AstraZeneca PLC — Regulatory Filings 2014

Nov 17, 2014

FORM 6-K

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Report of Foreign Issuer

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

For the month of November 2014

Commission File Number: 001-11960

AstraZeneca PLC

2 Kingdom Street, London W2 6BD

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F X Form 40-F __

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ______

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes __ No X

If “Yes” is marked, indicate below the file number assigned to the Registrant in connection with Rule 12g3-2(b): 82-_______

Publication of Supplemental Prospectus

Following a routine technical update in June 2014 of the Company's Euro Medium Term Note ("EMTN") programme established in 2007, the following supplemental prospectus has been approved by the UK Listing Authority and is available for viewing:

Supplemental Prospectus for the AstraZeneca PLC U.S.$5,000,000,000 Euro Medium Term Note Programme (the "Supplemental Prospectus")

The Supplemental Prospectus should be read in connection with, and forms part of, the base prospectus dated 24 June 2014 prepared by the Company in connection with the EMTN programme (the "Base Prospectus").

To view the full Supplemental Prospectus, please paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/2358X_-2014-11-17.pdf

To view the full Base Prospectus, please paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/4351K_1-2014-6-24.pdf

A copy of the Supplemental Prospectus will shortly be submitted to the National Storage Mechanism and will be available for inspection at:

http://www.morningstar.co.uk/uk/NSM

A C N Kemp

Company Secretary

17 November 2014

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

AstraZeneca PLC

Date: 17 November 2014
Name: Adrian Kemp
Title: Company Secretary