Alkermes plc. — Director's Dealing 2016

Oct 7, 2016

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Alkermes plc. (ALKS)
CIK: 0001520262
Period of Report: 2016-10-05

Reporting Person: FRATES JAMES M (SVP, Alks Inc; CFO ALKS)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2016-08-04	Ordinary Shares	G	4437	—	Disposed	61924	Direct
2016-10-05	Ordinary Shares	M	5000	—	Acquired	91785	Direct
2016-10-05	Ordinary Shares	F	2353	$46.43	Disposed	89432	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2016-10-05	Performance Restricted Stock Units	$	M	5000	Disposed		Ordinary Shares (5000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares	4000	Indirect
Ordinary Shares	41041	Indirect
Ordinary Shares	16562	Indirect
Ordinary Shares	30000	Indirect

Footnotes

F1: Includes 9,760 shares received on June 2, 2016 pursuant to an annuity payment from the James M. Frates Grantor Retained Annuity Trust dated March 14, 2014 (the "2014 GRAT"), which was exempt from reporting obligations by virtue of Rule 16a-13 promulgated under the Securities Exchange Act of 1934, as amended.

F2: Includes 24,861 shares received on September 9, 2016 pursuant to an annuity payment from the James M. Frates Grantor Retained Annuity Trust dated May 29, 2015 (the "2015 GRAT"), which was exempt from reporting obligations by virtue of Rule 16a-13 promulgated under the Securities Exchange Act of 1934, as amended.

F3: Shares held by James M. Frates Grantor Retained Annuity Trust dated March 14, 2014 (the "GRAT"). The Reporting Person is a trustee and beneficiary of the GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the GRAT.

F4: Shares held by the James M. Frates Grantor Retained Annuity Trust dated May 29, 2015 (the "2015 GRAT"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT.

F5: Shares held by the James M. Frates Grantor Retained Annuity Trust No. 2 dated November 25, 2015 (the "2015 GRAT No. 2"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT No. 2.

F6: Each performance restricted stock unit represented a contingent right to receive one ordinary share of Alkermes plc.

F7: This performance restricted stock unit, which was granted to the reporting person on March 3, 2014, is fully vested in accordance with its terms.