AstraZeneca PLC

Director's Dealing • Nov 14, 2025

National Storage Mechanism | Additional information

RNS Number : 6116H

AstraZeneca PLC

14 November 2025

14 November 2025

Transaction by Person Discharging Managerial Responsibilities

AstraZeneca PLC (the Company) announces that, on 13 November 2025, it was notified of a transaction in the Company's American Depositary Shares (ADSs) by Aradhana Sarin, Executive Director and Chief Financial Officer, as set out below. Two ADSs are equivalent to one of the Company's ordinary shares of $0.25 each.

PDMR	Position	Nature of the transaction	Quantity	Price per Ordinary Share
Aradhana Sarin	Executive Director and Chief Financial Officer	Sale of ADSs	15,000	$88.6345

Further details are set out in the attached notification, made in accordance with the requirements of the EU Market Abuse Regulation (as it forms part of UK law pursuant to the European Union (Withdrawal) Act 2018).

1

Details of the person discharging managerial responsibilities / person closely associated

a)

Name

Aradhana Sarin

2

Reason for the notification

a)

Position/status

Chief Financial Officer

b)

Initial notification /Amendment

Initial notification

3

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

a)

Name

AstraZeneca PLC

b)

LEI

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4

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a)

Description of the financial instrument, type of instrument

Identification code

AstraZeneca PLC American Depositary Shares

CUSIP: 046353108

b)

Nature of the transaction

Sale of AstraZeneca PLC American Depositary Shares

c)

Price(s) and volume(s)

Price(s)	Volume(s)
$88.6345	15,000

d)

Aggregated information

- Aggregated volume

- Price

Not applicable - single transaction

e)

Date of the transaction

12 November 2025

f)

Place of the transaction

XNAS

AstraZeneca

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca's innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit www.astrazeneca.com and follow the Company on social media @AstraZeneca.

Contacts

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Matthew Bowden

Company Secretary

AstraZeneca PLC

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