AstraZeneca PLC — Proxy Solicitation & Information Statement 2025

Sep 29, 2025

AstraZeneca PLC: Joining Instructions General Meeting Monday 3 November 2025

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Shareholder Reference Number

Further to the announcement made by AstraZeneca PLC (the Company) in relation to the proposed harmonisation of its equity listing structure, the General Meeting of the Company (the General Meeting) will be a digitally-enabled meeting, to be held and broadcast on Monday 3 November 2025 at 2:30 p.m. (GMT).

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The digitally-enabled General Meeting is optimised for online participation. Content and presentation will be optimised for that format.

For the reasons set out in the Circular and Notice of General Meeting, shareholders are encouraged to participate in the General Meeting via the online platform.

Join the meeting online:

https://meetings.lumiconnect.com/100-392-363-424

You will then be prompted to enter your Shareholder Reference Number (SRN) and PIN.

Please note that your PIN is the first two and last two digits of your SRN printed below.

Full details on how to join can be found on pages 38 to 39 of the Circular and Notice of General Meeting.

Please read the explanatory notes to the Proxy Form overleaf before completing the Proxy Form.

AstraZeneca PLC: Proxy Form – General Meeting Monday 3 November 2025

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I, the undersigned, being a member of AstraZeneca PLC, hereby appoint the Chair of the Shareholder Reference Number General Meeting* or

Name of Proxy

as my proxy, to vote for me on my behalf at the General Meeting of the Company to be held on the Lumi online platform and at the broadcast venue, The Kia Oval, Kennington, London, SE11 5SS on Monday 3 November 2025 at 2:30 p.m. (GMT), and at any adjournment thereof.

Please indicate your vote by marking the box below in black ink like this: X

1200-0196

Special Resolution For Against Withheld

1.To adopt the articles of association produced to the meeting (and for the purpose of identification signed by the Chair of the General Meeting) as the articles of association of the Company in substitution for and to the exclusion of the existing articles of association of the Company, with effect from the conclusion of the meeting.

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Signed	Dated

Vote

Please mark this box with an 'X' if this Proxy Form is one of multiple instructions being given

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* Please see explanatory notes if you wish to appoint a person other than the Chair of the General Meeting as your proxy.

AstraZeneca PLC: Explanatory notes to the Proxy Form

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General notes

A shareholder may appoint one or more proxies (whether shareholders or not) to attend and vote in their place. If you wish to appoint a proxy other than the Chair of the General Meeting, delete the words 'the Chair of the General Meeting' and insert in block letters in the space provided the name of your proxy who need not be a shareholder of the Company.

If the Proxy Form is signed and returned without any indication as to how the proxy should vote, the proxy will exercise discretion as to how votes are cast, whether or not to abstain from voting and how to act in relation to other business transacted at the General Meeting. The proxy will exercise this discretion as they see fit on any other business which may properly fall to be considered at the General Meeting and at any adjournment of the General Meeting.

The Vote Withheld option is provided to enable you to abstain from voting on the resolution. It should be noted that a Vote Withheld is not a vote in law and will not be counted as a vote For or Against the resolution.

To be effective, the Proxy Form (together with the power of attorney or other authority (if any) under which it is signed, or a notarised copy of that power or authority) must be received by the Company's registrar, Equiniti at Aspect House, Spencer Road, Lancing, West Sussex, BN99 6DA, by 2:30 p.m. (GMT) on 30 October 2025, or if this General Meeting is adjourned, not less than 48 hours (excluding any part of a day that is not a working day) before the time for holding such adjourned meeting.

This Proxy Form should not be used for any comments, change of address notification or other queries. Please send separate instructions to Equiniti.

Entitlement to attend and vote

Pursuant to Regulation 41 of the Uncertificated Securities Regulations 2001, only holders of ordinary shares at 6:30 p.m. (GMT) on 30 October 2025, or if this General Meeting is adjourned, in the register of members by 6:30 p.m. (GMT) two working days prior to any adjourned meeting, (or, in each case, their duly appointed proxies or nominated persons) are entitled to attend or vote at the General Meeting in respect of the number of ordinary shares registered in their name at that time. Changes to the entries in the register of members after 6:30 p.m. (GMT) on 30 October 2025, or if this meeting is adjourned, in the register of members after 6:30 p.m. (GMT) two working days prior to any adjourned meeting, shall be disregarded in determining the rights of any person to attend or vote at the General Meeting.

The completion and return of this form will not preclude a holder of ordinary shares from attending the meeting and voting in person.

Voting electronically

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You may register the appointment of your proxy vote electronically either via Shareview, www.shareview.co.uk, or if you hold your shares through CREST, using the CREST electronic proxy appointment service. Institutional investors may also be able to appoint a proxy electronically via the Proxymity platform, www.proxymity.io. Instructions for these electronic methods are included in the Notes to the Circular and Notice of General Meeting. To use Shareview you will need your usual user ID and password. Once logged in, click 'View' on the 'My Investments' page, click the link to vote and follow the on-screen instructions. You will need to allow sufficient time to register to use Shareview, if you have not registered for a Shareview portfolio previously. To use the CREST service, please refer to the Notes to the Circular and Notice of General Meeting. Please note that any electronic communication found to contain a computer virus will not be accepted.

Documents available for inspection

The following documents are available for inspection on the National Storage Mechanism at https://data.fca.org.uk/#/nsm/nationalstoragemechanism and on the Company's website at https://www.astrazeneca.com/investor-relations/ shareholder-information.html#2025-0 from the date of this document until the conclusion of the General Meeting:

• (1) a copy of the Company's existing articles of association, marked up to show the proposed changes which shareholders are being asked to approve at the General Meeting; and
• (2) a copy of the Company's new articles of association, in respect of which the resolution is proposed.

On the day of the General Meeting, the above documents will also be available for inspection on the online platform at:

https://meetings.lumiconnect.com/100-392-363-424 and at the broadcast venue of the General Meeting for at least 15 minutes prior to, and during, the General Meeting.

Visit Shareview for answers to frequently asked questions or to register the appointment of your proxy vote electronically.

Scan the QR code to go directly to www.shareview.co.uk

This document is important. If you are in any doubt about its contents you should consult your Independent Financial Adviser. If you have sold or transferred all of your AstraZeneca PLC ordinary shares you should send this complete document with the Circular and Notice of General Meeting (or with the communication informing you of the availability of those documents on the AstraZeneca PLC website) to the purchaser or transferee or to the stockbroker, bank or other agent through whom the sale or transfer was effected for transmission to the purchaser or transferee.

Please tear along the dotted line.

JOB: 25-26326-2 CYCLE#;BL#: 4; 0 TRIM: 8.27" x 11.69" AS: London: 011-44-20-7422-6100

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