Alpha Cognition Inc. — Director's Dealing 2026

Feb 24, 2026

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Alpha Cognition Inc. (ACOG)
CIK: 0001655923
Period of Report: 2026-02-20

Reporting Person: Opaleye Management Inc. (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2026-02-20	Common Stock, no par value	P	10000	$5.8411	Acquired	2135000	Indirect
2026-02-20	Common Stock, no par value	P	2819	$5.8411	Acquired	70819	Indirect
2026-02-23	Common Stock, no par value	P	95819	$5.8923	Acquired	2230819	Indirect
2026-02-23	Common Stock, no par value	P	4181	$5.8923	Acquired	75000	Indirect
2026-02-24	Common Stock, no par value	P	53591	$5.8004	Acquired	2284410	Indirect
2026-02-24	Common Stock, no par value	P	5000	$5.8004	Acquired	80000	Indirect

Footnotes

F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

F3: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.75 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F4: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.59 to $5.99. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F5: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.615 to $5.95. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.