Alkermes plc. — Director's Dealing 2014

May 9, 2014

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Alkermes plc. (ALKS)
CIK: 0001520262
Period of Report: 2014-05-07

Reporting Person: FRATES JAMES M (SVP & CFO, Alkermes plc)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2014-05-07	Ordinary Shares	M	1870	$12.30	Acquired	38514	Direct
2014-05-07	Ordinary Shares	M	5130	$14.90	Acquired	43644	Direct
2014-05-07	Ordinary Shares	S	6000	$45.5962	Disposed	37644	Direct
2014-05-07	Ordinary Shares	S	1000	$46.78	Disposed	36644	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2014-05-07	Non Qualified Stock Option (Right to Buy)	$12.30	M	1870	Disposed	2014-07-12	Ordinary Shares (1870)	Direct
2014-05-07	Non Qualified Stock Option (Right to Buy)	$14.90	M	5130	Disposed	2014-12-17	Ordinary Shares (5130)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares	4000	Indirect
Ordinary Shares	57000	Indirect

Footnotes

F1: This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.30 to $45.86. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4: Shares held by James M. Frates Grantor Retained Annuity Trust dated March 14, 2014 (the "GRAT"). The Reporting Person is a trustee and beneficiary of the GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the GRAT.

F5: These options are fully vested in accordance with their terms.