aTYR PHARMA INC — Proxy Solicitation & Information Statement 2016

Apr 12, 2016

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

Filed by the Registrant x Filed by a Party other than the Registrant o

Check the appropriate box:

o Preliminary Proxy Statement

o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

o Definitive Proxy Statement

x Definitive Additional Materials

o Soliciting Material under §240.14a-12

ATYR PHARMA, INC.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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*** Exercise Your Right to Vote *** Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on May 24, 2016. Meeting Information ATYR PHARMA, INC Meeting Type: Annual Meeting of Stockholders For holders as of: March 24, 2016 Date: May 24, 2016 Time: 8:30 AM PDT Location: 3545 John Hopkins Court Suite 250 San Diego, California 92121 You are receiving this communication because you hold shares in the company named above. ATYR PHARMA, INC 3545 JOHN HOPKINS CT #250 This is not a ballot. You cannot use this notice to vote these SAN DIEGO, CA 92121 shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at www.proxyvote.com or easily request a paper copy (see reverse side). We encourage you to access and review all of the important information contained in the proxy materials before voting. See thereversesideofthisnoticetoobtainproxymaterialsandvotinginstructions. E03530- P74365

Before You Vote How to Access the Proxy Materials Proxy Materials Available to VIEW or RECEIVE: ANNUALREPORTONFORM10-KNOTICEANDPROXYSTATEMENTHowtoViewOnline: Havetheinformationthatisprintedintheboxmarkedbythearrow.XXXXXXXXXXXXXXXX(locatedonthefollowingpage)andvisit:www.proxyvote.com. How to Request and Receive a PAPER or E-MAIL Copy: Ifyouwanttoreceiveapaperore-mailcopyofthesedocuments,youmustrequestone.ThereisNOchargeforrequestingacopy.Pleasechooseoneofthefollowingmethodstomakeyourrequest: 1)BYINTERNET:www.proxyvote.com2)BYTELEPHONE:1-800-579-16393)BYE-MAIL*:sendmaterial@proxyvote.com*Ifrequestingmaterialsbye-mail,pleasesendablanke-mailwiththeinformationthatisprintedintheboxmarkedbythearrow.XXXXXXXXXXXXXXXX(locatedonthefollowingpage)inthesubjectline. Requests, instructions and other inquiries sent to this e-mail address will NOT before warded to your investmentadvisor.PleasemaketherequestasinstructedaboveonorbeforeMay10, 2016 to facilitate timely delivery. How To Vote Please Choose One of the Following Voting Methods E03531- P74365VoteInPerson:Manystockholdermeetingshaveattendancerequirementsincluding,butnotlimitedto,thepossessionofanattendanceticketissuedbytheentityholdingthemeeting.Pleasecheckthemeetingmaterialsforanyspecialrequirementsformeetingattendance.Atthemeeting,youwillneedtorequestaballottovotetheseshares. Vote by Internet: To vote now by Internet, go to www.proxyvote.com. Have the information that is printed in the box marked by the arrow. XXXXXXXXXXXXXXXX (located on the following page) available and follow the instructions. Vote by Mail

Voting Items The Board of Directors recommends you vote FOR the following: 1. Election of three Class 1 Directors: 01) John K. Clarke 02) Amir H. Nash at, Sc.D. 03) Paul Schimmel, Ph.D. The Board of Directors recommends you vote FOR proposal 2: 2. To ratify the appointment of Ernst & Young LLP as a Tyr Pharm a’s independent registered public accounting firm for the fiscal year ending December 31, 2016. 3. Such other business as may properly come before the meeting or any adjournment thereof. E03532- P74365 E03533-P74365

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