AstraZeneca PLC — Director's Dealing 2025

Sep 25, 2025

National Storage Mechanism | Additional information

RNS Number : 8839A

AstraZeneca PLC

25 September 2025

25 September 2025

Transaction by Person Discharging Managerial Responsibilities

AstraZeneca PLC (the Company) announces that it was notified on 25 September 2025 that Karen Knudsen, Non-Executive Director, had acquired 9 American Depositary Shares (ADSs)  in the Company on 9 September 2025 , pursuant to the reinvestment of the first interim dividend in respect of the year ending 31 December 2025, paid by the Company on 8 September 2025. Two ADSs are equivalent to one of the Company's ordinary shares of $0.25 each .

Further details are set out in the attached notification, made in accordance with the requirements of the EU Market Abuse Regulation (since it forms part of UK law pursuant to the European Union (Withdrawal) Act 2018).

1

Details of the person discharging managerial responsibilities / person closely associated

a)

Name

Karen Knudsen

2

Reason for the notification

a)

Position/status

Non-Executive Director

b)

Initial notification /Amendment

Initial notification

3

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

a)

Name

AstraZeneca PLC

b)

LEI

PY6ZZQWO2IZFZC3IOL08

4

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a)

Description of the financial instrument, type of instrument

Identification code

AstraZeneca PLC American Depositary Shares

CUSIP: 0463531089

b)

Nature of the transaction

Acquisition of AstraZeneca PLC American Depositary Shares through the reinvestment of the first interim dividend of the Company, in respect of the year ending 31 December 2025, paid by the Company on 8 September 2025.

c)

Price(s) and volume(s)

Price(s)	Volume(s)
$81.0499	9.0737

d)

Aggregated information

- Aggregated volume

- Price

Not applicable - single transaction

e)

Date of the transaction

9 September 2025

f)

Place of the transaction

XNAS

AstraZeneca  

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca's innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit  astrazeneca.com  and follow the Company on social media  @AstraZeneca  

Contacts

For details on how to contact the Investor Relations Team, please click here . For Media contacts, click here .

Matthew Bowden

Company Secretary

AstraZeneca PLC

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