AMP LIMITED — Major Shareholding Notification 2007

Aug 30, 2007

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Date: 31-Aug-07

The Manager Listings Department Australian Stock Exchange Limited

No. of Pages (incl.): 2

NOTICE OF CHANGE OF INTERESTS OF SUBSTANTIAL HOLDER

Dear Sir/Madam,

Pursuant to Section 671B of the Corporations Law, AMP Limited hereby advises of a change in its relevant interest in Prana Biotechnology Limited.

The enclosed ASIC Form 604 discloses all required details.

Yours faithfully,

Justin Christopher Head of Custody BNP Paribas Securities Services Phone: 02 9222 0029

BNP PARIBAS FUND SERVICES AUSTRALASIA PTY LTD Level 6 60 Castlereagh Street Sydney NSW 2000 Australia PO BOX R209 Royal Exchange NSW 1225 Australia Tel: +61 2 9222 0000 - Fax: +61 2 9222 0255 ABN 71 002 655 674

Form 604 Corporations Law Section 671B

Notice of Change of Interests of Substantial Holder

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----- Start of picture text ----- To: Prana Biotechnology LimitedACN/ARSN: 080 699 0651. Details of substantial holderName: AMP Limited ACN 079 354 519 and its related bodies corporate.There was a change in the interests of the substantial holder on 29-Aug-2007The previous notice was given to the company on 15-Dec-2006The previous notice was dated 13-Dec-20062. Previous and present voting powerThe total number of votes attached to all the voting shares in the company or voting interests in thescheme that the substantial holder or an associate had a relevant interest in when last required,and when now required, to give a substantial holding notice to the company or scheme, are as follows:Previous notice Present noticeClass of securities Person’s votes Voting power Person’s votes Voting powerFully Paid Ordinary 11,204,482 7.78% 9,641,383 6.36%----- End of picture text -----

3. Changes in relevant interests

Particulars of each change in, or change in the nature of, relevant interests of the substantial holder or an associate in voting securities of the company since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

	Person whose relevant		Consideration given in	Class and number		Person’s votes
Date of change	interest changed	Nature of change	relation to change	of shares affected		affected
				Fully Paid Ordinary
				Shares
23-Feb-2007to1-May-2007	AMP LifeLimited	Share acquisition	$124,737.93	336,250		336,250
				Fully Paid Ordinary
				Shares
4-Apr-2007to20-Aug-2007	AMP LifeLimited	Share disposal	-$27,391.16	-77,258		-77,258
				Fully Paid Ordinary
				Shares
19-Feb-2007to20-Aug-2007	ARIAScheme	Share disposal	-$58,178.30	-157,559		-157,559
				Fully Paid Ordinary
	Cogent Nominees Pty			Shares
16-Aug-2007to20-Aug-2007	Limited	Share disposal	-$22,309.06	-76,408		-76,408
				Fully Paid Ordinary
				Shares
19-Feb-07	CogentNomineesPtyLimiteShare acquisition		$3,839.63	10,239		10,239
				Fully Paid Ordinary
				Shares
23-Feb-2007to20-Aug-2007	CogentNomineesPtyLimiteShare disposal		-$610,371.00	-1,855,724		-1,855,724
				Fully Paid Ordinary
	Government Employees			Shares
4-Apr-07	Superannuation Board	Share acquisition	$96,274.00	260,200		260,200
				Fully Paid Ordinary
	Government Employees			Shares
16-Aug-2007to20-Aug-2007	Superannuation Board	Share disposal	-$828.92	-2,839		-2,839

4. Present relevant interests

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:

	Registered holder of	Person entitled to be		Class and number	Person’s votes
Holder of relevant interest	securities	_registered as holder _	Nature of relevant interest	of securities	affected
AMP Life Limited	AMP Life Limited	AMP Life Limited	AMP Life is entitled to be	Fully Paid Ordinary:	2,236,889
			the registered holder of the	2,236,889
			class and number of
			securities listed beside its
			name AMP Life Limited is a
			controlled body corporate of
			AMP Limited within the
			meaning of Section 608(3)
			of the Corporations Law
AMP Capital Investors Limited	Cogent Nominees Pty	Cogent Nominees Pty	AMP Capital, in its capacity	Fully Paid Ordinary:	5,637,224
('AMP Capital')	Limited	Limited <SMP	as the investment manager	5,637,224
		Accounts>	for the persons or trusts
			listed besides its name, has
			the power to control voting
			and/or the disposal of
			securities. AMP Capital is a
			controlled body corporate of
			AMP Limited within the
			meaning of Section 608(3)
			of the Corporations Law
	Cogent Nominees Pty	Cogent Nominees Pty		Fully Paid Ordinary:	896,611
	Limited	Limited		896,611
	JP Morgan Nominees	Public Sector Super		Fully Paid Ordinary:	613,298
	AustraliaLimited	Scheme		613,298
	National Nominees Pty	QLD Local Government		Fully Paid Ordinary:	257,361
	Limited	Superannuation Board		257,361
		of WA - Sustainable
		Fund
				Total:	9,641,383

5. Change in association

The persons who have become associates of, ceased to be associates of, or have changed the nature of their association with, the substantial shareholder in relation to voting interests In the company or scheme are as follows:

Name and ACN Nature of association No Changes

6. Addresses

The addresses of persons named in this form are as follows:

Name Address AMP Life Limited Level 24, 33 Alfred Street, Sydney NSW 2000 Cogent Nominees Pty Limited Level 6, 60 Castlereagh Street, Sydney NSW 2000 Government Employee Superannuation Board PO Box J755, Perth WA 6842 JP Morgan Nominees Australia Limited 259 George Street, Sydney NSW 2000 QLD Local Government Superannuation Board Of GPO Box 264, Brisbane QLD 4001

This notice of change of interests of substantial holder (ASIC Form 604) comprises 1 page/s in total.