ANAPTYSBIO, INC — Director's Dealing 2026

Jan 8, 2026

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ANAPTYSBIO, INC (ANAB)
CIK: 0001370053
Period of Report: 2026-01-06

Reporting Person: MULROY DENNIS (N/A)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2026-01-06	Common Stock	M	5245	—	Acquired	19575	Direct
2026-01-07	Common Stock	S	1908	$45.11	Disposed	17667	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2026-01-06	Restricted Stock Unit	$	M	5245	Disposed		Common Stock (5245)	Direct
2026-01-06	Restricted Stock Unit	$	A	21400	Acquired		Common Stock (21400)	Direct
2026-01-06	Stock Option (right to buy)	$43.91	A	29000	Acquired	2036-01-05	Common Stock (29000)	Direct

Footnotes

F1: Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F2: The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.

F3: The RSUs vests as to 25% of the total RSUs annually commencing on January 6, 2024 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F4: The RSUs vests as to 25% of the total RSUs annually commencing on January 6, 2027 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F5: The stock option vests as to 25% of the total shares on January 6, 2027, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.