ADHERIUM LIMITED — Share Issue/Capital Change 2017

Apr 17, 2017

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Adherium Limited Collins Square, Tower 4 Level 18, 727 Collins Street Melbourne VIC 3000 Australia

18 April 2017

Level 2, 204 Quay Street Auckland 1010 New Zealand

ASX Market Announcements ASX Limited Level 4 North Tower, Rialto 525 Collins Street Melbourne VIC 3000

Dear Sir/Madam

BUY BACK AND CANCELLATION OF EMPLOYEE SHARE PLAN LOAN-FUNDED SHARES

Adherium Limited (ASX:ADR) confirms 708,383 ordinary shares have now been cancelled as per the previous notification (refer Appendix 3B dated 31[st] March 2017).

Following this cancellation, the number of listed ordinary shares is 136,205,168 and the total number of ordinary shares on issue is 171,699,192. The difference being those ordinary shares currently held in escrow and due for release on 26[th] August 2017.

In accordance with Listing Rule 3.8A, we attach a copy of the ASIC Form 484 lodged with ASIC today to reflect this share cancellation.

Yours faithfully

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Rob Turnbull

Chief Financial Officer and Joint Company Secretary