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ANAGENICS LIMITED AGM Information 2017

Nov 22, 2017

64383_rns_2017-11-22_acb283b5-a840-4980-8c3a-388e116d4331.pdf

AGM Information

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ANNUAL GENERAL MEETING

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23 NOVEMBER 2017

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Maria Halasz CEO & Managing Director

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IMPORTANT NOTICE

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Forward looking statements

This presentation contains forward-looking statements that are subject to risks and uncertainties. Such statements involve known and unknown risks that may cause the actual results, performance or achievements of Cellmid to be materially different from the statements in this presentation. Actual results could differ materially depending on factors such as the availability of resources, regulatory environment, the results of advertising, sales activities and competition.

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CELLMID (CDY:ASX)

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Fully Paid Ordinary Shares (22 November 2017)

1,068,456,303

Market Capitalisation (22 November 2017)

A$ 21 million

Unlisted options

32,500,000

Cash Position (30 September 2017)

A$ 3.85 million

Debt ($2 million due Feb 2019, secured against R&D Tax Credit)

A$ 2.0 million

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CORPORATE AND BUSINESS STRUCTURE

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LYRA MID KINE RA

Novel FGF5 inhibitor hair growth products sold as OTC, non-prescription natural medicines and cosmetics

Midkine antibodies for the treatment of fibrosis, chronic kidney disease and cancer

Midkine protein for the treatment of postischemic conditions including heart failure

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Dr David King | Chairman

An experienced independent chairman with expertise in high growth companies, David has a track record in building business ventures and developing them into attractive take-over targets.

Maria Halasz| CEO and Managing Director

With over 24 years in the life sciences sector Maria started in corporate finance before joining Cellmid ten years ago as CEO. Maria led the acquisition of the company’s current portfolio of midkine and FGF5 inhibitor assets.

Dr Martin Cross | Non-Executive Director

Dr Cross is a highly regarded pharmaceutical executive with over 30 years’ experience in industry leadership roles as Chairman of Medicines Australia, Country Head and Managing Director of Novartis Australia and Managing Director of Alphapharm.

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BOARD MEMBERS

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Bruce Gordon | Non-Executive Director

Bruce is a seasoned audit partner and corporate finance specialist with over 35 years’ industry experience. Bruce brings significant expertise in valuations, mergers and acquisitions, restructuring and transaction support.

Dr Fintan Walton | Non-Executive Director

Fintan has over 33 years experience in the global pharmaceutical and biotechnology sectors and is the founder and CEO of PharmaVentures Ltd, a leading UK based corporate advisory firm.

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FINANCIAL PERFORMANCE

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Financial Results 2014-2017 2014 2015 2016 2017
Total revenue and other income $ 1,898,037
$ 2,930,518

$ 4,611,108

$ 5,560,121
Consumer health revenue $ 1,150,931
$ 1,842,804

$ 2,962,306

$ 4,453,208
Midkine and license revenue $ 1,009,188
$ 99,263

$ 205,390

$ 247,606
R&D tax credit/grants $ 747,106
$ 988,451

$ 1,121,562

$ 831,408
Total expenditure $ 5,023,890
$ 6,301,547

$ 8,098,979

$ 9,530,994
R&D spending $ 1,660,236
$ 2,196,558

$ 2,124,360

$ 2,176,925
Current assets $ 4,499,891
$ 4,173,616

$ 5,131,104

$ 6,562,302
Sales Revenue/Expenditure* 23% 29% 36% 46%

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CONSUMER HEATH REVENUE 2014 – 2017

Consumer Health Revenue

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2014 2015 2016 2017
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TOTAL REVENUE 2014 – 2017

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Total Revenue
2014 2015 2016 2017
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Targets for 2017 Achieved in FY2017
évolis® Professional retail
partnership in the US
Signed Neiman Marcus partnership on 3 August 2017 with online launch on 1
September 2017 and stores in mid 2018.
Additional retail groups are expected to come on line.
Grow direct customer base to
10,000
Currently customer data base of around 7,000 with plans to initiate a campaign to
increase this once the new évolis® website is completed.
Increase QVC Japan sales FY2016 HIGHLIGHTS
Sales in this channel continued to increase during FY2017 with an overall Japanese
revenue increase from $2.1 million in FY2016 to $3.0 million in FY2017.
Open concept store in Japan in
late 2017
Hair Biology concept store opened on 25 October 2017 and expected to become
profitable by mid 2018
Increase sell through in Australian
pharmacies and broaden
distribution
Increased per store sales and reduced below the line marketing costs in the
pharmacy channel, increasing overall sales from $812K in FY2016 to $1.46 million in
FY2017 and opening the road to profitability
Expand distribution to other
geographical regions
Resumed Lexilis sales in China
Continued progress on Chinese e-commerce strategy
Commenced sales in New Zealand and internationally on e-commerce platform

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Additional milestones achieved Additional milestones achieved
US distribution partnership with Colour
Collective
The partnership for the development, branding and marketing of the
évolis® Professional product range was formed and as a result, three
new product ranges (REVERSE, PROMOTE and PREVENT) were developed
and launched in the US during the FY2017 financial year
Quarterly sales exceeded $1 million for the
first time in Q1 FY2017

Since October 2016 quarterly sales have been consistently on or above
$1 million for the consumer health business
US midkine patent granted for alopecia ~~FY2016 HIGHLIGHTS~~
The Company’s assets grew with another midkine alopecia patent in the
US, a major potential market
US consumer experience study was
completed
The study had 79 participants testing the entire évolis® Professional
product range. This was the first study when participants used the
Activator, Shampoo and Conditioner as a three-step system to resolve
multiple hair challenges
Chinese import permits received Import permit for Lexilis and Jo-Ju have been received and shipping to
China resumed.
FGF5 inhibitor clinical study published Published clinical study data and FGF5 inhibitory assays in the journal
_Clinical, Cosmetic and Investigational Dermatology_in Marc 2017. The
paper describes the results of the 32 patient, blinded and placebo
controlled study and the selective assays used to identify FGF5 inhibitors
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for the Company’s products.

Key objectives FY2018 and beyond

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Develop and launch new évolis® website. Building a global website with improved sales capabilities, potential for subscription and better customer data management, which is expected to result in an increase in e-commerce sales in Australia, the USA and China.

Continue to build retail partnerships. Targeting continued growth in the number of retail partnerships for the évolis® Professional range in the US and Australia, the évolis® pharmacy range in the US, Australia and Japan and the Jo-Ju and Lexilis brands in Japan and China.

Grow the professional salon business. Increase penetration into the barbershop/salon market in all three geographical FY2016 HIGHLIGHTS regions. Although the business models and margins are different, accessing the stylists, the hair experts, to represent the FGF5 inhibitor products is a key target.

Increase international sales. Primarily via e-commerce we expect to implement targeted sales campaigns to specific markets in Asia and Europe.

Continue research and development. As a key element in product leadership, and the most significant differentiating factor, we expect to continue research in hair biology and active ingredients with the view to publish new data. To that end our partnerships with research and commercial groups will play a critical part.

Continue innovation and product development. Planning to launch three new products by the end of 2018 which can be included in the pharmacy and the professional ranges.

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RESULTS OF CONSUMER USAGE STUDY

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100% 97% 96% Of users experienced Of users saw an Of users experienced less hair fall improvement in hair new hair growth texture

Of users experienced new hair growth

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87% Of users improved their position on the Hamilton Norwood/Ludwig Scales

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30 days 60 days 90 days 120 days Never

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  • In a 2017 Consumer Usage Study of 67 users conducted by Colour Collective, Dallas TX13

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REAL USERS. REAL RESULTS.

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BIG PLANS FOR HAIR

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Revive & Liftspray

Non-comedogenic dry shampoo, effortlessly refreshes hair without clogging hair follicles.

Lash Creator

Dual Purpose; lengthens and defines in one step. Formulated using FGF5 inhibiting natural actives plus lash building polymers to lengthen and thicken.

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Style & Magnifycream

Silicone free styling cream tames hair with touchable polymers while magnifying each strands circumference. Hair appears thicker, fuller and under control.

Brow Generator

Restore brows with new Brow Generator. Contains FGF5 inhibiting natural actives to replenish thin brows in 6 to 8 weeks when used daily.

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LYRA MID KINE RA

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Midkine (MK): a novel and compelling target
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Discovered in 1988, subject of over 815 publications (300+ in oncology)*

  • Retinoic acid-inducible heparin binding growth factor critical for cell-cell interactions in organ development

  • Prominent in embryogenesis and wound healing but barely detectable in healthy adults

  • MK expression in cancer is strongly prognostic of poor patient outcomes

  • Biological activities include:

  • Pro-angiogenic (especially in hypoxic settings)

  • Enhances aberrant lymphangiogenesis

  • Facilitates cell migration (metastasis)

  • Immuno-modulatory

  • Anti-apoptotic

  • Promotes inflammatory cell tissue infiltration

  • Promotes cell growth and differentiation

Inappropriate activation in chronic conditions creates vicious cycle leading to inflammatory disorders and cancer

Lim et al (2013) Biochem J Pedro Nieto-Solera et al (2016) Chem Eur J

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CONFIDENTIAL

* PubMed keyword search “midkine” July 2017

Targets for 2017

Achievements in FY2017

LYRA MID KINE RA

Continue preclinical Secured Australian government funding for pre-clinical kidney program development of antibody and Continued collaboration on glioblastoma program midkine assets Continued collaboration on our bone healing program Commenced preclinical efficacy studies in chronic kidney disease at Westmead Commenced preclinical efficacy studies in chronic kidney disease at Macquarie University Developed validation protocol for large animal study for midkine in myocardial infarct FY2016 HIGHLIGHTS Increase KOL engagement and Publication in Nature demonstrating key role of midkine in metastatic melanoma midkine’s profile in the clinical Set up relationships with leading experts in kidney disease, heart disease, cancer, and community as a validated inflammatory diseases disease target Presented data on midkine in a number of clinical and research meetings Pursue partnerships for Lyramid Engaged with a number of biotechnology and pharma companies as well as and Kinera specialised venture funds and charitable organisations to secure partnership for the clinical development of the midkine assets

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Key objectives for Lyramid and Kinera for FY2018 and beyond

Secure partnerships to complete preclinical studies and enter clinical development. Lyramid and Kinera together have the largest intellectual property assets around midkine, a novel therapeutic target and agent. Both companies have reached a late pre-clinical stage and will require substantial funding to enter clinical development. It FY2016 HIGHLIGHTS is envisaged that funding for these programs will be secured through partnerships. Continue to build efficacy and safety evidence to strengthen asset base. There has been a strong body of preclinical efficacy and clinical diagnostic evidence around midkine’s importance in a number of disease indications. Lyramid and Kinera have a research collaborations that will continue to strengthen our position for a partnerships, create new intellectual property opportunities and increase asset value.

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SUMMARY

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  • Balanced portfolio of life sciences assets with strong global revenue growth from consumer health

  • Track record of delivering sales growth year on year in the consumer health division

  • Revenue growth expected to continue as entering major new markets in USA and China

  • High value midkine assets close to clinical development subject to securing development partnerships

  • Experienced management team and strong partners to deliver on growth prospects

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Cellmid Limited

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Suite 1802, Level 18, 15 Castlereagh Street Sydney NSW 2000 AUSTRALIA T: +61 2 9221 6830 F: +61 2 9233 8975 www.cellmid.com.au www.evolisproducts.com.au www.evolisprofessional.com.au

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