Alkermes plc. — Director's Dealing 2017

Nov 9, 2017

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Alkermes plc. (ALKS)
CIK: 0001520262
Period of Report: 2017-06-09

Reporting Person: FRATES JAMES M (SVP, Alks Inc; CFO ALKS)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2017-06-09	Ordinary Shares	G	2000	—	Disposed	127477	Direct
2017-11-08	Ordinary Shares	M	20932	$12.29	Acquired	164971	Direct
2017-11-08	Ordinary Shares	S	20932	$47.5831	Disposed	144039	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2017-11-08	Employee Stock Option (Right to Buy)	$12.29	M	20932	Disposed	2018-05-27	Ordinary Shares (20932)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares	4000	Indirect
Ordinary Shares	31940	Indirect
Ordinary Shares	11421	Indirect

Footnotes

F1: Includes 16,562 shares received on August 1, 2017 pursuant to an annuity payment from the James M. Frates Grantor Retained Annuity Trust dated May 29, 2015 (the "2015 GRAT"), which was exempt from reporting obligations
by virtue of Rule 16a-13 promulgated under the Securities Exchange Act of 1934, as amended.

F2: This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 6/9/17.

F3: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 6/9/17.

F4: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $47.06 to $48.00. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5: Shares held by James M. Frates Grantor Retained Annuity Trust dated March 14, 2014 (the "2014 GRAT"). The Reporting Person is a trustee and beneficiary of the 2014 GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2014 GRAT.

F6: Shares held by the James M. Frates Grantor Retained Annuity Trust No. 2 dated November 25, 2015 (the "2015 GRAT No. 2"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT No. 2.

F7: These options are fully vested in accordance with their terms.