AMICUS THERAPEUTICS, INC. — Major Shareholding Notification 2014

Jun 3, 2014

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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

Amicus Therapeutics, Inc.

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(Name of Issuer)

Common Stock

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(Title of Class of Securities)

03152W109

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(CUSIP Number)

May 31, 2014

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(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

| o | Rule
13d-1(b) |
| --- | --- |
| x | Rule
13d-1(c) |
| o | Rule
13d-1(d) |

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

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CUSIP No. 03152W109 13G Page 2 of 8 Pages

| 1. — 2. | names
of reporting persons i.r.s.
identification no. of above persons (entities only) Perceptive
Advisors LLC — check
the appropriate box if a group* | | ( a) o ( b) o |
| --- | --- | --- | --- |
| 3. | sec
use only | | |
| 4. | citizenship
or place of organization Delaware,
United States of America | | |
| number
of shares | 5. | sole
voting power | 0 |
| beneficially owned by | 6. | shared
voting power | 8,339,444 |
| each reporting | 7. | sole
dispositive power | 0 |
| person
with: | 8. | shared
dispositive power | 8,339,444 |
| 9. | aggregate
amount beneficially owned by each reporting person | | 8,339,444 |
| 10. | check
box if the aggregate amount in row (9) excludes certain shares (See Instructions) | | o |
| 11. | percent
of class represented by amount in row (9) | | 12.96% |
| 12. | type
of reporting person (See Instructions) | | IA |

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CUSIP No. 03152W109 13G Page 3 of 8 Pages

| 13. — 14. | names
of reporting persons i.r.s.
identification no. of above persons (entities only) Joseph
Edelman — check
the appropriate box if a group* | | ( a) o ( b) o |
| --- | --- | --- | --- |
| 15. | sec
use only | | |
| 16. | citizenship
or place of organization United
States of America | | |
| number
of shares | 17. | sole
voting power | 0 |
| beneficially owned by | 18. | shared
voting power | 8,339,444 |
| each reporting | 19. | sole
dispositive power | 0 |
| person
with: | 20. | shared
dispositive power | 8,339,444 |
| 21. | aggregate
amount beneficially owned by each reporting person | | 8,339,444 |
| 22. | check
box if the aggregate amount in row (9) excludes certain shares (See Instructions) | | o |
| 23. | percent
of class represented by amount in row (9) | | 12.96% |
| 24. | type
of reporting person (See Instructions) | | IN |

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CUSIP No. 03152W109 13G Page 4 of 8 Pages

| 25. — 26. | names
of reporting persons i.r.s.
identification no. of above persons (entities only) Perceptive
Life Sciences Master Fund Ltd — check
the appropriate box if a group* | | ( a) o ( b) o |
| --- | --- | --- | --- |
| 27. | sec
use only | | |
| 28. | citizenship
or place of organization Cayman
Islands | | |
| number
of shares | 29. | sole
voting power | 0 |
| beneficially owned by | 30. | shared
voting power | 7,283,425 |
| each reporting | 31. | sole
dispositive power | 0 |
| person
with: | 32. | shared
dispositive power | 7,283,425 |
| 33. | aggregate
amount beneficially owned by each reporting person | | 7,283,425 |
| 34. | check
box if the aggregate amount in row (9) excludes certain shares (See Instructions) | | o |
| 35. | percent
of class represented by amount in row (9) | | 11.32% |
| 36. | type
of reporting person (See Instructions) | | FI |

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CUSIP No. 03152W109 13G Page 5 of 8 Pages

ITEM 1.

(a) Name of Issuer: Amicus Therapeutics, Inc.

(b) Address of Issuer’s Principal Executive Offices: 1 Cedar Brook Drive Cranbury, NJ 08512

| Item
2. | |
| --- | --- |
| (a) Name
of Person Filing: | This
Schedule 13G (the “Schedule”) is being filed with respect to shares of Common Stock (as defined below) of Amicus
Therapeutics, Inc. ( the “Issuer”) which are beneficially owned
by Perceptive Advisors LLC, Joseph Edelman and Perceptive Life Sciences Master Fund Ltd. (together, the “Reporting Persons”). See
Item 4 below. |

(b) Address of Principal Business Office or, if none, Residence: 499 Park Avenue, 25 th Floor New York, NY 10022

(c) Citizenship: Perceptive Advisors LLC is a Delaware limited liability company, Joseph Edelman is a United States Citizen and Perceptive Life Sciences Master Fund Ltd is a Cayman Islands exempted company.

(d) Title of Class of Securities: Common Stock

(e) CUSIP Number: 03152W109

ITEM 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

| (a) | o | Broker
or dealer registered under section 15 of the Act (15 U.S.C. 78o). |
| --- | --- | --- |
| (b) | o | Bank
as defined in section 3(a)(6) of the Act (15 U.S.C. 78c). |
| (c) | o | Insurance
company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c). |
| (d) | o | Investment
company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8). |
| (e) | o | An
investment adviser in accordance with §240.13d-1(b)(1)(ii)(E); |
| (f) | o | An
employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F); |
| (g) | o | A
parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G); |
| (h) | o | A
savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813); |
| (i) | o | A
church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company
Act of 1940 (15 U.S.C. 80a-3); |
| (j) | o | Group,
in accordance with §240.13d-1(b)(1)(ii)(J). |

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CUSIP No. 03152W109 13G Page 6 of 8 Pages

ITEM 4. Ownership.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned: Perceptive Advisors LLC and Joseph Edelman beneficially own 8,339,444 shares of Common Stock, 7,283,425 of which are held by Perceptive Life Sciences Master Fund Ltd, a private investment fund (the “Fund”) to which Perceptive Advisors LLC serves as the investment manager, and 1,056,019 of which are held in a trading account (the “Account”) to which Perceptive Advisors LLC serves as the investment manager. Mr. Edelman is the managing member of Perceptive Advisors LLC.

(b) Percent of class: Perceptive Advisors LLC’s and Joseph Edelman’s beneficial ownership of 12.96%, and Perceptive Life Sciences Master Fund Ltd’s beneficial ownership of 11.32%, is based on the sum of 64,340,526 shares of Common Stock as reflected on the Issuer’s Form 10-Q filed with the SEC on May 5, 2014.

(c) Number of shares as to which the person has: Perceptive Advisors LLC and Joseph Edelman:

(i)	Sole power to vote or to direct the vote:	0
(ii)	Shared power to vote or to direct the vote:	8,339,444
(iii)	Sole power to dispose or to direct the disposition of:	0
(iv)	Shared power to dispose or to direct the disposition of:	8,339,444

Perceptive Life Sciences Master Fund Ltd:

(i)	Sole power to vote or to direct the vote:	0
(ii)	Shared power to vote or to direct the vote:	7,283,425
(iii)	Sole power to dispose or to direct the disposition of:	0
(iv)	Shared power to dispose or to direct the disposition of:	7,283,425

ITEM 5. Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: o .

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CUSIP No. 03152W109 13G Page 7 of 8 Pages

ITEM 6. Ownership of More Than Five Percent on Behalf of Another Person.

The Fund and the Account described in Item 4 have the right to receive or the power to direct the receipt of dividends from, or the proceeds from, the sale of the securities held in its account. Filing of this statement by the Reporting Persons shall not be deemed an admission that they beneficially own the securities reported herein. The Reporting Persons expressly disclaim beneficial ownership of all securities reported herein.

ITEM 7. Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

Not applicable.

ITEM 8. Identification and Classification of Members of the Group.

Not applicable.

ITEM 9. Notice of Dissolution of Group.

Not applicable.

Item 10.	Certification.
(a)	The following certification
shall be included if the statement is filed pursuant to §240.13d-1(c): By signing below I certify that, to
the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or
with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or effect. x

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CUSIP No. 03152W109 13G Page 8 of 8 Pages

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

June 3, 2014
Date
PERCEPTIVE ADVISORS LLC
/s/ Joseph Edelman
Signature
Joseph Edelman/Managing Member
Name/Title
June 3, 2014
Date
/s/ Joseph Edelman
Signature
Joseph Edelman
Name/Title
June 3, 2014
Date
PERCEPTIVE LIFE SCIENCES MASTER FUND LTD
By: Perceptive Advisors LLC
/s/ Joseph Edelman
Signature
Joseph Edelman/Managing Member
Name/Title

The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative’s authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature.

NOTE : Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties for whom copies are to be sent.

Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001)