Applied Therapeutics, Inc. — Director's Dealing 2019

May 21, 2019

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Applied Therapeutics Inc. (APLT)
CIK: 0001697532
Period of Report: 2019-05-16

Reporting Person: ALEXANDRIA REAL ESTATE EQUITIES INC (10% Owner)
Reporting Person: Alexandria Venture Investments, LLC (10% Owner)
Reporting Person: Alexandria Equities No. 7, LLC (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2019-05-16	Common Stock	C	2415576	—	Acquired	2415576	Indirect
2019-05-16	Common Stock	P	975000	$10	Acquired	975000	Indirect

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2019-05-16	Series A Preferred Stock	$	C	800716	Disposed		Common Stock (800716.0)	Indirect
2019-05-16	Series B Preferred Stock	$	C	1614860	Disposed		Common Stock (1614860.0)	Indirect

Footnotes

F1: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into shares of Issuer's common stock, without payment of additional consideration, on a one-for-one basis, immediately upon the closing of the Issuer's initial public offering on May 16, 2019.

F2: These shares are held directly by Alexandria Venture Investments, LLC ("AVI"), a wholly owned subsidiary of Alexandria Real Estate Equities, Inc. ("ARE"). Of these shares, 1,243,977 shares are held by AVI as nominee for Alexandria Equities No. 7, LLC ("AE7"), another wholly owned subsidiary of Alexandria Real Estate Equities, Inc. AVI disclaims beneficial ownership of the shares held as nominee for AE7.

F3: These shares are held directly by AE7. Does not include 1,243,977 shares held directly by AVI as nominee for AE7, as described in footnote (2), which shares may be deemed to be beneficially owned by AE7.

F4: Not applicable