ARDELYX, INC. — Director's Dealing 2025

Aug 29, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ARDELYX, INC. (ARDX)
CIK: 0001437402
Period of Report: 2025-08-26

Reporting Person: Williams Laura A (Chief Patient Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-08-26	Common Stock	M	50000	$0.99	Acquired	446322	Direct
2025-08-26	Common Stock	S	50000	$6.121	Disposed	396322	Direct
2025-08-26	Common Stock	S	30000	$6.121	Disposed	366322	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-08-26	Stock Option (Right to Buy)	$0.99	M	50000	Disposed	2032-01-06	Common Stock (50000)	Direct

Footnotes

F1: This transaction was executed in multiple trades in prices ranging from $6.04 to $6.20, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2: The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 6, 2022, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.