Ascletis Pharma Inc. — Share Issue/Capital Change 2021

Sep 30, 2021

Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.

Ascletis Pharma Inc. 歌禮製藥有限公司

(incorporated in the Cayman Islands with limited liability)

(Stock Code: 1672)

GRANT OF SHARE OPTIONS

This announcement is made pursuant to Rule 17.06A of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited (the “ Listing Rules ”).

The board (the “ Board ”) of directors (the “ Directors ”) of Ascletis Pharma Inc. (the “ Company ”) hereby announces that the Company granted share options (the “ Options ”) to 17 participants （the “ Grantees ”） on September 30, 2021 under the share option scheme adopted by the Company on June 6, 2019 to subscribe for an aggregate of 2,400,000 ordinary shares of US$0.0001 each of the Company (the “ Share(s) ”). Details of the Options granted are set out as follows:

Date of grant: September 30, 2021 (the “ Grant Date ”) Number of Grantees: 17 Total number of new Shares 2,400,000 Shares to be subscribed upon exercise of the Options granted: Exercise price of the Options granted: HK$2.696 per Share Validity period of the Options: Ten (10) years from the Grant Date

The Options granted are subject to any of the requirements as set out in the relevant agreement to be entered into between the Grantees and the Company.

The subscription price of the Options of HK$2.696 per Share represents the higher of (i) the closing price of the Shares of HK$2.65 per Share as stated in the daily quotation sheet issued by The Stock Exchange of Hong Kong Limited (the “ Stock Exchange ”) on the Grant Date and (ii) the average closing price of the Shares of HK$2.696 per Share as stated in the daily quotation sheets issued by the Stock Exchange for the five trading days immediately preceding the Grant Date.

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Among the Options granted above, none of the Options were granted to any of the Directors, chief executive officer and substantial shareholders of the Company or an associate (as defined under the Listing Rules) of any of them.

By order of the Board Ascletis Pharma Inc. 歌禮製藥有限公司 Jinzi Jason WU Chairman

Hangzhou, the People’s Republic of China September 30, 2021

As at the date of this announcement, the Board comprises Dr. Jinzi Jason WU and Mrs. Judy Hejingdao WU, as executive Directors; and Dr. Yizhen WEI, Mr. Jiong GU and Ms. Lin HUA, as independent non-executive Directors.

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