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ANTEOTECH LTD — AGM Information 2013
Oct 30, 2013
64304_rns_2013-10-30_0894e407-95a8-464f-8ac3-e550c9a8f928.pdf
AGM Information
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Anteo Diagnostics (ASX:ADO)
Annual General Meeting 31[st] October 2013 Welcome
MEETING FORMAT
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Introductions
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Formal Resolutions
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CEO Report
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Other Business
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Meeting Close
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Introductions
Anteo Diagnostics Limited
Mark Bouris– Non Executive Chairman
Geoff Cumming – CEO
- Richard Martin – Executive Director
Sandra Andersen – Non Executive Director John Hurrell – Non Executive Director
Grant Thornton
- Matthew Bell – Partner
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Formal Resolutions
Resolution 1:
Adoption of Directors’ Remuneration Report
Resolution 2: Resolution 3: Resolution 4:
Election of Director (Mr John Hurrell)
Re - Election of Director (Mr Mark Bouris) Issue of 3,000,000 Options (Mr John Hurrell)
Issue of 6,000,000 Options (Dr Geoff Cumming)
Resolution 5: Resolution 6: Approval of 10% placement facility
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RESOLUTIONS – PROXY COUNT
| Description | For | Against | Open | Abstain | Totals | |
|---|---|---|---|---|---|---|
| Resolution 1 | Adoption of Directors’ Remuneration Report |
213,920,864 | 13,576,457 | 19,868,474 | 1,514,450 | 247,365,795 |
| Resolution 2 | Election of Director( Mr John Hurrell) |
209,578,975 | 4,000,063 | 34,512,706 | 788,501 | 248,091,744 |
| Resolution 3 | Re- Election of Director (Mr Mark Bouris) |
209,419,275 | 4,162,263 | 34,510,206 | 788,501 | 248,091,744 |
| Resolution 4 | Issue of 3,000,000 Options (Mr John Hurrell) |
207,688,892 | 5,804,605 | 34,302,176 | 1,084,572 | 247,795,673 |
| Resolution 5 | Issue of 6,000,000 Options (Dr Geoff Cumming) |
208,456,592 | 5,036,905 | 34,302,176 | 1,084,572 | 247,795,673 |
| Resolution 6 | Approval of 10% placement facility |
160,764,061 | 52,983,253 | 34,512,706 | 620,225 | 248,260,020 |
CEO UPDATE
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Mix&Go[TM] – A Universal “Glue” For Clinical Diagnostics, Life Sciences and Beyond
Investor Presentation October 2013 Dr. Geoff Cumming, CEO Anteo Diagnostics Ltd (ASX:ADO)
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Anteo Diagnostics Overview
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A Biotech company with highly experienced Board and Management team
D evelops, manufactures and commercialises proprietary surface coatings for healthcare industry O ur Mix&Go[TM] is a novel “glue” with a ubiquitous array of applications
Diagnostics (IVD) and Life Sciences (LS) – here and now
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Launch of commercial Mix&Go products in 2010
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Enables strong yet flexible binding of biomolecules to a broad variety of synthetic surfaces without causing damage to their structure or activity
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Improves the outcome of pathology tests, such as blood tests
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Commercial agreements with several companies: Bangs, Merck, Affymetrix, One World Lab, Gennova etc.
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Extensive patents protect technology and applications
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Cash flow positive through 2014
– Bioseparations the next opportunity
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Unique market opportunity to provide cost-effective solution
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Focus on rapidly growing therapeutics market
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Mix&Go makes it practical to replace current cumbersome methods with magnetic separation – a desirable but so far uneconomical solution
Anteo – Corporate Overview
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Business Model
Revenues from product sales Royalties from license agreements Paid R&D collaborations with IVD & LS companies
Proven Technology Platform
Proprietary technology licensed to major international healthcare companies with additional deals anticipated
Patented Technology
Significant and growing patent portfolio
Clear Development Path
Mix&Go development is progressing from diagnostics to next market sector: bioseparations Significant additional opportunities exist
Robust Deal Portfolio
Over 80 companies are actively assessing Mix&Go in-house or through collaborative work
Sound Commercialisation Strategy
Combination of licensing, collaborations and product sale provide diversified portfolio of revenue streams with clear path to profitability
Recent Highlights
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Commercial agreements
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02/13 Partnership agreement with U.S. based One World Lab 02/13 Commenced paid feasibility study with global leader in lateral flow POC test manufacture
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05/13 Sales partnership agreement with Spanish based Gennova Scientific for Europe & Latin America
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06/13 Feasibility agreement with major global healthcare company for development of a POC device
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08/13 Commenced further paid studies with lateral flow POC company
Patents
06/13 Granted European patent
08/13 Filed 2 new patent applications
Government Grants
07/13 Received 2-year $1.7m grant from Commercialisation Australia
Mix&Go – A Game Changing Technology
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Mix&Go - A Game Changing Technology
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Surface coatings are crucial in many industries and serve many purposes, e.g.:
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Provide adhesive properties, i.e. act like a “glue”
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Confer optical properties
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Add magnetic or electrical properties
Mix&Go is a universal “glue” that is uniquely suited for applications in diagnostics and life sciences:
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Gentle “glue” that maintains the activity of fragile biomolecules
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Improves pathology tests earlier disease detection
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Reduces cost of test development and manufacture
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Applicable to numerous large healthcare segments:
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Pathology/diagnostic tests
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Point-of-care diagnostics
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Bioseparation
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Drug discovery and development
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Well suited to “glue” in a variety of applications and industries outside of healthcare, e.g. Resources and Cleantech
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Current Focus: Diagnostics and Life Sciences
Laboratory Diagnostics
Point-of-care
Rapid Test Products
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Global IVD: $44B (2011)
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Immunoassays: $8.8B
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Drivers: aging population = more tests, higher Asian demand, technology innovations
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$8 B (2011)
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$38B (2017 forecast)
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Drivers: price pressure, lack of qualified staff , need for immediate information, decentralisation, bedside testing
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$3.7B in 2012
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Drivers: decentralised testing, broadening applications, direct to consumer marketing
Life Science R&D
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Very large and diverse
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Drivers: price pressure, efficiency
Mix&Go – The Secret Sauce
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3D structure is Orientation is Undamaged,
damaged random oriented
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Proprietary solution:
metal polymers
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Without Mix&Go
With Mix&Go
Consequences
Vast majority of proteins are nonfunctional
Lower sensitivity, LOD, dynamic range
More protein needed
Characteristics
Undamaged, fully functional proteins on surface
Less protein and/or beads required
Easy and fast to use and manufacture
Improved reproducibility
Benefits
Increased performance Less non-specific binding Improved protein stability
Reduced cost Saves valuable, expensive proteins
Improves efficiency Simpler test procedures Manufacturing faster, easier, more scalable Improved accuracy with improved %CV
The Proof Is In The Data
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Sensitivity Sensitivity improvement 4 to 50-fold!
Cost
More than 8-fold reduction in cost of goods sold
| Mix&Go™ | Mix&Go™ | Traditional | Traditional | Improvement | |
|---|---|---|---|---|---|
| IL4 | 0.05 pg/mL | 0.2 pg/mL | 4x | ||
| Troponin I | 5 pg/mL | 50 pg/mL | 10x | ||
| TNF-α | 5 pg/mL | > 250 pg/mL | 50x | ||
| HBcAg | <10 pg/mL | 150 pg/mL | 15x | ||
| TSH | <0.001 uIU/mL | 0.006 uIU/mL | 6x | ||
| Mix&Go™ | Traditional | ||||
| Capture antibody (CaB) concentration |
0.125 mg/mL | 1.0 mg/mL | |||
| cAb Cost per Plate* | $1.10 | $8.80 | |||
| Plate Cost* | $0.55 | $4.92 | |||
Total Cost |
$1.65 | $13.72 | |||
| * Cost in AUD$ |
Stability
Stability even at high temperatures - better shelf life
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Freshly Coated ° °
14 Days @ 25 C 14 Days @ 37 C
20,000
15,000
10,000
5,000
0
200 μg/mL 50 μg/mL 10 μg/mL
200 μg/mL 50 μg/mL 10 μg/mL 200 μg/mL 50 μg/mL 10 μg/mL
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Mix&Go – Better Tests Faster!
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Mix&Go can improve all aspects of test development and manufacture so better tests can be developed faster
Performance Is Key, e.g. sensitivity, limit of detection
Fast Development Increases speed to market
Less Raw Materials Improved margins
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New Test Possible for fragile proteins
Ease of Manufacture User-friendly, stable, robust
Scalable
From R&D to manufacturing without changes in procedure
– Bioseparations A Significant Market Opportunity
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Bioseparation or How to Get a Pure Protein
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Bioseparation : isolating rare proteins or cells from a complex mixture without contamination, e.g. the purification of
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Therapeutic antibodies/biologic drugs
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Vaccines for human and veterinary use
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Rare cells, e.g. stem cells or circulating tumor cells
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Proteins for R&D purposes
Anteo’s Solution: Mix&Go
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Enables preferred magnetic isolation approach which currently is too expensive
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Easy scale-up from R&D batches to large scale manufacturing batches
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Easy to automate, a critical aspect in large scale manufacturing
Mix&Go can change the way proteins are purified, positively impacting large industries from biological drug and vaccine manufacturing to stem cell research
Bioseparation – The Opportunity
Current Approach Chromatography:
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Time consuming
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Expensive
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Hard to automate
Paradigm Shift With Mix&Go magnetic separation can become reality
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technically superior solution
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economically advantageous
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Capacity constraints
Alternative
Magnetic separation:
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Technically superior
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• Currently unaffordable
Large Opportunity
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Protein and protein drug manufacturing: $3-5B
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Vaccine manufacturing: $620M in 2015
Leverage Mix&Go in bioseparations to create significant long-term revenue streams for Anteo
Bioseparations: Why Now?
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Internal Drivers
External Drivers
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Proof of concept - Mix&Go approaches show better performance than conventional methods
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Improvement - Mix&Go can generate novel, versatile approaches for bio-separation
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Patent Application Filed securing a strong IP position
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Increased importance Biologics/protein drugs play an ever more important role:7 out of the top 10 drugs sold in 2012 were biologics
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Market need - expressed desire by users to move to magnetic separation but unfavorable economics currently prevent that move
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Opportunity to move up value chain
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Global network and relationships developed through Mix&Go that will fast-track market penetration
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– an ever
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Changing needs increasing variety of biological molecules requiring new approaches
Additional Opportunities
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Capitalise on Diagnostics/POC
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Expand on Diagnostics/POC Life Science Research
Capitalise on Bioseparations
Expand on Drug screening
Develop Bioseparations
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Capitalise on Diagnostics/POC Life Science Research
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Expand on Bioseparations
Initiate Bioseparations
Explore Cleantech,Resources Drug screening
Diagnostics/POC Life Science Research
Targets and Timeline
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Agreement with top-tier POC company
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2-3 agreements with LS companies
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Agreement with top-tier POC company
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Agreement with midsize IVD
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Agreement w/ top tier IVD
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Agreement(s) w/ mid-tier IVD
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Agreement(s) w/ POC company
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Deal(s) w/ LS companies
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Additional deals in IVD, POC and LS
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Agreements in bioseparations, resources, cleantech, other
Keypoints
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Mix&Go is a proprietary platform technology with broad applicability in diagnostics, life sciences, bioseparations and beyond
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Mix&Go is proven licensed and gaining significant traction in commercial markets
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Mix&Go success means Anteo is becoming cash flow positive
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Focus on diagnostics and life sciences with expansion into bioseparations provides Anteo significant revenue opportunities
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Strong leadership - Board and management team in place to drive growth
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Global team resources and network to capitalise on growth opportunity
Anteo’s Mix&Go is an enabling technology beneficial to many industries and applications. Mix&Go is quickly gaining traction in the diagnostic and life sciences industries and has significant mid-term potential in bioseparations and long term in a large number of applications in health care and other industries.
OTHER BUSINESS AND QUESTION TIME
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