Apontis Pharma AG — Investor Presentation 2021

Aug 11, 2021

APONTIS PHARMA

The Single Pill Company

H1 2021 Results

Disclaimer

The following presentation, including any printed or electronic copy of these slides, the talks given by the presenters, the information communicated during any delivery of the presentation and any question and answer session and any document or material distributed at or in connection with the presentation (together, the "Presentation"), has been prepared by APONTIS PHARMA AG (the "Company"), is not an offer to sell any securities or an invitation to purchase securities or the solicitation of an offer to buy securities. This Presentation is not an advertisement and not a prospectus for the purposes of Regulation (EU) 2017/1129 of the European Parliament and of the Council of June 14, 2017, as amended.

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APONTIS PHARMA Management's Presenters

Karlheinz Gast

Chief Executive Officer

• Strategy
• Marketing & Sales
• Human Resources
• Finance
• Investor Relations

Thomas Milz

Chief Product Officer

• Business Development
• Market Access
• Medical & Regulatory Affairs
• Product Development
• Supply Chain

"Drug non-compliance is a stealth epidemic exacting a heavy toll on the healthcare system – our broad portfolio of Single Pills is designed to help tackle this epidemic"

IPO at Frankfurt Stock Exchange in May 2021

APONTIS PHARMA: The Single Pill Company

• § German heritage business of SCHWARZ PHARMA
• § Formed in 2018
• § Acquisition by PARAGON PARTNERS from publicly listed UCB

§ Unique salesforce – 130 sales reps § Target group 23k physicians § Total visits > 200k p.a.

• § Lean business model (no production or storage)
• § Integrated pharma business (R&D, regulatory, quality, medical, market access, sales and beyond)

§ Headquarter: Monheim (GER)

§ Single Pill leader in the German market with a focus on cardiovascular diseases ("CVD")

H1 2021

§ EURm 24 revenues (+36%)

• § EURm 2.8 EBITDA adj. (+EURm 4.3)
• § 230k Single Pill patients (+100%)

"No More Grandma's Muesli" – Single Pill Therapy on the Rise

Single Pills' High Effectiveness and Increased Health Benefits Confirmed

• § 60,000 participants
• § Led by IPAM/ INGRESS Institute based on AOK PLUS health insurance data
• § Data on adherence collected over 1 year
• § 7 different Single Pills and 8 clinical outcomes

Key findings:

• ü Greater adherence to therapy
• ü Better prognosis for patients
• ü Lower overall patient cost

Notes: (1) Reduction is understood as a change up to the respective percentage figure indicated and compared to event rate of conventional treatment with multi pill therapy (2) Cost reduction is reflecting total costs (hospital costs, office-based costs, medication costs and costs for curative means and aids) per patient per year in Germany Source: START Study, IPAM / INGRESS Institute

APONTIS Has a Unique and Powerful Position in the Single Pill Market

Sales Force with Excellent Access to Physicians Driven by Holistic Approach

Sales force position : Entry barrier and key strength

• Strongest sales force in Germany with 130 reps leveraging unique multi channel approach
• Experience and good relationship to 23,000 physicians in Germany

Value-adding services "beyond the pill" for patients and physicians

• Optimization of patient management
• Optimization of doctors' office processes
• Consulting on hygiene certification
• Cardio-pulmonary reanimation training

Strong Share of Voice Position in Single Pill Market*

Next Steps Towards Growth Following the Successful IPO

APONTIS PHARMA: The Single Pill Strategy – Repeating Success

Many more commonly used combinations are only available as loose combinations – APONTIS can leverage existing know-how and market access to new Single Pills

The Development of a Single Pill: Many Steps – One Goal

Short-term Pipeline: Accelerating the Development of Single Pills

1 Field of application	Tonotec Lipid	RosuvaEze	Caramlo HCT	Caramlo Lipid
Planned market launch	Q1 2022	July 2022	July 2023	December 2023
Status	§ Registration submission process already started	§ Negotiations with supplier, already developed in Europe	§ Dosages split across two suppliers, development ongoing	§ Supplier contract signed, development ongoing
Competitive environment	§ No other Single Pill provider with this combination	§ Other Single Pill provider with this combination	§ No other Single Pill provider with this combination	§ No other Single Pill provider with this combination
Patient potential²	661k	151k	330k	486k
Total development cost	EURm 1.9	EURm 0.0 (exclusive licensing agreement)	EURm 1.3	EURm 2.5
Mid-term annual revenue potential	EURm 5	EURm 3	EURm 9	EURm 3

Notes: (1) Main application essential hypertension; (2) Patient potential: Number of patients with same substance class combination in loose form Source: Patient INSIGHTS Analytics (PIA). A web-based pharma tool from INSIGHT Health GmbH & Co. KG; Company information

Mid-term Development Pipeline: Continuous Market Opportunities

Single Pill	Product	Patient potential	Development costs (estimate in EURm)	Estimated launch (in years from now)	Revenue potential (Y5 after launch, in EURm)
	1.	2,467	1.8 - 2.2	3.5	20.2
	2.	1,267	0.5 - 1.5	2.5	6.0
	3.	305	1.8 - 2.2	2.5	1.4 - 2.8
	4.	270	1.8 - 2.2	4.0	6.5
Development	5.	2,467	0.5 - 1.5	2.5	2.3
candidates	6.	188	2.5 – 3.0	4.0	12.0
	7.	216	1.8 - 2.2	8.0	7.5
	8.	499	0.5 - 1.5	3.5	10.0
	9.	409	0.5 - 1.5	3.5	12.0
	…
	1.	1,440	0.0	0.5	4.5 - 5.0
Exclusive	2.	378	0.4	0.7	4.5 - 5.0
licensing agreements	3.	240	0.3	0.5	3.5 - 4.0
	…

Clear Target of +20 Single Pills Portfolio Generating Revenues in 2026

Source: Patient INSIGHTS Analytics (PIA). A web-based pharma tool from INSIGHT Health GmbH & Co. KG; Company information 16

Top-line growth driven by Single Pill Revenues

Operational Profitability Driven by Disproportionately Low Costs Rise in Face of Strong Increase in Revenues

Solid Financial Position: Well-Funded for Planned Activities

Source: Company information

APONTIS PHARMA on the Capital Market

Share price performance (IPO to date)

Share price information (IPO to date)

Issue Price		EUR 19.00
Low	4 June 2021	EUR 16.60
High	4 August 2021	EUR 23.70
Close	10 August 2021	EUR 22.50
Performance		+18.4%
Market Cap		EUR 193.5 Mio.

Analyst Coverage

Update	Institute	Recommendation	Target Price
17 June 2021	Warburg	BUY	41.00
29 July 2021	Hauck & Aufhäuser	BUY	31.00
11 May 2021	Edison	*	*

Notes: Edison Investment Research's qualitative research reports for scale issuers were prepared on behalf of Deutsche Börse without a price target or recommendation. Source: Deutsche Börse, Company information

Investment Highlights

• First mover and category leader in Germany for Single Pills with a focus on cardiovascular diseases ("CVD")
• Most comprehensive Single Pill portfolio in the market protected by high entry barriers due to intellectual property, long lead times with development cycles of 3.5 - 5 years and best in class sales team
  • Attractive growth prospects resulting from aging population, hypertension as a major chronic health issue and the high Single Pill adoption rates
• € %

1st

• High visibility on growth driven by significant potential to increase market share with existing products and a full product pipeline with new Single Pill products to be launched short term as well as medium-term
• Scalable business model with highly attractive unit economics to support 30% EBITDA margins in the medium-term
• Strong strategic push to accelerate the commercialization and development of the product pipeline with attractive payback times per Single Pill product of 2 years on average

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YOUR QUESTIONS PLEASE!

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THANK YOU FOR YOUR ATTENTION!

ir@apontis-pharma.de T: +49 2173 89 55 4900 F: +49 2173 89 55 1521

Alfred-Nobel-Str. 10 40789 Monheim am Rhein Deutschland

apontis-pharma.de

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APONTIS PHARMA Management's long-standing track record in pharma

Karlheinz Gast Chief Executive Officer Joined 1997

33 Years in Pharma

• Strategy
• Marketing & Sales
• Human Resources
• Finance
• Investor Relations

Thomas Milz Chief Product Officer Joined 1991

30 Years in Pharma

• Business Development
• Market Access
• Medical and Regulatory Affairs
• Product Development
• Supply Chain

Dr. med. Matthias Wendl Head of Sales 19 Years in Pharma

Harald Weyand Head of Marketing 32 Years in Pharma

Extended Management

Dr. rer. nat. Susanne Endreß Head of Regulatory Affairs 26 Years in Pharma

Dr. med. Olaf Randerath Head of Medical Affairs 23 Years in Pharma

"Drug non-compliance is a stealth epidemic exacting a heavy toll on the healthcare system – our broad portfolio of Single Pills is designed to help tackle this epidemic"

User Market Tailwinds: Ageing Society and Rise of Chronic Diseases

• Continuing trend and need for medical attention
• Prevalence of chronic diseases rises with age
• The increase in older people will increase the Single Pills demand drastically, since they profit though ease of use and limit of side-effects

30- 40- 50- 60- 70- Rise of Chronic Diseases Like Hypertension

Repeated Purchases

• APONTIS has a focus on Single Pills for CVD (e.g. hypertension)
• Chronic and incurable illness patients buy drug on a regular basis

Hypertension – An Epidemic

• CVD is the leading cause of death in Germany
• A large untapped market for APONTIS

Reached necessary target blood pressure 9.0m

• Accurately diagnosed 21.8m
• Germans suffering from hypertension 35.0m

German population 83.8m