AstraZeneca PLC — Capital/Financing Update 2016

May 11, 2016

FINAL TERMS

Final Terms dated 11 May 2016

AstraZeneca PLC
Issue of EUR 800,000,000 1.250 per cent. Notes due 12 May 2028
under the U.S.$5,000,000,000
Euro Medium Term Note Programme

PART A — CONTRACTUAL TERMS

Terms used herein shall be deemed to be defined as such for the purposes of the Conditions (the "Conditions") set forth in the base prospectus dated 5 May 2016 (the "Base Prospectus") for the purposes of the Prospectus Directive (as defined below). This document constitutes the Final Terms of the Notes described herein for the purposes of Article 5.4 of the Prospectus Directive. These Final Terms contain the final terms of the Notes and must be read in conjunction with the Base Prospectus. The expression "Prospectus Directive" means Directive 2003/71/EC (as amended, including by Directive 2010/73/EU) and includes any relevant implementing measures in the Relevant Member State.

Full information on the Issuer and the offer of the Notes described herein is only available on the basis of the combination of these Final Terms and the Base Prospectus. The base prospectus is available for viewing at the website of the London Stock Exchange (www.londonstockexchange.com) and copies may be obtained from the specified office of the Principal Paying Agent, being currently located at Winchester House, 1 Great Winchester Street, London, EC2N 2DB.

1. Issuer:	AstraZeneca PLC
2. (i) Series Number:	8
(ii) Tranche Number:	1
3. Specified Currency or Currencies:	Euro ("EUR")
4. Aggregate Nominal Amount:	EUR 800,000,000
5. Issue Price:	98.670 per cent. of the Aggregate Nominal Amount
6. (i) Specified Denominations:	EUR 100,000 and integral multiples of EUR 1,000 in excess thereof up to and including EUR 199,000. Definitive Notes will not be issued in denominations in excess of EUR 199,000.
(ii) Calculation Amount:	EUR 1,000
7. (i) Issue Date:	12 May 2016
(ii) Interest Commencement Date:	Issue Date
8. Maturity Date:	12 May 2028
9. Interest Basis:	1.250 per cent. Fixed Rate
10. Redemption/Payment Basis:	Redemption at par
11. Change of Interest or Redemption/Payment Basis:	Not Applicable
12. Put/Call Options:	Issuer Call
13. (i) Status of the Notes:	Senior
(ii) Date Board approval for issuance of	28 April 2016

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Notes obtained:

PROVISIONS RELATING TO INTEREST (IF ANY) PAYABLE

1. Fixed Rate Note Provisions
   Applicable
   (i) Rate of Interest: 1.250 per cent. per annum payable in arrear on each Interest Payment Date
   (ii) Interest Payment Date(s): 12 May in each year
   (iii) Fixed Coupon Amount: EUR 12.50 per Calculation Amount
   (iv) Broken Amount(s): Not Applicable
   (v) Day Count Fraction: Actual/Actual(ICMA)
   (vi) Determination Dates: Not Applicable

2. Floating Rate Note Provisions
   Not Applicable

3. Zero Coupon Note Provisions
   Not Applicable

PROVISIONS RELATING TO REDEMPTION

1. Call Option
   Applicable
   (i) Optional Redemption Date(s): Any Business Day
   (ii) Optional Redemption Amount(s) of each Note and method, if any, of calculation of such amount(s): Make-Whole Redemption Amount
   (iii) If redeemable in part:
   (a) Minimum Redemption Amount: Not Applicable
   (b) Maximum Redemption Amount: Not Applicable

2. Put Option
   Not Applicable

3. Final Redemption Amount of each Note
   EUR 1,000 per Calculation Amount

4. Early Termination Amount
   As set out in the Conditions

Early Redemption Amount (Tax) and Early Termination Amount per Calculation Amount payable on redemption for taxation reasons or, as the case may be, on event of default:

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GENERAL PROVISIONS APPLICABLE TO THE NOTES

1. Form of Notes:
   Temporary Global Note exchangeable for a Permanent Global Note which is exchangeable for Definitive Notes in the limited circumstances specified in the Permanent Global Note.

2. New Global Note Form:
   Applicable

3. Additional Financial Centre(s) or other special provisions relating to Payment Dates:
   London

4. Talons for future Coupons or Receipts to be attached to Definitive Notes (and dates on which such Talons mature):
   No

5. Consolidation provisions:
   Not Applicable

Signed on behalf of the Issuer:

By:
Duly authorised

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PART B — OTHER INFORMATION

1. LISTING AND ADMISSION TO TRADING

(i) Admission to trading:
Application is expected to be made by the Issuer (or on its behalf) for the Notes to be admitted to trading on the Regulated Market of the London Stock Exchange with effect from 12 May 2016.

(ii) Estimate of total expenses related to admission to trading:
£3,650

2. RATINGS

Ratings:
The Notes to be issued have been rated:
Standard & Poor's Credit Market Services Europe Limited: A- (stable)
Moody's Deutschland GmbH: A3 (stable)

3. INTERESTS OF NATURAL AND LEGAL PERSONS INVOLVED IN THE ISSUE/OFFER

Save as discussed in "Subscription and Sale" in the Base Prospectus, so far as the Issuer is aware, no person involved in the offer of the Notes has an interest material to the offer.

4. Fixed Rate Notes Only — YIELD

Indication of yield:
1.371 per cent.

5. OPERATIONAL INFORMATION

ISIN Code:
XS1411404426

Common Code:
141140442

Any clearing system(s) other than Euroclear Bank S.A./N.V. and Clearstream Banking S.A. and the relevant identification number(s):
Not Applicable

New Global Note intended to be held in a manner which would allow Eurosystem eligibility:
Yes. Note that the designation "Yes" simply means that the Notes are intended upon issue to be deposited with one of the ICSDs as common safekeeper and does not necessarily mean that the Notes will be recognised as eligible collateral for Eurosystem monetary policy and intra-day credit operations by the Eurosystem either upon issue or at any or all times during their life. Such recognition will depend upon the European Central Bank being satisfied that Eurosystem eligibility criteria have been met.

Delivery:
Delivery against payment

Names and addresses of additional paying agent(s) (if any):
Not Applicable

TEFRA:
The D Rules are applicable

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