 (870) 523,145 2021 Gross Net carrying Loss carrying DKK thousand amount allowance amount Trade receivables Not past due date 374,583 - 374,583 Overdue by 0-3 months 6,936 (139) 6,797 Overdue by 0-3 months 271 (27) 244 Trade receivables 381,790 (166) 381,624 Accounting policies Receivables are measured at initial recognition at fair value and subsequently at amortized value usually equal to the nominal value, net of impairment based on expected credit losses. Write-downs are calculated using the ‘full lifetime expected credit losses’ method, whereby the likelihood of non-fulfilment throughout the lifetime of the finan- cial instrument is taken into consideration. A provision account is used for this purpose. Bavarian Nordic recognizes a loss allowance for expected credit losses and writes off trade receivables when there is information indicating that the debtor is in severe financial difficulty and there is no realistic prospect of recovery. Subsequent recovery of amounts previously written down is credited against sales and distribution costs. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 93 Note 20 Other receivables 2022 2021 DKK thousand Deposits 5,086 4,778 Receivable VAT and duties - 55,973 Derivative financial instruments at fair value 31,894 191 Interest receivables 11,369 10,353 Other receivables 48,349 71,295 Classified as: Non-current assets 5,086 4,778 Current assets 43,263 66,517 Other receivables 48,349 71,295 Note 21 Prepayments 2022 2021 DKK thousand Prepayments to CMO's 351,322 135,750 Other prepayments 10,149 11,475 Prepayments 361,471 147,225 Classified as: Non-current assets 207,537 38,385 Current assets 153,934 108,840 Prepayments 361,471 147,225 Scale-up activities to prepare for future production of drug substance for commercial launch of ABNCoV2 is taking place at the CMO who also produced the Phase 3 clincial trial materials. Costs related to the scale-up activities are recognized as prepayments and will be recognized as inventory in concurrence with future purchase of products from the CMO. As per December 31, 2022 DKK 192.6 million (DKK 21.8 million) has been recognized as non-current prepayments. As part of the scale-up activity future commercial batches have been produced. Since the ABNCoV2 product is not yet approved the costs for this produc- tion, DKK 131.7 million, have been recognized as current prepayments. Will be reclassified to inventory once product approval is obtained. Part of the technology transfer of the production and packaging activities for Encepur and Rabipur/RabAvert takes place at CMO's (filing of Encepur, labelling and packing). Costs related to the technology transfer activ- ities are recognized as prepayments when costs incur and then recognized as inventory in concurrence with purchase of production services from the CMO's. As per December 31, 2022 DKK 14.9 million (DKK 16.6 million) has been recognized as non-current prepayments. Accounting policies Receivables are measured at initial recognition at fair value and subsequently at amortized value usually equal to the nominal value, net of impairment, to counter the loss after an individual assessment of risk of loss. Accounting policies Prepayments recognized under assets include costs paid in respect of subsequent financial years, including project costs incurred that relate to revenue of subse- quent years. Prepayments are measured at cost. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 94 Note 22 Other liabilities 2022 2021 DKK thousand Financial instruments at fair value 8,302 1,351 Liability relating to phantom shares 11,102 23,917 Payable salaries, holiday accrual etc. 107,952 68,491 Gross to net deduction accrual 97,679 37,134 Other accrued costs 22,319 20,101 Payable VAT and duties 10,215 - Other liabilities 257,569 150,994 Accounting policies Derivative financial instruments and liability relating to phantom shares are measured at fair value. For further details regarding measurement of fair value for phantom shares see note 30. Other financial liabilities are measured at initial recognition at fair value less any transaction costs. Subsequent other financial liabilities are measured at amortized cost using the effective interest method, whereby the difference between proceeds and the nominal value is recognized in the income statement as a financial expense over the period. Amortized cost usually equal to the nominal value. For a further description of financial instruments see note 23. The phantom share programs are described in note 30. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 95 Note 23 Financial risks and financial instruments 2022 2021 DKK thousand Categories of financial instruments Trade receivables 523,145 381,624 Other receivables 16,455 71,104 Cash and cash equivalents 575,407 591,820 Financial assets measured at amortized cost 1,115,007 1,044,548 Securities 1,184,843 2,626,261 Transferred securities that are not derecognized 1,084,916 498,534 Derivative financial instruments at fair value through the income statement (repo transactions) - 191 Financial assets measured at fair value through the income statement 2,269,759 3,124,986 Derivative financial instruments to hedge future cash flows (exchange rate) 30,025 - Derivative financial instruments to hedge future cash flows (interest) 1,869 - Financial assets used as hedging instruments 31,894 - Deferred consideration 2,612,093 3,146,757 Debt to credit institutions 18,930 393,269 Security lending (repo transactions) 1,103,661 500,000 Prepayment and loan from Government 566,420 160,511 Lease liabilities 70,321 78,813 Trade payables 605,928 263,611 Other liabilities 238,165 125,726 Financial liabilities measured at amortized cost 5,215,518 4,668,687 Derivative financial instruments at fair value through the income statement (repo transactions) 8,302 - Liability relating to phantom shares 11,102 23,917 Financial liabilities measured at fair value through the income statement 19,404 23,917 Derivative financial instruments to hedge future cash flows (exchange rate) - 646 Derivative financial instruments to hedge future cash flows (interest) - 705 Financial liabilities used as hedging instruments - 1,351 Accounting policies Derivative financial instruments On initial recognition, derivative financial instruments are measured at the fair value on the settlement date. Directly attributable costs related to the purchase or issuance of the individual financial instruments (transaction costs) are added to the fair value on initial recognition, unless the financial asset or the financial liability is measured at fair value with recognition of fair value adjustments in the income statement. Subse- quently, they are measured at fair value at the balance sheet date based on the official exchange rates, market interest rates and other market data such as volatility adjusted for the special characteristics of each instru- ment. Changes in the fair value of derivative financial instru- ments designated as and qualifying for recognition as effective hedges of future transactions (cash flow hedges) are recognized as comprehensive income. The ineffective portion is recognized immediately in the income statement. When the hedged transactions are realized, cumulative changes are recognized in the income statement together with the hedged transac- tion or in respect of a non-financial item as part of the cost of the transactions in question. For derivative financial instruments that do not qualify for hedge accounting, changes in fair value are recog- nized as financials in the income statement as they occur. The Company has designated certain derivative finan- cial instruments as cash flow hedges as defined under IFRS 9 "Financial Instruments". Hedge accounting is classified as a cash flow hedge when the hedges of a particular risk is associated with the cash flows of highly probable forecast transactions. Securities Securities consist of listed bonds, which are measured at fair value on initial recognition and as of the balance sheet date. The Group’s portfolio of securities is treated as "financial items at fair value through profit or loss", as the portfolio is accounted for and valued on the basis of the fair value in compliance with the Company's investment policy. Both realized and unrealized value adjustments are recognized in the income statement under financials. Policy for managing financial risks Through its operations, investments and financing the Group is exposed to fluctuations in exchange rates and interest rates. These risks are managed centrally in the Parent Company, which manages the Group´s liquidity. The Group pursues a treasury policy approved by the Board of Directors. The policy operates with a low risk profile, so that exchange rate risks, interest rate risks and credit risks arise only in commercial relations. The Group therefore does not undertake any active specula- tion in financial risk. The Group´s capital structure is regularly assessed by the Board of Directors relative to the Group´s cash flow position and cash flow budgets. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 96 Note 23 Financial risks and financial instruments (continued) Accounting policies (continued) Exchange rate risks on recognized financial assets and liabilities Cash and cash equivalents, Net DKK thousand securities Receivables Liabilities position 2022 EUR 294,207 355,193 (3,156,284) (2,506,884) USD 237,026 148,254 (156,497) 228,783 CHF 2,175 2,692 (39,532) (34,665) 2021 EUR 107,199 193,837 (3,416,438) (3,115,402) USD 68,481 205,224 (319,201) (45,496) CHF 2,216 1,471 (28,375) (24,688) Sensitivity analysis on exchange rates Likely change Hypothetical Hypothetical in exchange change in change in rate equity net result DKK thousand 2022 Change if higher USD-rate than actual rate 15% 75,638 56,962 Change if higher EUR-rate than actual rate 1% (22,207) (23,911) Change if higher CHF-rate than actual rate 5% (583) (1,004) 2021 Change if higher USD-rate than actual rate 15% 34,724 21,921 Change if higher EUR-rate than actual rate 1% (28,638) (30,165) Change if higher CHF-rate than actual rate 5% 140 (235) Market risks The pharmaceutical market is characterized by the aim of authorities to reduce or cap healthcare costs in general. Market changes such as price reductions and launch of competing generic products may have a considerable impact on the earnings potential of phar- maceuticals. As a pharmaceutical production company Bavarian Nordic will be exposed to risks from instability in the supply chain, where lack of, or delays in, certain materials may impact the companys ability to deliver and hence the companys profitability. The Company is highly dependent on a stable IT environment and risks, incl. cyberattacks, may impact the profibaility of the Company. at maximum one year ahead. Regular assessments are made of whether the remaining net position should be hedged by currency forward contracts or currency option contracts. The exposure to EUR is not hedged as management believes that fluctuations in EUR are limited due to the Danish fixed-rate policy which is expected to be maintained. Thus the fluctuations in EUR do not have a significant impact on financial performance. The table shows the net effect it would have had on equity and profit for the year if the year-end exchange rates of USD, EUR and CHF had been 15%, 1% or 5%, respectively, higher than the actual exchange rates. A corresponding decrease in the actual exchange rates would have had an opposite (positive/negative) effect on net result and equity. Interest rate risk It is the Group's policy to hedge interest rate risks on loans whenever it is deemed that interest payments can be hedged at a satisfactory level relative to the related costs. Hedging will then consist of interest rate swaps that convert floating rate loans to fixed rate loans. Management determines the economic relation- ship between the hedged item and the hedging instru- ment to ensure a high hedge effectiveness. The interest rate risk involved in placing cash funds and investing in securities is managed on the basis of duration. Exchange rate risks The Group’s exchange rate exposure is primarily to USD and EUR. The exchange rate exposure to USD is hedged to the greatest possible extent by matching incoming and outgoing payments denominated in USD, looking Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 97 Note 23 Financial risks and financial instruments (continued) Accounting policies (continued) Cash risks The Group´s bank deposits are placed in deposit accounts without restrictions. The Group's cash and cash equivalents totaled DKK 575.4 million as of December 31, 2022 (DKK 591.8 million). The Group's fixed rate bond portfolio expires as shown below. Amounts are stated excluding interest. Cash flow hedge – forward currency contracts Fair value Contract adjustment amount Fair value recognized in based on as of other compre- DKK thousand Forward price agreed rates December 31 hensive income 2022 Forward currency contracts (USD/DKK) 7.19 - 7.29 543,454 30,025 30,671 30,025 30,671 2021 Forward currency contracts (USD/DKK) 7,538 (646) (646) (646) (646) Cash flow hedge – interest rate swap Fair value Contract adjustment amount Fair value recognized in based on as of other compre- DKK thousand agreed rates December 31 hensive income 2022 Interest rate swap DKK – fixed rate 0.9625% p.a. (expiry 2031) 19,192 1,869 2,574 1,869 2,574 2021 Interest rate swap DKK – fixed rate 0.9625% p.a. (expiry 2031) 21,332 (705) 709 (705) 709 Derivative financial instruments not designated as hedge accounting Currency forward contracts and currency option contracts which are not designated as hedge accounting are classified as financial assets/liabilities measured at fair value with value adjustments recog- nized through the income statement. There were no open currency contracts as of December 31, 2022 or as per December 31, 2021 not designated as hedge accounting. Hedging of expected future cash flows The Company has concluded currency forward contracts of USD 75 million to hedge net cash position during 2023. In 2016 the Company refinanced the old mortgage loans (fixed rate) and obtained a new mortgage loan with floating rate. The Company also concluded an interest rate swap to convert the floating rate loan to a fixed rate loan. The interest rate swap has the same maturity date and nominal amount as the mortgage loan to secure high effectiveness of the hedge. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 98 Note 23 Financial risks and financial instruments (continued) 2022 2021 Fair value as of Effective Fair value as of Effective DKK thousand December 31 interest December 31 interest Bond portfolio Within 0-2 years 1,226,652 3.4% 1,201,688 -0.5% Within 3-5 years 492,898 3.5% 1,118,304 -0.1% After 5 years 550,208 3.7% 804,803 1.0% Total 2,269,758 3.5% 3,124,795 0.0% Fluctuations in interest rate levels affect the Group's bond portfolio. An change in the interest rate level by 1 percentage point relative to the interest rate level on the balance sheet date would have had an impact of DKK 73.3 million on the Group´s net result and equity (DKK 46.9 million). Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 99 Note 23 Financial risks and financial instruments (continued) With respect to the Group´s debt to credit institutions, a change in the applicable interest rate by 1 percentage point would have had an impact on the Group's net result and equity of DKK 0.2 million (DKK 4.0 million). The European Investment Bank loan obtained in 2017 was fully repaid in October 2022 (DKK 372.2 million). During 2022 the Company entered into further repo loan contracts (security lending) and increased the position to DKK 1,104 million (DKK 500 million). Further described below. Debt to credit institutions also include a mortgage loan of DKK 18.9 million (DKK 21.1 million), further described in note 26. The Group has a credit facility of DKK 20 million (DKK 20 million) at Nordea. As of December 31, 2022, DKK 0.2 million (DKK 0.2 million) of the credit facility is utilized for bank guarantees. sand (DKK 166 thousand) has been recognized as of December 31, 2022, cf. note 19. To manage credit risk regarding financial counterpar- ties, Bavarian Nordic only enters into derivative finan- cial contracts and money market deposits with financial counterparties possessing a satisfactory long-term credit rating from at least two out of the three selected ratings agencies: Standard and Poor’s, Moody’s and Fitch. Cash and cash equivalents are not deemed to be subject to any special credit risk as they are deposited with Nordea. The bond portfolio is invested in either Danish government bonds, Danish mortgage bonds or bonds issued by Danish banks with high ratings. Maturity of financial liabilities (including interest) 2022 Due within Due between Due after DKK thousand 1 year 1 and 5 years 5 years Total Deferred consideration 1) 297,460 2,506,101 - 2,803,561 Credit institutions 1,103,003 10,355 9,423 1,122,781 Prepayment and loan from Government 2) - 519,932 70,503 590,435 Lease liabilities 24,487 45,834 - 70,321 Trade payables 605,928 - - 605,928 Other liabilities 265,775 - - 265,775 Non-derivative financial liabilities 2,296,653 3,082,222 79,926 5,458,801 2021 Due within Due between Due after DKK thousand 1 year 1 and 5 years 5 years Total Deferred consideration 1) 594,912 2,803,523 - 3,398,435 Credit institutions 887,689 9,106 10,409 907,204 Prepayment and loan from Government 2) - 164,184 - 164,184 Lease liabilities 21,266 57,547 - 78,813 Trade payables 263,611 - - 263,611 Other liabilities 154,032 - - 154,032 Non-derivative financial liabilities 1,921,510 3,034,360 10,409 4,966,279 Derivative financial liabilities 705 - - 705 1) Further explained in note 24. 2) Further explained in note 25. Optimization of capital structure Management regularly assesses whether the Group´s capital structure best serves the interests of the Group and its shareholders. The overall goal is to ensure that the Group has a capital structure which supports its long-term strategy and growth target. Transferred financial assets that are not derecognized In 2022 the Company entered into transactions that transfer ownership of securities to a counterparty, while the Company retains the risks associated with the holding of the securities. As the Company retains all risks, the securities remain in the balance sheet, and the transactions are accounted for as loans received against collateral (repo transactions and security lending). The transactions involve selling the securities Credit risks The primary credit risk relates to trade receivables. The Company assesses the expected credit losses also considering changes in the macro environment that might impose an increased risk of losses. This is compared to the previous model where indications of credit losses were needed for the Company to recognize an expected loss. The Group´s customers are predominantly public authorities and renowned phar- maceutical companies and wholesalers, and the credit risk on the Group's receivables is therefore considered to be very low. A loss allowance of DKK 870 thou- Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 100 Note 23 Financial risks and financial instruments (continued) to be repurchased at a fixed price at a later date. Coun- terparties are entitled to sell the securities or deposit them as collateral for loans. Securities (level 1) The portfolio of publicly traded government bonds, publicly traded mortgage bonds and bank bonds is valued at listed prices and price quotas. Transferred financial assets that are not derecognized DKK thousand 2022 2021 Carrying amount of transferred securities 1,084,916 498,534 Carrying amount of associated liabilities (security lending) (1,103,661) (500,000) Net position (18,745) (1,466) Fair value hierarchy for financial instruments measured at fair value 2022 DKK thousand Level 1 Level 2 Total Securities 2,269,759 - 2,269,759 Financial assets measured at fair value through the income statement 2,269,759 - 2,269,759 Derivative financial instruments to hedge future cash flow (currency) - 30,025 30,025 Derivative financial instruments to hedge future cash flow (interest) - 1,869 1,869 Financial assets/liabilities used as hedging instruments - 31,894 31,894 Derivative financial instruments at fair value (repo transactions) - (8,302) (8,302) Liability relating to phantom shares - (11,102) (11,102) Financial liabilities measured at fair value through the income statement - (19,404) (19,404) 2021 DKK thousand Level 1 Level 2 Total Securities 3,124,795 - 3,124,795 Derivative financial instruments at fair value (repo transactions) - 191 191 Financial assets measured at fair value through the income statement 3,124,795 191 3,124,986 Derivative financial instruments to hedge future cash flow (currency) - (646) (646) Derivative financial instruments to hedge future cash flow (interest) - (705) (705) Financial assets/liabilities used as hedging instruments - (1,351) (1,351) Liability relating to phantom shares - (23,917) (23,917) Financial liabilities measured at fair value through the income statement - (23,917) (23,917) Derivative financial instruments (level 2) Currency forward contracts, currency option contracts and currency swap contracts are valued according to generally accepted valuation methods based on rele- vant observable swap curves and exchange rates. Liability relating to phantom shares is determined using the Black-Scholes. The valuation is based on observable share price, interest rates and volatility rates. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 101 Note 24 Deferred consideration License agreement Under the terms of the license and collaboration agree- ment concluded with AdaptVac July 2020, the Company is committed to payment of potential future develop- ment and sales milestones and tiered royalties. In December 2021, the Company announced positive topline results from the Phase 2 clinical trial. These results was confirmed by the six-month follow-up analysis in October 2022, showing that the strong booster responses are maintained after six months post vaccination at levels associated with a high degree of efficacy. In September 2022, the Company initiated the Phase 3 clinical trial. The read-out are expected in beginning of 2023. Based on the positive clinical results Management assesses that the likelyhood of future regulatory approval of the Company's COVID-19 vaccine is high, hence milestone payments to AdaptVac are expected to become payable. Based on current regu- latory plans and expectations for future revenue from sale of the COVID-vacine all sales milestones and part of the development milestones are assumed probable and recognized as deferred consideration. The carrying amount are measured using a discount rate of 3.7% per annum. The discount rate has been determined at intial recognition based on an interest rate on a similar loan of the same size and maturity as the contingent milestone payments and the Company's credit rating as of December 31, 2021. The fair value of the deferred consideration as per December 31, 2022 amounts to DKK 553 million (DKK 596 million), measured using the updated discount rate of 6.7% (3.7%). The discount rate has been determined based on the same components as described above. Royalties payable under the license and collaboration agreement with AdaptVac will be expensed in concur- rence with future sales, hence not assessed and recog- nized as a liability as of December 31, 2022. The cash flow from payment of deferred consideration will be recognized as cash flow from investment activ- ities. Due within Due between Due after DKK thousand 1 year 1 and 5 year 5 years Total 2022 Deferred consideration, product rights - 2,020,638 - 2,020,638 Deferred consideration, license agreement 287,436 304,019 - 591,455 Total 287,436 2,324,657 - 2,612,093 2021 Deferred consideration, product rights 577,667 1,972,862 - 2,550,529 Deferred consideration, license agreement - 596,228 - 596,228 Total 577,667 2,569,090 - 3,146,757 Accounting policies Deferred consideration including contingent milestone payments is recognized when its payment is probable and it can be measured reliably and is at initial recog- nition measured at fair value which equals present value of future deferred payments. Subsequently, the deferred consideration is measured at amortized cost. This means that the difference between the present value of the consideration and the nominal amounts due is recognized in the income statement as a finan- cial expense over the period until expected payment date using the effective interest method. The expected phasing of future payments and the probability of contingent payments are assessed on each reporting date and the impact is recognized as a financial item. Product rights The Asset Purchase Agreement with GlaxoSmithKline includes milestone payments relating to transfer and registration of marketing authorizations, technology transfer of different steps of the production and pack- aging activities as well as a milestone payment when all services agreed to be rendered by GlaxoSmithKline has been completed. In total EUR 470 million. During 2022 two milestone payments of a total of EUR 80 million was paid. The payments are presented as cash flow from investment activities in the cash flow statement. The majority of the remaining milestone payments are expected to be payable in 2024. The completion milestone is expected to be payable begin- ning of 2025. The Asset Purchase Agreement with GlaxoSmithKline also includes a sales milestone of EUR 25 million. As per December 31, 2022 Management does not judge the sales milestone to be probable and therefore the sales milestone has not been recognized as either part of the product rights (note 15) nor the deferred consideration. The carrying amount are measured using a discount rate of 4% per annum. The discount rate was deter- mined at intial recognition based on an interest rate on a similar loan of the same size and maturity as the contingent milestone payments and the Company's credit rating as of December 31, 2019. The fair value of the deferred consideration as per December 31, 2022 amounts to DKK 1,937 million (DKK 2,564 million), measured using the updated discount rate of 6.7% (3.7%). The discount rate has been deter- mined based on the same components as described above. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 102 Note 25 Prepayment and loan from Government repay the amount to the Danish Ministry of Health. Since the split between supply of vaccines and royalty payments is unknown at this stage Management has decided to recognize the received milestone payments under one common line item "Prepayment and loan from Government". Subsequent the financial liability part is measured at amortized cost. The prepayment part is accounted for as a prepayment under IFRS 15. The interest rate used that is implicit in the transaction is based on an assess- ment of the company’s incremental borrowing rate. The amortizations and the implicit interest are presented as amortization expenses under financial expenses. Due within Due between Due after DKK thousand 1 year 1 and 5 year 5 years Total 2022 Prepayment and loan from Government - 566,420 - 566,420 Total - 566,420 - 566,420 2021 Prepayment and loan from Government - 160,511 - 160,511 Total - 160,511 - 160,511 Accounting policies Prepayment and loan from Government consists of an upfront payment and additional milestone payments from the Danish Ministry of Health to support the completion of the development of ABNCoV2, the Company’s COVID-19 vaccine candidate. The additional payments are contingent upon reaching of a number of predefined development milestones. All payments are potentially subject to repayment, however only upon successful marketing authorization of the vaccine by the European Commission. Half of the repayments shall be paid by delivery of vaccines to the Danish Ministry of Health whereas the remaining part of the repayments can be settled in either royalty payments from the sale of the vaccine to other customers or by delivery of further vaccines. Royalty payments are only triggered upon reaching a certain volume in sales. Upon approval of the vaccine the repayment obligation is adjusted by inflation. The Company considers it probably that approval will be obtained and the received payments will be repaid to the Danish Ministry of Health. The repayment obligation is accounted for as a prepayment in respect of the part that shall be repaid by delivery of vaccines whereas the part that can be repaid either by delivery of further vaccines or by royalty payments is accounted for as a financial liability. Initially the payments from the Danish Ministry of Health is measured at the amount received that is considered equal to the fair value of the obligation to Agreement with Danish Ministry of Health In August 2021, the Company entered a funding agree- ment with the Danish Ministry of Health to further advance the development of ABNCoV2. The agreement is valued at up to DKK 800 million and aims to support the completion of the development towards licensure of ABNCoV2 as a booster vaccine. Under the agreement, Bavarian Nordic is entitled to an upfront payment of DKK 80 million, in addition to payments of up to DKK 720 million, which are contin- gent upon reaching a number of predefined milestones including among others Phase 3 development mile- stones and milestones related to upscaling of manu- facturing for commercial production of the vaccine. As per December 31, 2022 the Company has received the upfront payment of DKK 80 million and milestone payments amounting to DKK 480 million. The Danish Ministry of Health could be entitled to an additional, capped royalty payment if the sales reach a certain threshold above the sales volume for the ordi- nary royalty payment. Based on current sales forecasts this additional royalty payment is not deemed likely and therefore not recog- nized. If the payment becomes current it will be recog- nized as a financial expense as the additional royalty payment is seen as an extra interest payment. The cap for the additional royalty payment is a fixed amount, calculated as a percentage of the loan amount. Significant accounting judgments Management has made the following accounting judg- ment which affect the recognition in the consolidated financial statements: Management assesses a high likelyhood of regula- tory approval of the vaccine, hence assumes that the already received milestone payments and the mile- stone payments to be received in the comming year will be repaid in either supply of vaccines or royalty payments. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 103 Note 26 Debt to credit institutions Due within Due between Due after DKK thousand 1 year 1 and 5 year 5 years Total 2022 Mortgage 1) 1,922 8,283 8,725 18,930 Security lending (repo transactions) 1,103,661 - - 1,103,661 Total 1,105,583 8,283 8,725 1,122,591 2021 Mortgage 1) 2,178 8,673 10,223 21,074 European Investment Bank (loan in DKK) 2) 372,195 - - 372,195 Security lending (repo transactions) 500,000 - - 500,000 Total 874,373 8,673 10,223 893,269 1) Floating interest – swapped to fixed interest of 0.9625% – expiry 2031 2) Fixed interest of 3.532% - bullet loan repaid in October 2022 Cash flow from financing activities January Cash Non-cash December DKK thousand 1, 2022 movement movement 31, 2022 2022 Mortgage 21,074 (2,144) - 18,930 European Investment Bank (loan in DKK) 372,195 (372,195) - - Security lending (repo transactions) 500,000 603,661 - 1,103,661 Prepayment and loan from Government 160,511 400,000 5,909 566,420 Lease liabilities 78,813 (21,981) 13,489 70,321 Total liabilities from financing activities 1,132,593 607,341 19,398 1,759,332 January Cash Non-cash December DKK thousand 1, 2021 movement movement 31, 2021 2021 Mortgage 23,247 (2,173) - 21,074 European Investment Bank (loan in DKK) 372,195 - - 372,195 Security lending (repo transactions) - 500,000 - 500,000 Prepayment and loan from Government - 160,000 511 160,511 Lease liabilities 74,623 (19,507) 23,697 78,813 Total liabilities from financing activities 470,065 638,320 24,208 1,132,593 The fair value of the debt to credit institutions amounts to DKK 1,122.6 million (DKK 893.5 million). The fair value of mortgage debt is based on the market value of the underlying bonds set by the bank (level 2), whereas the fair value of the security lending is based on a discounted cash analysis flow of future payments of interest and principal by applying a market based discount rate (level 2). The tables below detail changes in the Group's liabil- ities arising from financing activities, both cash and non-cash changes. Liabilities arising from financing activities are those for which cash flows were, or future cash flows will be, classified in the Group's consolidated statement of cash flow as cash flows from financing activities. Accounting policies Loans are measured at the time of borrowing at fair value less any transaction costs. Subsequently, debt is measured at amortized cost. This means that the differ- ence between the proceeds of the loan and the amount to be repaid is recognized in the income statement over the term of the loan as a financial expense using the effective interest method. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 104 Note 27 Lease liabilities DKK thousand 2022 2021 Non-current 45,834 57,547 Current 24,487 21,266 Lease liabilities 70,321 78,813 Due within Due between Due after DKK thousand 1 year 1 and 5 year 5 years Total 2022 Lease liabilities 24,487 45,834 - 70,321 Total 24,487 45,834 - 70,321 2021 Lease liabilities 21,266 57,547 - 78,813 Total 21,266 57,547 - 78,813 Accounting policies The lease liability is initially measured at the present value of the future lease payments (see further in note 17), discounted by using an incremental country specific borrowing rate ranging from 2.5% to 3.0% applying only a single discount rate for a portfolio of lease assets with reasonable similar characteristics. The lease liability is subsequently measured by increasing the carrying amount to reflect interest on the lease liability using the effective interest method and by reducing the carrying amount to reflect the lease payments made. The lease liability is remeasured and corresponding adjustments are made to the related right-of-use-asset whenever: • The lease term has changed, in which case the lease liability is remeasured by discounting the revised lease payments using a revised discount rate. • The lease payments change due to changes in an index or rate, in which case the lease liability is remeasured by discounting the revised lease payments using an unchanged discount rate. • A lease contract is modified and the lease modifi- cation is not accounted for as a seperate lease, in which case the lease liability is remeasured based on the lease term of the modified lease by discounting the revised lease payments using a revised discount rate at the effective date of the modification. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 105 Note 28 Prepayment from customers 2022 2021 DKK thousand Prepayment from customers as of January 1 16,904 74,347 Prepayments received during the year - 33,850 Recognized as revenue during the year (16,904) (91,293) Prepayment from customers as of December 31 - 16,904 Note 29 Related party transactions The Group Management and Board of Directors of Bavarian Nordic A/S are considered related parties. Besides the remuneration of the Board of Directors and the Executive Management, cf. note 8, and the share- based payments, cf. note 30, there are no transactions with related parties. Transactions with subsidiaries are eliminated in the consolidated financial statements, in accordance with the accounting policies. The HPV license and collaboration agreement with Janssen regarding production of Master Seed Virus has been terminated and therefore the upfront payment of DKK 16.9 million (USD 2.5 million) has been recognized as revenue in 2022. The recognition of revenue is described in note 3. Accounting policies Prepayments are recognized under liabilities and will be recognized in the income statement as the delivery of paid products takes place. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 106 Note 30 Share-based payment Accounting policies Share-based incentive plans in which employees can only opt to buy shares in the Company (warrants) are measured at the equity instruments’ fair value at the grant date and recognized in the income statement over the vesting period. The balancing item is recog- nized directly in equity. The fair value on the date of grant is determined using the Black-Scholes model. Cash-based incentive programs in which employees can have the difference between the agreed exer- cise price and the actual share price settled in cash (phantom shares) are measured at fair value at the date of grant and recognized in the income statement over the period when the final right of cash-settlement is obtained. Granted rights are subsequently re-measured on each balance sheet date and upon final settlement, and any changes in the fair value of the programs are recognized in the income statement. The balancing item is recognized under other liabilities. The fair value of the cash-based incentive programs is determined using the Black-Scholes model. Restricted stock units are measured at fair value at grant date. Based on the achieved cash bonus for members of the Executive Management, subject to the Board of Directors’ decision on the portion that should be converted to restricted stock units, the number of restricted stock units are calculated by dividing the allocated cash bonus amount by the share price of the Company at grant date. As the cash bonus has already been accrued and expensed in the income statement, the grant of restricted stock units has no additional impact on the income statement. The accrued liability for the converted cash bonus is reclassified to equity. Matching shares are measured at the same fair value as the initial restricted stock units and expensed over the three year vesting period. The balancing item is recognized directly in equity. Restricted stock units granted as sign-on bonus for members of the Executive Management and restricted stock units granted to the Board of Directors are expensed at grant date with the balancing item recognized directly in equity. The warrants are granted in accordance with the authorizations given to the Board of Directors by the shareholders. The Board of Directors has fixed the terms of and the size of the grants of warrants, taking into account authorizations from the shareholders, the Group's guidelines for incentive pay, an assessment of expectations of the recipient´s work efforts and contri- bution to the Group´s growth, as well as the need to motivate and retain the recipient. Grant takes place on the date of establishment of the program. Exercise of warrants is by default subject to continuing employ- ment with the Group. The warrants granted are subject to the provisions of the Danish Public Companies Act regarding termination of employees prior to their exercise of warrants in the case of recipients who are subject to the act. Incentive plans In order to motivate and retain key employees and encourage the achievement of common goals for employees, management and shareholders, the Company has established incentive plans by way of warrant programs and restricted stock units programs, the latter only for members of the Executive Manage- ment and Board of Directors. Furthermore, the Company has established three-year phantom share programs for all employees of the Group except for Executive Management and other employees receiving warrants. Warrants The Board of Directors has been granting warrants to the Company´s management and selected employees of the Company and its subsidiaries. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 107 Note 30 Share-based payment (continued) Outstanding Outstanding Can be Average as of as of exercised as of exercise Warrant overview – 2022 January 1 Additions Exercised Annulled Terminated December 31 December 31 price (DKK) December 2016 77,661 - - - (77,661) - - 206 July 2017 34,074 - - - (34,074) - - 340 November 2017 189,609 - (60) (1,526) (188,023) - - 240 November 2018 515,684 - (266,923) (8,053) - 240,708 240,708 142 November 2019 625,984 - - (26,491) - 599,493 - 147 January 2020 30,039 - - - - 30,039 - 156 November 2020 1,176,964 - - (64,894) - 1,112,070 - 207 November 2021 706,469 - - (50,695) - 655,774 - 353 April 2022 - 81,872 - - - 81,872 - 190 December 2022 - 932,051 - - - 932,051 - 225/271 Total 3,356,484 1,013,923 (266,983) (151,659) (299,758) 3,652,007 240,708 Outstanding Outstanding Recognized costs in 2022 DKK 42.9 million compared to as of as of DKK 31.3 million in 2021. Warrant overview – 2022 January 1 Additions Exercised Annulled Terminated Transferred December 31 Corporate Management 743,346 126,487 - - (143,901) - 725,932 Other Executive Management 418,163 185,457 - - - (174,070) 429,550 Other employees 1,880,363 701,979 (145,833) (151,659) (65,579) (237,144) 1,982,127 Resigned employees 314,612 - (121,150) - (90,278) 411,214 514,398 Total 3,356,484 1,013,923 (266,983) (151,659) (299,758) - 3,652,007 Weighted average exercise price (DKK) 219 253 142 242 242 - 231 Weighted average share price at exercise (DKK) 247 Number of warrants which can be exercised as of December 31, 2022 240,708 at a weighted average exercise price of DKK 142 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 108 Note 30 Share-based payment (continued) Outstanding Outstanding as of as of Warrant overview – 2021 January 1 Additions Exercised Annulled Terminated Transferred December 31 Corporate Management 439,402 137,030 - - - 166,914 743,346 Other Executive Management 723,326 108,788 (31,709) - - (382,242) 418,163 Other employees 2,062,360 470,438 (327,617) (241,960) (14,725) (68,133) 1,880,363 Resigned employees 167,901 - (135,275) - (1,475) 283,461 314,612 Total 3,392,989 716,256 (494,601) (241,960) (16,200) - 3,356,484 Weighted average exercise price (DKK) 188 307 217 194 206 - 219 Weighted average share price at exercise (DKK) 327 Number of warrants which can be exercised as of December 31, 2021 301,344 at a weighted average exercise price of DKK 242 Specification of parameters for Black-Scholes model Nov. 2018 Nov. 2019 Jan. 2020 Nov. 2020 Nov. 2021 Apr. 2022 Dec. 2022 3) Average share price 159.00 154.05 171.20 179.84 307.20 171.35 224.70 Average exercise price at grant 179.60 185.40 197.00 206.82 353.06 190.11 270.91 Average exercise price at grant - Executive Management 224.70 Average exercise price determined at date of rights issue March 30, 2020 142.00 146.60 155.80 Applied volatility rate 2) 53.3% 52.2% 53.0% 39.8% 41.8% 42.3% 41.8% Expected life (years) 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Expected dividend per share - - - - - - - Risk-free interest rate p.a. -0.43% -0.69% -0.65% -0.66% -0.53% 0.39% 2.04% Fair value per share at grant 1) 52 45 53 41 76 47 64 Fair value per share at grant - Executive Management 1) 78 1) Fair value of each warrant at grant date applying the Black-Scholes model. 2) The applied volatility is based on the historical volatility of the Bavarian Nordic share, except for programs issued since November 2020 where the volatility is based on the volatility for a peer group. 3) The December 2022 program has two set of exercise conditions. Executive Management can subscribe future shares at a exercise price of DKK 224.70 per share equivalent to the market price of Bavarian Nordic's shares at the time of grant. Vesting of the warrants is subject to prior fulfilment of KPI's as determined by the Board of Directors. Other employees can subscribe future shares at a exercise price of DKK 270.91 per share, determined as the average market price (closing price) of the Company's shares on Nasdaq Copenhagen over a period of 15 business days prior to grant plus 15%. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 109 Note 30 Share-based payment (continued) Exercise periods Can be exercised wholly or partly in a period of 14 days commencing from the day of publication of: December 2022 Annual Report 2025 Interim Report Q1 2026 Interim Report Q2 2026 Interim Report Q3 2026 Annual Report 2026 Interim Report Q1 2027 Interim Report Q2 2027 Interim Report Q3 2027 April 2022 Interim Report Q2 2025 Interim Report Q3 2025 Annual Report 2025 Interim Report Q1 2026 Interim Report Q2 2026 Interim Report Q3 2026 Annual Report 2026 Interim Report Q1 2027 November 2021 Annual Report 2024 Interim Report Q1 2025 Interim Report Q2 2025 Interim Report Q3 2025 Annual Report 2025 Interim Report Q1 2026 Interim Report Q2 2026 Interim Report Q3 2026 November 2020 Annual Report 2023 Interim Report Q1 2024 Interim Report Q2 2024 Interim Report Q3 2024 Annual Report 2024 Interim Report Q1 2025 Interim Report Q2 2025 Interim Report Q3 2025 January 2020 Annual Report 2022 Interim Report Q1 2023 Interim Report Q2 2023 Interim Report Q3 2023 Annual Report 2023 Interim Report Q1 2024 Interim Report Q2 2024 Interim Report Q3 2024 November 2019 Annual Report 2022 Interim Report Q1 2023 Interim Report Q2 2023 Interim Report Q3 2023 Annual Report 2023 Interim Report Q1 2024 Interim Report Q2 2024 Interim Report Q3 2024 November 2018 Annual Report 2021 Interim Report Q1 2022 Interim Report Q2 2022 Interim Report Q3 2022 Annual Report 2022 Interim Report Q1 2023 Interim Report Q2 2023 Interim Report Q3 2023 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 110 Note 30 Share-based payment (continued) Phantom shares In 2018, the Company established a three-year phantom share program for all employees of the Group except for management and other employees receiving warrants. The employees receive up to four phantom shares per month free of charge during the period from January 1, 2019 to December 31, 2021. Each employee who is a full-time employee during the entire term of the plan will be eligible to receive a maximum of 144 phantom shares. Following the rights issues in March 2020 the monthly grant increased to five phantom shares for the remaining grant period and the maximum increased to 183 phantom shares. The program exercised in January 2022. In 2019, the Company established a three-year phantom share program for all employees of the Group except for management and other employees receiving warrants. The employees receive up to four phantom shares per month free of charge during the period from January 1, 2020 to December 31, 2022. Each employee who is a full-time employee during the entire term of the plan will be eligible to receive a maximum of 144 phantom shares. Following the rights issues in March 2020 the monthly grant increased to five phantom shares for the remaining grant period and the maximum increased to 183 phantom shares. The program will exercise in January 2023. In 2020, the Company established a three-year phantom share program for all employees of the Group except for management and other employees receiving warrants. The employees receive up to five phantom shares per month free of charge during the period from January 1, 2021 to December 31, 2023. Each employee who is a full-time employee during the entire term of the plan will be eligible to receive a maximum of 180 phantom shares. Grants are made on a monthly basis during the life of the programs as long as the employee is employed with the Group. On expiry of the programs, the employees may exer- cise the phantom shares granted to them and thus be entitled to a cash bonus calculated on the basis of the increase in the price of the Company´s shares. The exer- cise is conditional on the price of the Company´s shares being at least DKK 5 higher than the exercise price at the time of exercise. On expiry of the programs, former employees are entitled to settlement of the phantom shares granted during their term of employment. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 111 Note 30 Share-based payment (continued) 2021-2023 phantom share program DKK thousand 2022 2021 Outstanding as of January 1 37,996 - Granted during the year 41,136 37,996 Outstanding phantom shares as of December 31 79,132 37,996 Liability in DKK thousand as of December 31 3,732 3,589 Specification of parameters for Black-Scholes model Share price December 31 213 269 Average share exercise price 203 203 Expected volatility rate 47% 42% Expected life (years) 1.0 2.0 Expected dividend per share - - Risk-free interest rate p.a. 3.46% 0.11% 2020-2022 phantom share program DKK thousand 2022 2021 2020 Outstanding as of January 1 68,873 30,921 - Granted during the year 41,627 37,952 29,554 Adjustment following rights issue March 2020 - - 1,367 Outstanding phantom shares as of December 31 110,500 68,873 30,921 Liability in DKK thousand as of December 31 7,370 8,604 1,864 Specification of parameters for Black-Scholes model Share price December 31 213 269 187 Average share exercise price 147 147 147 Expected volatility rate 47% 42% 40% Expected life (years) - 1.0 2.0 Expected dividend per share - - - Risk-free interest rate p.a. - -0.02% -0.17% The expected volatility is based on the volatility for a peer group. Phantom shares granted in 2022 provided an expense of DKK 1.9 million, whereas the revaluation of previ- ously granted phantom shares provided an income of DKK 1.8 million, total net expense of DKK 0.1 million (net expense 2021: DKK 3.6 million). The liability is included in other liabilities, cf. note 22. The expected volatility is based on the volatility for a peer group. The 2020-2022 program will exercise in January 2023 if the average share price for the period January 2 - January 13, 2023 will exceed the exercise price of DKK 146.70. Otherwise the program will expire without exercise. Phantom shares granted in 2022 provided an expense of DKK 2.8 million, whereas the revaluation of previ- ously granted phantom shares provided an income of DKK 4.0 million, total net income of DKK 1.2 million (net expense 2021: DKK 6.7 million). The liability is included in other liabilities, cf. note 22. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 112 Note 30 Share-based payment (continued) 2019-2021 phantom share program DKK thousand 2022 2021 2020 2019 Outstanding as of January 1 92,531 55,095 19,213 - Granted during the year - 37,436 29,437 19,213 Adjustment following rights issue March 2020 - - 6,445 - Exercised during the year (85,367) - - - Expired during the year (7,164) - - - Outstanding phantom shares as of December 31 - 92,531 55,095 19,213 Liability in DKK thousand as of December 31 - 11,724 2,985 864 Specification of parameters for Black-Scholes model Share price December 31 269 187 171 Average share exercise price 142 142 180 Expected volatility rate 42% 40% 51% Expected life (years) - 1.0 2.0 Expected dividend per share - - - Risk-free interest rate p.a. - -0.15% -0.17% The expected volatility for 2020 and 2021 is based on Revaluation of granted phantom shares and reversal of the volatility for a peer group, whereas the volatility for not exercised phantom shares provided a net income of 2019 is based on the historic volatility of the Company. DKK 3.6 million (net expense 2021: DKK 8.7 million). The 2019-2021 program exercised in January 2022 at a The liability is included in other liabilities, cf. note 22. share price of DKK 241.61. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 113 Note 30 Share-based payment (continued) Restricted stock units In March 2021, the Board of Directors decided to post- pone the payment of half of the achieved cash bonus for members of the Other Executive Management for 3 years, converting the postponed bonus of DKK 3.6 million into 16,413 unconditional restricted stock units using the share price of the Company at grant date (DKK 222). The Board of Directors decided to grant additional restricted stock units free of charge on expiry of a 3 years period (so-called ""matching shares"") upon the recipient still being employed in March 2024. One matching share is granted for each two acquired restricted stock units. The maximum number of matching shares is 8,207. The initial granted restricted stock units and the potential matching shares total 24,620 shares. At the annual general meeting in April 2021, the Board of Directors were granted a total of 7,127 unconditional restricted stock units corresponding to 50% of the annual fixed fee of DKK 2.0 million (excl. committee fee). The restricted stock units will be delivered after 3 years in April 2024. Outstanding restricted stock units 2022 Outstanding Outstanding Granted Released as of Value at grant as of January 1 during the year during the year December 31 date (DKK) Vesting date Executive Management: Conversion of cash bonus for 2021 - 22,578 - 22,578 163 Mar. 2025 Matching shares - bonus 2021 - 11,288 - 11,288 163 Mar. 2025 CEO retention plan - 17,109 - 17,109 156 Apr. 2025 Matching shares - CEO retention plan - 8,554 - 8,554 156 Apr. 2025 Sign-on bonus COO - 4,446 - 4,446 165 Apr. 2025 Matching shares - sign-on COO - 2,223 - 2,223 165 Apr. 2025 Conversion of cash bonus for 2020 16,413 - - 16,413 222 Mar. 2024 Matching shares - bonus 2020 8,207 - - 8,207 222 Mar. 2024 Conversion of cash bonus for 2019 11,003 - - 11,003 240 Mar. 2023 Matching shares - bonus 2019 5,500 - - 5,500 240 Mar. 2023 Sign-on bonus CMO 8,651 - - 8,651 149 May 2023 Matching shares - sign-on CMO 4,325 - - 4,325 149 May 2023 Conversion of cash bonus for 2018 16,080 - (16,080) - 144 Mar. 2022 Matching shares - bonus 2018 8,039 - (8,039) - 144 Mar. 2022 Executive Management 78,218 66,198 (24,119) 120,297 Board of Directors: Fee 2022 - 11,467 - 11,467 153 Apr. 2025 Fee 2021 7,127 - - 7,127 273 Apr. 2024 Fee 2020 7,111 - - 7,111 190 Jun. 2023 Fee 2019 12,340 - (12,340) - 138 Apr. 2022 Board of Directors 26,578 11,467 (12,340) 25,705 Total 104,796 77,665 (36,459) 146,002 In May/June 2021, the Company bought back 31,747 of its own shares to meet the obligation to deliver up to 31,747 shares to the members of the Executive Manage- ment and the Board of Directors in March/April 2024. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 114 Note 30 Share-based payment (continued) The grant of the initial restricted stock units to the Exec- utive Management (22,578 shares) had no impact on the income statement for 2022, as the corresponding cash bonus (DKK 3.7 million) was accrued in 2021, though the amount has been reclassified from "Salary and wages" to "Share-based payment" in the staff cost note (note 8). The obligation related to the matching shares amount to DKK 1.8 million measured at the same fair value as the initial restricted stock units (DKK 163). The obligation will be expensed over the three year vesting period. During 2022, DKK 9.2 million has been expensed and recognized as share-based payment related to Execu- tive Management, this includes the expensing of CEO retention plan and sign-on bonus to COO. The grant of restricted stock units to the Board of Directors (11,467 shares - DKK 1.8 million) were fully expensed at grant. Outstanding restricted stock units 2021 Outstanding Outstanding Granted Released as of Value at grant as of January 1 during the year during the year December 31 date (DKK) Vesting date Executive Management: Conversion of cash bonus for 2020 - 16,413 - 16,413 222 Mar. 2024 Matching shares – bonus 2020 - 8,207 - 8,207 222 Mar. 2024 Conversion of cash bonus for 2019 11,003 - - 11,003 240 Mar. 2023 Matching shares – bonus 2019 5,500 - - 5,500 240 Mar. 2023 Sign-on bonus CMO 8,651 - - 8,651 149 May 2023 Matching shares – sign-on CMO 4,325 - - 4,325 149 May 2023 Conversion of cash bonus for 2018 16,080 - - 16,080 144 Mar. 2022 Matching shares – bonus 2018 8,039 - - 8,039 144 Mar. 2022 Sign-on bonus CFO 1) 8,554 - (8,554) - 156 Nov. 2021 Matching shares – sign-on CFO 1) 4,277 - (4,277) - 156 Nov. 2021 Conversion of cash bonus for 2017 8,734 - (8,734) - 244 Mar. 2021 Matching shares – bonus 2017 4,366 - (4,366) - 244 Mar. 2021 Executive Management 79,529 24,620 (25,931) 78,218 Board of Directors: Fee 2021 - 7,127 - 7,127 273 Apr. 2024 Fee 2020 7,111 - - 7,111 190 Jun. 2023 Fee 2019 12,340 - - 12,340 138 Apr. 2022 Fee 2018 8,666 - (8,666) - 175 Apr. 2021 Board of Directors 28,117 7,127 (8,666) 26,578 Total 107,646 31,747 (34,597) 104,796 1) At vesting 6,400 shares were transferred to CFO Henrik Juuel, the remaining 6,431 restricted stock units were converted to a cash bonus of DKK 2.0 million. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 115 Note 30 Share-based payment (continued) Note 31 Contingent liabilities and other contractual obligations DKK thousand 2022 2021 Collaborative agreements Contractual obligations with research (CRO) and manufacturing (CMO) partners for long- term research projects. – Due within 1 year 260,082 131,865 Total share-based payments Below a specification of all share-based payments expensed in 2022 and 2021. The amounts reconcile to note 8. DKK thousand 2022 2021 Warrants 42,937 31,265 Restricted stock units 11,039 7,319 Share-based payment recognized directly in equity 53,976 38,584 2021-2023 phantom share program 143 3,589 2020-2022 phantom share program (1,234) 6,740 2019-2021 phantom share program (3,601) 8,739 Share-based payment recognized as a liability (change during the year) (4,692) 19,068 Total share-based payment expensed, cf. note 8 49,284 57,652 Restricted stock units converted to cash bonus at exercise - (795) Non-cash adjustment in cash flow statement 49,284 56,857 Sales milestone to GlaxoSmithKline The Asset Purchase Agreement with GlaxoSmithKline regarding the acquisition of the product rights to Rabipur/RabAvert and Encepur includes a sales mile- stone of EUR 25 million. As per December 31, 2022 Management does not judge the sales milestone to be probable and therefore the sales milestone has not been recognized as either part of the product rights (note 15) nor the deferred consideration for product rights (note 24). 24. The remaining developement milestones related to filing for approval in further countries are not deemed likely and therefore not recognized. Agreement with Danish Ministry of Health Under the agreement with the Danish Ministry of Health to fund the development of ABNCoV2 the Company has an obligation of payment of an additional, capped royalty payment if the sales reach a certain threshold. Based on current sales forecasts this addi- tional royalty payment is not deemed likely and there- fore not recognized. If the payment becomes current it will be recognized as a financial expense as the additional royalty payment is seen as an extra interest payment. The cap for the additional royalty payment is a fixed amount, calculated as a percentage of the loan amount. License and collaboration agreement AdaptVac Under the license and collaboration agreement with AdaptVac the Company has an obligation of payment of potential future development and sales milestones and tiered royalties. Based on current regulatory plans and expectations for future sale of the Company's COVID-19 vaccine all sales milestones and part of the development milestones are deemed probable as per December 31, 2022 and the net present value of those future milestone payments have been recognized as deferrred consideration, see further description in note Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 116 Note 31 Contingent liabilities and other contractual obligations (continued) Note 32 Significant events after the balance sheet date License agreements National Cancer Institute The Group has license agreements with the National Cancer Institute (NCI) and Public Health Service (PHS) in the U.S. for PROSTVAC, CV301 and BN-Brachyury, respec- tively. The agreements include contingent liabilities for the Group to pay performance-based royalties, if and when certain milestone events are achieved. Further, the agreements include potential contingent liabilities for the Group to pay additional sublicensing royalties on the fair market value of consideration received, if and when the Group grants such sublicenses. Payments considered remote are not included in the amounts above. Company mortgage The Company has by letter of indemnity granted Nordea a floating charge on unsecured claims arising from the sale of goods and services and stocks of raw materials, intermediate products and finished products, DKK 150 million (DKK 150 million). The floating charge secures the operating credit line of DKK 20 million and the line for trading in financial instruments, DKK 50 million (DKK 50 million). On February 15, 2023, the Company announced an update on its late-stage pipeline programs. The anal- ysis of data from the completed Phase 3 trial of the RSV vaccine candidate, MVA-BN® RSV, is progressing according to plan and topline results from the study are still anticipated in mid-2023. In the Phase 3 trial of the COVID-19 booster vaccine candidate, ABNCoV2, the recruitment of subjects ≥65 years of age is taking longer than anticipated, pushing the expected comple- tion of enrollment into the second quarter of 2023 with topline results now anticipated around mid-2023. On February 15, 2023, the Company announced an agreement with Emergent BioSolutions Inc. to acquire two marketed travel vaccines, Vivotif® for the preven- tion of typhoid fever and Vaxchora® against cholera as well as a Phase 3 vaccine candidate for the prevention of Chikungunya virus for a total consideration of up to USD 380 million, including USD 270 million in an upfront payment and up to USD 110 million in future conditional milestone payments. The acquisition also includes facil- ities and key personnel related to the acquired assets. On February 20, 2023, The Company announced successful completion of a directed issue and private placement of 7,046,839 new shares at an offer price of DKK 233 per share, raising gross proceeds of DKK 1,642 million. Except as noted above, there have been no significant events between December 31, 2022 and the date of approval of these financial statements that would require a change to or additional disclosure in the financial statements. Lawsuits Based on management's assessment the Group is not involved in any lawsuits or arbitration cases which could have a material impact on the Group's financial position or results of operations. Note 33 Approval of the consolidated financial statements The consolidated financial statements were approved by the Board of Directors and Corporate Management and authorized for issue on March 2, 2023. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 117 Financial statements – Parent company Contents Financial statements Notes 12. Right-of-use-assets 13. Investment in subsidiaries 14. Inventories Income statements 1. Significant accounting policies and significant accounting estimates and judgments Statements of financial position – Assets Statements of financial position – Equity and liabilities Statements of changes in equity 2. Revenue 3. Research and development costs 4. Staff costs 15. Lease liabilities 16. Prepayment from customers 5. Depreciation, amortization and impairment losses 6. Fees to auditor appointed at the annual general meeting 7. Financial income 17. Other liabilities 18. Related party transactions 19. Contingent liabilities and other contractual obligations 20. Mortgages and collateral 8. Financial expenses 9. Tax for the year 21. Proposed appropriation of net profit/(loss) 22. Significant events after the balance sheet date 10. Intangible assets 11. Property, plant and equipment Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 118 Income statements For the years ended December 31, 2022 and 2021 DKK thousand Note 2022 2021 Note Revenue 2 2,939,164 1,401,431 1,537,733 1,938,362 1,266,481 671,881 Notes with reference to the consolidated financial statements Production costs Gross profit 4,5 Revenue 3 4 5 7 Production costs Sales and distribution costs Administrative costs Sales and distribution costs Research and development costs Administrative costs 4 3,4,5 4,5,6 182,880 1,206,121 386,992 168,903 405,649 327,031 901,583 Total operating costs 1,775,993 Income before interest and tax (EBIT) (238,260) (229,702) Income from investments in subsidiaries Financial income 13 7 124,551 112,534 (131,075) 82,643 Financial expenses 8 341,274 192,014 Income before company tax (342,449) (470,148) Tax on income for the year 9 28 - Net result for the year 21 (342,477) (470,148) Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 119 Statements of financial position – Assets December 31, 2022 and 2021 DKK thousand Note 2022 2021 DKK thousand Current assets Note 2022 2021 Non-current assets Product rights 4,639,895 1,013,484 13,795 4,912,830 733,770 21,360 Inventories 14 881,346 407,632 Acquired rights and development in progress Software Trade receivables Receivables from subsidiaries Other receivables Prepayments 399,936 56,561 253,850 154,035 85,239 Other intangible assets in progress Intangible assets 274,490 134,371 51,462 10 5,941,664 5,802,331 343,492 851,451 125,411 618,535 Land and buildings 629,829 1,428 345,536 1,882 Receivables Leasehold improvements Securities 2,269,759 563,812 3,124,795 573,893 Plant and machinery 321,589 489,558 184,280 254,530 207,498 560,551 1,369,997 Cash and cash equivalents Securities, cash and cash equivalents Other fixtures and fittings, other plant and equipment Assets under construction 2,833,571 3,698,688 4,566,368 4,724,855 12,383,424 12,107,828 Property, plant and equipment 11 1,626,684 Total current assets Total assets Right-of-use assets 12 13 18,953 25,871 Investments in subsidiaries Other receivables 210,422 14,878 4,455 163,970 16,559 4,245 Other financial non-current assets Financial assets 229,755 184,774 Total non-current assets 7,817,056 7,382,973 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 120 Statements of financial position – Equity and liabilities December 31, 2022 and 2021 DKK thousand Note 2022 2021 Note Equity Notes with reference to the consolidated financial statements Trade receivables Share capital 707,354 (1,462) 704,684 (1,111) 19 21 23 24 25 26 28 30 Treasury shares Retained earnings Reserve for development costs Other reserves Equity Prepayments 5,901,428 395,015 6,556,902 19,275 Financial risks and financial instruments Deferred consideration for product rights Prepayment and loan from Government Debt to credit institutions 149,787 95,455 7,152,122 7,375,205 Prepayment from customers Liabilities Share-based payment Deferred consideration Prepayment and loan from Government Credit institutions 2,324,657 566,420 17,008 2,569,090 160,511 18,896 Lease liabilities 15 7,732 16,186 Non-current liabilities 2,915,817 2,764,683 Deferred consideration for product rights Credit institutions 287,436 1,105,583 12,526 577,667 874,373 11,367 Lease liabilities 15 16 Prepayment from customers Trade payables - 16,904 584,731 153,788 171,421 2,315,485 246,271 157,175 84,183 Payables to subsidiaries Other liabilities 17 Current liabilities 1,967,940 Total liabilities 5,231,302 4,732,623 12,383,424 12,107,828 Total equity and liabilities Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 121 Statements of changes in equity December 31, 2022 Reserve for costs Share capital Treasury shares Retained development Other reserves DKK thousand earnings Equity Equity as of January 1, 2022 704,684 (1,111) 6,556,902 19,275 95,455 7,375,205 Net result for the year - - - - (342,477) (5,182) - - - - (342,477) (5,182) Exchange rate adjustments Change in fair value of financial instruments entered into to hedge future cash flows - - - - 33,245 33,245 Share-based payment - - - 46,145 - 53,976 53,976 Warrant programs exercised Warrant recharged 2,670 - - (10,897) 37,918 - - 8,876 - - 8,876 Warrant programs expired - - - 17,898 - (17,898) - Costs related to issue of new shares Purchase of treasury shares Transfer regarding restricted stock units Reserve for development costs Equity as of December 31, 2022 - (111) - - (111) - (716) 365 (8,612) 3,729 - - - (4,094) - (9,328) - - - - - (375,740) 5,901,428 375,740 395,015 707,354 (1,462) 149,787 7,152,122 Transactions on the share capital and rules on changing Articles of Associations, see statement of changes in Group equity. Other reserves consist of costs for share-based payments and hedging reserves. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 122 Note 1 Note 2 Revenue Significant accounting policies and significant accounting estimates and judgments DKK thousand 2022 2021 Accounting policies The financial statements of the Parent Company Bavarian Nordic A/S have been prepared in accordance with the Danish Financial Statements Act (Class D). statement of comprehensive income in the consol- idated financial statements are recognized directly in the statement of changes in equity in the Parent Company’s financial statements. MVA-BN smallpox vaccine sale Rabipur/RabAvert Encepur 1,730,447 669,061 733,593 544,274 301,100 365,091 The financial statements are presented in Danish kroner (DKK), which also is the functional currency of the Parent Company. The accounting policies are unchanged from previous year. Other product sale Sale of goods 105,139 260,220 Warrant recharged to subsidiaries is treated as the Parent Company’s issuance of equity in exchange for cash. 2,805,747 1,903,178 Milestone payments Contract work 83,048 50,369 - 35,184 35,184 Changes in accounting policies The accounting policies are unchanged from last year. The recharge is subsequently recognized in the income statement under the cost plus agreements with the subsidiaries. Income tax effects relating to warrant recharged is recognized in the income statement. Sale of services 133,417 Revenue 2,939,164 1,938,362 Supplementary accounting policies for the Parent Company Accounting policies for investments in subsidiaries are described in note 13. Total revenue includes: As allowed under section 86 (4) of the Danish Finan- cial Statements Act, no cash flow statement has been prepared for the Parent Company, as it is included in the consolidated cash flow statement. Fair value adjustment concerning financial instruments entered into to hedge revenue - (7,072) The Group's sale of RabAvert in US is handled and recognized in Bavarian Nordic Inc.. The Group's sale of Encepur and Rabipur in Switzerland is handled and recognized in Bavarian Nordic Switzerland AG. Both Bavarian Nordic Inc. and Bavarian Nordic Switzerland AG operate under a distribution agreement and purchase the products from Bavarian Nordic A/S. The internal sale of Rabipur/RabAvert has been lower than the sale to external customers in US and Switzerland, hence the Group Rabipur/RabAvert revenue is higher than the revenue recognized in the Group. In 2021 the situation was opposite due to high inventory build up in US at year-end 2021.The internal sale of Encepur in 2022 exceeded the sale to customers in Switzerland, hence the Encepur revenue recognized in the Parent Company is higher than the Encepur revenue recognized in the Group. The contract with the United States Department of Defense for the development of a prophylactic vaccine against the equine encephalitis virus is concluded with Bavarian Nordic, Inc., whereas all costs related to the contract are covered by Bavarian Nordic A/S. Bavarian Nordic A/S re-invoice those costs to Bavarian Nordic, Inc. Net Bavarian Nordic, Inc. earns a mark-up, reducing the contract work revenue in the Parent Company compared to the contract work revenue in the Group. Pursuant to the schedule requirements of the Danish Financial Statements Act, entries recognized in the For further disclosures see the consolidated financial statements note 3. Accounting policies and significant accounting estimates See consolidated financial statements note 3. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 123 Note 3 Note 4 Research and development costs Staff costs DKK thousand 2022 2021 DKK thousand 2022 2021 Research and development costs incurred this year 1,226,008 427,527 Wages and salaries Contribution based pension Social security expenses Other staff expenses Share-based payment Staff costs 458,504 38,552 3,749 371,127 32,724 3,928 Of which: Contract costs recognized as production costs Research and development costs recognized in the income statement (19,887) (21,878) 405,649 34,529 49,656 584,990 25,308 53,290 486,377 1,206,121 Fair value adjustment concerning financial instruments entered into to hedge research and development costs 30,201 - Staff expenses are distributed as follows: Production costs 311,474 12,862 243,502 21,834 Accounting policies See consolidated financial statements note 6. Sales and distribution costs Research and development costs Administrative costs 69,798 65,148 149,025 41,831 116,609 39,284 Capitalized salaries Staff costs 584,990 486,377 Average number of employees converted to full-time 604 688 511 533 Number of employees as of December 31 converted to full-time Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 124 Note 4 Staff costs (continued) CEO and President of the Company Paul Chaplin and CFO Henrik Juuel constitute the Corporate Management in the Parent Company. The CEO's contract of employment contains standard DKK thousand 2022 2021 terms for members of the management of Danish listed companies, including the extended period of notice that both parties are required to give. For the Company, the notice is maximum 18 months. In the event of a change of control, the term of notice for the Company will be extended to maximum 24 months. Staff costs include the following costs: COO Russell Thirsk and CPO Anu Kerns constitute the Company's member of the Other Executive Manage- ment. Former COO Henrik Birk resigned by the end of March 2022. Board of Directors: Remuneration 5,475 1,750 7,225 5,202 1,950 7,152 Share-based payment Remuneration to Board of Directors Accounting policies See consolidated financial statements note 8. Incentive programs for management and other employees are disclosed in the consolidated financial statements note 30. Executive Management: Salary 9,873 2,068 692 8,661 3,956 678 Paid bonus Other employee benefits Contribution based pension Share-based payment Corporate Management 1,367 13,485 27,485 2,048 9,035 24,378 Salary 5,211 1,775 163 5,981 1,917 207 Paid bonus Other employee benefits Contribution based pension Share-based payment Salary and benefits in notice period Other Executive Management 698 752 3,698 7,851 19,396 3,869 7,378 20,104 Remuneration to Executive Management Total Management remuneration 46,881 54,106 44,482 51,634 Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 125 Note 5 Note 6 Depreciation, amortization and impairment losses Fees to auditor appointed at the annual general meeting DKK thousand 2022 2021 DKK thousand 2022 2021 Depreciation and amortization included in: Production costs Audit of financial statements Other assurance services Tax advisory 1,961 176 1,942 160 349,893 2,599 346,012 2,340 Research and development costs Administrative costs 20 135 27,807 24,954 Other services 143 213 Depreciation and amortization 380,299 373,306 Fees 2,300 2,450 Hereof profit ()/loss from disposed fixed assets 1,175 5,259 Impairment losses included in: Production costs - 618 Impairment losses - 618 For further disclosures see the consolidated financial statements note 9. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 126 Note 7 Note 8 Financial income Financial expenses DKK thousand 2022 2021 DKK thousand 2022 2021 Financial income from bank and deposit contracts Financial income from subsidiaries 27 30,256 19,543 1,739 22,875 11,045 32,185 1,677 Interest expenses on debt 15,346 3,205 17,011 2,374 39,056 133,573 - Financial expenses to subsidiaries Financial income from securities Fair value adjustments on securities 190,301 103,049 11,597 Adjustment of deferred consideration due to change in estimated timing of payments Currency adjustment deferred consideration Net foreign exchange gains 54,390 - Unwinding of the discount related to deferred consideration Currency adjustment deferred consideration Net loss on derivative financial instruments at fair value in the income statement Financial expenses 8,318 112,534 13,122 82,643 17,776 - Financial income 341,274 192,014 Accounting policies Accounting policies See consolidated financial statements note 11. See consolidated financial statements note 12. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 127 Note 9 Tax for the year DKK thousand 2022 2021 Accounting policies See consolidated financial statements note 13. lishment in Finland since we have one employee hired by the Parent Company working from home in Finland. Tax recognized in the income statement 'Income()/expenses that are not taxable/deductible for tax purposes' primarily relates to the 30% step up deduc- tion on research and development costs according to Section 8B of the Danish Tax Assessment Act. Current tax on profit for previous years 28 - Deferred tax Tax for the year recognized in the income statement 28 - Recognized deferred tax assets relate to temporary differences between valuations for accounting and taxa- tion purposes and tax losses carried forward. Tax on income for the year is explained as follows: Income before company tax (342,449) (75,339) (470,148) (103,432) Current tax on profit for previous years relates to prelim- inary tax assessment from the Finnish Tax Authorities as they deem the Parent Company has a permanent estab- For further disclosures see the consolidated financial statements note 13. Calculated tax (22.0%) on income before company tax Tax effect on: Income from investments in subsidiaries (27,401) (16,871) 28 28,837 2022 Income()/expenses that are not taxable/deductible for tax purposes Current tax on profit for previous years Special tax credit (16,699) Adjustment Recognized - January 1, to previous in the income Recognized December 31, DKK thousand Product rights 2022 year statement in equity 2022 (46,946) 166,557 - - 94,007 (2,713) - Change in non-recognized tax asset (10,421) - - 73,302 - 62,881 Adjustment to previous years non-recognized tax asset Tax on income for the year Acquired rights and development in progress 28 - 60,500 370 (2,659) - - - - - (2,659) 88,124 287 Property, plant and equipment Right-of-use-asset 4,184 23,440 Tax recognized in equity (83) Tax for the year recognized in equity - - Development projects for sale Receivables 32,446 37 - - 154 32,446 191 - Financial instruments 297 - - (7,314) (7,017) 27,405 449,015 (650,673) - Share-based payment 27,994 361,415 (472,638) - - 20,479 (24,663) - 5,282 67,121 (166,557) - (5,871) Tax losses carried forward Not recognized tax asset Recognized deferred tax assets - 13,185 - Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 128 Note 10 Intangible assets 2022 Acquired Other rights and intangible assets in progress Product development DKK thousand rights in progress Software Total Costs as of January 1, 2022 Additions 5,458,700 733,770 279,714 - 95,930 3,007 134,371 142,691 (2,572) 6,422,771 425,412 - - - Transfer 2,572 Cost as of December 31, 2022 5,458,700 1,013,484 101,509 274,490 6,848,183 Amortization as of January 1, 2022 Amortization 545,870 272,935 818,805 - - - 74,570 13,144 87,714 - - - 620,440 286,079 906,519 Amortization as of December 31, 2022 Carrying amount as of December 31, 2022 Carrying amount as of December 31, 2021 4,639,895 4,912,830 1,013,484 733,770 13,795 21,360 274,490 134,371 5,941,664 5,802,331 Accounting policies See consolidated financial statements note 15. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 129 Note 11 Property, plant and equipment 2022 Other fixtures and fittings, other plant and Land and Leasehold Plant and machinery Assets under construction DKK thousand buildings improvement equipment Total Costs as of January 1, 2022 Additions 545,592 73,769 238,004 - 4,456 424,289 25,866 73,919 250,852 138,479 165,702 (428) 560,551 101,356 (477,627) - 1,785,740 339,470 - - Transfer 2 - Disposals (9,864) 514,210 (10,292) 2,114,918 Cost as of December 31, 2022 857,365 4,458 554,605 184,280 Depreciation and impairment losses as of January 1, 2022 200,056 27,480 - 2,574 456 169,759 31,060 43,354 21,994 (301) - - - - 415,743 80,990 Depreciation Disposals - (8,198) (8,499) Depreciation and impairment losses as of December 31, 2022 227,536 3,030 192,621 65,047 488,234 Carrying amount as of December 31, 2022 Carrying amount as of December 31, 2021 629,829 1,428 1,882 321,589 254,530 489,558 207,498 184,280 560,551 1,626,684 1,369,997 345,536 For collateral see the consolidated financial statements note 16. Accounting policies See consolidated financial statements note 16. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 130 Note 12 Note 13 Right-of-use-assets Investment in subsidiaries 2022 DKK thousand 2022 Rent facility Car Costs as of January 1, 2022 Additions 691,254 49,198 DKK thousand leasing Equipment Total Right-of-use assets as of January 1, 2022 Additions 24,428 917 536 1,375 1,058 - 907 25,871 2,292 Cost as of December 31, 2022 740,452 - Net revaluation as of January 1, 2022 Net share of profit/loss for the year Change in unrealized intra-group profits Exchange rate adjustments (649,399) 898 Modifications 3,290 (2,412) (10,545) 909 - - 4,348 Disposals (2,412) (12,055) 909 123,653 (5,182) Depreciations (1,071) - (439) - Reversal depreciations Right-of-use assets as of December 31, 2022 Net revaluation as of December 31, 2022 (530,030) 16,587 1,898 468 18,953 Carrying amount as of December 31, 2022 Carrying amount as of December 31, 2021 210,422 163,970 2021 Car Rent DKK thousand facility leasing Equipment Total Non-current receivables from Bavarian Nordic, Inc. is recognized as part of "Investments in subsidiaries". During 2022 the receivables increased by DKK 49.2 million, shown as an addition in the table. Impact from applying IFRS 16 as of January 1, 2021 33,717 - 1,284 287 515 768 38 35,516 1,055 Additions Voting rights Modifications 518 (46) 510 Company summary Domicile Ownership Depreciations (9,807) 24,428 (989) 536 (414) 907 (11,210) 25,871 Subsidiaries Right-of-use assets as of December 31, 2021 Bavarian Nordic GmbH Germany USA 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% Bavarian Nordic, Inc. DKK thousand 2022 2021 Bavarian Nordic Switzerland AG Bavarian Nordic Sweden AB Aktieselskabet af 1. juni 2011 I Aktieselskabet af 1. juni 2011 II Switzerland Sweden Denmark Denmark Amounts included in the income statement Interest expense leases 598 12,055 145 685 11,210 293 Depreciation recognized on right-of-use assets Cost recognized for short term leases (less than 12 months) Accounting policies See consolidated financial statements note 17. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 131 Note 13 Note 14 Investment in subsidiaries (continued) Inventories Upon distribution of profit or loss, net revaluation of investments in subsidiaries is transferred to the net revaluation reserve according to the equity method under equity, if the net revaluation is positive. If the net revaluation is negative, it is recognized in retained earnings in equity. DKK thousand 2022 2021 Accounting policies Investments in subsidiaries are recognized and meas- ured under the equity method. This means that, in the balance sheet, investments are measured at the pro rata share of the subsidiaries' equity plus or less unam- ortized positive, or negative, goodwill and plus or less unrealized intra-group profits or losses. Raw materials and supply materials Work in progress 198,839 641,182 203,744 (162,419) 881,346 79,068 79,904 Manufactured goods and commodities Write-down on inventory Inventories 421,601 (172,941) 407,632 Goodwill is calculated as the difference between cost of the investments and the fair value of the assets and liabilities acquired which have been measured at fair value at the date of acquisition. The amortization period for goodwill is usually five years. Subsidiaries with a negative equity value are measured at zero value, and any receivables from these subsidi- aries are written down by the Company’s share of such negative equity if it is deemed irrecoverable. If the negative equity exceeds the amount receivable, the remaining amount is recognized under provisions if the Company has a legal or constructive obligation to cover the liabilities of the relevant subsidiary. Write-down on inventory as of January 1 Write-down for the year (172,941) (78,101) 46,031 (63,537) (171,643) 62,239 - Use of write-down Reversal of write-down 42,592 Investments in subsidiaries are written down to the lower of recoverable amount and carrying amount. Write-down on inventory as of December 31 (162,419) (172,941) Cost of goods sold amounts to 603,598 481,916 Income from investments in subsidiaries' contains pro rata share of subsidiaries profits or losses after elimina- tion of unrealized intra-group profits and losses. For further details regarding development in inventory values see consolidated financial statements note 18. Accounting policies and significant accounting estimates See consolidated financial statements note 18. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 132 Note 15 Note 16 Lease liabilities Prepayment from customers DKK thousand 2022 2021 DKK thousand 2022 2021 Non-current Current 7,732 12,526 20,258 16,186 11,367 27,553 Prepayment from customers as of January 1 Prepayments received during the year 16,904 74,347 33,850 (91,293) 16,904 - (16,904) - Lease liabilities Recognized as income during the year Prepayment from customers as of December 31 For further details of prepayment from customers, see consolidated financial statements note 28. Due within Due between Due after 5 years DKK thousand 1 year 1 and 5 year Total Accounting policies See consolidated financial statements note 28. 2022 Lease liabilities 12,526 7,732 - - 20,258 2021 Lease liabilities 11,367 16,186 27,553 Accounting policies See consolidated financial statements note 27. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 133 Note 17 Note 18 Other liabilities Related party transactions The Corporate Management and Board of Directors of Bavarian Nordic A/S are considered related parties as they have significant influence over the Company. Bavarian Nordic Switzerland AG distributes and sells Encepur and Rabipur in Switzerland on behalf of Bavarian Nordic A/S. This is done under a Distribution Agreement. DKK thousand 2022 2021 Derivative financial instruments at fair value in the income statement Liability relating to phantom shares Payable salaries, holiday accrual etc. Gross to net deduction accrual Other accrued costs 8,302 11,142 1,351 23,917 49,165 5,017 4,733 - Main intercompany transactions: Bavarian Nordic GmbH provides research and develop- ment services to Bavarian Nordic A/S. 75,495 55,387 8,317 Bavarian Nordic Switzerland AG provides global commercial services to Bavarian Nordic A/S. Bavarian Nordic, Inc. distributes and sells RabAvert in the US on behalf of Bavarian Nordic A/S. This is done under a Distribution Agreement. Bavarian Nordic Sweden AB provides regional commer- cial services to Bavarian Nordic A/S. Payable VAT and duties 12,778 171,421 Other liabilities 84,183 All services except for the distribution agreements are delivered under cost plus agreements and on arms length conditions. For further details of derivative financial instruments, see consolidated financial statements note 23. The phantom share programs are disclosed in the consoli- dated financial statements note 30. Bavarian Nordic, Inc. provides research and develop- ment services to Bavarian Nordic A/S. Bavarian Nordic, Inc. also provides services to Bavarian Nordic A/S in terms of commercial affair work towards the U.S. Government, with the purpose of ensuring an efficient communication and service to U.S. authorities, in order to maintain existing contracts and explore new product/contract opportunities on the U.S. market. The distribution agreements are honored according to OECD's guidelines for a Limited Risk Distributor. Accounting policies See consolidated financial statements note 22. Apart from intra-group transactions mentioned above and the remuneration of the Board of Directors and Corporate Management, cf. note 8 and note 30 in the consolidated financial statements, there are no transac- tions with related parties. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 134 Note 19 Contingent liabilities and other contractual obligations Repayment obligation Repayment obligation regarding received prepayments see the consolidated financial statements note 28. Agreement with Danish Ministry of Health Under the agreement with the Danish Ministry of Health to fund the development of ABNCoV2 the DKK thousand 2022 2021 Collaborative agreements Company has an obligation of payment of an additional, capped royalty payment if the sales reach a certain threshold. Based on current sales forecasts this addi- tional royalty payment is not deemed likely and there- fore not recognized. If the payment becomes current it will be recognized as a financial expense as the additional royalty payment is seen as an extra interest payment. The cap for the additional royalty payment is a fixed amount, calculated as a percentage of the loan amount. Contractual obligations with research (CRO) and manufacturing (CMO) partners for long- term research projects. Sales milestone to GlaxoSmithKline The Asset Purchase Agreement with GlaxoSmithKline regarding the acquisition of the product rights to Rabipur/RabAvert and Encepur includes a sales mile- stone of EUR 25 million. As per December 31, 2022 Management does not judge the sales milestone to be probable and therefore the sales milestone has not been recognized as either part of the product rights nor the deferred consideration for product rights. – Due within 1 year 260,082 127,300 License and collaboration agreement AdaptVac Under the license and collaboration agreement with AdaptVac the Company has an obligation of payment of potential future development and sales milestones and tiered royalties. Based on current regulatory plans and expectations for future sale of the Company's COVID-19 vaccine all sales milestones and part of the development milestones are deemed probable as per December 31, 2022 and the net present value of those future milestone payments have been recognized as deferrred consideration, see further description in note 24 in the consolidated financial statements. The remaining developement milestones related to filing for approval in further countries are not deemed likely and therefore not recognized. Joint taxation The Company is jointly taxed with all Danish subsid- iaries. As the administration company the Company stands surety with the other companies in the joint taxation of Danish corporate taxes and also withholding taxes on dividends, interest and royalties. Corpora- tion taxes and withholding taxes payable in the joint taxation pool was DKK 0 as of December 31, 2022. Any adjustments of the taxable joint taxation income or taxes withheld at source may have the effect that the Company's liability increases. Incentive agreements, company mortgage and lawsuits See the consolidated financial statements note 32. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 135 Note 20 Note 21 Mortgages and collateral Proposed appropriation of net profit/(loss) DKK thousand 2022 2021 DKK thousand 2022 2021 Guarantees for subsidiaries Retained earnings (342,477) (342,477) (470,148) (470,148) The Parent Company stands surety for a credit facility to a subsidiary of a maximum of The Parent Company stands surety for letter of credit to subsidiaries of a maximum of 3,532 2,335 3,435 2,335 Total Mortgages See description regarding property, plant and equip- ment in note 16 in the consolidated financial state- ments. Note 22 Significant events after the balance sheet date See description in note 32 in the consolidated financial statements. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 136 Hellerup, March 2, 2023 Statement by Corporate Management management on Paul John Chaplin President and CEO Henrik Juuel Executive Vice President and CFO the Annual Report The Board of Directors and the Corporate Manage- ment have today considered and approved the Annual Report of Bavarian Nordic A/S for the finan- cial year January 1 - December 31, 2022. In our opinion, the management commentary contains a fair review of the development of the Group's and the Parent’s business and financial matters, the results for the year and of the Parent’s financial position and the financial position as a whole of the entities included in the consolidated financial statements, together with a description of the principal risks and uncertainties that the Group and the Parent face. Board of Directors The consolidated financial statements are presented in accordance with International Financial Reporting Standards as adopted by the EU. The parent financial statements are presented in accordance with the Danish Financial Statements Act. Further, the Annual Report is prepared in accordance with Danish disclo- sure requirements for listed companies. Gerard W.M. van Odijk Chairman of the Board Anders Gersel Pedersen Deputy Chairman In our opinion, the Annual Report with the file name bava-2022-12-31-en.zip is prepared, in all material respects, in accordance with the ESEF Regulation. Peter H. Kürstein-Jensen Frank A.G.M. Verwiel Anne Louise Eberhard In our opinion, the consolidated financial statements and the parent financial statements give a true and fair view of the Group’s and the Parent’s financial position at December 31, 2022, as well as of the results of their operations and the Group’s cash flows for the financial year January 1 - December 31, 2022. We recommend the Annual Report for adoption at the Annual General Meeting Thomas Alex Bennekov Employee-elected Anja Gjøl Employee-elected Karen Merete Jensen Employee-elected Linette Munksgaard Andersen Employee-elected Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 137 Independent auditor's report To the shareholders of Bavarian Nordic A/S Report on the Financial Statements Opinion position at 31 December 2022, and of the results of its operations and cash flows for the financial year 1 January 2022 – 31 December 2022 in accordance with International Financial Reporting Standards as endorsed by the EU and additional requirements under the Danish Financial Statements Act. additional requirements applicable in Denmark. Our responsibilities under those standards and require- ments are further described in the Auditor’s respon- sibilities for the audit of the consolidated financial statements and the parent financial statements section of this auditor’s report. We are independent of the Group in accordance with the International Ethics Standards Board for Accountants’ International Code of Ethics for Professional Accountants (IESBA Code) and the additional ethical requirements appli- cable in Denmark, and we have fulfilled our other ethical responsibilities in accordance with these requirements and the IESBA Code. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion. After Bavarian Nordic A/S was listed on Nasdaq OMX Copenhagen in 1998, we were appointed auditors at the Annual General Meeting held on May 27, 1999 for the 1999 financial year. We have been reap- pointed annually at the Annual General Meeting for a total consecutive engagement period of 24 years up to and including the 2022 financial year. We have audited the consolidated financial state- ments and the parent financial statements of Bavarian Nordic A/S for the financial year 1 January 2022 – 31 December 2022, which comprise the income statement, statements of financial position, statement of changes in equity and notes, including a summary of significant accounting policies, for the Group as well as the Parent, and the statement of comprehensive income and the cash flow statement of the Group (collectively referred to as the “Finan- cial Statements”). The consolidated financial state- ments are prepared in accordance with International Financial Reporting Standards as endorsed by the EU and additional requirements of the Danish Financial Statements Act, and the parent financial statements are prepared in accordance with the Danish Financial Statements Act. Further, in our opinion, the parent financial state- ments give a true and fair view of the Parent’s financial position at 31 December 2022, and of the results of its operations for the financial year 1 January 2022 – 31 December 2022 in accordance with the Danish Financial Statements Act. Key audit matters Key audit matters are those matters that, in our professional judgement, were of most significance in our audit of the consolidated financial state- ments and the parent financial statements for the financial year 1 January 2022 – 31 December 2022. These matters were addressed in the context of our audit of the consolidated financial statements and the parent financial statements as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters. Our opinion is consistent with our Long-form Audi- tor’s report issued to the Audit Committee and the Board of Directors. To the best of our knowledge and belief, we have not provided any prohibited non-audit services as referred to in Article 5(1) of Regulation (EU) No 537/2014. Basis for opinion We conducted our audit in accordance with Inter- national Standards on Auditing (ISAs) and the In our opinion, the consolidated financial statements give a true and fair view of the Group’s financial Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 138 Key audit matter How our audit addressed the key audit matter Statement on the management commentary Management is responsible for the management commentary. Capitalisation of development costs and prepayments related to ABNCoV2 We have assessed the appropriateness of capitalizing the develop- ment costs regarding ABNCoV2. In this context, we: Acquired rights and incurred development costs related to ABNCoV2 development project (COVID-19 booster vaccine), now in Phase 3, amount to DKK 1,013 million, and prepayments for CMO product supply amount to DKK 324 million. Intangible assets in progress related to costs for the scale up activities amounts to DKK 14 million. Total capitalised development costs and prepayments related to the ABNCoV2 development project amount to DKK 1,351 million as of 31 December 2022. • inquired Management about the overall development of the Phase 3 study and their assessment of the criteria for capitalisation of development costs. Based on our knowledge of the study and the industry, we have challenged their judgement of the criteria and obtained an understanding of Management’s process for the judge- ment and tested internal controls over the judgement. Our opinion on the consolidated financial state- ments and the parent financial statements does not cover the management commentary, and we do not express any form of assurance conclusion thereon. During the past two years, significant development activities have been conducted and directly related development costs from commencement of the Phase 2 studies have been capitalised together with the cost of the acquired rights as Management considers the feasibility of completing a final compound and obtaining regulatory approval probable. Management’s assessment is based on that the development of other COVID-19 vaccine candidates in the market based on similar technology have shown successful completion rates. • evaluated the nature and the attribution of the capitalised develop- ment costs consisting of capitalised future milestone payments for the acquired rights, external CMO costs, investment in production facilities, test inventory batches and internal labor costs, based on documentation obtained from Management. In connection with our audit of the consolidated financial statements and the parent financial state- ments, our responsibility is to read the management commentary and, in doing so, consider whether the management commentary is materially inconsistent with the consolidated financial statements and the parent financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. • • tested the external costs, on a sample basis, by agreeing such costs to contracts and external invoices and evaluated the attribution to the ABNCoV2 development project. Management has obtained significant funding from the Danish Ministry of Health to support the development activities and a significant part of the purchase price for the acquired rights is deferred. Repayment of the funding to the Danish Ministry of Health and the milestone payment for the acquired rights are contingent on obtaining certain milestones after completion of Phase 3. obtained specification of hours incurred by employees that are directly attributable to the development activities, which were approved by Management. We tested the hours incurred on the development project to approved timesheets. We discussed with project managers to understand the nature of work performed by these employees. Moreover, it is our responsibility to consider whether the management commentary provides the information required under the Danish Financial Statements Act. The audit of capitalised development costs regarding ABNCoV2 is considered a key audit matter due to the significant judgement involved in assessing whether the capitalisation criteria have been met. Based on the work we have performed, we conclude that the management commentary is in accordance with the consolidated financial statements and the parent financial statements and has been prepared in accordance with the requirements of the Danish Finan- cial Statements Act. We did not identify any material misstatement of the management commentary. • evaluated agreements and assessed whether the disclosures; note 1, 2, 15, 21, 24 and note 25 in the consolidated financial statements meet the requirements of IFRS. Refer to note 1 “Significant accounting policies”, note 2 “Significant accounting esti- mates and judgements”, note 15 “Intangible assets”, note 21 “Prepayments”, note 24 “Deferred consideration” and note 25 “Prepayment and loan from Government” to the consolidated financial statements. Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 139 Management's responsibilities for the Financial Statements Auditor's responsibilities for the audit of the Financial Statements to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control. statements and the parent financial statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor’s report. However, future events or condi- tions may cause the Group and the Entity to cease to continue as a going concern. Management is responsible for the preparation of consolidated financial statements that give a true and fair view in accordance with International Financial Reporting Standards as endorsed by the EU and additional requirements of the Danish Financial Statements Act as well as the preparation of parent financial statements that give a true and fair view in accordance with the Danish Financial Statements Act, and for such internal control as Management determines is necessary to enable the preparation of consolidated financial statements and parent financial statements that are free from material misstatement, whether due to fraud or error. Our objectives are to obtain reasonable assurance about whether the consolidated financial statements and the parent financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with ISAs and the additional requirements applicable in Denmark will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these consolidated financial statements and these parent financial statements. • Obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circum- stances, but not for the purpose of expressing an opinion on the effectiveness of the Group’s and the Parent’s internal control. • Evaluate the overall presentation, structure and content of the Financial Statements, including the disclosures in the notes, and whether the Financial Statements represent the underlying transactions and events in a manner that gives a true and fair view. • Evaluate the appropriateness of accounting poli- cies used and the reasonableness of accounting estimates and related disclosures made by Management. • Obtain sufficient appropriate audit evidence regarding the financial information of the enti- ties or business activities within the Group to express an opinion on the consolidated financial statements. We are responsible for the direc- tion, supervision and performance of the group audit. We remain solely responsible for our audit opinion. In preparing the consolidated financial statements and the parent financial statements, Management is responsible for assessing the Group’s and the Parent’s ability to continue as a going concern, for disclosing, as applicable, matters related to going concern, and for using the going concern basis of accounting in preparing the consolidated financial statements and the parent financial statements unless Management either intends to liquidate the Group or the Entity or to cease operations, or has no realistic alternative but to do so. As part of an audit conducted in accordance with ISAs and the additional requirements applicable in Denmark, we exercise professional judgement and maintain professional scepticism throughout the audit. We also: • Conclude on the appropriateness of Manage- ment’s use of the going concern basis of accounting in preparing the consolidated financial statements and the parent financial statements, and, based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Group's and the Parent’s ability to continue as a going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor’s report to the related disclosures in the consolidated financial We communicate with those charged with govern- ance regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit. • Identify and assess the risks of material misstate- ment of the consolidated financial statements and the parent financial statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 140 We also provide those charged with governance with a statement that we have complied with rele- vant ethical requirements regarding independence, and to communicate with them all relationships and other matters that may reasonably be thought to bear on our independence, and, where applicable, safeguards put in place and measures taken to eliminate threats. Delegated Regulation (EU) 2019/815 on the European Single Electronic Format (ESEF Regulation), which includes requirements related to the preparation of the annual report in XHTML format and iXBRL tagging of the consolidated financial statements including notes. issue a report that includes our opinion. The nature, timing and extent of procedures selected depend on the auditor’s judgement, including the assessment of the risks of material departures from the require- ments set out in the ESEF Regulation, whether due to fraud or error. The procedures include: Copenhagen, 2 March 2023 Deloitte Statsautoriseret Revisionspartnerselskab Business Registration No 33 96 35 56 Management is responsible for preparing an annual report that complies with the ESEF Regulation. This responsibility includes: • Testing whether the annual report is prepared in XHTML format; From the matters communicated with those charged with governance, we determine those matters that were of most significance in the audit of the Financial Statements of the current period and are therefore the key audit matters. We describe these matters in our auditor’s report unless law or regula- tion precludes public disclosure about the matter or when, in extremely rare circumstances, we deter- mine that a matter should not be communicated in our report because the adverse consequences of doing so would reasonably be expected to outweigh the public interest benefits of such communication. • Obtaining an understanding of the company’s iXBRL tagging process and of internal control over the tagging process; • Evaluating the completeness of the iXBRL tagging of the consolidated financial statements including notes; • Evaluating the appropriateness of the company’s use of iXBRL elements selected from the ESEF taxonomy and the creation of extension elements where no suitable element in the ESEF taxonomy has been identified; • Evaluating the use of anchoring of extension elements to elements in the ESEF taxonomy; and • Reconciling the iXBRL tagged data with the audited consolidated financial statements. • The preparing of the annual report in XHTML format; • The selection and application of appropriate iXBRL tags, including extensions to the ESEF taxonomy and the anchoring thereof to elements in the taxonomy, for financial information required to be tagged using judgement where necessary; • Ensuring consistency between iXBRL tagged data and the consolidated financial statements presented in human readable format; and • For such internal control as Management deter- mines necessary to enable the preparation of an annual report that is compliant with the ESEF Regulation. Kirsten Aaskov Mikkelsen State-Authorised Public Eskild Nørregaard Jakobsen State-Authorised Public Report on compliance with the ESEF Regulation Accountant Accountant As part of our audit of the Financial Statements of Bavarian Nordic A/S, we performed procedures to express an opinion on whether the annual report of Bavarian Nordic A/S for the financial year 1 January 2022 to 31 December 2022 with the file name bava-2022-12-31-en.zip is prepared, in all mate- rial respects, in compliance with the Commission Identification No (MNE) no 21358 Identification No (MNE) no 21358 In our opinion, the annual report of Bavarian Nordic A/S for the financial year 1 January to 31 December 2022 with the file name bava-2022-12-31-en.zip is prepared, in all material respects, in compliance with the ESEF Regulation. Our responsibility is to obtain reasonable assurance on whether the annual report is prepared, in all mate- rial respects, in compliance with the ESEF Regulation based on the evidence we have obtained and to Introduction Our strategy and business Sustainability Corporate information Financial review Financial statements Bavarian Nordic Annual Report 2022 141 Other information Forward-looking statement This annual report contains forward looking state- ments. The words “believe”, “expect”, “anticipate”, “intend” and “plan” and similar expressions iden- tify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materi- ally include, among others, risks associated with product discovery and development, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affil- iated entities, changes and developments in tech- nology which may render our products obsolete, and other factors. For a further discussion of these risks, please refer to the section “Risk Manage- ment” in this Annual Report. Bavarian Nordic does not undertake any obligation to update or revise forward looking statements in this Annual Report nor to confirm such statements in relation to actual results, unless required by law. Bavarian Nordic A/S Philip Heymans Alle 3 DK-2900 Hellerup Denmark CVR no: 16 27 11 87 RabAvert®, Rabipur®, Encepur®, JYNNEOS®, IMVANEX®, IMVAMUNE® and MVA-BN® are registered trademarks owned by Bavarian Nordic.