ARTRYA LIMITED — Director's Dealing 2023

Feb 22, 2023

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Coronary Artery Disease. We see you.

ASX ANNOUNCEMENT

MARKET RELEASE

23 February 2023

DIRECTORS’ INTERESTS

Perth, Western Australia - Australian medical technology company, Artrya Limited (ASX: AYA, Artrya or the Company ) creator of the AI-based solution, Artrya Salix, that supports physicians in the diagnosis of coronary artery disease, provides the attached Initial Director’s Interest Notice for Kate Hill and the Final Director’s Notice for John Konstantopoulos following the recent announcement of Board changes.

This announcement was approved by the Artrya Managing Director and CEO.

For further information please contact:

Investor Enquiries: John Barrington Artrya Limited +61 419 850 502 investors@artrya.com

About Artrya

Based in Perth, Western Australia, Artrya was founded in 2018 and commenced operations in early 2019. Artrya Ltd is listed on the Australian Securities Exchange (ASX: AYA). Artrya is an applied artificial intelligence healthcare company that works alongside clinicians to improve the diagnosis of coronary heart disease and develop a holistic overview of a patient at risk. Artrya has developed deep learning algorithms that will streamline how medical care for heart disease is delivered. Artrya USA Inc. is a wholly owned subsidiary of Artrya Limited.

For more information, see www.artrya.com

Artrya Limited ACN 624 005 741 1257 Hay Street, West Perth WA 6005 PO Box 567, West Perth WA 6872 www.artrya.com T: +61 8 6478 7816

Appendix 3X Initial Director’s Interest Notice

Rule 3.19A.1

Appendix 3X

Initial Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity Artrya Limited ABN 624 005 741

We (the entity) give ASX the following information under listing rule 3.19A.1 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Catherine (Kate) Hill
Date of appointment	22 February 2023

Part 1 - Director’s relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

Nil

• See chapter 19 for defined terms.

11/3/2002

Appendix 3X Page 1

Appendix 3X Initial Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of Number & class of Securities interest Note: Provide details of the circumstances giving rise to the relevant interest. Nil

Part 3 – Director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	N/a
Nature of interest	N/a
Name of registered holder (if issued securities)	N/a
No. and class of securities to which interest relates	N/a

• See chapter 19 for defined terms.

Appendix 3X Page 2

11/3/2002

Appendix 3Z Final Director’s Interest Notice

Rule 3.19A.3

Appendix 3Z

Final Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/9/2001.

Name of entity Artrya Limited ABN 624 005 741

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	John Konstantopoulos
Date of last notice	26 November 2021
Date that director ceased to be director	22 February 2023

Part 1 – Director’s relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

Nil

• See chapter 19 for defined terms.

11/3/2002

Appendix 3Z Page 1

Appendix 3Z Final Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of interest Note: Provide details of the circumstances giving rise to the relevant interest Erika Henriette Konstantopoulos (IEMK Family A/C> (spouse of John Konstantopoulos)	Number & class of securities • 742 ordinary fully paid shares • 6,999,258 ordinary fully paid shares (Shares) subject to ASX escrow until 26 November 2023 • 3,000,000 Options exercisable at $0.001 each on or before 25 March 2024, subject to ASX escrow until 26 November 2023. • 2,000,000 Options exercisable at $1.00 each on or before 9 July 2026, subject to ASX escrow until 26 November 2023.

Part 3 – Director’s interests in contracts

Detail of contract	N/a
Nature of interest	N/a
Name of registered holder (if issued securities)	N/a
No. and class of securities to which interest relates	N/a

• See chapter 19 for defined terms.

Appendix 3Z Page 2

11/3/2002