AMPLIA THERAPEUTICS LIMITED — Director's Dealing 2021

Dec 20, 2021

ABN 16 165 160 841

21 December 2021

ASX RELEASE

==> picture [165 x 52] intentionally omitted <==

Change of Director’s Interest Notice – Appendix 3Y: Dr Warwick Tong

Appendix 3Y Change of Director’s Interest Notice for Dr. Warwick Tong is attached.

This ASX announcement was approved and authorised for release by the Company Secretary of Amplia Therapeutics Limited.

• End -

For further information:

Andrew J. Cooke Company Secretary andrew@ampliatx.com www.ampliatx.com

About Amplia Therapeutics Limited

Amplia Therapeutics Limited is an Australian pharmaceutical company advancing a pipeline of Focal Adhesion Kinase (FAK) inhibitors for cancer and fibrosis. FAK is an increasingly important target in the field of cancer immunology and Amplia has a particular development focus in pancreatic and ovarian cancer. FAK also plays a significant role in a number of chronic diseases, such as idiopathic pulmonary fibrosis (IPF).

Level 21, 90 Collins Street, Melbourne VIC 3000

Email info@ampliatx.com

www.ampliatx.com

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity Amplia Therapeutics Limited ABN 16 165 160 841

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Warwick Bonner Tong
Date of last notice	18 September 2020

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Direct
Nature of indirect interest(including registered holder)Note: Provide details of the circumstancesgiving rise to the relevant interest.
Date of change	15 December 2021
No. of securities held prior to change	2,355,140 Fully Paid Ordinary Shares400,000 Fully Paid Ordinary Shares40,000 Options Exercise Price A$0.15 Expiry Date 30 June2022125,000 Options Exercise Price A$0.15 Expiry Date 30 June2022
Class	Fully Paid Ordinary SharesATXO Listed Options Ex Price $0.28 Exp 31 Dec 2023
Number acquired	100,000 Shares33,334 ATXO Listed Options

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

Number disposed	Nil
Value/ConsiderationNote: If consideration is non-cash, providedetails and estimated valuation	$0.18 per share (with free attaching Option on 1 for 3basis)
No. of securities held after change	2,355,140 Fully Paid Ordinary Shares500,000 Fully Paid Ordinary Shares40,000 Options Exercise Price A$0.15 Expiry Date 30 June2022125,000 Options Exercise Price A$0.15 Expiry Date 30 June202233,334 ATXO Listed Options Ex Price $0.28 Exp 31 Dec 2023
Nature of changeExample: on-market trade, off-market trade,exercise of options, issue of securities underdividend reinvestment plan, participation inbuy-back	Participation in Entitlement Offer

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Nil
Nature of interest
Name of registered holder(if issued securities)
Date of change
No. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changed
Interest acquired
Interest disposed
Value/ConsiderationNote: If consideration is non-cash, provide detailsand an estimated valuation
Interest after change

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

Part 3 –[+] Closed period

Part 3 –+Closed period
Were the interests in the securities or contracts detailedabove traded during a+closed period where prior writtenclearance was required?	No
If so, was prior written clearance provided to allow the tradeto proceed during this period?
If prior written clearance was provided, on what date was thisprovided?

21 December 2021

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 3