ADHERIUM LIMITED — Major Shareholding Notification 2021

May 9, 2021

Form 604 Corporations Act 2001 Section 671B

Notice of Change of Interests of Substantial Holder

To: ADHERIUM LIMITED

ACN/ARSN:

1. Details of substantial holder (1)

Name: FIL Limited and the entities listed in Annexure A ("FIL") ACN/ARSN (if applicable)

There was a change in the interests of the substantial holder on The previous notice was given to the company on The previous notice was dated

07 May 2021 10 June 2020 10 June 2020

2. Previous and present voting power

The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows:

Class of	Previous Notice	Previous Notice	Present Notice	Present Notice
Securities (4)	Person’s votes	Voting Power (5)	Person’s votes	Voting Power (5)
COMMON	44,681,769	7.43%	211,645,356	9.96%
STOCK

3. Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

Date of	Person	Nature of	Consideratio	Class and	Person’s votes
Change	whose	change (6)	n given in	number of	affected
	relevant		relation to	securities
	interest		change (7)	affected
	changed
				COMMON	COMMON
				STOCK	STOCK
03/24/2021	FIL	PLACEMENT	0.0150 AUD	2,454,822	2,454,822
03/24/2021	FIL	PLACEMENT	0.0150 AUD	21,184,300	21,184,300
05/07/2021	FIL	PLACEMENT	0.0150 AUD	14,883,636	14,883,636
05/07/2021	FIL	PLACEMENT	0.0150 AUD	128,440,829	128,440,829
			Total	166,963,587	166,963,587
			Placement

4. Present Relevant Interest

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:

Refer to Annexure A

5. Changes in Association

The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows:

Name and ACN/ARSN (if applicable) Nature of association N/A

6. Addresses

The addresses of persons named in this form are as follows:

Refer to Annexure A

==> picture [107 x 45] intentionally omitted <==

Sign Here ____________________________________

Dated: 07 May 2021 Jen Li

Head of Regulatory Reporting, Asia Pacific Duly authorized under Powers of Attorney by and on behalf of FIL Limited

Annexure A

	Investment Manager	Address	Custodian	Nature of Relevant Interest	Sum of Numerator Shares
	FIL Investment	Level 21, Two Pacific	BROWN BROS HARRIMN
					192,315,918
	Management (Hong	Place, 88 Queensway,	LTD LUX(C)
	Kong) Limited	Admiralty, Hong Kong	CLEARSTREAM BANKING
				Investment Discretion /	18,812,311
			SA LUX(C)
				Voting Power
	FIL Limited	Pembroke Hall, 42
			STATE STREET BANK
		Crow Lane, Pembroke,			517,127
			AND TR CO
		Bermuda
	Grand Total				211,645,356