ARDELYX, INC. — Director's Dealing 2022

May 23, 2022

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ARDELYX, INC. (ARDX)
CIK: 0001437402
Period of Report: 2022-05-20

Reporting Person: Rosenbaum David P. (Chief Development Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2022-05-20	Common Stock	S	1489	$0.6714	Disposed	347920	Direct
2022-05-20	Common Stock	S	524	$0.6714	Disposed	107502	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	77592	Indirect

Footnotes

F1: Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

F2: Reflects the adjusted total which includes the purchase of 3,000 shares under the Ardelyx Employee Stock Purchase Plan on February 28, 2022.

F3: The shares are directly held by the Reporting Person's wife.

F4: The shares are directly held by David Paul Rosenbaum and Susan Edelstein Rosenbaum, Trustees of the David Paul Rosenbaum Family Trust.