AstraZeneca PLC — Regulatory Filings 2014

Jan 27, 2014

FORM 6-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

Report of Foreign Issuer

Pursuant to Rule 13a-16 or 15d-16 of the Securities Exchange Act of 1934 For the month of January 2014

Commission File Number: 001-11960

AstraZeneca PLC

2 Kingdom Street, London W2 6BD

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F X Form 40-F __

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ______

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ______

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes __ No X

If “Yes” is marked, indicate below the file number assigned to the Registrant in connection with Rule 12g3-2(b): 82-_______

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES i
1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii	AstraZeneca plc
2 Reason for the notification (please tick the appropriate box or boxes):
An acquisition or disposal of voting rights	X
An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached
An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments
An event changing the breakdown of voting rights
Other (please specify):
3. Full name of person(s) subject to the notification obligation: iii	The Capital Group Companies, Inc.
4. Full name of shareholder(s) (if different from 3.): iv	See Schedule A
5. Date of the transaction and date on which the threshold is crossed or reached: v	22 January 2014
6. Date on which issuer notified:	23 January 2014
7. Threshold(s) that is/are crossed or reached: vi, vii	Above 3%

8. Notified details:
A: Voting rights attached to shares viii, ix
Class/type of shares if possible using the ISIN CODE	Situation previous to the triggering transaction		Resulting situation after the triggering transaction
	Number of Shares	Number of Voting Rights	Number of shares	Number of voting rights		% of voting rights x
			Direct	Direct xi	Indirect xii	Direct	Indirect
Ordinary Shares (ISIN: GB0009895292)	34,401,384	34,401,384			34,702,744		2.7604%
ADRs (ISIN: US0463531089)	3,229,300	3,229,300			3,229,300		0.2569%
B: Qualifying Financial Instruments
Resulting situation after the triggering transaction
Type of financial instrument	Expiration date xiii	Exercise/ Conversion Period xiv		Number of voting rights that may be acquired if the instrument is exercised/ converted.		% of voting rights
C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi
Resulting situation after the triggering transaction
Type of financial instrument	Exercise price	Expiration date xvii	Exercise/ Conversion period xviii	Number of voting rights instrument refers to		% of voting rights xix, xx
						Nominal	Delta
Total (A+B+C)
Number of voting rights			Percentage of voting rights
37,932,044			3.0173%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi
See Schedule A
Proxy Voting:
10. Name of the proxy holder:
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:
13. Additional information:
14. Contact name:	Martin Bennett, Assistant Company Secretary
15. Contact telephone number:	020 7604 8157

Schedule A

As of 22 January 2014

AstraZeneca plc

	Number of Shares	Percent of Outstanding
The Capital Group Companies, Inc. ("CG") holdings	37,932,044	3.017%
Holdings by CG Management Companies and Funds:
Capital Guardian Trust Company	15,992	0.001%
Capital International Limited	7,100	0.001%
Capital International Sàrl	1,092	0.000%
Capital Research and Management Company	37,907,860	3.015%

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

AstraZeneca PLC

Date: 27 January 2014
Name: Adrian Kemp
Title: Company Secretary