AstraZeneca PLC — Proxy Solicitation & Information Statement 2026

Mar 10, 2026

AstraZeneca

VOTE

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You may vote online or by phone instead of mailing this card.

Votes submitted electronically must
be received by April 7, 2026 at
14:30 (BST) / 09:30 (ET).

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Go to www.investorvote.com/AZN or scan
the QR code – login details are located in
the shaded bar below.

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The 2026 Annual General Meeting (the AGM) of AstraZeneca PLC (the Company) will be a digitally-enabled meeting, to be held on the Lumi online platform and at the Kia Oval, Kennington, London, SE11 5SS on Thursday April 9, 2026 at 14:30 (BST) / 09:30 (ET).

Using a black ink pen, mark your votes with an X as shown in this example.
Please do not write outside the designated areas.

2026 Annual General Meeting (“AGM”) - Proxy Form

▼ IF VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE. ▼

A Resolutions – The Board of Directors recommend a vote FOR Resolutions 1 - 13, inclusive

1. To receive the Company's Accounts, the Reports of the Directors and Auditor and the Strategic Report for the year ended December 31, 2025	For	Against	Abstain	(i) Anna Manz	For	Against	Abstain
2. To confirm the 2025 interim dividends	☐	☐	☐	(k) Sheri McCoy	☐	☐	☐
3. To appoint KPMG LLP as Auditor	☐	☐	☐	(l) Tony Mok	☐	☐	☐
4. To authorize the Directors to agree the remuneration of the Auditor	☐	☐	☐	(m) Marcus Wallenberg	☐	☐	☐
5. To re-elect the following Directors:				6. To approve the annual statement of the Chair of the Remuneration Committee and the Annual Report on Remuneration for the year ended December 31, 2025	☐	☐	☐
(a) Michel Demaré	☐	☐	☐
(b) Pascal Soriot	☐	☐	☐	7. To renew the authorization to grant awards under the French Appendix 3 of the AstraZeneca Performance Share Plan 2020	☐	☐	☐
(c) Aradhana Sarin	☐	☐	☐	8. To authorize limited political donations	☐	☐	☐
(d) Philip Broadley	☐	☐	☐	9. To authorize the Directors to allot shares	☐	☐	☐
(e) Euan Ashley	☐	☐	☐	10. To authorize the Directors to disapply pre-emption rights¹	☐	☐	☐
(f) Birgit Conix	☐	☐	☐	11. To authorize the Directors to further disapply pre-emption rights for acquisitions and specified capital investments¹	☐	☐	☐
(g) Rene Haas	☐	☐	☐	12. To authorize the Company to purchase its own shares¹	☐	☐	☐
(h) Karen Knudsen	☐	☐	☐	13. To reduce the notice period for general meetings¹	☐	☐	☐
(i) Diana Layfield	☐	☐	☐	¹ Special Resolutions	☐	☐	☐

1UPX

048SKD

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Direct holders of the Company's ordinary shares listed on the New York Stock Exchange can join the meeting online at: https://meetings.lumiconnect.com/100-005-666-228.

To join, enter your Control Number (shown in the shaded bar on the front of this card) and the PIN

Full details are included in the Notice of AGM, which is available at: www.astrazeneca.com/noticeofmeeting2026

The Company's Annual Report and Form 20-F Information 2025 is available at: www.astrazeneca.com/annualreport2025

Notes to the Proxy Form

1. A shareholder may appoint one or more proxies (whether shareholders or not) to attend the AGM and vote in their place. If you wish to appoint a proxy other than the Chair of the AGM, insert the name of the proxy in block letters in the box provided below.
2. You may register your voting instructions online or by phone, instead of returning this Proxy Form, by following the instructions overleaf. If you wish to appoint a proxy other than the Chair of the AGM, you must return this paper Proxy Form to do so.
3. If the Proxy Form is signed and returned without any indication as to how the proxy should vote, the proxy will exercise discretion as to how votes are cast, whether or not to abstain from voting and how to act in relation to other business transacted at the AGM. The proxy will exercise this discretion as they see fit on any other business which may properly fall to be considered at the AGM and at any adjournment of the AGM.
4. The 'Abstain' option is provided to enable you to abstain on any particular resolution. It should be noted that an abstention is not a vote in law and will not be counted as a vote For or Against a resolution.
5. To be effective, the Proxy Form (together with any power of attorney or other authority under which it is signed, or a notarised copy of that power or authority) must be received by the Company's registrar, Computershare Trust Company, N.A. at P.O. Box 43101, Providence, RI 02940-5067, USA by 14:30 (BST) / 09:30 (ET) on April 7, 2026, or if this AGM is adjourned, not less than 48 UK business hours before the time for holding such adjourned meeting.
6. In the case of a shareholder which is a company, the Proxy Form must be executed under its common seal or signed on its behalf by an officer of the company or an attorney for the company.
7. You may appoint more than one proxy provided each is appointed to exercise rights attached to different ordinary shares in the Company. To appoint more than one proxy, please contact Computershare on +1 888 697 8018. If the proxy is being appointed with authority to vote less than your total holding, please indicate in the box marked with an asterisk below the number of shares your proxy is to vote. If the box marked with an asterisk is left blank, your proxy will be deemed to be authorized to vote your total holding.
8. Only holders of the Company's ordinary shares at 18:30 (BST) / 13:30 (ET) on April 7, 2026 (or their duly appointed proxies), or if this AGM is adjourned, in the register of members by 18:30 (UK time) two UK business days prior to any adjourned meeting, are entitled to attend or vote at the AGM in respect of the number of ordinary shares registered in their name at that time. Changes to the entries in the register of members after this time shall be disregarded in determining the rights of any person to attend or vote at the AGM.
9. Please refer to the Notice of AGM for further information and the full resolutions to be voted on.

▼ IF VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE. ▼

AstraZeneca PLC

2026 Annual General Meeting

Proxy Solicited by Board of Directors for Annual General Meeting – April 9, 2026

The Chair of the AGM or

(see note 1 above)

(see note 7 above)

is hereby authorized to represent and vote the shares of the undersigned, with all the powers which the undersigned would possess if personally present, at the Annual General Meeting of AstraZeneca PLC to be held on Thursday April 9, 2026 at 14:30 (BST) / 09:30 (ET) or at any postponement or adjournment thereof.

Shares represented by this proxy will be voted by the shareholder. If no such directions are indicated, the Proxies will have authority to exercise their discretion as to whether, and if so how, they vote on Resolutions 1-13, inclusive.

In their discretion, the Proxies are authorized to vote upon such other business as may properly come before the Annual General Meeting and at any adjournment of the Annual General Meeting.

(Items to be voted appear on reverse side)

1 Authorized Signatures – This section must be completed for your vote to count. Please date and sign below.

Please sign exactly as name(s) appears hereon. Joint owners should each sign. When signing as attorney, executor, administrator, corporate officer, trustee, guardian, or custodian, please give full title.

Date (mm/dd/yyyy) – Please print date below.

Signature 1 – Please keep signature within the box.

Signature 2 – Please keep signature within the box.