AGIOS PHARMACEUTICALS, INC. — Director's Dealing 2015

May 28, 2015

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: AGIOS PHARMACEUTICALS INC (AGIO)
CIK: 0001439222
Period of Report: 2015-03-12

Reporting Person: Schenkein David P (Director, Chief Executive Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2015-03-12	Common stock	G	190	$0.00	Disposed	94511	Indirect
2015-05-27	Common stock	S	8929	$120.05	Disposed	85582	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common stock	238772	Indirect

Footnotes

F1: Reflects a gift of shares from the reporting person to Brother Wolf Animal Rescue.

F2: Shares held by Amy P. Schenkein 2004 Revocable Trust, of which the reporting person's spouse is trustee and beneficiary.

F3: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $120.00 to $120.81. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F5: Shares held by David P. Schenkein 2004 Revocable Trust, of which the reporting person is trustee and beneficiary.