AstraZeneca PLC — AGM Information 2025

Mar 7, 2025

AstraZeneca PLC: Joining Instructions Annual General Meeting Friday 11 April 2025

The 2025 Annual General Meeting (the AGM) of AstraZeneca PLC (the Company) will be a digitally-enabled meeting, to be broadcast on Friday 11 April 2025 at 14:30 (BST).

Digitally-enabled AGMs are optimised for online participation. Content and presentation will be optimised for that format. For the reasons set out in the Notice of AGM, shareholders are strongly encouraged to participate in the AGM via the online platform. Join the meeting online:

https://web.lumiagm.com/197795672

You will then be prompted to enter your Shareholder Reference Number (SRN) and PIN.

Please note that your PIN is the first two and last two digits of your SRN printed below.

Full details on how to join can be found on pages 13 to 15 of the Notice of AGM.

Please read the explanatory notes to the Proxy Form overleaf before completing the Proxy Form.

AstraZeneca PLC: Proxy Form – Annual General Meeting Friday 11 April 2025

as my proxy, to vote for me on my behalf at the Annual General Meeting of the Company to be held on the Lumi online platform and at the broadcast venue, the Kia Oval, Kennington, London, SE11 5SS, on Friday 11 April 2025 at 14:30 (BST), and at any adjournment thereof.					1200-0188
Please indicate your vote by marking the boxes below in black ink like this:			x
Resolution	For		Vote Against Withheld	Resolution		For		Vote Against Withheld
1. To receive the Company's Accounts, the Reports of the Directors and Auditor and the Strategic Report for the year ended 31 December 2024 2. To confirm the 2024 interim dividends 3. To re-appoint PricewaterhouseCoopers LLP as Auditor 4. To authorise the Directors to agree the remuneration of the Auditor 5. To elect or re-elect the following Directors: (a) Michel Demaré (b) Pascal Soriot (c) Aradhana Sarin (d) Philip Broadley (e) Euan Ashley (f) Birgit Conix (g) Rene Haas (h) Karen Knudsen (i) Diana Layfield				(j) Anna Manz (k) Sheri McCoy (l) Tony Mok (m) Nazneen Rahman (n) Marcus Wallenberg 6. To approve the annual statement of the Chair of the Remuneration Committee and the Annual Report on Remuneration for the year ended 31 December 2024 7. To authorise limited political donations 8. To authorise the Directors to allot shares 9. To authorise the Directors to disapply pre-emption rights1 10. To authorise the Directors to further disapply pre-emption rights for acquisitions and specified capital investments1 11. To authorise the Company to purchase its own shares1 12. To reduce the notice period for general meetings1

Please mark this box with an 'X' if this Proxy Form is one of multiple instructions being given.

* Please see explanatory notes if you wish to appoint a person other than the Chair of the AGM as your proxy.

1 Special Resolution.

AstraZeneca PLC: Explanatory notes to the Proxy Form

General notes

A shareholder may appoint one or more proxies (whether shareholders or not) to attend and vote in their place. If you wish to appoint a proxy other than the Chair of the AGM, delete the words 'the Chair of the AGM' and insert in block letters in the space provided the name of your proxy who need not be a shareholder of AstraZeneca PLC (the Company).

If the Proxy Form is signed and returned without any indication as to how the proxy should vote, the proxy will exercise discretion as to how votes are cast, whether or not to abstain from voting and how to act in relation to other business transacted at the AGM. The proxy will exercise this discretion as they see fit on any other business which may properly fall to be considered at the AGM and at any adjournment of the AGM.

The Vote Withheld option is provided to enable you to abstain on any particular resolution. It should be noted that a Vote Withheld is not a vote in law and will not be counted as a vote For or Against a resolution.

To be effective, the Proxy Form (together with the power of attorney or other authority (if any) under which it is signed, or a notarised copy of that power or authority) must be received by the Company's registrar, Equiniti, Aspect House, Spencer Road, Lancing, West Sussex, BN99 6DA, by 14:30 (BST) on 9 April 2025, or if this AGM is adjourned, not less than 48 hours before the time for holding such adjourned meeting.

This Proxy Form should not be used for any comments, change of address notification or other queries. Please send separate instructions to Equiniti.

Entitlement to attend and vote

Pursuant to Regulation 41 of the Uncertificated Securities Regulations 2001, only holders of ordinary shares at 18:30 (BST) on 9 April 2025 (or their duly appointed proxies), or if this AGM is adjourned, in the register of members by 18:30 (BST) two days prior to any adjourned meeting, are entitled to attend or vote at the AGM in respect of the number of ordinary shares registered in their name at that time. Changes to the entries in the register of members after 18:30 (BST) on 9 April 2025, or if this meeting is adjourned, in the register of members after 18:30 (BST) two days prior to any adjourned meeting, shall be disregarded in determining the rights of any person to attend or vote at the AGM.

Voting electronically

You may register the appointment of your proxy vote electronically either via Shareview, www.shareview.co.uk, or if you hold your shares through CREST, using the CREST electronic proxy appointment service. Institutional investors may also be able to appoint a proxy electronically via the Proxymity platform, www.proxymity.io. Instructions for these electronic methods are included in the General Notes in the Notice of AGM. To use Shareview you will need your usual user ID and password. Once logged in, click 'View' on the 'My Investments' page, click the link to vote and follow the on-screen instructions. You will need to allow sufficient time to register to use Shareview, if you have not registered for a Shareview portfolio previously. To use the CREST service, please refer to the General Notes in the Notice of AGM. Please note that any electronic communication found to contain a computer virus will not be accepted.

Documents available for inspection

The following may be inspected during business hours at the Company's registered office and at the offices of Freshfields Bruckhaus Deringer LLP at 100 Bishopsgate, London, EC2P 2SR until the conclusion of the AGM:

(1) A statement of the interests and transactions of Directors and their connected persons in the share capital of the Company and any of its subsidiaries.

(2) The Annual Report and Form 20-F Information 2024.

On the day of the AGM, the above will also be available for inspection on the online platform.

Visit Shareview for answers to frequently asked questions or to register the appointment of your proxy vote electronically.

Scan the QR code to go directly to www.shareview.co.uk

This document is important. If you are in any doubt about its contents you should consult your Independent Financial Adviser. If you have sold or transferred all of your AstraZeneca ordinary shares you should send this complete document with the Notice of Annual General Meeting 2025 and Shareholders' Circular (or with the communication informing you of the availability of those documents on the AstraZeneca website) to the purchaser or transferee or to the stockbroker, bank or other agent through whom the sale or transfer was effected for transmission to the purchaser or transferee.

Please tear along the dotted line