ARIX BIOSCIENCE PLC — Regulatory Filings 2022

May 12, 2022

12 May 2022

Dear Shareholder

Arix Bioscience Plc (the "Company") Shareholder Communications

We are taking this opportunity to ask our shareholders to confirm how they wish to receive shareholder communications namely, the Annual Report and Accounts and dividends from the Company. Please take a few minutes to read this letter. We prefer to use our website (www.arixbioscince.com) for general communications with our shareholders wherever possible.

Receiving communications from the Company electronically provides certain advantages to shareholders and the company, including:

• easier and quicker access to documents;
• saving paper and helping the Company to reduce its environmental impact; and
• reducing the cost of printing and delivery of documents.

Please choose one of the following options:

Website & Email Notification

Receive email notifications informing you when shareholder communications are available on the Company's website.

To choose this option, please visit www.shareview.co.uk, to register for a 'Shareview Portfolio' and select 'electronic' as your preferred method of delivery of Arix Bioscience plc communications.*

*In order to register, you will need your shareholder reference number, which can be found in the enclosed form.

Website & Letter Notification

Receive paper notifications informing you when shareholder communications are available on the Company's website.

To choose this option, no further action is required. We will notify you by post when new shareholder information has been published on our website.

Hard Copy by Post

Receive paper copies of shareholder communications by post.

To choose this option, please select Option 3 on the enclosed election form and return it to our registrar, Equiniti.

Please note that if you do not return the attached election form or register online by 10 June 2022 you will be deemed to have elected for Option 2. This means that you will receive written notification when shareholder communications are available via the Arix Bioscience plc website. You can of course change your election at any time by writing to Equiniti, Aspect House, Spencer Road, Lancing, West Sussex BN99 6DA, or by logging into your Shareview account. Notwithstanding any election the Company may at its sole discretion send any notification or document to shareholders in hard copy form if we feel it is appropriate to do so.

If you have any questions concerning these options or would like additional information, please contact Equiniti by telephone on 0371 384 2030 or +44 121 415 7047 if calling outside the UK.

Yours faithfully,

!

Peregrine Moncreiffe,

Chairman, Arix Bioscience Plc

Shareholder Communications Election Form

Shareholder reference number (Please insert your number)

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To continue to receive shareholder documents in hard copy format please place an "X" in the box and return it in an envelope using the freepost address on the reverse to Equiniti.

Please note that if you do not return this form before 10 June 2022 you will be treated as having agreed to receive future shareholder information through the Company's website.

Freepost RTHJ–CLLL–KBKU Equiniti Aspect House Spencer Road LANCING BN99 8LU

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