ANI PHARMACEUTICALS INC — Regulatory Filings 2011

May 27, 2011

*As filed with the Securities and Exchange Commission on May 27, 2011*

*Registration No. 333-*

*UNITED STATES*

*SECURITIES AND EXCHANGE COMMISSION*

*Washington, D.C. 20549*

*FORM S-8*

*REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933*

*BIOSANTE PHARMACEUTICALS, INC.*

(Exact Name of Registrant as Specified in its Charter)

Delaware (State or Other Jurisdiction of Incorporation or Organization) 58-2301143 (I.R.S. Employer Identification Number)

*111 Barclay Boulevard, Lincolnshire, IL 60069*

(Address of Principal Executive Office) (Zip Code)

*BioSante Pharmaceuticals, Inc. Second Amended and Restated*

*2008 Stock Incentive Plan*

(Full Title of the Plan)

*Phillip B. Donenberg*

*Senior Vice President of Finance, Chief Financial Officer and Secretary*

*BioSante Pharmaceuticals, Inc.*

*111 Barclay Boulevard*

*Lincolnshire, IL 60069*

*(847) 478-0500*

(Name and Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent For Service)

*Copies requested to:*

*Amy E. Culbert, Esq.*

Oppenheimer Wolff & Donnelly LLP

45 South Seventh Street, Suite 3300

Minneapolis, Minnesota 55402-1509

(612) 607-7287

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer o	Accelerated filer x
Non-accelerated filer (Do not check if a smaller reporting company) o	Smaller reporting company o

*CALCULATION OF REGISTRATION FEE*

Title of Securities to be Registered	Amount to be Registered(1)	Proposed Maximum Offering Price Per Share(2)	Proposed Maximum Aggregate Offering Price(2)	Amount of Registration Fee
Common Stock, par value $0.001 per share	2,000,000 shares	$ 2.895	$ 5,790,000	$ 673.00

(1)

The number of shares of common stock, par value $0.001 per share, of BioSante (“Common Stock”), stated above represents an increase in the total number of shares available for issuance under the BioSante Pharmaceuticals, Inc. Second Amended and Restated 2008 Stock Incentive Plan (the “Plan”). An aggregate of 4,000,000 shares have been registered previously under registration statements on Form S-8 (File Nos. 333-151663 and 333-168842). In addition, the maximum number of shares of Common Stock that may be issued under the Plan is subject to adjustment in accordance with certain provisions of the Plan. Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), to the extent additional shares of Common Stock may be issued or issuable as a result of a stock split or other distribution declared at any time by the Board of Directors while this registration statement is in effect, this registration statement is hereby deemed to cover all such additional shares of Common Stock.

(2)

Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) under the Securities Act and calculated based on the average of the high and low sales prices of the Common Stock, as reported on the NASDAQ Global Market on May 24, 2011.

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*STATEMENT UNDER GENERAL INSTRUCTION E— REGISTRATION OF ADDITIONAL SECURITIES*

The registrant, BioSante Pharmaceuticals, Inc. (“BioSante” or “Registrant”), previously filed registration statements on Form S-8 (SEC File Nos. 333-151663 and 333-168842) with the Securities and Exchange Commission (the “Commission”) in connection with the registration of an aggregate of 4,000,000 shares of BioSante’s common stock to be issued under the BioSante Pharmaceuticals, Inc. Second Amended and Restated 2008 Stock Incentive Plan and the initial and subsequent versions of such plan after amendments (the “Plan”).

Pursuant to General Instruction E of Form S-8, this registration statement on Form S-8 (this “Registration Statement”) is filed by BioSante solely to register an additional 2,000,000 shares of BioSante’s common stock available for issuance under the Plan. This increase was approved by BioSante’s Board of Directors and stockholders. Pursuant to Instruction E, the contents of BioSante’s previously filed Registration Statements on Form S-8 (SEC File Nos. 333-151663 and 333-168842), including without limitation periodic reports that BioSante filed, or will file, after this Registration Statement to maintain current information about BioSante, are hereby incorporated by reference into this Registration Statement pursuant to General Instruction E of Form S-8, with the exception of Items 3 and 8 of Part II of such prior Registration Statement, each of which is amended and restated in its entirety herein.

*PART I*

*INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS*

The documents containing the information specified in Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) of the Securities Act of 1933, as amended (the “Securities Act”). In accordance with the instructions of Part I of Form S-8, such documents will not be filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. These documents and the documents incorporated by reference pursuant to Item 3 of Part II of this Registration Statement, taken together, constitute a prospectus as required by Section 10(a) of the Securities Act.

*PART II*

*INFORMATION REQUIRED IN THE REGISTRATION STATEMENT*

*Item 3. Incorporation of Documents by Reference*

The following documents previously filed by BioSante with the Commission are incorporated by reference into this Registration Statement:

(a) BioSante’s Annual Report on Form 10-K for the year ended December 31, 2010 (including information specifically incorporated by reference into BioSante’s Form 10-K from its definitive proxy statement for its 2011 annual meeting of stockholders);

(b) BioSante’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2011;

(c) BioSante’s Current Reports on Form 8-K filed with the Commission on January 27, 2011, March 4, 2011 and May 27, 2011; and

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(d) the description of BioSante’s common stock contained in its registration statement on Form 8-A and any amendments or reports filed for the purpose of updating such description.

In addition, all documents filed with the Commission by BioSante (other than portions of such documents which are furnished and not filed) pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all such securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the time of filing of such documents.

Any statement contained in the documents incorporated or deemed to be incorporated by reference into this Registration Statement shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference into this Registration Statement modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

*Item 8. Exhibits*

The following exhibits are filed with or incorporated by reference into this Registration Statement:

Exhibit No.	Description
4.1	Restated Certificate of Incorporation of BioSante Pharmaceuticals, Inc. (incorporated by reference to Exhibit 3.1 to BioSante’s Current Report on Form 8-K as filed with the Securities and Exchange Commission on October 14, 2009 (File No. 001-31812))
4.2	Amended and Restated Bylaws of BioSante Pharmaceuticals, Inc. (incorporated by reference to Exhibit 3.1 to BioSante’s Current Report on Form 8-K as filed with the Securities and Exchange Commission on June 11, 2010 (File No. 001-31812))
4.3	Specimen Stock Certificate Representing Common Stock of BioSante Pharmaceuticals, Inc. (incorporated by reference to Exhibit 4.3 to BioSante’s Registration Statement on Form S-3, as amended (File No. 333-159606))
5.1	Opinion of Oppenheimer Wolff & Donnelly LLP (filed herewith)
10.1	BioSante Pharmaceuticals, Inc. Second Amended and Restated 2008 Stock Incentive Plan (incorporated by reference to Exhibit 10.1 to BioSante’s Current Report on Form 8-K as filed with the Securities and Exchange Commission on May 27, 2011 (File No. 001-31812))
23.1	Consent of Deloitte & Touche LLP (filed herewith)
23.2	Consent of Oppenheimer Wolff & Donnelly LLP (included as part of Exhibit 5.1)
24.1	Power of Attorney (included on the signature page to this Registration Statement)

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*SIGNATURES*

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Lincolnshire, State of Illinois on May 27, 2011.

BIOSANTE PHARMACEUTICALS, INC.
By:	/s/ Stephen M. Simes
	Stephen M. Simes
	Vice Chairman, President and Chief Executive Officer
	(principal executive officer)
By:	/s/ Phillip B. Donenberg
	Phillip B. Donenberg
	Senior Vice President of Finance, Chief Financial Officer and Secretary
	(principal financial and accounting officer)

*POWER OF ATTORNEY*

Each person whose signature appears below hereby authorizes and appoints Stephen M. Simes and Phillip B. Donenberg, or either of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agents or any of them, their, or his or her, substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

Name and Signature	Title	Date
/s/ Stephen M. Simes	Vice Chairman, President and Chief Executive	May 27, 2011
Stephen M. Simes	Officer
/s/ Phillip B. Donenberg	Senior Vice President of Finance, Chief
Phillip B. Donenberg	Financial Officer and Secretary	May 27, 2011
/s/ Louis W. Sullivan, M.D.
Louis W. Sullivan, M.D.	Chairman of the Board	May 26, 2011

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Name and Signature	Title	Date
/s/ Fred Holubow	Director	May 26, 2011
Fred Holubow
/s/ Ross Mangano
Ross Mangano	Director	May 26, 2011
/s/ John T. Potts, Jr. M.D.
John T. Potts, Jr., M.D.	Director	May 26, 2011
/s/ Edward C. Rosenow, III, M.D.
Edward C. Rosenow, III, M.D.	Director	May 26, 2011
/s/ Stephen A. Sherwin, M.D.
Stephen A. Sherwin, M.D.	Director	May 26, 2011

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*BIOSANTE PHARMACEUTICALS, INC. REGISTRATION STATEMENT ON FORM S-8 EXHIBIT INDEX*

Exhibit No.	Description	Method of Filing
4.1	Restated Certificate of Incorporation of BioSante Pharmaceuticals, Inc.	Incorporated by reference to Exhibit 3.1 to BioSante’s Current Report on Form 8-K as filed with the Securities and Exchange Commission on October 14, 2009 (File No. 001-31812)
4.2	Amended and Restated Bylaws of BioSante Pharmaceuticals, Inc.	Incorporated by reference to Exhibit 3.1 to BioSante’s Current Report on Form 8-K as filed with the Securities and Exchange Commission on June 11, 2010 (File No. 001-31812)
4.3	Specimen Stock Certificate Representing Common Stock of BioSante Pharmaceuticals, Inc.	Incorporated by reference to Exhibit 4.3 to BioSante’s Registration Statement on Form S-3, as amended (File No. 333-159606)
5.1	Opinion of Oppenheimer Wolff & Donnelly LLP	Filed herewith
10.1	BioSante Pharmaceuticals, Inc. Second Amended and Restated 2008 Stock Incentive Plan	Incorporated by reference to Exhibit 10.1 to BioSante’s Current Report on Form 8-K as filed with the Securities and Exchange Commission on May 27, 2011 (File No. 001-31812)
23.1	Consent of Deloitte & Touche LLP	Filed herewith
23.2	Consent of Oppenheimer Wolff & Donnelly LLP	Included as part of Exhibit 5.1
24.1	Power of Attorney	Included on the signature page to this Registration Statement

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